Pipe stent with double-layered structure and preparation method of pipe stent

A pipeline stent, double-layer structure technology, applied in stents, medical science, surgery, etc., can solve the problem of poor biocompatibility of stents, and achieve the effects of excellent therapeutic effect, simple formula and low energy consumption

Inactive Publication Date: 2012-07-25
广西南宁博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing stents are not very biocompatible

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step 1: Fully mix the mixture of 9g polylactic acid and 0.5g barium sulfate with 100ml solvent methylene chloride to obtain suspension A;

[0023] Step 2: Add the stirred suspension A to 1 ml / cm in the fume hood 2 The ratio of is poured into the glass tank mold Z, and kept ventilated in the fume hood for a certain period of time, until the surface of the film B obtained by the solution volatilization has no specular reflection;

[0024] Step 3: 5g chitosan is dissolved in 100ml 2wt% acetic acid solution, press 1 ml / cm 2 The ratio is poured into the glass tank mold Z with film B at the bottom, and kept ventilated in the fume hood for a certain period of time until the chitosan solution forms a film on film B to obtain composite film C;

[0025] Step 4: Cut the double-layer film C into a strip with a width of 3mm with a blade, and wrap the strip-shaped double-layer film on an iron wire or a small rod with a diameter of 5mm. The adjacent winding strips neither overlap nor...

Embodiment 2

[0029] Step 1: Fully mix the mixture of 8g polylactic acid and 0.5g barium sulfate with 100ml solvent methylene chloride to obtain suspension A;

[0030] Step 2: In the fume hood, mix the stirred suspension A with 0.5 ml / cm 2 The ratio of is poured into the glass tank mold Z, and kept ventilated in the fume hood for a certain period of time, until the surface of the film B obtained by the solution volatilization has no specular reflection;

[0031] Step 3: Dissolve 8g chitosan in 100ml 2wt% acetic acid solution, press 1 ml / cm 2 The ratio is poured into the glass tank mold Z with film B at the bottom, and kept ventilated in the fume hood for a certain period of time until the chitosan solution forms a film on film B to obtain composite film C;

[0032] Step 4: Cut the double-layer film C into a strip with a width of 3mm with a blade, and wrap the strip-shaped double-layer film on an iron wire or a small rod with a diameter of 7mm. The adjacent winding strips neither overlap no...

Embodiment 3

[0036] Step 1: Fully mix the mixture of 9g poly-L-lactic acid (PLLA) and 0.5g barium sulfate with 100ml solvent methylene chloride to obtain suspension A;

[0037] Step 2: Add the stirred suspension A to 1 ml / cm in the fume hood 2 The ratio of is poured into the glass tank mold Z, and kept ventilated in the fume hood for a certain period of time, until the surface of the film B obtained by the solution volatilization has no specular reflection;

[0038] Step 3: 5g chitosan is dissolved in 100ml 2wt% acetic acid solution, press 1 ml / cm 2 The ratio is poured into the glass tank mold Z with film B at the bottom, and kept ventilated in the fume hood for a certain period of time until the chitosan solution forms a film on film B to obtain composite film C;

[0039] Step 4: Cut the double-layer film C into a strip with a width of 3mm with a blade, and wrap the strip-shaped double-layer film on an iron wire or a small rod with a diameter of 8mm. The adjacent winding tapes neither ov...

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Abstract

A pipe stent with a double-layered structure comprises an inner layer and an outer layer. Components of the inner layer include polylactic acid and barium sulfate, the weight ratio of the polylactic acid to the barium sulfate is 1-100:1, components of the outer layer include one or more than one of chitosan, hyaluronic acid and collagen, the thickness of the inner layer ranges from 0.1mm to 2mm, and the thickness of the outer layer ranges from 0.01mm to 1mm. The multilayered pipe stent is a degradable pipe stent, the inner layer is a substrate layer and consists of degradable high polymers, the outer layer consists of one or more than one natural high polymers and has the function of antibiosis repair, and stimulation to a pipe due to the stent is relieved. The stent is non-toxic, can be absorbed completely, and is excellent in treatment effect after being tested and verified in an animal experiment. In addition, the method is simple in formula and feasible in preparation process, and has the advantages of low temperature, vacuum, energy consumption and pollution, and the like.

Description

Technical field [0001] The present invention is the field of biomedical materials technology, especially the caner pipeline brackets and preparation methods involving good biocompatibility. Background technique [0002] In clinical practice, human pipelines are often encountered, such as narrow urethra, biliary stenosis, etc.Due to the prostate hyperplasia causes urethral stenosis and causes urine retention; benign urethra hyperplasia, urethral tumor disease is accompanied by posterior urethral stenosis and obstruction can also cause urinary retention.The current commonly used method is to place a bracket in the narrowing of the urethra, which holds the narrow or obstructive urethra in the stenosis.Biliary stents are also needed during biliary surgery.The existing brackets are generally made of stainless steel, synthetic fiber silicone or nickel titanium alloy, and the stenosis of the pipeline expands the original narrow -closed pipeline.The existing stent biocompatibility is not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L31/12
Inventor 甘少磊
Owner 广西南宁博恩康生物科技有限公司
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