127results about How to "Good slow release" patented technology

The invention relates to a multifunctional soil conditioner for yellow sand soil and a preparation method thereof, and is characterized in that the soil conditioner is a granular fertilizer and comprises a core layer and a coating layer wrapping the core layer, and the mass ratio of the core layer to the coating layer is (3-5): (60-85); wherein the core layer is prepared from the following raw materials in parts by weight: 25 to 30 parts of ground phosphate rock, 15 to 25 parts of insoluble potassium mineral powder, 5 to 10 parts of humic acid and 15 to 20 parts of microbial agent; the component of the coating layer is modified sodium alginate. The modified sodium alginate outer envelope prepared by the invention has a uniform pore structure, and can store water, provide a microenvironment required by reproduction of beneficial microorganisms in soil, increase the content of the beneficial microorganisms in the soil and gradually decompose and release the phosphorus-potassium fertilizer.

The invention relates to the field of essential oil slow release, and discloses a mildew-proof tablet containing plant essential oil and a preparation method and application thereof.The mildew-proof tablet containing the plant essential oil comprises two epidermal layers and an essential oil slow-release layer arranged between the two epidermal layers, the preparation method comprises the following steps: grafting sodium abietate and aminated mesoporous silica to prepare functionalized mesoporous silica, loading plant essential oil on the functionalized mesoporous silica to obtain a core material, introducing dihydroxyl polyhedral oligomeric silsesquioxane into a polyurethane main chain, wrapping the core material to prepare an essential oil slow-release agent, taking lignin as a base material, taking the essential oil slow-release agent as an effective component, and preparing the essential oil slow-release agent. And preparing to obtain the essential oil slow-release layer. The prepared essential oil slow-release layer can achieve the effects of essential oil slow release and antibiosis and mildew prevention, the slow-release effect is remarkable under the normal-temperature and high-temperature conditions, the good slow-release effect is still kept in the humid environment, and the efficacy period of the material is greatly prolonged.

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The invention relates to the technical field of bactericides, and discloses an oilfield flooding bactericide containing plant bactericidal components and a preparation method thereof. The preparation method comprises the following steps: loading the plant-based traditional Chinese medicine extract and the isothiazolinone-based corrosion inhibitor on the silver-loaded cyclodextrin metal organic framework to prepare an antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material, and mixing the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material with methyl methacrylate to prepare the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material. The bactericide obtained by carrying out copolymerization reaction on modified hydroxyquinoline, vinyl quaternary phosphonium salt and methacrylic acid through an in-situ polymerization method can effectively kill and inhibit the breeding of sulfate reducing bacteria and other bacteria in oilfield reinjection water, and has a certain corrosion inhibition effect.

The invention relates to the field of pharmaceutical preparations, in particular to a diclofenac sodium sustained release tablet and a preparation method thereof. The diclofenac sodium sustained release tablet is prepared from the following components: diclofenac sodium, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, mannitol, organic acid salt, a flow aid and a lubricant. The diclofenac sodium sustained-release tablet provided by the invention can be stably released, has an excellent sustained-release effect, and is simple in preparation process, low in cost and suitable for industrial mass production.

The invention provides a preparation method of a water and fertilizer retention type soil amendment, and belongs to the technical field of soil amendments. Biomass polysaccharide with abundant carboxyl functional groups is combined with metal ions to form a three-dimensional network structure capable of effectively coating soil nutrients; meanwhile, the soil conditioner is endowed with obvious pH responsiveness, and targeted remediation can be performed according to different soil conditions; the biomass-based soil conditioner provided by the invention has excellent water-retaining property and good slow-release performance, can improve the soil moisture content, prolong the retention time of soil moisture, and slowly release inclusions while releasing the system moisture, thereby achieving the effect of improving the soil fertility and realizing the improvement of the water-retaining and fertilizer-retaining capabilities of the soil. Meanwhile, the soil conditioner prepared by the invention can also improve the drought stress resistance of crops.

The invention discloses a method for preparing microcapsules from beta-cyclodextrin inclusion compound microcrystal stabilized sandalwood essential oil, and belongs to the technical field of microcapsule preparation. The method comprises the following steps: preparing sandalwood essential oil / beta-cyclodextrin inclusion compound microcrystals, emulsifying and dispersing the sandalwood essential oil by using the inclusion compound microcrystals as an emulsifier, adding resin, and carrying out a condensation reaction to prepare the microcapsule suspension. According to the preparation method, firstly, beta-cyclodextrin and essential oil are embedded to obtain clathrate microcrystals, then the clathrate microcrystals serve as an emulsifying agent, the emulsifying effect of the essential oil is improved, resin microcapsules are convenient to prepare, and the microcapsules prepared through the method are high in essential oil embedding rate and good in stability; beta-cyclodextrin inclusion compound microcrystals are selected as a Pickering emulsion stabilizer, so that the emulsifying and stabilizing effects are good, and the microcapsule emulsion is not layered.

The invention discloses epigallocatechin gallate starch nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the method, high-proportion branched-chain cassava starch is used as a raw material, ultrasonic microwave assistance is adopted, in the nanometer starch alcohol precipitation process, epigallocatechin gallate is synchronously packaged to form nanometer-level epigallocatechin gallate starch nanometer particles, and embedding of epigallocatechin gallate is completed. The embedding rate of the epigallocatechin gallate starch nanoparticles can reach 50.20%, the drug loading capacity can reach 311mg / g, the drug slow release performance is obvious in the process of simulating gastrointestinal digestion, the sustained release time can be 20 hours, the drug release capacity can reach 72.33% and 90.10% respectively, and the preparation process is simple, easy to operate, low in preparation cost and suitable for large-scale production and application.

The invention discloses a slow-release temperature-controlled antifouling agent microsphere and a preparation method and application thereof, the method comprises the following steps: (1) mixing sodium alginate, copper pyrithione and a CaCl2 solution for reaction, freeze-drying, grinding and crushing to prepare intermediate product particles; and (2) mixing the intermediate product particles in the step (1) with a chitosan solution for reaction, then adding a glutaraldehyde solution for continuous reaction, and freeze-drying to obtain the antifouling agent microspheres. The sodium alginate and chitosan double-crosslinking preparation method adopted by the invention is novel, a double-layer drug-loading structure is constructed by virtue of the crosslinking effect of sodium alginate and calcium ions and the electrostatic interaction between anions and cations of sodium alginate and chitosan, and the thought is novel.

The invention relates to a method for preparing an NMN hydrogel microcapsule based on an ionic gelation technology, which comprises the following steps: taking an NMN solution as an active molecule solution, respectively carrying out ionized cross-linking reaction on a cationic hydrogel polymer and an anionic hydrogel polymer under the triggering action of a cationic cross-linking agent, and embedding NMN in a hydrogel film layer to form the NMN hydrogel microcapsule. The NMN hydrogel microcapsule prepared by the method has excellent slow-release performance, the particle size of the prepared microcapsule is uniform, the whole preparation process is green and environment-friendly, an organic solvent and a heating reaction are not needed, and natural and nontoxic cationic hydrogel polymer and anionic hydrogel polymer are selected as materials for preparing a hydrogel film layer, so that the hydrogel film layer is more stable in performance. And the hydrogel has good biocompatibility and biodegradability, is harmless to a human body and is high in safety.

The invention belongs to the technical field of cement grinding aids, and particularly relates to an efficient cement grinding aid and a preparation method thereof.The efficient cement grinding aid is prepared from, by weight, 15%-30% of polyhydric alcohol compounds, 10%-15% of organic acid salt, 12%-20% of a surfactant, 10%-15% of a reinforcing agent and 0.3%-5% of a defoaming agent; the invention further discloses a preparation method of the efficient cement grinding aid. The preparation method comprises the following preparation steps: S1, raw material pretreatment; s2, mixing and dispersing; s3, preparing solid raw material spherical particles; s4, dissolving; s5, adding nano silicon dioxide and modified starch; and S6, post-processing. The cement grinding aid disclosed by the invention can be used for refining cement particles and optimizing particle composition, so that the specific surface area of cement is increased, the problems of caking of raw materials and non-uniform local concentration are effectively avoided, and the mixing effect is improved.

The invention relates to preparation and application of a methotrexate-loaded silk fibroin gel drug release system, in particular to a methotrexate-containing gel preparation which contains methotrexate, silk fibroin and BDDE in a weight ratio of (1-2): (30-50): (6-10), the invention further provides a preparation method of the gel preparation, and the preparation method comprises the following steps: preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system, and preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system. The preparation method comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, adding BDDE, and standing to form gel; the method specifically comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, stirring at 50-70 DEG C for 0.5-2 hours, adding BDDE, and standing at 50-70 DEG C for 2-4 hours to form gel.

The present invention provides a slow-release fertilizer composite hydrogel and a preparation method and application thereof, belonging to the technical field of slow-release fertilizers. The slow-release fertilizer composite hydrogel comprises the following raw materials in parts by weight: 2 to 58 parts of lignocellulose nanofiber suspension, 0.05 to 0.15 parts of clinoptilolite, 5 to 15 parts of acrylic acid, 5 to 15 parts of acrylamide, 1 to 2 parts of initiator, 0.1 to 0.3 parts of cross-linking agent and 5 to 15 parts of urea. The present invention also provides a preparation method of the slow-release fertilizer composite hydrogel and its application in agricultural planting. The slow-release fertilizer composite hydrogel of the present invention has good overall stability, presents an obvious porous structure, has small internal pores and uniform pores, has good water absorption, swelling and water retention effects, has ideal controlled release performance and urea slow release effect, and can be well used in the planting of agricultural crops and forestry plants, as well as the ecological restoration of difficult sites in urban and rural areas.

The invention relates to the technical field of microcapsules, in particular to a pesticide sustained-release microcapsule as well as a preparation method and application thereof. The shell material of the pesticide sustained-release microcapsule provided by the invention is organic silicon modified polyurethane, and the core material of the pesticide sustained-release microcapsule is an original pesticide; wherein the organic silicon modified polyurethane is obtained by reacting isocyanate, organic silicon dihydric alcohol and degradable dihydric alcohol. The low-polarity and low-surface-energy organic silicon is introduced into the shell material of the pesticide sustained-release microcapsule, so that the contact angle of the microcapsule emulsion is reduced, and the microcapsule emulsion is easier to wet and spread on crops; the degradable dihydric alcohol is introduced, so that the microcapsule is degraded and broken for a long time, the internally wrapped pesticide is fully released, and the release rate and the utilization rate of the pesticide are improved.

The invention discloses traditional Chinese medicine granules as well as a preparation method and application thereof, and belongs to the technical field of preparation of traditional Chinese medicine granules. The traditional Chinese medicine granules are prepared from extracts of traditional Chinese medicine formula raw materials, a filling agent, a disintegrating agent, a sustained release agent and a flavoring agent, wherein the traditional Chinese medicine formula raw materials are prepared from radix rehmanniae preparata, fructus corni, radix cyathulae, rhizoma alismatis, poria cocos, roasted rhizoma atractylodis macrocephalae, obscured homalomena rhizome, radix clematidis, rhizoma corydalis and liquorice root. The traditional Chinese medicine formula granules with good treatment significance on cartilage repair are obtained, the traditional Chinese medicine formula granules are convenient to carry and store and have positive treatment significance on cartilage repair, the innovative process formula has a slow release effect, and compared with a water decoction, the medicine release time is prolonged, the administration frequency can be reduced, and the life quality of a patient can be improved.

The invention discloses a glycocholic acid sustained release preparation and a production process thereof. The glycocholic acid sustained-release preparation comprises glycocholic acid sustained-release pellets, and the preparation method of the glycocholic acid sustained-release preparation comprises the following steps: firstly, preparing glycocholic acid and auxiliary materials into a drug-containing pellet core according to a formula, then coating the drug-containing pellet core with a sustained-release material to obtain the sustained-release pellets, and finally, filling the sustained-release pellets into capsules to obtain the glycocholic acid sustained-release preparation. The preparation method comprises the following steps: carrying out wet granulation-extrusion rolling to obtain wet pills, drying, and coating with a fluidized bed to obtain the glycocholic acid sustained-release pellets. The quality of the drug-loaded pellet is controlled according to indexes such as roundness, bulk density, yield and the like, the drug release effect of the sustained-release pellet is evaluated according to the dissolution rate, and the release mechanism and the initial stability of the glycocholic acid sustained-release pellet are investigated. The invention has the advantages of favorable sustained-release effect, reduced medication frequency, simple and feasible preparation process, favorable reproducibility and favorable drug stability, is suitable for industrial production, aims at supporting the research and development of the compound sustained-release drug, and has obvious social and economic benefits.

The invention discloses an aminobutyric acid synergistic fertilizer and a preparation method thereof, and belongs to the technical field of fertilizers. The synergistic fertilizer comprises the following raw materials in parts by weight: 80-90 parts of fertilizer effect particles and 20-40 parts of a coating solution. The coating solution is prepared by the following steps: adding modified chitosan into an acetic acid solution with the volume concentration of 1%, and uniformly stirring at 300-500r / min to obtain the coating solution, and a preparation method of the modified chitosan comprises the following steps: adding chitosan into a citric acid solution, stirring until the chitosan is dissolved, then adding epoxy chloropropane, stirring at 400r / min for 4 hours, then adding humic acid, and stirring for 0.5 hour to obtain a mixed solution; dropwise adding the mixed solution into a 0.2 mol / L NaOH solution, stirring for 12 hours, eluting residual NaOH in a product with distilled water, drying at 80 DEG C for 12 hours, taking out, and grinding into powder, so as to obtain the modified chitosan. The aminobutyric acid synergistic fertilizer prepared by the invention has excellent slow release performance.

The present application relates to a novel long-acting solid coated slow-release acid and a preparation method. The solid coated slow-release acid has a core-shell structure, the shell layer comprises a polymer, and the core comprises an acid former; the acid former is at least one selected from chlorinated aromatic hydrocarbons, chlorinated acid esters and acid chlorides, and the polymer is at least one selected from polyesters, poly(meth)acrylates, epoxy resins, polyolefins, polyacrylonitriles, polyimides, polyvinyl alcohols. The solid coated slow-release acid has the advantages of small environmental pollution, long acid release time, excellent deep penetration performance, high acid generating efficiency, easy storage and transportation, good slow-release performance and simple preparation.

This invention discloses a method for preparing a multifunctional slow-release fertilizer. First, a porous carrier is prepared by co-precipitation and calcination of iron tailings acid leaching solution and aluminum salts. Nutrient solution is loaded onto the carrier, dried, and granulated to obtain fertilizer particles. A bio-based composite coating precursor solution is prepared by mixing nanocellulose whiskers, sodium alginate, polyacrylic acid, and fumed silica, and a calcium chloride-chitosan solution is used as a crosslinking agent to obtain fertilizer particles. Finally, fluidized bed coating technology is used to sequentially spray the coating precursor solution and crosslinking agent solution onto the surface of the fertilizer particles. After two coating processes and drying, a multifunctional slow-release fertilizer is obtained. This invention combines the preparation of an industrial solid waste resource utilization carrier, the construction of a bio-based composite coating, and a rhizosphere-responsive slow-release design to prepare a multifunctional slow-release fertilizer. This fertilizer not only has low preparation cost but is also rich in nutrients, has good slow-release performance, and excellent mechanical stability.

The present invention discloses a diquafosol composition, a pharmaceutical preparation containing the same and an application thereof. The present invention provides a diquafosol resin composition, which comprises diquafosol or a pharmaceutically acceptable salt thereof, an anion exchange resin and water. The diquafosol composition provided by the present invention has a high drug adsorption rate and drug loading, can achieve controlled release of the drug, improve the bioavailability of the drug, and is conducive to the drug exerting a stable and sustained therapeutic effect.

The invention provides an application of a sustained-release film coating premix in preparation of methylphenidate hydrochloride tablets. The provided slow-release film coating premix is prepared from the following components in parts by weight: 35-55 parts of a film forming material, 18-32 parts of a plasticizer, 14-22 parts of a coloring agent, 1-4 parts of a dispersing agent, 5-15 parts of an anti-sticking agent and 40-60 parts of a solvent, and the film forming material is prepared from hydroxypropyl methylcellulose, polyvinyl alcohol and povidone K30; the plasticizer comprises polyethylene glycol 6000 and propylene glycol; the solvent is water. The sustained-release film-coated premix is used for preparing the methylphenidate hydrochloride sustained-release tablet, the release speed of the medicine can be controlled, and the stability, safety and effectiveness of the medicine are improved.

The application belongs to the technical field of fertilizers, and particularly relates to a humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate and a preparation method thereof. The humic acid organic-inorganic compound fertilizer comprises the following raw materials in parts by weight: 22-30 parts of biogas residue, 35-55 parts of humic acid, 8-13 parts of fine columnar algae powder, 5-8 parts of urea, 12-17 parts of ammonium sulfate, 12-15 parts of superphosphoric acid calcium, 15-20 parts of potassium sulfate and 10-15 parts of slow release coating suspension. Test results show that the humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate prepared by the application can reduce the nitrogen and phosphorus release rates of the humic acid inorganic compound fertilizer, has better slow release effect, significantly promotes the plant height, stem diameter and root length of soybeans and corn, has obvious growth promotion effect, and has wide application prospect.

The present application provides a kind of pesticide composite drug delivery system and its preparation and application, the pesticide composite drug delivery system includes pesticide, MOF-NH2 and nano calcium carbonate, the pesticide is respectively loaded on MOF-NH2 and nano calcium carbonate, and the nano calcium carbonate of loading pesticide is covered outside the MOF-NH2 of loading pesticide.The pesticide composite drug delivery system of the present application overcomes the problem that the MOF-NH2 drug delivery system of loading pesticide in the prior art occurs easily in the process of application in acidic or high salinity environment Skeleton collapse, affect its drug loading performance and pesticide slow-release effect problem.The composite drug delivery system containing pesticide of the present application has good application and popularization prospect.

The invention provides an eleczyme sustained-release dry suspension, which comprises the following components in percentage by mass: 10% to 30% of eleczyme, 30% to 60% of a sustained-release carrier, 10% to 57% of a filler, 1% to 5% of a suspending agent, 1% to 4% of a pH regulator, 0.2% to 1% of a flavoring agent, and 0.2% to 1% of an aromatic flavoring agent; wherein the sustained-release carrier is selected from one or both of stearic acid and glyceryl monostearate; and the suspending agent is selected from one or more of xanthan gum, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, and sodium alginate. The sustained-release dry suspension has good suspension uniformity after adding water, has no precipitation or stratification problems, has good sustained-release performance, and does not have a pungent taste.

The invention provides a pH / GSH dual-response type Fe-based MOF drug carrier as well as a synthesis method and application thereof, and belongs to the technical field of drug carrier synthesis. Fe-based MOF is synthesized from MOF containing GSH sensitive bonds, then an anti-cancer drug model DOX is entrapped in channels of the Fe-based MOF, a functional material is modified on the surface of the Fe-based MOF, and the pH / GSH double-response type Fe-based MOF drug carrier is obtained. The Fe-based MOF drug carrier achieves the purpose of inhibiting or killing tumor cells through mutual cooperation of ferroptosis and chemotherapy, has good application in cancer resistance, and has good practicability.

The invention belongs to the technical field of feed additives, and particularly relates to a compound feed additive for fattening cattle and a preparation method of the compound feed additive. The compound feed additive for fattening cattle comprises the following raw materials in parts by weight: 5-10 parts of gelatinized starch urea, 1-3 parts of guanidinoacetic acid, 0.5-1 part of modified diatomite, 0.1-0.5 part of rumen bypass vitamin C and 0.3-0.5 part of a hail vegetable extract. The modified diatomite in the composite additive has good slow-release performance and can improve the performance of the traditional Chinese medicine polypeptide, and the hail vegetable extract has certain film-forming property, can improve the stability of the modified diatomite in vitro, is easy to digest and absorb in animal bodies and can improve the utilization rate of nutrients by animals. The additive is creatively added into feed, so that the proportion of soybean meal in daily ration can be reduced, the feeding cost is reduced, and the growth and development capability of cattle is improved.

The invention provides a preparation method of small-size ligustrazine-loaded silk fibroin nano-microspheres, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: S1, mixing and dissolving degummed silk and a ternary solution containing anhydrous calcium chloride, double distilled water and absolute ethyl alcohol, dialyzing with deionized water, and centrifugally removing impurities to obtain a silk fibroin solution; s2, uniformly mixing the silk fibroin solution with the ligustrazine solution to obtain a mixed solution; s3, dropwise adding the mixed solution into acetone in a microfluidic manner, standing at room temperature, centrifuging, and discarding supernate to obtain a precipitate; s4, re-dissolving the precipitate with deionized water, centrifuging, discarding the supernatant, and repeating for 2-5 times; finally, re-dissolving with deionized water, filtering and collecting filtrate to obtain a ligustrazine silk fibroin nano-microsphere solution; s5, performing freeze drying on the ligustrazine silk fibroin nano-microsphere solution to obtain ligustrazine-loaded silk fibroin nano-microsphere powder; the prepared silk fibroin nano-microspheres are small in particle size and uniform in distribution.

The present invention belongs to the technical field of tertiary oil recovery, and in particular to a corrosion inhibitor for acid fracturing and a preparation method thereof. The preparation method is as follows: (hydroxymethyl) triphenylphosphonium chloride, N, N-dimethylformamide, and a catalyst are sequentially added to an autoclave, the reactor is purged with nitrogen, vacuumized, heated at the same time, ethylene oxide is passed, the temperature is raised and the reaction is kept warm, the reaction pressure gradually decreases, and when the pressure no longer decreases, the reaction is stopped, and the reaction is cooled to less than 60 ° C; propylene oxide is passed, the temperature is raised and the reaction is kept warm, the reaction pressure gradually decreases, and when the pressure no longer decreases, the reaction is stopped, and the reaction is cooled to less than 60 ° C, pH7-8 is adjusted with hydrochloric acid, and N, N-dimethylformamide is distilled off under reduced pressure to obtain a product corrosion inhibitor. The present invention has the advantages of wide adaptability to temperature and good sustained release effect.

The present invention discloses an EGCG nanocomposition with strong antioxidant and anti-photoaging effects, and a preparation method and application thereof. The EGCG nanocomposition is formed by encapsulating the functional active substance EGCG through two-step functionalized phospholipid self-assembly, firstly preparing a nanocomposition precursor to encapsulate EGCG, then self-assembling and protecting the nanocomposition precursor through phospholipids, and simultaneously using two membrane material stabilizers of different properties to compound and regulate the phospholipid membrane to obtain the EGCG nanocomposition. The EGCG nanocomposition of the present invention has good stability, encapsulation rate, antioxidant effect, sustained release performance and skin permeability. The EGCG nanocomposition of the present invention also has excellent DNA damage repair effect and protein carbonylation inhibition effect, and can be used in skin topical preparations to play an antioxidant, anti-photoaging and skin yellowing effect, and its efficacy is better than that of EGCG aqueous solution.

The invention relates to the field of concrete functional additives, in particular to a concrete internal curing agent with a hydration temperature rise regulation effect, a preparation method of the concrete internal curing agent and a concrete shrinkage-reducing and anti-cracking functional material. Wherein the raw materials comprise a polymeric monomer, a cross-linking monomer, an initiator, a polyhydroxy carbohydrate and water; wherein the polymeric monomer is composed of 70-100% by mass of an acrylamide monomer and the balance of an acrylic acid monomer, the polyhydroxy carbohydrate is a starch hydrolysate dextrin compound, and the DE value of the dextrin compound is greater than 0 but not greater than 15. The internal curing agent effectively solves the problem that an existing commercially available super absorbent polymer (SAP) internal curing material is poor in water absorption and water retention capacity on a cement pore solution containing divalent ions and trivalent ions, and the internal curing agent has the effects of internal curing and cement hydration heat release regulation and control.