38results about How to "Good slow release" patented technology

The invention relates to the field of essential oil slow release, and discloses a mildew-proof tablet containing plant essential oil and a preparation method and application thereof.The mildew-proof tablet containing the plant essential oil comprises two epidermal layers and an essential oil slow-release layer arranged between the two epidermal layers, the preparation method comprises the following steps: grafting sodium abietate and aminated mesoporous silica to prepare functionalized mesoporous silica, loading plant essential oil on the functionalized mesoporous silica to obtain a core material, introducing dihydroxyl polyhedral oligomeric silsesquioxane into a polyurethane main chain, wrapping the core material to prepare an essential oil slow-release agent, taking lignin as a base material, taking the essential oil slow-release agent as an effective component, and preparing the essential oil slow-release agent. And preparing to obtain the essential oil slow-release layer. The prepared essential oil slow-release layer can achieve the effects of essential oil slow release and antibiosis and mildew prevention, the slow-release effect is remarkable under the normal-temperature and high-temperature conditions, the good slow-release effect is still kept in the humid environment, and the efficacy period of the material is greatly prolonged.

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The invention relates to the technical field of bactericides, and discloses an oilfield flooding bactericide containing plant bactericidal components and a preparation method thereof. The preparation method comprises the following steps: loading the plant-based traditional Chinese medicine extract and the isothiazolinone-based corrosion inhibitor on the silver-loaded cyclodextrin metal organic framework to prepare an antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material, and mixing the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material with methyl methacrylate to prepare the antibacterial agent / silver-loaded cyclodextrin metal organic framework composite material. The bactericide obtained by carrying out copolymerization reaction on modified hydroxyquinoline, vinyl quaternary phosphonium salt and methacrylic acid through an in-situ polymerization method can effectively kill and inhibit the breeding of sulfate reducing bacteria and other bacteria in oilfield reinjection water, and has a certain corrosion inhibition effect.

The invention discloses a slow-release temperature-controlled antifouling agent microsphere and a preparation method and application thereof, the method comprises the following steps: (1) mixing sodium alginate, copper pyrithione and a CaCl2 solution for reaction, freeze-drying, grinding and crushing to prepare intermediate product particles; and (2) mixing the intermediate product particles in the step (1) with a chitosan solution for reaction, then adding a glutaraldehyde solution for continuous reaction, and freeze-drying to obtain the antifouling agent microspheres. The sodium alginate and chitosan double-crosslinking preparation method adopted by the invention is novel, a double-layer drug-loading structure is constructed by virtue of the crosslinking effect of sodium alginate and calcium ions and the electrostatic interaction between anions and cations of sodium alginate and chitosan, and the thought is novel.

The invention relates to preparation and application of a methotrexate-loaded silk fibroin gel drug release system, in particular to a methotrexate-containing gel preparation which contains methotrexate, silk fibroin and BDDE in a weight ratio of (1-2): (30-50): (6-10), the invention further provides a preparation method of the gel preparation, and the preparation method comprises the following steps: preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system, and preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system. The preparation method comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, adding BDDE, and standing to form gel; the method specifically comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, stirring at 50-70 DEG C for 0.5-2 hours, adding BDDE, and standing at 50-70 DEG C for 2-4 hours to form gel.

The present invention provides a slow-release fertilizer composite hydrogel and a preparation method and application thereof, belonging to the technical field of slow-release fertilizers. The slow-release fertilizer composite hydrogel comprises the following raw materials in parts by weight: 2 to 58 parts of lignocellulose nanofiber suspension, 0.05 to 0.15 parts of clinoptilolite, 5 to 15 parts of acrylic acid, 5 to 15 parts of acrylamide, 1 to 2 parts of initiator, 0.1 to 0.3 parts of cross-linking agent and 5 to 15 parts of urea. The present invention also provides a preparation method of the slow-release fertilizer composite hydrogel and its application in agricultural planting. The slow-release fertilizer composite hydrogel of the present invention has good overall stability, presents an obvious porous structure, has small internal pores and uniform pores, has good water absorption, swelling and water retention effects, has ideal controlled release performance and urea slow release effect, and can be well used in the planting of agricultural crops and forestry plants, as well as the ecological restoration of difficult sites in urban and rural areas.

The present application relates to a novel long-acting solid coated slow-release acid and a preparation method. The solid coated slow-release acid has a core-shell structure, the shell layer comprises a polymer, and the core comprises an acid former; the acid former is at least one selected from chlorinated aromatic hydrocarbons, chlorinated acid esters and acid chlorides, and the polymer is at least one selected from polyesters, poly(meth)acrylates, epoxy resins, polyolefins, polyacrylonitriles, polyimides, polyvinyl alcohols. The solid coated slow-release acid has the advantages of small environmental pollution, long acid release time, excellent deep penetration performance, high acid generating efficiency, easy storage and transportation, good slow-release performance and simple preparation.

This invention discloses a method for preparing a multifunctional slow-release fertilizer. First, a porous carrier is prepared by co-precipitation and calcination of iron tailings acid leaching solution and aluminum salts. Nutrient solution is loaded onto the carrier, dried, and granulated to obtain fertilizer particles. A bio-based composite coating precursor solution is prepared by mixing nanocellulose whiskers, sodium alginate, polyacrylic acid, and fumed silica, and a calcium chloride-chitosan solution is used as a crosslinking agent to obtain fertilizer particles. Finally, fluidized bed coating technology is used to sequentially spray the coating precursor solution and crosslinking agent solution onto the surface of the fertilizer particles. After two coating processes and drying, a multifunctional slow-release fertilizer is obtained. This invention combines the preparation of an industrial solid waste resource utilization carrier, the construction of a bio-based composite coating, and a rhizosphere-responsive slow-release design to prepare a multifunctional slow-release fertilizer. This fertilizer not only has low preparation cost but is also rich in nutrients, has good slow-release performance, and excellent mechanical stability.

The present invention discloses a diquafosol composition, a pharmaceutical preparation containing the same and an application thereof. The present invention provides a diquafosol resin composition, which comprises diquafosol or a pharmaceutically acceptable salt thereof, an anion exchange resin and water. The diquafosol composition provided by the present invention has a high drug adsorption rate and drug loading, can achieve controlled release of the drug, improve the bioavailability of the drug, and is conducive to the drug exerting a stable and sustained therapeutic effect.

The invention provides an application of a sustained-release film coating premix in preparation of methylphenidate hydrochloride tablets. The provided slow-release film coating premix is prepared from the following components in parts by weight: 35-55 parts of a film forming material, 18-32 parts of a plasticizer, 14-22 parts of a coloring agent, 1-4 parts of a dispersing agent, 5-15 parts of an anti-sticking agent and 40-60 parts of a solvent, and the film forming material is prepared from hydroxypropyl methylcellulose, polyvinyl alcohol and povidone K30; the plasticizer comprises polyethylene glycol 6000 and propylene glycol; the solvent is water. The sustained-release film-coated premix is used for preparing the methylphenidate hydrochloride sustained-release tablet, the release speed of the medicine can be controlled, and the stability, safety and effectiveness of the medicine are improved.

The application belongs to the technical field of fertilizers, and particularly relates to a humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate and a preparation method thereof. The humic acid organic-inorganic compound fertilizer comprises the following raw materials in parts by weight: 22-30 parts of biogas residue, 35-55 parts of humic acid, 8-13 parts of fine columnar algae powder, 5-8 parts of urea, 12-17 parts of ammonium sulfate, 12-15 parts of superphosphoric acid calcium, 15-20 parts of potassium sulfate and 10-15 parts of slow release coating suspension. Test results show that the humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate prepared by the application can reduce the nitrogen and phosphorus release rates of the humic acid inorganic compound fertilizer, has better slow release effect, significantly promotes the plant height, stem diameter and root length of soybeans and corn, has obvious growth promotion effect, and has wide application prospect.

The present application provides a kind of pesticide composite drug delivery system and its preparation and application, the pesticide composite drug delivery system includes pesticide, MOF-NH2 and nano calcium carbonate, the pesticide is respectively loaded on MOF-NH2 and nano calcium carbonate, and the nano calcium carbonate of loading pesticide is covered outside the MOF-NH2 of loading pesticide.The pesticide composite drug delivery system of the present application overcomes the problem that the MOF-NH2 drug delivery system of loading pesticide in the prior art occurs easily in the process of application in acidic or high salinity environment Skeleton collapse, affect its drug loading performance and pesticide slow-release effect problem.The composite drug delivery system containing pesticide of the present application has good application and popularization prospect.

The invention provides an eleczyme sustained-release dry suspension, which comprises the following components in percentage by mass: 10% to 30% of eleczyme, 30% to 60% of a sustained-release carrier, 10% to 57% of a filler, 1% to 5% of a suspending agent, 1% to 4% of a pH regulator, 0.2% to 1% of a flavoring agent, and 0.2% to 1% of an aromatic flavoring agent; wherein the sustained-release carrier is selected from one or both of stearic acid and glyceryl monostearate; and the suspending agent is selected from one or more of xanthan gum, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, and sodium alginate. The sustained-release dry suspension has good suspension uniformity after adding water, has no precipitation or stratification problems, has good sustained-release performance, and does not have a pungent taste.

The present invention discloses an EGCG nanocomposition with strong antioxidant and anti-photoaging effects, and a preparation method and application thereof. The EGCG nanocomposition is formed by encapsulating the functional active substance EGCG through two-step functionalized phospholipid self-assembly, firstly preparing a nanocomposition precursor to encapsulate EGCG, then self-assembling and protecting the nanocomposition precursor through phospholipids, and simultaneously using two membrane material stabilizers of different properties to compound and regulate the phospholipid membrane to obtain the EGCG nanocomposition. The EGCG nanocomposition of the present invention has good stability, encapsulation rate, antioxidant effect, sustained release performance and skin permeability. The EGCG nanocomposition of the present invention also has excellent DNA damage repair effect and protein carbonylation inhibition effect, and can be used in skin topical preparations to play an antioxidant, anti-photoaging and skin yellowing effect, and its efficacy is better than that of EGCG aqueous solution.

The invention relates to the field of concrete functional additives, in particular to a concrete internal curing agent with a hydration temperature rise regulation effect, a preparation method of the concrete internal curing agent and a concrete shrinkage-reducing and anti-cracking functional material. Wherein the raw materials comprise a polymeric monomer, a cross-linking monomer, an initiator, a polyhydroxy carbohydrate and water; wherein the polymeric monomer is composed of 70-100% by mass of an acrylamide monomer and the balance of an acrylic acid monomer, the polyhydroxy carbohydrate is a starch hydrolysate dextrin compound, and the DE value of the dextrin compound is greater than 0 but not greater than 15. The internal curing agent effectively solves the problem that an existing commercially available super absorbent polymer (SAP) internal curing material is poor in water absorption and water retention capacity on a cement pore solution containing divalent ions and trivalent ions, and the internal curing agent has the effects of internal curing and cement hydration heat release regulation and control.

The utility model discloses a medical dressing with medicine loading groove, medical dressing includes polyurethane film and antiseized layer, be equipped with a plurality of medicine loading groove on the polyurethane film, be equipped with hydrogel layer in the medicine loading groove, fill in the medicine of hydrogel layer, one side of the antiseized layer with polyurethane film is equipped with medicine loading groove and is close -fitted. The utility model discloses medical dressing is equipped with medicine loading groove on polyurethane film, fills hydrogel layer in medicine loading groove inner chamber, and the medicine is loaded in hydrogel, can promote the slow -release capacity of medical dressing. The medicine is distributed on the slow -release skeleton, and the slow -release skeleton is prepared through three -dimensional micro -nanometer printing, and the inner chamber is hollow, and the shape of slow -release skeleton is customized according to the shape of medicine loading groove, makes the quantity of slow -release skeleton in medicine loading groove maximization, forms medicine -skeleton load structure, can accommodate more medicine in medicine loading groove to good slow -release effect.

The invention relates to the technical field of biomedical administration, and particularly discloses double-layer hydrogel suitable for the interior of a bladder. The double-layer hydrogel comprises a hydrophilic adhesion slow-release layer and a hydrophobic protective layer; the hydrophilic adhesive slow-release layer and the hydrophobic protective layer are respectively obtained by curing a hydrophilic adhesive slow-release hydrogel precursor solution and a hydrophobic protective hydrogel precursor solution. By adopting a layered progressive double-hydrogel synergistic structure, an integrated administration barrier of mucous membrane adsorption-drug sustained release-physical protection is formed, so that the double-layer hydrogel has excellent bladder mucous membrane adhesion performance in a water environment and a stable and controllable drug sustained release effect, and the problems that an existing bladder perfusion drug is easily diluted and washed by urine, and the drug sustained release effect is poor are solved. The medicine action time is short, and the bioavailability is low.

The invention discloses a modified graphene film packaged slow-release fertilizer and a preparation method thereof, and belongs to the technical field of fertilizers. Specific monomers including maleic anhydride, acrylamide and methyl methacrylate are adopted as raw materials for emulsion polymerization, graphene oxide is added in situ for reaction in the polymer emulsion preparation process, and graphene oxide is further reduced to prepare the modified graphene film packaging material. After the potassium nitrate fertilizer is coated, the fertilizer with a slow release function is finally obtained. The product has comprehensive properties such as swelling property, water solubility, mechanical property and the like through the technical means, so that the finally prepared modified graphene oxide film packaged slow-release fertilizer has an ideal slow-release effect.

The invention belongs to the field of macromolecules, and relates to an aerogel compound fertilizer, a biodegradable film and a preparation method and application thereof. The aerogel compound fertilizer comprises a bio-based high-molecular material carrier and a fertilizer loaded on the bio-based high-molecular material carrier, and is prepared by reacting a bio-based high-molecular material, an auxiliary agent and a water-soluble fertilizer, the bio-based high polymer material is a plant hormone; the auxiliary agent is a long-chain aliphatic compound and an N-vinyl amide polymer; based on 100 parts by weight of the aerogel compound fertilizer, the use amount of the bio-based high polymer material is 20-60 parts by weight, the use amount of the long-chain aliphatic compound is 1-10 parts by weight, the use amount of the N-vinyl amide polymer is 1-10 parts by weight, and the use amount of the water-soluble fertilizer is 10-80 parts by weight. The film prepared from the biodegradable composition disclosed by the invention has the characteristics of good mechanical property, good weather resistance, good fertilizer slow release performance, biodegradability and the like.

This invention provides a drug-loaded halloysite material, its preparation method, and its application. The drug-loaded halloysite material is prepared from halloysite, a drug, and an encapsulation material. Halloysite has good loading and sustained-release effects on drugs such as ciprofloxacin, diclofenac sodium, and nicotinic acid. Encapsulation with the encapsulation material further delays the release of the drug, resulting in slow release in the intestine and stomach, achieving targeted and controlled release. In addition, its preparation method is simple and can achieve rapid encapsulation, further avoiding drug loss during the encapsulation process. It can be used in the biomedical field, especially in the application of sustained-release drugs and intestinal targeted drug delivery, showing good application prospects.

The present invention discloses a silicone hydrogel contact lens material and its preparation method and application. The silicone hydrogel contact lens material includes the following raw materials by weight: 0.2-0.8 parts of L-arginine zwitterion derivative monomer, 40-80 parts of hydrophilic monomer, 20-40 parts of siloxane monomer, 0.5-2 parts of initiator, and 0.5-2 parts of cross-linking agent. The L-arginine zwitterion derivative of the present invention has dense guanidine active sites. By combining it with the contact lens material, it can intelligently respond to the reactive oxygen generated in the microenvironment of the inflammation site of the eye, continuously release NO, reduce ROS, and alleviate eye inflammation. The preparation method of the present invention is simple and efficient. The L-arginine zwitterion derivative monomer, hydrophilic monomer, and siloxane monomer initiate double bond polymerization under ultraviolet light irradiation, so that the compound is more stable, not easy to be eluted, and has excellent biocompatibility performance. The continuously released NO can reduce intraocular pressure and nourish the visual nerve.

This invention relates to the field of drug delivery technology, and more particularly to a ZIF-8-based composite hydrogel, its preparation method, and its applications. By adjusting the mass ratio of gelatin, this invention constructs a novel pH-responsive hydrogel drug delivery system—the ZIF-8-based composite hydrogel. By introducing ZIF-8 material into the gelatin hydrogel system, this invention improves the adaptability of the ZIF-8-based composite hydrogel for local drug delivery, demonstrating strong local compatibility. Through a series of characterizations, this invention proves that the ZIF-8-based composite hydrogel possesses good extensibility and adhesion properties. Furthermore, blood compatibility indicates that the ZIF-8-based composite hydrogel exhibits excellent biocompatibility. The construction of this drug delivery system provides new insights for the development of pH-responsive hydrogels.

This invention discloses a slow-release granule formulation of sodium alginate-biochar loaded with thiamethoxam, its preparation method, and its application. The slow-release granule uses biochar as the adsorbent carrier to adsorb thiamethoxam and sodium alginate as the encapsulating material, which is then cross-linked and solidified by dripping calcium chloride solution. The mass ratio of biochar to thiamethoxam is (10~30):1, the mass-to-volume ratio of sodium alginate to water is 1.5~2.0 g:100 mL, and the concentration of the calcium chloride solution is 1.5%~3.0%. The prepared slow-release granule has a cumulative release time of over 90 hours in distilled water, with no obvious burst release phenomenon. Pot experiments show that it maintains a continuous control effect on eggplant thrips for 7 days after application, which is superior to conventional spraying treatment. This invention has a simple preparation process, is environmentally friendly, and has excellent slow-release performance, making it suitable for green control of agricultural pests.

This invention discloses a sustained-release cocrystal of insect behavior regulators, its preparation method, and its applications. The cocrystal of this invention is formed from raw materials including insect behavior regulators and ligands; the ligands are selected from at least one of agrochemicals. The novel cocrystal of insect behavior regulators and ligands provided by this invention exhibits excellent sustained-release performance, a constant release rate, a long sustained-release period, and stable effects, surpassing existing pure insect behavior regulators and commercially available rubber stopper carriers, and has promising application prospects.

The invention discloses a composite Chinese medicine preparation for chronic osteomyelitis, and its raw materials include: Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, calcium chloride; the mass ratio of Wuwei Xiaoduyin extractant, sodium alginate, p-toluenesulfonic acid, cyclodextrin, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, emulsifier, chitosan, sodium chloride, and calcium chloride is 10-20: 1-3: 0.1-0.2: 2-8: 0.01-0.1: 0.1-0.2: 1-2: 0.1-0.2: 0.1-0.2. The invention also discloses a preparation method of the composite Chinese medicine preparation for chronic osteomyelitis. The present invention can not only solve the disadvantage that antibiotics are difficult to penetrate into the bone to form an effective antibacterial concentration, but also the method is easy to implement, simple to prepare, and convenient to use.

The invention relates to the technical field of skin care product preparation, and discloses a carbon essence preparation process, which comprises: S1, carbon material pretreatment: crushing a carbon material until the particle size is 10-50 nm, and carrying out surface treatment on the carbon material by using a surface modifier so as to form active sites on the surface of the carbon material; s2, preparation of a molecularly imprinted carbon material: mixing the pretreated carbon material with a template molecule, a monomer and a cross-linking agent, and carrying out a copolymerization reaction on the surface of the carbon material to form a molecularly imprinted structure; and S3, after the reaction is completed, removing the template molecules by using a washing solvent. A molecular imprinting structure is constructed on the surface of a carbon material, accurate adsorption and utilization rate improvement of active ingredients are achieved, long-acting slow release is achieved through a plant fiber composite carrier, a double-phase or multi-phase layered storage design is adopted, freshness and high efficiency of the ingredients are ensured, meanwhile, the composite carrier forms a water-locking protection layer on the skin surface, and the skin-care effect is achieved. The moisturizing effect of the product is enhanced.

The present invention provides a formaldehyde removal color-changing gel and a preparation method thereof, wherein the formaldehyde removal color-changing gel comprises a component A paste and a component B activation liquid, and the preparation of the component A paste comprises the following raw materials by weight: 0.5-1 parts of chlorite, 10-20 parts of composite glue, 10-20 parts of polymer sustained-release agent, 5-10 parts of stabilizer, 5-10 parts of modified chitosan, 0.2-1 parts of color indicator, and 40-50 parts of deionized water; the preparation of the component B activation liquid comprises the following raw materials: 5-15 parts of organic acid and 85-95 parts of deionized water. The formaldehyde removal color-changing gel provided by the present invention has the characteristics of good antibacterial property, high temperature resistance and high formaldehyde removal rate, can be widely used in the field of environmental protection technology, and has good commercial application value.

The invention belongs to the technical field of medicine, and particularly relates to a degradable sustained-release local anesthetic microsphere and a preparation method and application thereof.The degradable sustained-release local anesthetic microsphere comprises a drug core and a carrier shell wrapping the outer layer of the drug core, the drug core is a local anesthetic, and the carrier shell wraps the outer layer of the drug core. The carrier shell is a composite material of a modified polylactic acid-glycolic acid copolymer (PLGA) and a biocompatible auxiliary material. According to the invention, the modified PLGA is used as a carrier material, the hydrophilicity and the drug compatibility of the carrier are improved through PEG modification, the encapsulation efficiency (greater than or equal to 85%) and the drug loading capacity (10%-30%) of the local anesthetic are obviously improved, the drug waste is reduced, and the drug utilization rate is improved.

The invention discloses a preparation method of pH gradient active drug loading type maqui berry anthocyanin-curcumin compound lipidosome, belongs to the fields of biological medicines, food science and nutritional health-care products, and particularly relates to a nano drug delivery system and preparation of functional foods and dietary supplements. According to the method, the water-soluble maqui berry anthocyanin and the fat-soluble curcumin are efficiently entrapped at the same time by utilizing a unique double-layer structure of the lipidosome and through a film dispersion-hydration technology. Soybean lecithin and cholesterol are used as main membrane materials, tea polyphenol or vitamin E and other antioxidants are combined, and curcumin is induced to transmembrane-transfer from a lipid bilayer membrane to an internal water phase through precise pH gradient control and mild heating, so that the encapsulation efficiency of curcumin is remarkably improved. Then, through the steps of high-pressure microjet homogenization, low-temperature dialysis and the like, the maqui berry anthocyanin-curcumin compound liposome which is uniform in particle size, high in stability and excellent in encapsulation efficiency is prepared.

The invention relates to the technical field of agricultural planting, in particular to a method for improving bacterial leaf blight resistance of rice through induction treatment, an amino modified nano silicon dioxide-salicylic acid composite inducer is adopted for induction treatment, and the composite inducer is composed of an amino modified nano silicon dioxide carrier and supported salicylic acid; the treatment method comprises seed soaking and foliage spraying in a seedling stage, and specifically comprises the following steps: (1) seed soaking treatment; (2) foliage spraying; according to the technical scheme, through scientific component selection, process design and treatment mode combination, the control effect of rice on bacterial blight is remarkably improved (the control rate can reach 67% or above), the yield loss caused by diseases is effectively reduced, the use amount of chemical pesticides is reduced, the development requirement of green agriculture is met, and the method is worthy of popularization and application. The method has important practical application value and popularization prospect.