36 results about "Coronary stent" patented technology

The invention relates to the technical field of medical engineering, in particular to a hemodynamic simulation analysis system for coronary stent implantation. The system comprises a coronary blood vessel anatomical structure aided design module, a coronary stent finite element model design module, a post-implantation hemodynamic simulation analysis module and a pre-implantation and post-implantation blood flow state evaluation module, and can obtain coronary medical image data of a patient and perform blood vessel anatomical structure geometric analysis and blood vessel three-dimensional model aided design. Generating a three-dimensional model of the coronary vessel anatomical structure of the patient; a coronary stent finite element model is designed and generated through a geometric feature set of the coronary stent, a hemodynamic feature parameter set before stent implantation is obtained, blood flow boundary limitation analysis and coronary stent implantation dynamics simulation analysis are carried out, and meanwhile blood flow state evaluation analysis before and after stent implantation is carried out. And generating a blood flow state simulation evaluation report before and after stent implantation. According to the method, the change of the blood flow state after the stent is implanted can be efficiently and accurately analyzed.

The invention provides a three-dimensional semi-supervised segmentation method and device for a stent in a coronary artery. The method comprises the steps that an initial image to be segmented is input into a three-dimensional semi-supervised segmentation deep learning network model trained in advance, the three-dimensional semi-supervised segmentation deep learning network model comprises a shared encoder, a BiFormer module and a decoding module which are connected in sequence, and the decoding module comprises a plurality of decoders adopting different attention mechanisms; the average value of result prediction probabilities output by all decoders in the decoding module is obtained, a prediction result is obtained, and three-dimensional segmentation of the stent in the coronary artery is achieved; in the model training process, model parameter optimization is carried out through a plurality of generated prediction output results with perception deviation and a cross pseudo-supervised training strategy. According to the three-dimensional semi-supervised segmentation deep learning network model designed by the invention, the problem that model training lacks annotation supervision is solved, model parameters are optimized through a cross pseudo-supervised training strategy, and the problem that segmentation of a support depends on the number of annotated data is solved.

The invention relates to a degradable coronary stent with a negative Poisson's ratio structure and an optimization design method of the degradable coronary stent, aims to make up for the defects of comprehensive mechanical properties of an existing stent, and belongs to the field of interventional medical instruments. The stent structure is formed by arranging concave hexagons serving as representative structural units in the axial direction and the circumferential direction, and the stent structure is made of degradable polymers. According to the optimization design method, on the basis that finite element simulation analysis is conducted on key mechanical properties of the support, an optimization problem is defined, design parameters are used for representing the geometrical shape of the support, a design space is established, a Kriging agent model and finite element simulation are combined to determine the approximate relation between an optimization target and the design parameters, and the optimization problem is solved. And multi-objective optimization is carried out through the NSGA-II. And when the optimal solution meets a convergence condition, outputting a final optimization design result of the stent. By adopting the optimization design method of the proxy model, the precision is ensured while the design efficiency is improved, and the optimized degradable coronary stent with the negative Poisson's ratio structure shows excellent comprehensive mechanical properties.

The invention provides a coronary stent with a gradually-changed section length structure, which adopts a degradable zinc-based material matrix and comprises the following components in percentage by mass: 0.4-0.1% of Li, 0.8-0.05% of Mn and the balance of zinc. A degradable polymer or a metal coating with drugs can be arranged on the surface of the stent base body. The stent base body is of a cylindrical net-shaped structure with gradually-changed section lengths, and the difference between the adjacent section lengths is 1-5 microns. The stent with the structure can effectively reduce the expansion speed of the stent along with the deformation of the balloon, so that the stent is stressed more uniformly in the expansion process, the influence of the dog bone effect on the stent is reduced, and the stability and the safety of the stent are improved. The preparation method comprises the steps of pipe drawing, laser cutting, cleaning, coating, electrolytic polishing, heat treatment and the like. The stent disclosed by the invention has good biocompatibility, flexibility and radial supporting force, is suitable for vascular interventional therapy, is beneficial to vascular recovery and reconstruction, and is degraded after vascular repair is completed.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

This invention discloses a coronary artery stent detection method based on an improved YOLOv5 network. The method includes: acquiring and expanding detection images containing coronary artery stents to obtain a coronary artery stent detection training sample library; annotating the detection images with coronary artery stents to obtain an annotated coronary artery stent detection training set and a coronary artery stent detection test set; data augmentation; improving the YOLOv5 network for small object detection; introducing an attention mechanism to obtain an improved YOLOv5 network; and using the improved YOLOv5 network to detect coronary artery stents in the detection images in the coronary artery stent detection test set to obtain coronary artery stent detection results. This invention, based on an improved YOLOv5 network, enables one-step detection from image input to output, offering advantages such as fast detection speed and excellent detection results. It improves the detection accuracy of coronary artery stents in OCT images, bringing convenience to medical detection.

This disclosure provides a crown remover, applicable to the field of medical device technology. The crown remover includes: a plate-shaped support portion including a first through hole penetrating the plate-shaped support portion; a cylindrical drive portion disposed on the upper surface of the plate-shaped support portion, with a second through hole at the axis of the cylindrical drive portion; a crown removal portion including a stretching portion penetrating the first and second through holes, with a force-bearing plate on the side of the stretching portion near the upper surface of the plate-shaped support portion, and crown removal grippers on the side of the stretching portion near the lower surface of the plate-shaped support portion; and a heating coil disposed on the circumferential side of the cylindrical drive portion. The cylindrical drive portion and the crown removal grippers are made of shape memory alloy material, and the austenitic phase transformation initiation temperature A of the cylindrical drive portion is... s1 ≥40℃, excluding the austenitic phase transformation termination temperature A of the crown clamps f1 ≤20℃; When the heating coil is energized, the cylindrical drive part is heated and transforms from martensitic phase to austenitic phase, elongating and pushing the force plate, thereby driving the crown removal claw on the stretching part to move along the axial direction of the cylindrical drive part.

The utility model discloses a novel anti-drop coronary stent protection device, which relates to the technical field of medical appliances, and comprises a coronary stent body, one side of the coronary stent body is fixedly connected with an enlarged ring opening stent, the coronary stent body is internally sleeved with a balloon, the balloon is internally sleeved with a catheter, and the catheter is fixedly connected with the balloon. One end of the catheter is fixedly connected with a catheter head, the middle part of the catheter is fixedly connected with a developing ring, the other end of the catheter is fixedly connected with a catheter base, and the upper surface of the catheter is fixedly connected with a first marking ring; according to the utility model, through the arrangement of the coronary stent body and the enlarged ring port stent, the effect of rapid circulation is achieved during use, and through the enlarged ring ports on the two sides, the blood circulation speed can be accelerated, so that clots in blood can be conveniently taken away, the clots are prevented from being excessively accumulated on the coronary stent, the blood is prevented from being not circulated, and the blood quality is improved. And the unobstructed effect is improved.

The present invention discloses a coronary stent with a composite metal coating and self-developing drug eluting, comprising a bare metal stent, a pure titanium coating, a pure tantalum coating, a tantalum-silver coating, a drug carrier layer, a drug mixed coating and a drug protective layer, wherein the bare metal stent comprises a stent head end circulation unit, a stent head connecting rod, a stent middle circulation unit, a stent middle connecting rod and a stent end circulation unit. The vascular stent of the present invention effectively solves the material problems of the existing metal stent platform, such as the release of harmful metal ions, poor X-ray fluoroscopic development, poor biocompatibility, and poor radial support; the silver element contained in the material can effectively inhibit the generation of inflammation, and reduce the secondary restenosis problem of the stent after the drug release is completed; the drug coating with a lower concentration and time-sequential control can accurately inhibit the proliferation of smooth muscle cells, shorten the speed of endothelialization of the drug stent, and effectively solve the problem of thrombotic inflammation.

The application belongs to the technical field of arterial stents, and particularly relates to a degradable coronary arterial stent and a preparation method thereof. The degradable coronary arterial stent is prepared into a tubular network structure by a main frame and a connecting rib member. The main frame is an open net structure and is provided with an anchoring point at a node. The connecting rib member is detachably connected to and locked with the main frame through the anchoring point, so as to form an integral rigid structure, effectively resist the elastic retraction force after vascular implantation, avoid vascular collapse, gradually degrade and lose the locking ability along with the vascular repair advancement, synchronously release the rapamycin loaded therein, accurately inhibit the proliferative smooth muscle cells, reduce the restenosis risk in the stent, and meanwhile, the main frame restores the activity and slightly deforms along with the vascular pulsation, so as to reduce the vascular intima damage and inflammatory reaction.

A coronary stent recovery catheter belongs to the field of medical devices, and discloses a catheter for recovering a coronary stent after it is unloaded, including a recovery tube and a connecting tube, one end of the recovery tube and the connecting tube are fixedly connected, and the other end of the recovery tube is a head end, which is arranged as a bell mouth, and the small end of the bell mouth is integrally connected with the recovery tube, and a fold from the edge to the center is arranged on the bell mouth, so that the bell mouth can be folded and contracted along the fold; the other end of the connecting tube is connected to a handle. The present invention has a simple structure and a novel concept, and can effectively wrap the unloaded stent to pull it back into the guiding catheter, has a high success rate, has low requirements on the operator, and can prevent the stent steel beam from scratching and damaging the inner wall of the head end of the guiding catheter.

To provide a delivery system for percutaneous coronary intervention particularly adapted to intravascular balloon angioplasty and coronary stent delivery.SOLUTION: Provided is a guide catheter extension / pre-dilation system that includes an outer delivery sheath 36, an inner member 34 extending within the sheath 36, and a mechanism for engagement / disengagement of the inner member 34 relative to the sheath 36. The inner member 34 is configured with a tapered distal tip having a delivery microcatheter 46 and a pre-dilatation balloon member 44 attached to the tapered distal tip proximate the microcatheter 46. The outer delivery sheath 36 and inner member 34 may be modified for operation of different engagement / disengagement mechanisms. The delivery microcatheter 46 provides improved mobility of the balloon member 44 to the treatment site in an atraumatic, rapid, and convenient manner.SELECTED DRAWING: Figure 1

The present disclosure relates to multi-layered polymeric systems for the directional and temporal release of drugs from medical devices. Incorporation of drugs into selected layers within the multi-layered polymeric system allows for the release of drugs in a desired direction over a desired time frame. When more than one drug is delivered, the direction, duration and release rate of each drug can be controlled independently of each other. These multi-layered polymeric systems can be used as is or can be installed into various peripheral stent systems such as drug-eluting coronary stent systems and carotid, hepatic, iliac, femoral, popliteal and renal artery stenting. Methods of manufacture are also described.

The invention provides an automatic virtual coronary intervention planning method based on multi-target heuristic optimization, and the method carries out coronary stent layout planning based on coronary CT or angiography sequence data, and comprises the steps: obtaining the current coronary CT or angiography sequence data, generating a coronary vessel structure model according to a coronary cavity surface and a center line point set, and carrying out coronary stent layout planning according to the coronary vessel structure model. Carrying out topology analysis and smoothing processing on the coronary blood vessel structure model to generate a finite element grid; generating performance feedback indexes according to the finite element mesh and a preset hemodynamic simulation model, wherein the performance feedback indexes comprise blood pressure distribution, a flow velocity field and a fractional flow reserve value; determining an optimal region of a strategy solution set according to the blood pressure distribution, the flow velocity field and the fractional flow reserve value; and determining an optimal individualized coronary intervention planning scheme according to the optimal region and a preset constraint rule, so that the search efficiency and the calculation speed are improved on the premise of ensuring the simulation precision, and the decision-making efficiency and the operation effect are improved.

The invention provides a coronary stent shaping device which is of a hollow tubular structure, a U-shaped or nearly U-shaped notch is formed in one end of a tube, the inner diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of an unexpanded coronary stent, the length of the hollow tubular structure is larger than that of the unexpanded coronary stent, and the length of the hollow tubular structure is larger than that of the unexpanded coronary stent. The width of the notch is smaller than or equal to the outer diameter of the unexpanded stent and larger than or equal to the width of the single mesh. According to the stent shaping device, the risks of stent deformation and damage can be remarkably reduced, the risk of stent deloading is reduced, and the success rate of stent implantation operation is increased.

The invention discloses a system for evaluating a coronary stent inner lumen through photon CT single energy and metal artifact removal, and belongs to the technical field of medical instruments. The invention discloses a system for evaluating a coronary stent inner lumen through photon CT single energy and metal artifact removal. The system comprises a photon CT scanning module, a single energy imaging optimization module, a metal artifact removal module, an intelligent evaluation analysis module and a data storage module. The problem that in the prior art, image blurring is likely to occur, and judgment of the lumen stenosis degree is affected is solved. The method is high in artifact removal accuracy, can truly recover the lumen form, realizes automatic measurement of key parameters, introduces a standard phantom calibration model to calibrate the measurement result, further improves the measurement precision, automatically recognizes common complications based on the measurement parameters and image features, and clarifies the types, positions and degrees of abnormities. The change trend of the condition of the lumen in the stent is visually presented, potential complication risks can be found early, and the occurrence rate of adverse events is reduced.

Disclosed is an Everolimus-eluting cobalt chromium coronary stent comprising a biodegradable polymer-based coating disposed on the abluminal surface thereof The coating comprises a mixture of Everolimus and one or more polymers. The polymers are biodegradable ensuring controlled, monodirectional release of Everolimus over time.

The present invention relates to metal-based coronary stents designed to reduce or eliminate the release of metal ions into the physiological environment. The invention further provides a method of manufacturing such stents, wherein a metal alloy tube is laser-cut to form a stent platform comprising longitudinal and circumferential struts, followed by cleaning, electropolishing, heat-treatment, passivation and ultrasonic ethanol cleaning. The processed platform is coated with a ceramic layer of titanium nitride having a uniform thickness in the range of 200-3000 nm using physical vapor deposition. The titanium nitride coating acts as a biocompatible ion-barrier, improving hemocompatibility and reducing complications such as restenosis, inflammation, thrombogenicity, and long-term metal ion elution, while maintaining mechanical integrity and radial strength required for vascular deployment.

The cardiac vascular stent comprises a catheter, a guide mechanism is arranged in the catheter, an expansion mechanism is connected to the guide mechanism in a sliding mode, and a taking-out mechanism is installed on the expansion mechanism; the guide wire is inserted into the top of a cardiac vessel from a radial artery, the catheter is inserted into the vessel through guiding of the guide wire, the trachea provided with the taking-out mechanism is inserted into the cardiac vessel along the inside of the catheter, the air bag is moved to a cardiac stent through imaging equipment, and air is input into the air inlet head to expand the air bag for a certain distance. The distance between the flexible metal plate and the heart stent is reduced, the electromagnet controller is started to magnetize the flexible connecting piece, the flexible metal plate also magnetizes at the moment, the flexible metal plate sucks the stent on the inner wall of the blood vessel, the trachea is pulled to enable the heart stent to enter the catheter, and damage of the heart stent to the blood vessel is reduced. When the heart stent is completely pulled out from the inside of the catheter, the heart stent is taken out, and the vascular elasticity and follow-up treatment of a patient are protected.

The invention discloses a heat treatment device for a metal degradable heart coronary stent, which is applied to the technical field of coronary stent heat treatment, and comprises a heat treatment mechanism, and the heat treatment mechanism comprises a shell assembly. When the supporting plate moves out of the shell and gradually arrives at the other end of the bottom plate, the rack and the meshing gear are arranged to drive the guide plate to operate, and therefore the guide plate can stretch out. And then an operator pushes the external storage rack loaded with the bracket materials to gradually reach the guide plate and reach the supporting plate through the arrangement of the guide plate, then the guide plate returns to the inner side of the supporting plate again through the arrangement of the rack and the meshing gear in the return stroke movement of the supporting plate, and the automatic storage condition is achieved. By means of the arrangement, inconvenience of existing manual feeding can be distinguished, meanwhile, the operation risk and complexity that workers enter the shell in the feeding process are avoided, and the use convenience of the heat treatment device is improved.

The invention discloses implantation surgery operation auxiliary equipment for a coronary stent, and belongs to the technical field of heart treatment equipment. The driving guide mechanism comprises a bottom plate, a supporting frame is fixedly installed at the top of the bottom plate, a motor is connected to one end of the supporting frame, an output shaft of the motor penetrates through the supporting frame and extends to a lead screw shaft, and a strip-shaped groove is connected to the lead screw shaft in the length direction of the supporting frame; a sliding block arranged in the strip-shaped groove is arranged on the lead screw shaft in a spiral transmission mode. The extending positions of the two ends of the sliding block are movably connected with first rolling wheels arranged on the side wall of the supporting frame. The problems that fat obstructions at different positions of the inner wall of a blood vessel are different in size, so that the propulsive force cannot be adaptively adjusted in the catheter insertion process, the catheter is deviated in the insertion process, the placement position precision of a coronary stent is affected, and the coronary stent is difficult to be inserted can be solved. The technical problem is solved.

The invention belongs to the technical field of medical apparatus and instruments, and relates to a polylactic acid-caprolactone copolymer PLCL degradable coronary stent with a hybrid interpenetrating network structure and a preparation method of the polylactic acid-caprolactone copolymer PLCL degradable coronary stent. The scaffold is composed of linear polylactic acid (PLLA) and a star-shaped polylactic acid-caprolactone copolymer (PLCL) macromonomer with a photoreactive crosslinking end group, a chemical crosslinking network is formed through photocrosslinking, a physical crystallization network is formed through controlled annealing and programmed crystallization, the two are interpenetrated to form a hybrid interpenetrating network structure, and the cross-linked network and the physical crystallization network are interpenetrated to form a cross-linked network. Therefore, the contradiction between the radial support maintenance and the degradation controllability of the degradable stent is improved. The stent has good radial supporting performance, controllable degradation behavior and good biocompatibility, and is suitable for interventional therapy of coronary artery diseases.

A method of inhibiting coagulation in a patient having undergone implantation of a cardiac device includes administering tecarfarin to the patient, in an amount and for a period of time, effective to inhibit coagulation. The cardiac device could be a blood pump, prosthetic heart valve or a coronary stent.

The invention provides a super-smooth anticoagulant functional material and a preparation method and application method thereof, and the functional material comprises a base material and a coating formed on the base material through a noradrenaline monomer self-assembly synthesis reaction, the surface of the coating formed by the self-assembly synthesis reaction of the noradrenaline monomer is provided with a sustained-release medicine which can be covalently grafted with phenolic hydroxyl groups or amino groups. Through a noradrenaline monomer self-assembly synthesis reaction, an ultra-smooth polymer coating with the thickness of 1-500nm is formed on the surface of the coronary stent. The surface of the coating has extremely high smoothness, adhesion of biomacromolecules can be effectively reduced, and the risk of thrombosis is reduced; the surface of the coating is rich in functional groups with chemical activity, so that the carrying capacity and the loading rate of the medicine can be greatly improved, and the medicine release time is prolonged; the coating can effectively fix trace NO gas in the blood vessel and enhance the elasticity and relaxation function of the blood vessel; the hydrophilic and chemical active functional groups on the surface of the coating significantly improve the biocompatibility of the stent.

The utility model provides a device for shaping a coronary stent, which is of a hollow tubular structure, a U-shaped or nearly U-shaped notch is arranged at one end of a tube, the inner diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of an unexpanded coronary stent, and the outer diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of the unexpanded coronary stent. The length of the hollow tubular structure is larger than that of the unexpanded coronary artery stent, the depth of the notch is larger than or equal to the height of a single-circle mesh of the stent, and the width of the notch is smaller than or equal to the outer diameter of the unexpanded stent and larger than or equal to the width of a single mesh. According to the stent shaping device, the risks of deformation and damage of the stent can be remarkably reduced, the risk of stent deloading is reduced, and the success rate of stent implantation operation is increased.

The invention provides an automatic virtual coronary intervention planning method and device based on deep reinforcement learning, and the method comprises the following steps: obtaining a geometric model and physiological parameters of a target coronary artery, and generating a state vector representing a blood vessel environment based on a state encoder; according to the state vector, outputting an action vector based on an Actor network in an Actor-Critic model of Bayesian optimization; calculating a corresponding hemodynamic index based on the coronary artery virtual implantation simulation environment according to the action vector and the geometric model, and calculating a reward value according to the index; according to the reward value, the action vector is evaluated based on a Critic network, and parameters of an Actor-Critic network model are updated; and iteratively executing the steps of state vector generation, action vector output, reward value calculation and model parameter updating until a preset convergence condition is reached, and outputting a final stent implantation planning scheme. Through interaction of a state-action-reward-update circulation mechanism of reinforcement learning, output of an optimal implantation scheme of the coronary stent is realized.

The utility model relates to the field of medical instruments, and discloses a novel anti-drop coronary stent protection device which comprises a guide wire and a net rack, a balloon is fixedly arranged at the outer end of the guide wire, a supporting frame is fixedly arranged at the outer end of the net rack, a plurality of clamping blocks are fixedly arranged at the two ends of the supporting frame, and anti-drop mechanisms are movably arranged at the two ends of the supporting frame. According to the utility model, when the net rack and the support frame are positioned in a blood vessel, the two magnesium-based alloys of the first layer have good compatibility with human tissues, inflammatory response can be effectively reduced, the risk of thrombosis can be reduced, and the polyglycolic acid of the second layer and the polylactic acid of the third layer can be used as drug release carriers, so that after the stent is implanted, the drug release can be effectively released. The anti-off-loading support ring has the advantages that anti-inflammatory and anti-hyperplasia drugs are slowly released, the risk of restenosis is further reduced, the anti-off-loading support ring can be taken out from a blood vessel together with the balloon after the balloon releases part of air, stimulation to endangium is reduced, and the risk of thrombosis is reduced at the same time.

The present invention relates to the technical field of coronary stents, and specifically to a drug eluting coronary stent, comprising a main stent assembly and a release stent wire, wherein the main stent assembly comprises a main body ring frame mounted on both sides of the release stent wire, a plurality of compression assemblies are arranged inside the main body ring frame, and the compression assemblies comprise a plurality of limiting disks fixedly arranged in an annular manner inside the main body ring frame, a plurality of the limiting disks are interspersed and slidably arranged with pushers in the middle, the pushers are located on a side away from each two limiting disks and are fixedly sleeved with compression disks, the outer surface of the pushers is sleeved with springs used in conjunction with the limiting disks, the outer walls between each two release stent wires are connected with a supporting assembly, which is beneficial to preventing vascular plaques from eroding and covering the stent, and can quantitatively release the amount of drugs according to the expansion of the plaques, timely treat the plaques, avoid the limitations of carrying drugs, and improve the utilization efficiency of the stents.

The invention discloses a multifunctional and high-plasticity degradable Zn-Mn-Ga zinc alloy and a preparation method thereof, and belongs to the technical field of medical degradable metal material component design and preparation. The Zn-Mn-Ga zinc alloy comprises the following components in percentage by weight: 60 to 99.98 percent by weight of zinc, 0.01 to 20 percent by weight of manganese and 0.01 to 20 percent by weight of gallium, wherein the total weight of the Zn-Mn-Ga zinc alloy is 100 percent. The antibacterial rate of the Zn-Mn-Ga zinc alloy is larger than or equal to 85%, release of rat anti-inflammatory factors is remarkably promoted, the collagen deposition efficiency of wounds is improved, the yield strength is larger than or equal to 250 MPa, the tensile strength is larger than or equal to 280 MPa, the hardness is larger than or equal to 65 HV, the tensile strength is larger than or equal to 580 MPa, and the elongation is larger than or equal to 90%; after 60 days of soaking, the corrosion pit size is less than or equal to 12 microns, and the uniformity coefficient of corrosion pit distribution is greater than or equal to 85%. The Zn-Mn-Ga zinc alloy is suitable for preparing medical implants such as degradable coronary stents and intravascular stents, and can also be used for preparing soluble bridge plugs, soluble ball seats and the like for petroleum drilling.