24 results about "Coronary stent" patented technology

The invention provides a coronary stent with a gradually-changed section length structure, which adopts a degradable zinc-based material matrix and comprises the following components in percentage by mass: 0.4-0.1% of Li, 0.8-0.05% of Mn and the balance of zinc. A degradable polymer or a metal coating with drugs can be arranged on the surface of the stent base body. The stent base body is of a cylindrical net-shaped structure with gradually-changed section lengths, and the difference between the adjacent section lengths is 1-5 microns. The stent with the structure can effectively reduce the expansion speed of the stent along with the deformation of the balloon, so that the stent is stressed more uniformly in the expansion process, the influence of the dog bone effect on the stent is reduced, and the stability and the safety of the stent are improved. The preparation method comprises the steps of pipe drawing, laser cutting, cleaning, coating, electrolytic polishing, heat treatment and the like. The stent disclosed by the invention has good biocompatibility, flexibility and radial supporting force, is suitable for vascular interventional therapy, is beneficial to vascular recovery and reconstruction, and is degraded after vascular repair is completed.

The invention belongs to the technical field of artery stents, and particularly relates to a degradable coronary artery stent and a preparation method thereof. Wherein the degradable coronary stent is of a tubular network structure prepared by a main frame and connecting rib components, the main frame is of an open network structure, anchoring points are arranged at nodes, and the connecting rib components are detachably connected and lock the main frame through the anchoring points to form an integral rigid structure, so that the elastic retraction force after a blood vessel is implanted is effectively resisted; the connecting rib component is gradually degraded and loses the locking capacity along with the promotion of vascular repair, the loaded rapamycin is synchronously released, smooth muscle cells with active proliferation are accurately inhibited, the risk of restenosis in the stent is reduced, meanwhile, the activity of the main framework is recovered, the main framework slightly deforms along with vascular pulsation, and vascular intimal injury and inflammatory response are reduced.

This invention discloses a coronary artery stent detection method based on an improved YOLOv5 network. The method includes: acquiring and expanding detection images containing coronary artery stents to obtain a coronary artery stent detection training sample library; annotating the detection images with coronary artery stents to obtain an annotated coronary artery stent detection training set and a coronary artery stent detection test set; data augmentation; improving the YOLOv5 network for small object detection; introducing an attention mechanism to obtain an improved YOLOv5 network; and using the improved YOLOv5 network to detect coronary artery stents in the detection images in the coronary artery stent detection test set to obtain coronary artery stent detection results. This invention, based on an improved YOLOv5 network, enables one-step detection from image input to output, offering advantages such as fast detection speed and excellent detection results. It improves the detection accuracy of coronary artery stents in OCT images, bringing convenience to medical detection.

This disclosure provides a crown remover, applicable to the field of medical device technology. The crown remover includes: a plate-shaped support portion including a first through hole penetrating the plate-shaped support portion; a cylindrical drive portion disposed on the upper surface of the plate-shaped support portion, with a second through hole at the axis of the cylindrical drive portion; a crown removal portion including a stretching portion penetrating the first and second through holes, with a force-bearing plate on the side of the stretching portion near the upper surface of the plate-shaped support portion, and crown removal grippers on the side of the stretching portion near the lower surface of the plate-shaped support portion; and a heating coil disposed on the circumferential side of the cylindrical drive portion. The cylindrical drive portion and the crown removal grippers are made of shape memory alloy material, and the austenitic phase transformation initiation temperature A of the cylindrical drive portion is... s1 ≥40℃, excluding the austenitic phase transformation termination temperature A of the crown clamps f1 ≤20℃; When the heating coil is energized, the cylindrical drive part is heated and transforms from martensitic phase to austenitic phase, elongating and pushing the force plate, thereby driving the crown removal claw on the stretching part to move along the axial direction of the cylindrical drive part.

The invention provides an automatic virtual coronary intervention planning method based on multi-target heuristic optimization, and the method carries out coronary stent layout planning based on coronary CT or angiography sequence data, and comprises the steps: obtaining the current coronary CT or angiography sequence data, generating a coronary vessel structure model according to a coronary cavity surface and a center line point set, and carrying out coronary stent layout planning according to the coronary vessel structure model. Carrying out topology analysis and smoothing processing on the coronary blood vessel structure model to generate a finite element grid; generating performance feedback indexes according to the finite element mesh and a preset hemodynamic simulation model, wherein the performance feedback indexes comprise blood pressure distribution, a flow velocity field and a fractional flow reserve value; determining an optimal region of a strategy solution set according to the blood pressure distribution, the flow velocity field and the fractional flow reserve value; and determining an optimal individualized coronary intervention planning scheme according to the optimal region and a preset constraint rule, so that the search efficiency and the calculation speed are improved on the premise of ensuring the simulation precision, and the decision-making efficiency and the operation effect are improved.

The invention provides a coronary stent shaping device which is of a hollow tubular structure, a U-shaped or nearly U-shaped notch is formed in one end of a tube, the inner diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of an unexpanded coronary stent, the length of the hollow tubular structure is larger than that of the unexpanded coronary stent, and the length of the hollow tubular structure is larger than that of the unexpanded coronary stent. The width of the notch is smaller than or equal to the outer diameter of the unexpanded stent and larger than or equal to the width of the single mesh. According to the stent shaping device, the risks of stent deformation and damage can be remarkably reduced, the risk of stent deloading is reduced, and the success rate of stent implantation operation is increased.

The invention discloses a system for evaluating a coronary stent inner lumen through photon CT single energy and metal artifact removal, and belongs to the technical field of medical instruments. The invention discloses a system for evaluating a coronary stent inner lumen through photon CT single energy and metal artifact removal. The system comprises a photon CT scanning module, a single energy imaging optimization module, a metal artifact removal module, an intelligent evaluation analysis module and a data storage module. The problem that in the prior art, image blurring is likely to occur, and judgment of the lumen stenosis degree is affected is solved. The method is high in artifact removal accuracy, can truly recover the lumen form, realizes automatic measurement of key parameters, introduces a standard phantom calibration model to calibrate the measurement result, further improves the measurement precision, automatically recognizes common complications based on the measurement parameters and image features, and clarifies the types, positions and degrees of abnormities. The change trend of the condition of the lumen in the stent is visually presented, potential complication risks can be found early, and the occurrence rate of adverse events is reduced.

Disclosed is an Everolimus-eluting cobalt chromium coronary stent comprising a biodegradable polymer-based coating disposed on the abluminal surface thereof The coating comprises a mixture of Everolimus and one or more polymers. The polymers are biodegradable ensuring controlled, monodirectional release of Everolimus over time.

The present invention relates to metal-based coronary stents designed to reduce or eliminate the release of metal ions into the physiological environment. The invention further provides a method of manufacturing such stents, wherein a metal alloy tube is laser-cut to form a stent platform comprising longitudinal and circumferential struts, followed by cleaning, electropolishing, heat-treatment, passivation and ultrasonic ethanol cleaning. The processed platform is coated with a ceramic layer of titanium nitride having a uniform thickness in the range of 200-3000 nm using physical vapor deposition. The titanium nitride coating acts as a biocompatible ion-barrier, improving hemocompatibility and reducing complications such as restenosis, inflammation, thrombogenicity, and long-term metal ion elution, while maintaining mechanical integrity and radial strength required for vascular deployment.

The cardiac vascular stent comprises a catheter, a guide mechanism is arranged in the catheter, an expansion mechanism is connected to the guide mechanism in a sliding mode, and a taking-out mechanism is installed on the expansion mechanism; the guide wire is inserted into the top of a cardiac vessel from a radial artery, the catheter is inserted into the vessel through guiding of the guide wire, the trachea provided with the taking-out mechanism is inserted into the cardiac vessel along the inside of the catheter, the air bag is moved to a cardiac stent through imaging equipment, and air is input into the air inlet head to expand the air bag for a certain distance. The distance between the flexible metal plate and the heart stent is reduced, the electromagnet controller is started to magnetize the flexible connecting piece, the flexible metal plate also magnetizes at the moment, the flexible metal plate sucks the stent on the inner wall of the blood vessel, the trachea is pulled to enable the heart stent to enter the catheter, and damage of the heart stent to the blood vessel is reduced. When the heart stent is completely pulled out from the inside of the catheter, the heart stent is taken out, and the vascular elasticity and follow-up treatment of a patient are protected.

The invention discloses implantation surgery operation auxiliary equipment for a coronary stent, and belongs to the technical field of heart treatment equipment. The driving guide mechanism comprises a bottom plate, a supporting frame is fixedly installed at the top of the bottom plate, a motor is connected to one end of the supporting frame, an output shaft of the motor penetrates through the supporting frame and extends to a lead screw shaft, and a strip-shaped groove is connected to the lead screw shaft in the length direction of the supporting frame; a sliding block arranged in the strip-shaped groove is arranged on the lead screw shaft in a spiral transmission mode. The extending positions of the two ends of the sliding block are movably connected with first rolling wheels arranged on the side wall of the supporting frame. The problems that fat obstructions at different positions of the inner wall of a blood vessel are different in size, so that the propulsive force cannot be adaptively adjusted in the catheter insertion process, the catheter is deviated in the insertion process, the placement position precision of a coronary stent is affected, and the coronary stent is difficult to be inserted can be solved. The technical problem is solved.

The invention belongs to the technical field of medical apparatus and instruments, and relates to a polylactic acid-caprolactone copolymer PLCL degradable coronary stent with a hybrid interpenetrating network structure and a preparation method of the polylactic acid-caprolactone copolymer PLCL degradable coronary stent. The scaffold is composed of linear polylactic acid (PLLA) and a star-shaped polylactic acid-caprolactone copolymer (PLCL) macromonomer with a photoreactive crosslinking end group, a chemical crosslinking network is formed through photocrosslinking, a physical crystallization network is formed through controlled annealing and programmed crystallization, the two are interpenetrated to form a hybrid interpenetrating network structure, and the cross-linked network and the physical crystallization network are interpenetrated to form a cross-linked network. Therefore, the contradiction between the radial support maintenance and the degradation controllability of the degradable stent is improved. The stent has good radial supporting performance, controllable degradation behavior and good biocompatibility, and is suitable for interventional therapy of coronary artery diseases.

A method of inhibiting coagulation in a patient having undergone implantation of a cardiac device includes administering tecarfarin to the patient, in an amount and for a period of time, effective to inhibit coagulation. The cardiac device could be a blood pump, prosthetic heart valve or a coronary stent.

The utility model provides a device for shaping a coronary stent, which is of a hollow tubular structure, a U-shaped or nearly U-shaped notch is arranged at one end of a tube, the inner diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of an unexpanded coronary stent, and the outer diameter of the hollow tubular structure is equal to 1.05-1.25 times of the outer diameter of the unexpanded coronary stent. The length of the hollow tubular structure is larger than that of the unexpanded coronary artery stent, the depth of the notch is larger than or equal to the height of a single-circle mesh of the stent, and the width of the notch is smaller than or equal to the outer diameter of the unexpanded stent and larger than or equal to the width of a single mesh. According to the stent shaping device, the risks of deformation and damage of the stent can be remarkably reduced, the risk of stent deloading is reduced, and the success rate of stent implantation operation is increased.

The invention provides an automatic virtual coronary intervention planning method and device based on deep reinforcement learning, and the method comprises the following steps: obtaining a geometric model and physiological parameters of a target coronary artery, and generating a state vector representing a blood vessel environment based on a state encoder; according to the state vector, outputting an action vector based on an Actor network in an Actor-Critic model of Bayesian optimization; calculating a corresponding hemodynamic index based on the coronary artery virtual implantation simulation environment according to the action vector and the geometric model, and calculating a reward value according to the index; according to the reward value, the action vector is evaluated based on a Critic network, and parameters of an Actor-Critic network model are updated; and iteratively executing the steps of state vector generation, action vector output, reward value calculation and model parameter updating until a preset convergence condition is reached, and outputting a final stent implantation planning scheme. Through interaction of a state-action-reward-update circulation mechanism of reinforcement learning, output of an optimal implantation scheme of the coronary stent is realized.

The utility model relates to the field of medical instruments, and discloses a novel anti-drop coronary stent protection device which comprises a guide wire and a net rack, a balloon is fixedly arranged at the outer end of the guide wire, a supporting frame is fixedly arranged at the outer end of the net rack, a plurality of clamping blocks are fixedly arranged at the two ends of the supporting frame, and anti-drop mechanisms are movably arranged at the two ends of the supporting frame. According to the utility model, when the net rack and the support frame are positioned in a blood vessel, the two magnesium-based alloys of the first layer have good compatibility with human tissues, inflammatory response can be effectively reduced, the risk of thrombosis can be reduced, and the polyglycolic acid of the second layer and the polylactic acid of the third layer can be used as drug release carriers, so that after the stent is implanted, the drug release can be effectively released. The anti-off-loading support ring has the advantages that anti-inflammatory and anti-hyperplasia drugs are slowly released, the risk of restenosis is further reduced, the anti-off-loading support ring can be taken out from a blood vessel together with the balloon after the balloon releases part of air, stimulation to endangium is reduced, and the risk of thrombosis is reduced at the same time.

The invention discloses a multifunctional and high-plasticity degradable Zn-Mn-Ga zinc alloy and a preparation method thereof, and belongs to the technical field of medical degradable metal material component design and preparation. The Zn-Mn-Ga zinc alloy comprises the following components in percentage by weight: 60 to 99.98 percent by weight of zinc, 0.01 to 20 percent by weight of manganese and 0.01 to 20 percent by weight of gallium, wherein the total weight of the Zn-Mn-Ga zinc alloy is 100 percent. The antibacterial rate of the Zn-Mn-Ga zinc alloy is larger than or equal to 85%, release of rat anti-inflammatory factors is remarkably promoted, the collagen deposition efficiency of wounds is improved, the yield strength is larger than or equal to 250 MPa, the tensile strength is larger than or equal to 280 MPa, the hardness is larger than or equal to 65 HV, the tensile strength is larger than or equal to 580 MPa, and the elongation is larger than or equal to 90%; after 60 days of soaking, the corrosion pit size is less than or equal to 12 microns, and the uniformity coefficient of corrosion pit distribution is greater than or equal to 85%. The Zn-Mn-Ga zinc alloy is suitable for preparing medical implants such as degradable coronary stents and intravascular stents, and can also be used for preparing soluble bridge plugs, soluble ball seats and the like for petroleum drilling.

The utility model discloses a medicament eluting coronary stent, which aims at solving the problem that the existing stent cannot be adjusted according to the diameter of a blood vessel when being used, and comprises a first arc-shaped stent, an arc-shaped adjusting frame, a limiting ball, an adjusting assembly and the like, the stent is expanded, and the arc-shaped adjusting frame slides in a second arc-shaped stent, so that the blood vessel can be conveniently and quickly eluted. When a limiting ball above the arc-shaped adjusting frame moves to the position of a through hole in the upper portion of the second arc-shaped support, the limiting ball is pushed out from the interior of the arc-shaped adjusting frame through a spring, the arc-shaped adjusting frame can be fixed into the second arc-shaped support, and when the blood vessel contracts to drive the limiting ball to contract towards the interior of the arc-shaped adjusting frame, the blood vessel can be fixed into the second arc-shaped support. The spring is driven to contract inwards through contraction of the limiting ball, so that the stent can contract and expand to a certain extent in the blood vessel, the blood vessel can be effectively protected against damage, proliferation of smooth muscles in the blood vessel cannot be stimulated, and thrombus in the blood vessel is effectively prevented.

The utility model discloses a drumstick-like head end interventional guide wire special for passing through a coronary stent, which can well prevent the guide wire from penetrating through stent meshes, reduce operation difficulty and reduce operation risks, and is named as the drumstick-like head end interventional guide wire special for passing through the coronary stent. According to the interventional guide wire special for passing through the drumstick-shaped head end of the coronary stent, good guidance quality and supporting force can be provided through the pushing rod and the shaping section, meanwhile, the outer portion of the pushing rod and the outer portion of the shaping section are coated with PTFE hydrophobic coatings, and friction and damage to the blood vessel wall can be effectively reduced; the guide head is a drumstick-shaped head with the diameter of 2 mm and has better trafficability, the diameter of the head end is larger than that of a common stent mesh, a guide wire can be well prevented from penetrating through the stent mesh, and the guide head has good flexibility and fatigue resistance due to the preparation of a polymer material.

The invention provides a coronary stent implantation planning method and system based on artificial intelligence, and belongs to the technical field of implantation planning, and the method comprises the steps: S1, determining whether a coronary stent needs to be implanted or not according to a coronary angiography image of a patient; and S2, in response to an instruction for indicating that the coronary stent needs to be implanted, determining an implantation planning scheme for implanting the coronary stent into the diseased region according to the focus characteristics of the target diseased region identified by the coronary angiography image. The method has the beneficial effects that whether the coronary stent needs to be implanted or not is determined according to the coronary angiography image of a patient, the limitation of judgment purely depending on doctor experience is abandoned, and the implantation decision is more scientific and objective; meanwhile, an implantation planning scheme can be determined according to the focus characteristics of the target diseased region, the improper implantation situation caused by insufficient experience or subjective judgment deviation is avoided, such as the problems of stent falling, stent breakage, blood vessel restenosis and the like, and the success rate and the safety of the coronary stent implantation operation are improved.

The utility model discloses an improved coronary artery stent conveying extension catheter. The improved coronary artery stent conveying extension catheter comprises a catheter body and a progressive inner core. The catheter body is of a cylindrical hollow flexible tubular structure, the length ranges from 2 cm to 3 cm, the outer diameter ranges from 1.7 mm to 1.8 mm, and the wall thickness ranges from 0.2 mm to 0.3 mm. A main body of the progressive inner core is of a solid flexible columnar structure, the head end of the progressive inner core is machined into a tapered conical part, the total length of the progressive inner core is 50-60 cm, the diameter of the progressive inner core is 0.5-1 mm, and the length of the conical head end is 1-1.5 cm; the gradual inner core is inserted into the tubular structure of the catheter body, and the conical head end extends out of the far-end opening of the catheter body to form the extension catheter.

The coronary stent system with the positioning device comprises a catheter, the positioning device, an elastic main control wire, a handle and a coronary stent body, the elastic main control wire is of a filiform structure, the handle is arranged at the tail end of the elastic main control wire, the catheter is embedded in the periphery of the elastic main control wire, and the positioning device is arranged between the elastic main control wire and the catheter. The coronary stent body is arranged between the elastic main control wire and the catheter, the working end of the positioning device is of a conical outward-opening structure composed of spirals, at least three involute positioning antennas perpendicular to the center line of the conical spirals are arranged at the tail ends of the conical spirals, and the positioning device is made of memory materials. The memory state of the positioning device is a positioning antenna and spiral unfolding state, and the positioning device is tightly wound into a columnar structure in the catheter. According to the device, posture adjustment of the positioning device for the coronary artery opening position is achieved in a spiral structure active correction mode, and the positioning precision is improved.

The invention discloses an absorbable coronary stent based on 3D printing and a preparation method of the absorbable coronary stent. The absorbable coronary stent comprises a plurality of annular units and connecting units, wherein the annular units are sequentially arranged in the axial direction, and the connecting units are used for connecting the adjacent annular units; the annular unit is a closed-loop annular base body, functional partition is conducted on the annular unit in the axial direction, and the annular unit specifically comprises a first unit used for providing radial supporting force and arranged in a calcification area; the second unit is used for realizing a drug release function and is arranged in the long lesion area; and the third unit is used for providing rigid-flexible transition and stress buffering and is arranged in the large bending area. Through collaborative partitioning of the structure, materials and functions, the contradiction between radial supporting force and flexibility of a traditional stent is solved, local stress concentration after the stent is implanted is effectively reduced, long-term compatibility of the stent to blood vessels is improved, and precise sequential release of drugs is achieved.