31results about How to "Release stability" patented technology

This invention discloses a micro-wedge splitting test device and a method for testing fracture parameters of quasi-brittle materials. The device includes a micro-sample, a groove on the upper part of the micro-sample, and a force-transmitting component. The force-transmitting component comprises a wedge, a roller, and a force-transmitting block connected in sequence. Compared with existing standard wedge splitting test devices, the ratio of the fracture cross-section to the volume of the micro-sample increases by more than 1.8 times, and the ratio of the shoulder width to half-width of the micro-sample decreases by less than 10%. By controlling the ratio of fracture cross-section to sample volume and the ratio of sample shoulder width to sample half-width, the device can reduce the size of the wedge splitting test device while ensuring that the crack forms and propagates stably at the center. Furthermore, by limiting the load rate to approximately 0.1 mm / min, the device ensures stable energy release during the micro-splitting test, making the micro-wedge splitting test device suitable for testing the fracture performance of small-sized functional components.

The invention relates to the technical field of sunshade equipment, in particular to a flexible double-property film flexible outer sunshade component which comprises a building outer wall, an electric reel structure and a guide rail module. An on-wall suspended supporting frame is installed on one side of the building outer wall, the other end of the on-wall suspended supporting frame is fixedly connected with a guide rail module, an electric reel structure is installed in the guide rail module, and a flexible film is installed below the electric reel structure. When not in use, the flexible thin film can be wound through the electric reel structure, when in use, the flexible thin film can naturally overhang through the electric reel structure, the electric reel structure can be driven to move in cooperation with the guide rail module, at the moment, the flexible thin film is driven to be subjected to position adjustment, the flexible thin film can swing along with wind, and surrounding air is promoted to flow. The heat dissipation effect is achieved; sunlight is sprayed through the yarn curtain, and the sun-shading effect is achieved.

The present invention discloses a controlled-release type polymeric ferric sulfate water treatment agent and its preparation method, belonging to the technical field of water treatment functional materials. The water treatment agent consists of polymeric ferric sulfate, an iron ion color indicator, a gel matrix, a cross-linking calcium agent, amino diatomaceous earth, a pore-forming agent and an inert filler. The preparation method includes: first preparing a network gel, then preparing soft materials, and finally obtaining the product through pill-making and drying. The present invention realizes the slow release and controllability of polymeric ferric sulfate, and the color indicator can directly reflect the consumption state of polymeric ferric sulfate, facilitating storage, transportation, dosing and recovery.

This invention discloses a dynamic adaptation method for organic agricultural product consumption scenarios based on multimodal perception. The method is executed by an edge server in the exhibition hall and includes: receiving a display collaboration request sent by a mobile terminal; determining a target video based on the source identifier of the streaming media content and product information; determining whether multiple public display terminals are available; and if a first public display terminal is determined to be available, sending the target video to the first public display terminal for playback and sending the terminal identifier of the first public display terminal to the mobile terminal to notify the user of the first public display terminal. This invention can improve the collaborative display efficiency between mobile streaming media content and public display resources in organic agricultural product exhibition halls and enhance the dynamic adaptation effect in agricultural product consumption scenarios.

The utility model discloses a kind of semiconductor constant-temperature wine decanter, belong to wine decanter technical field, including wine storage shell, its inside is provided with wine storage heat preservation groove, wine storage heat preservation groove bottom is provided with temperature-guiding cold aluminium seat, the cold end of semiconductor refrigeration sheet is abutted in temperature-guiding cold aluminium seat, the hot end of semiconductor refrigeration sheet is abutted on radiating fin, radiating fin is connected in fan cover, fan cover is provided with radiating fan, wine storage shell bottom is provided with a plurality of first radiating holes, radiating fan is towards a plurality of first radiating holes, wine storage shell bottom is provided with support seat. The utility model utilizes semiconductor refrigeration sheet to combine wine storage heat preservation groove, ensure that internal temperature is constant and is not affected, this structure will wine bottle be placed in wine storage heat preservation groove, guarantee the constant temperature of wine in bottle, so that under constant-temperature environment, volatile speed of aroma molecule is relatively stable, can make grape wine continuously, stably release various aroma, improve drinking experience.

The application relates to a scale-inhibiting alloy and a preparation method thereof and a scale-inhibiting sheet manufactured from the scale-inhibiting alloy. The scale-inhibiting alloy comprises the following components: 55wt%-70wt% of Cu, 15wt%-30wt% of Zn, 5wt%-15wt% of Ni, 0.5wt%-3wt% of Si, 1wt%-5wt% of P, 0.001wt%-0.05wt% of a modifying element, and the balance of inevitable impurities, wherein the modifying element is one or more of B, Ti and Zr. The scale-inhibiting alloy adds the Si element for strengthening, so as to improve the mechanical properties and corrosion resistance; the Zn element is added as a negative electrode and the P element is added as a positive electrode, the alloying forms alpha phase+beta phase+multi-element brittle compound phase, can well excite the active current, and prevents the generation of water scale. The scale-inhibiting alloy has low production cost, meets the comprehensive requirements of cost, processing performance, corrosion resistance, mechanical properties, health and market acceptance of water treatment products, and has a good application prospect.

The invention discloses a preparation method of inositol nicotinate tablets, and belongs to the technical field of pharmaceutical preparations. By optimizing the existing process and coating components, stable dissolution of drugs is realized, and the method comprises the following steps: dispersing inositol nicotinate in mixed oil to prepare an oil phase, mixing and emulsifying the oil phase and a water phase, performing spray drying to obtain drug milk powder, coating the drug milk powder with modified chitosan, and directly tabletting the coated drug milk powder and auxiliary materials. The preparation method comprises the following steps: uniformly dispersing inositol nicotinate in mixed oil to promote the inositol nicotinate to maintain the uniformity of the drug content in the subsequent process, and adsorbing solid particles on the surfaces of drug-containing oil drops through an emulsification technology to protect the drug components; coating components are reasonably designed, so that fixed-point release of the medicine is realized, the medicine is endowed with anti-pressure ability, and the medicine can be directly tableted; and the coated medicine particles are mixed with auxiliary materials and then are directly tableted, so that the process is simplified, and the coating structure of the medicine particles is protected at the same time. The preparation method can prepare the inositol nicotinate tablet with stable drug dissolution, and the inositol nicotinate tablet is good in taste and small in stimulation to gastric mucosa.

The application discloses a high-stability pedal support workpiece conveying device, and relates to the technical field of automatic conveying of automobile parts.The device comprises a conveying assembly, a positioning assembly and a grabbing assembly installed on a mechanical hand.The positioning assembly is arranged at one end of the conveying assembly, and workpieces are conveyed to the positioning assembly through the conveying assembly.The grabbing assembly is fixedly installed on the mechanical hand.The grabbing assembly comprises a support, a mounting block and a connecting pipe.The support is fixedly installed on the mechanical hand, the mounting block is fixedly installed on the support, one end of the connecting pipe is fixedly connected with the mounting block (32), the end of the connecting pipe away from the connecting pipe is a sleeving end for sleeving workpieces, and a magnetic block for adsorbing workpieces is installed in the connecting pipe.The mechanical limiting of the sleeving end of the connecting pipe and the magnetic force adsorption of the magnetic block form double fixing, effectively prevent workpieces from falling off, deviating or posture overturning during high-speed conveying, moving or vibration, solve the problem of unstable grabbing of traditional mechanical hands, and ensure the effect of keeping workpieces in a stable state during conveying.

The application discloses a preparation method of a novel hierarchical drug release lemon exosome nano preparation and application thereof in brain glioma treatment and belongs to the field of nano medicines. The method comprises the following steps: extracting and purifying lemon exosomes, introducing an anti-glioma drug and a first part of LRP1 up-regulating agent into the inner cavity of the exosomes through electroporation, instantaneously constructing a tumor microenvironment responsive nanogel core to fix the drug, embedding a second part of LRP1 up-regulating agent into the lipid layer of the exosome, modifying Angiopep-2 to realize brain targeting, and obtaining the nano preparation through purification. The preparation has the hierarchical drug release characteristics of outer layer early release and inner cavity delayed release, can improve the efficiency of drug crossing the blood-brain barrier and accumulation at the tumor site, enhance the anti-glioma effect, solves the technical problem that the existing drug loading system is difficult to realize multi-drug phased release, and provides a new strategy for brain glioma treatment.

This invention discloses a multi-field coupled excitation negative oxygen ion coating and its preparation method. The coating comprises the following components by weight: 30-60 parts of aqueous polymer emulsion; 10-30 parts of modified negative ion matrix powder; 2-10 parts of multi-component lanthanide rare earth compounds; 1-8 parts of nuclear magnetic resonance functional mineral powder; 1-6 parts of far-infrared radiation filler; 0.5-5 parts of photothermal synergistic catalytic powder; 0.5-3 parts of dispersant; 0.1-1.5 parts of defoamer; 0.1-2.5 parts of thickening rheology modifier; 0.5-4 parts of film-forming aid; and 5-50 parts of water. This invention's coating continuously ionizes air water molecules at room temperature without external power supply, releasing high concentrations and stably stable amounts of ecological-grade small-particle-size negative oxygen ions. The entire release process produces no ozone byproducts, and the internal radiation index meets the safety limits for indoor building materials. It also possesses functions such as formaldehyde and TVOC degradation, broad-spectrum antibacterial and antifungal properties, wall humidity regulation and heat insulation, and far-infrared bio-health benefits. The coating preparation method is simple and inexpensive, making it suitable for industrial production.

The application relates to the technical field of fresh-keeping materials, in particular to a glucosan-water-soluble cellulose antibacterial material and a preparation method and a fresh-keeping film thereof. The preparation method comprises the following steps: preparing a water-phase solution by using glucosan and water-soluble cellulose, wherein the mass concentration of the glucosan is 1.5-3.5%, and the mass concentration of the water-soluble cellulose is 1.0-2.5%; preparing an oil-phase solution by using an antibacterial agent and an emulsifier; adding the oil-phase solution into the water-phase solution and performing high-speed shearing emulsification to form a nano-emulsion; adding a crosslinking agent into the nano-emulsion to form a crosslinked emulsion with a reticular structure; and preparing the crosslinked emulsion into a slow-release capsule. The preparation method effectively wraps the antibacterial agent by using the mixed system of the glucosan and the water-soluble cellulose, and ensures that the antibacterial agent can be stably released.

The utility model belongs to the technical field of radiator machining, and particularly relates to an automatic screw locking machine for a radiator, which comprises an automatic screw feeding machine, a movable hole arranged on a feeding track of the automatic screw feeding machine and used for controlling screws to fall off, and a power-losing electromagnet used for controlling the movable hole to be opened and closed. A positioning mechanism used for fixing a radiator is arranged below the feeding track, a driving assembly capable of enabling the positioning mechanism to move is arranged below the positioning mechanism, a limiting plate is arranged on the positioning mechanism, a plurality of matching holes are formed in the limiting plate, and the matching holes correspond to screw holes in the radiator. The screws fall into the matching holes by controlling opening and closing of the movable holes and driving the positioning mechanism to move through the driving assembly, and the screws are tightened through the locking mechanism. Through the ingenious arrangement of the assemblies, the mode that a traditional locking mechanism sucks screws one by one for tightening is changed, the screws can directly and accurately fall into screw holes of a radiator, and therefore the working efficiency is greatly improved.

The invention discloses antibiotic bioactive glass and a preparation method thereof, and belongs to the technical field of bioactive glass, the antibiotic bioactive glass comprises the following raw materials by weight: 10-20 parts of bioactive glass powder; 5 to 15 parts of chitosan; 1 to 5 parts of lidocaine hydrochloride; 0.5 to 3 parts of vancomycin; 60-150 parts of a 1% acetic acid aqueous solution; 3-8 parts of a sodium tripolyphosphate solution; the invention aims to solve the problems of weak interface bonding force, difficult antibiotic release control and single function of the traditional material, and by introducing the phosphosilane strontium as an interface molecule, the two-phase interface bonding force is enhanced, the structural integrity and mechanical properties of the material are improved, the osteogenic differentiation is promoted, and the osteoclast activity is inhibited. The material is loaded with vancomycin and lidocaine at the same time, provides antibacterial and analgesic functions, has synergistic anti-infection, analgesic and bone repair capabilities, and is suitable for bone defect repair.

The invention discloses an interventional therapy device, and relates to the technical field of medical instruments. The interventional therapy device comprises an injector, an interventional therapy catheter, a driving assembly, a mechanical indication assembly and a pressure sensor. The mechanical indication assembly is arranged on the driving assembly and is used for indicating the preset extrusion force generated by the driving assembly during use; the pressure sensor is arranged between the driving assembly and the injector and used for indicating the actual extrusion force borne by the injector in the using process. Double monitoring of the preset extrusion force and the actual extrusion force is formed through the mechanical indication assembly and the pressure sensor. Wherein the preset extrusion force indicates the extrusion force expected to be output by the driving assembly, and the actual extrusion force actually borne by the injector is monitored in real time through the actual extrusion force. By comparing the difference value between the two, the difficult-to-perceive fault of the driving assembly can be found in time, and the problem of unstable release of the medicament caused by continuous use of the faulted driving assembly is avoided.

The invention belongs to the technical field of exosomes, and discloses a preparation method of an exosome-loaded vaseline hydrogel composite emulsion, which comprises the following specific steps: step 1, raw material preparation: preparing medical vaseline, sodium alginate, an emulsifier (Tween 80), glycerol, an antioxidant (vitamin E) and an exosome, and carrying out quality inspection on all the raw materials to ensure that no impurity or deterioration exists; and 2, melting the vaseline. According to the vaseline hydrogel composite emulsion, vaseline and hydrogel are fused, the defects of a single carrier are overcome, the vaseline hydrogel composite emulsion has good air permeability and moisturizing sealing performance, exosome can be stably released, the skin absorption efficiency is improved, wound surfaces are effectively protected, the vaseline hydrogel composite emulsion is high in stability and can be stored for a long time, damage to the exosome in the preparation process is reduced through optimization, and the vaseline hydrogel composite emulsion has good application prospects. The damage of high-temperature and high-shear to activity is avoided, and the activity of the exosome is ensured, so that the healing effect on the wound is improved, and a better scheme is provided for wound treatment.

This invention relates to a method for preparing glucose-responsive protamine insulin and its application. The method involves modifying chemical groups on the cysteine ​​residues of protamine and linking them with phenylboronic acid compounds to form a complex, which is then mixed with insulin to prepare glucose-responsive protamine insulin. This glucose-responsive insulin formulation achieves an intelligent glucose response regulation mechanism. Specifically, under normal blood glucose levels, the insulin is released slowly, while under hyperglycemic conditions, its release is accelerated, thereby achieving effective blood glucose control and preventing hypoglycemia.

The application provides a sustained-release preparation of beta-hydroxybutyric acid or a salt thereof, which comprises the following components by weight percentage: 40-50% of beta-hydroxybutyric acid or a salt thereof, 40-60% of a sustained-release skeleton matrix material, and 1-3% of an auxiliary material. The product of the application has excellent water dispersion performance, and can realize slow release of beta-hydroxybutyric acid or a salt, maintain stable and effective blood drug concentration for a long time in the body, and has very important significance for the practical application of beta-hydroxybutyric acid and a salt.

The utility model relates to the technical field of electronic cigarettes, in particular to an electronic cigarette cartridge with HNB particle filter cotton. The cigarette cartridge of the bright oil electronic cigarette comprises an atomizing core assembly and oil storage cotton, the atomization core assembly is wrapped by the oil storage cotton; the atomizer further comprises filter cotton, and the filter cotton is arranged between the atomizing core assembly and the oil storage cotton. According to the utility model, the problems of tobacco tar filtering and taste diversification are solved; the method can be applied to the electronic cigarette cartridge.

This utility model relates to the field of capsule technology and discloses a double-layer capsule for intestinal targeted drug delivery, comprising: an outer layer and an inner layer, the inner layer being disposed inside the outer layer, and a connecting sealing layer disposed on the outside of the inner layer. The outer layer has an outer thickness of 0.1–0.5 mm. The inner layer employs microporous membrane controlled-release technology, has a thickness of 0.5–2 mm, and includes a microporous membrane layer made of ethyl cellulose. The microporous membrane layer has micropores with a diameter of 0.1–10 micrometers on its outer surface. The connecting sealing layer is disposed between the outer and inner layers. The outer layer includes a hydroxypropyl methylcellulose phthalate shell, and the inner cavity of the inner layer has an inner liner layer, the inner cavity of which has an inner plate. This double-layer capsule for intestinal targeted drug delivery can achieve continuous drug release in the intestine, ensuring that an effective drug concentration is maintained in the intestine, thereby acting more effectively on the intestinal lesion site and improving the therapeutic effect on intestinal diseases.

The application relates to the technical field of sewage treatment, and discloses a biological filter rotating disc system based on replaceable composite fillers and a nitrogen and phosphorus removal method. 2+ The biological filter rotating disc system supports online filler replacement and is suitable for upgrading and reconstruction of sewage plants and advanced treatment of industrial wastewater.

The utility model relates to bearing steel pipe heating technical field, and disclose a kind of bearing steel pipe heating furnace, including heating furnace, heating element, first open furnace door hinged to the top end of heating furnace when heating, put material piece into furnace, the stress strip of connecting ring front end is inserted into steel pipe inside, rotate screw fixed rod terminal swivel, make screw fixed rod advance inwards using screw transmission, its front end moving end head pushes stress strip to overcome compression spring elasticity and expand outward, from inside hold steel pipe, prevent displacement, pass through control panel and start heating element installed on mounting block, realize stable even heating, and can real-time adjust parameter, simultaneously, rotate the handle of rotary cylinder, drive steel pipe rotation, make each part heat more evenly, after heating is completed, reverse rotation swivel and release hold, close heating element, take out material piece, and this heating furnace significantly improves heating quality and efficiency.

The invention discloses a controlled release capsule for regulating and controlling glass transition temperature based on chitosan molecular weight as well as a preparation method and application of the controlled release capsule, and belongs to the technical field of controlled release materials. The method comprises the following steps: emulsifying a core material and a sodium alginate solution to form an oil-in-water emulsion; dropwise adding the emulsion into a solution containing calcium ions, and forming calcium alginate gel microspheres through ionic crosslinking; immersing the gel microspheres into an acid solution containing chitosan with a specific molecular weight, and forming a sodium alginate-chitosan polyelectrolyte compound shell layer on the surfaces and in the microspheres through electrostatic complexation; and finally, washing and drying to obtain the controllable controlled-release capsule. According to the invention, chitosan solutions with different molecular weights are selected to prepare controlled release capsules with different glass transition temperature series. The accurate regulation and control of the glass-transition temperature of the final material are realized by utilizing the differential regulation effect on the entanglement density and rigidity of a polymer network after chitosan with different chain lengths are complexed with sodium alginate.

The invention provides a mugwort charcoal hot patch prepared by adopting a low-temperature slow baking process, and relates to the technical field of heating physiotherapy products. The mugwort charcoal hot patch prepared through the low-temperature slow baking process comprises a breathable inner layer, a mugwort charcoal functional layer, a heating layer and a protective outer layer, the breathable inner layer is made of full-bio-based degradable non-woven fabric, the mugwort charcoal functional layer is close to the breathable inner layer, the core component is mugwort charcoal subjected to composite modification treatment through the low-temperature slow baking process, and the protective outer layer is made of non-woven fabric. The mugwort charcoal functional layer can continuously and stably release active ingredients under the heat action of the heating layer. The mugwort charcoal is prepared by combining a low-temperature slow baking process with composite modification treatment, active ingredients in mugwort can be fully reserved, the mugwort charcoal and the mugwort leaf extract are synergistic at a heating temperature, trace ingredients with soothing, blood activating and aromatic effects can be continuously and stably released, far infrared rays radiated by the infrared emission ceramic powder are combined with thermal therapy, and the health care effect is achieved. And the physiotherapy effect is obviously improved.

The present application relates to a kind of hanging delivery device and unmanned aerial vehicle, belong to aerospace technology field, solve the reliability and stability of the hanging goods of the hanging delivery device in prior art, the problem of large load required when unlocking, unlocking component occupies large space.The present application includes shell, hook unit, drive unit and connecting unit;Hook unit includes drive arm, connecting rod and hook;Drive arm and hook are hinged to shell by first hinged shaft and second hinged shaft respectively, and the both ends of connecting rod are hinged to drive arm and hook by third hinged shaft and fourth hinged shaft respectively;Hook can rotate around second hinged shaft, to drive connecting rod and drive arm movement;When hook unit locking state, first hinged shaft, third hinged shaft and fourth hinged shaft are collinear.The present application can realize the stability and reliability of the hanging goods when locking state, unlocking only needs small load, unlocking component structure is compact, and occupies small space.

The invention relates to the technical field of medical instruments, and discloses a brain glioma virus slow-release injection device which comprises a slow-release injection cylinder, a sliding cavity is formed in the slow-release injection cylinder, the left side face of the slow-release injection cylinder is communicated with a conical cover, the left side face of the conical cover is communicated with an injection pipe, and the injection pipe is communicated with a sliding cavity. And the left side surface of the injection tube is communicated with a conical injection head. According to the brain glioma virus slow-release injection device, a slow-release control device is arranged, an annular handle is used for driving an annular rotating plate to rotate, a rotating screw rod is driven to rotate through meshing transmission of a fixed rack and a rotating gear, then a vertical sliding block is driven to slide along a guide sliding rod, and a pressing transverse block is driven to move up and down through a linkage rod and a linkage support; the extrusion degree of the injection tube is adjusted, so that the release rate of a virus preparation is accurately controlled, flexible adjustment can be achieved according to the tumor condition of a patient, individualized treatment requirements are met, and the problem that the release rate of an existing device cannot be adjusted is solved.

This invention discloses a herbal sleep-aiding cotton quilt, belonging to the field of bedding technology. It includes an outer cover and an inner herbal sleep-aiding cotton core. The herbal sleep-aiding cotton core is made using one or a combination of three structures: impregnated raw cotton layer, sandwich layer, and mixed fiber. The herbal sleep-aiding cotton core is loaded with a herbal sleep-aiding essence, with lavender extract as its core, and its active ingredients include linalyl acetate and linalool. This invention uses microencapsulation technology to load the herbal sleep-aiding essence, with lavender extract as its core, onto cotton fibers or a regenerated fiber carrier. Combined with processes such as multi-layer meshless weave, needle punching, and grinding, the sleep-aiding ingredients are organically integrated with the cotton core. The sleep-aiding ingredients are slowly released through human body pressure and friction, exerting a calming and sedative effect through olfaction and micro-contact with the skin, effectively improving sleep quality. This herbal sleep-aiding cotton quilt has the advantages of long-lasting and stable efficacy, a scientifically sound structure, and safety and comfort.

The application discloses an artificial wetland system, comprising an oxidation zone, a transition zone and a reduction zone arranged from top to bottom, wherein the reduction zone is filled with sodium bentonite loaded with nano-MgO, sulfur particles, straw biochar and quartz sand from top to bottom, and the sodium bentonite loaded with nano-MgO is prepared by the following steps: raw material pretreatment; sodium modification: mixing bentonite with Na2CO3 solution, and then washing and drying to obtain sodium bentonite; nano-MgO loading: dissolving Mg(NO3)2 6H2O in anhydrous ethanol to form a solution, adding sodium bentonite into the solution, then adding ammonia water into the dispersed mixture, aging, centrifuging to collect the precipitate, and calcining to obtain MgO / Na-Bent composite material; and filler formation. The application also discloses a sewage treatment method. Compared with the prior art, the application realizes improvement in the aspects of adsorption-release performance regulation of phosphorus, economic optimization of the technical scheme and stability control of the phosphorus release process.

This invention discloses the application of Z944 in the preparation of drugs for treating knee osteoarthritis. Z944 can simultaneously promote the repair of knee cartilage and inhibit neuropathic pain, overcoming the shortcomings of existing KOA therapies, such as single target, limited efficacy, and inability to block the core pathological cycle of the disease. The mechanism of action of Z944 lies in its ability to simultaneously inhibit abnormal discharge of pain neurons and block the catabolism signals of chondrocytes, thereby fundamentally intervening in the vicious cycle of cartilage degeneration and pain transmission in knee osteoarthritis. Compared with existing therapies that target only a single pathological link, this invention achieves a synergistic therapeutic effect greater than the sum of its parts (1+1>2). Its efficacy stems from blocking the core mechanism of the disease, thus being more fundamental and lasting.

This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.

The present application relates to a nicotine pellet composition, a nicotine pellet pouch and a preparation method thereof. The nicotine pellet composition comprises nicotine, a blank pellet core, a binder, a sweetener, a pH regulator, cellulose and cellulose derivatives, a high-molecular coating material, a lubricant, a flavoring agent and a solvent. The blank pellet core is loaded with the nicotine, and the high-molecular coating material forms a single layer or multiple layers of drug loading or coating on the blank pellet core. When the high-molecular coating material forms multiple layers of drug loading or coating, it comprises, from inside to outside, a separation layer, a drug-containing layer, a protective layer and a drug-loading layer. The present application provides a nicotine pellet composition and a nicotine pellet pouch with good fluidity, stable nicotine release and stable aroma release, which can be used for the treatment of smoking cessation or nicotine dependence.