16results about How to "Good slow release" patented technology

The present application relates to a novel long-acting solid coated slow-release acid and a preparation method. The solid coated slow-release acid has a core-shell structure, the shell layer comprises a polymer, and the core comprises an acid former; the acid former is at least one selected from chlorinated aromatic hydrocarbons, chlorinated acid esters and acid chlorides, and the polymer is at least one selected from polyesters, poly(meth)acrylates, epoxy resins, polyolefins, polyacrylonitriles, polyimides, polyvinyl alcohols. The solid coated slow-release acid has the advantages of small environmental pollution, long acid release time, excellent deep penetration performance, high acid generating efficiency, easy storage and transportation, good slow-release performance and simple preparation.

This invention discloses a method for preparing a multifunctional slow-release fertilizer. First, a porous carrier is prepared by co-precipitation and calcination of iron tailings acid leaching solution and aluminum salts. Nutrient solution is loaded onto the carrier, dried, and granulated to obtain fertilizer particles. A bio-based composite coating precursor solution is prepared by mixing nanocellulose whiskers, sodium alginate, polyacrylic acid, and fumed silica, and a calcium chloride-chitosan solution is used as a crosslinking agent to obtain fertilizer particles. Finally, fluidized bed coating technology is used to sequentially spray the coating precursor solution and crosslinking agent solution onto the surface of the fertilizer particles. After two coating processes and drying, a multifunctional slow-release fertilizer is obtained. This invention combines the preparation of an industrial solid waste resource utilization carrier, the construction of a bio-based composite coating, and a rhizosphere-responsive slow-release design to prepare a multifunctional slow-release fertilizer. This fertilizer not only has low preparation cost but is also rich in nutrients, has good slow-release performance, and excellent mechanical stability.

The application belongs to the technical field of fertilizers, and particularly relates to a humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate and a preparation method thereof. The humic acid organic-inorganic compound fertilizer comprises the following raw materials in parts by weight: 22-30 parts of biogas residue, 35-55 parts of humic acid, 8-13 parts of fine columnar algae powder, 5-8 parts of urea, 12-17 parts of ammonium sulfate, 12-15 parts of superphosphoric acid calcium, 15-20 parts of potassium sulfate and 10-15 parts of slow release coating suspension. Test results show that the humic acid organic-inorganic compound fertilizer with slow release and improved fertilizer utilization rate prepared by the application can reduce the nitrogen and phosphorus release rates of the humic acid inorganic compound fertilizer, has better slow release effect, significantly promotes the plant height, stem diameter and root length of soybeans and corn, has obvious growth promotion effect, and has wide application prospect.

The present application provides a kind of pesticide composite drug delivery system and its preparation and application, the pesticide composite drug delivery system includes pesticide, MOF-NH2 and nano calcium carbonate, the pesticide is respectively loaded on MOF-NH2 and nano calcium carbonate, and the nano calcium carbonate of loading pesticide is covered outside the MOF-NH2 of loading pesticide.The pesticide composite drug delivery system of the present application overcomes the problem that the MOF-NH2 drug delivery system of loading pesticide in the prior art occurs easily in the process of application in acidic or high salinity environment Skeleton collapse, affect its drug loading performance and pesticide slow-release effect problem.The composite drug delivery system containing pesticide of the present application has good application and popularization prospect.

The invention relates to the field of concrete functional additives, in particular to a concrete internal curing agent with a hydration temperature rise regulation effect, a preparation method of the concrete internal curing agent and a concrete shrinkage-reducing and anti-cracking functional material. Wherein the raw materials comprise a polymeric monomer, a cross-linking monomer, an initiator, a polyhydroxy carbohydrate and water; wherein the polymeric monomer is composed of 70-100% by mass of an acrylamide monomer and the balance of an acrylic acid monomer, the polyhydroxy carbohydrate is a starch hydrolysate dextrin compound, and the DE value of the dextrin compound is greater than 0 but not greater than 15. The internal curing agent effectively solves the problem that an existing commercially available super absorbent polymer (SAP) internal curing material is poor in water absorption and water retention capacity on a cement pore solution containing divalent ions and trivalent ions, and the internal curing agent has the effects of internal curing and cement hydration heat release regulation and control.

The utility model discloses a medical dressing with medicine loading groove, medical dressing includes polyurethane film and antiseized layer, be equipped with a plurality of medicine loading groove on the polyurethane film, be equipped with hydrogel layer in the medicine loading groove, fill in the medicine of hydrogel layer, one side of the antiseized layer with polyurethane film is equipped with medicine loading groove and is close -fitted. The utility model discloses medical dressing is equipped with medicine loading groove on polyurethane film, fills hydrogel layer in medicine loading groove inner chamber, and the medicine is loaded in hydrogel, can promote the slow -release capacity of medical dressing. The medicine is distributed on the slow -release skeleton, and the slow -release skeleton is prepared through three -dimensional micro -nanometer printing, and the inner chamber is hollow, and the shape of slow -release skeleton is customized according to the shape of medicine loading groove, makes the quantity of slow -release skeleton in medicine loading groove maximization, forms medicine -skeleton load structure, can accommodate more medicine in medicine loading groove to good slow -release effect.

The invention relates to the technical field of biomedical administration, and particularly discloses double-layer hydrogel suitable for the interior of a bladder. The double-layer hydrogel comprises a hydrophilic adhesion slow-release layer and a hydrophobic protective layer; the hydrophilic adhesive slow-release layer and the hydrophobic protective layer are respectively obtained by curing a hydrophilic adhesive slow-release hydrogel precursor solution and a hydrophobic protective hydrogel precursor solution. By adopting a layered progressive double-hydrogel synergistic structure, an integrated administration barrier of mucous membrane adsorption-drug sustained release-physical protection is formed, so that the double-layer hydrogel has excellent bladder mucous membrane adhesion performance in a water environment and a stable and controllable drug sustained release effect, and the problems that an existing bladder perfusion drug is easily diluted and washed by urine, and the drug sustained release effect is poor are solved. The medicine action time is short, and the bioavailability is low.

The invention belongs to the field of macromolecules, and relates to an aerogel compound fertilizer, a biodegradable film and a preparation method and application thereof. The aerogel compound fertilizer comprises a bio-based high-molecular material carrier and a fertilizer loaded on the bio-based high-molecular material carrier, and is prepared by reacting a bio-based high-molecular material, an auxiliary agent and a water-soluble fertilizer, the bio-based high polymer material is a plant hormone; the auxiliary agent is a long-chain aliphatic compound and an N-vinyl amide polymer; based on 100 parts by weight of the aerogel compound fertilizer, the use amount of the bio-based high polymer material is 20-60 parts by weight, the use amount of the long-chain aliphatic compound is 1-10 parts by weight, the use amount of the N-vinyl amide polymer is 1-10 parts by weight, and the use amount of the water-soluble fertilizer is 10-80 parts by weight. The film prepared from the biodegradable composition disclosed by the invention has the characteristics of good mechanical property, good weather resistance, good fertilizer slow release performance, biodegradability and the like.

This invention provides a drug-loaded halloysite material, its preparation method, and its application. The drug-loaded halloysite material is prepared from halloysite, a drug, and an encapsulation material. Halloysite has good loading and sustained-release effects on drugs such as ciprofloxacin, diclofenac sodium, and nicotinic acid. Encapsulation with the encapsulation material further delays the release of the drug, resulting in slow release in the intestine and stomach, achieving targeted and controlled release. In addition, its preparation method is simple and can achieve rapid encapsulation, further avoiding drug loss during the encapsulation process. It can be used in the biomedical field, especially in the application of sustained-release drugs and intestinal targeted drug delivery, showing good application prospects.

This invention discloses a slow-release granule formulation of sodium alginate-biochar loaded with thiamethoxam, its preparation method, and its application. The slow-release granule uses biochar as the adsorbent carrier to adsorb thiamethoxam and sodium alginate as the encapsulating material, which is then cross-linked and solidified by dripping calcium chloride solution. The mass ratio of biochar to thiamethoxam is (10~30):1, the mass-to-volume ratio of sodium alginate to water is 1.5~2.0 g:100 mL, and the concentration of the calcium chloride solution is 1.5%~3.0%. The prepared slow-release granule has a cumulative release time of over 90 hours in distilled water, with no obvious burst release phenomenon. Pot experiments show that it maintains a continuous control effect on eggplant thrips for 7 days after application, which is superior to conventional spraying treatment. This invention has a simple preparation process, is environmentally friendly, and has excellent slow-release performance, making it suitable for green control of agricultural pests.

The invention belongs to the technical field of medicine, and particularly relates to a degradable sustained-release local anesthetic microsphere and a preparation method and application thereof.The degradable sustained-release local anesthetic microsphere comprises a drug core and a carrier shell wrapping the outer layer of the drug core, the drug core is a local anesthetic, and the carrier shell wraps the outer layer of the drug core. The carrier shell is a composite material of a modified polylactic acid-glycolic acid copolymer (PLGA) and a biocompatible auxiliary material. According to the invention, the modified PLGA is used as a carrier material, the hydrophilicity and the drug compatibility of the carrier are improved through PEG modification, the encapsulation efficiency (greater than or equal to 85%) and the drug loading capacity (10%-30%) of the local anesthetic are obviously improved, the drug waste is reduced, and the drug utilization rate is improved.

The invention discloses a preparation method of pH gradient active drug loading type maqui berry anthocyanin-curcumin compound lipidosome, belongs to the fields of biological medicines, food science and nutritional health-care products, and particularly relates to a nano drug delivery system and preparation of functional foods and dietary supplements. According to the method, the water-soluble maqui berry anthocyanin and the fat-soluble curcumin are efficiently entrapped at the same time by utilizing a unique double-layer structure of the lipidosome and through a film dispersion-hydration technology. Soybean lecithin and cholesterol are used as main membrane materials, tea polyphenol or vitamin E and other antioxidants are combined, and curcumin is induced to transmembrane-transfer from a lipid bilayer membrane to an internal water phase through precise pH gradient control and mild heating, so that the encapsulation efficiency of curcumin is remarkably improved. Then, through the steps of high-pressure microjet homogenization, low-temperature dialysis and the like, the maqui berry anthocyanin-curcumin compound liposome which is uniform in particle size, high in stability and excellent in encapsulation efficiency is prepared.

The invention relates to the technical field of agricultural planting, in particular to a method for improving bacterial leaf blight resistance of rice through induction treatment, an amino modified nano silicon dioxide-salicylic acid composite inducer is adopted for induction treatment, and the composite inducer is composed of an amino modified nano silicon dioxide carrier and supported salicylic acid; the treatment method comprises seed soaking and foliage spraying in a seedling stage, and specifically comprises the following steps: (1) seed soaking treatment; (2) foliage spraying; according to the technical scheme, through scientific component selection, process design and treatment mode combination, the control effect of rice on bacterial blight is remarkably improved (the control rate can reach 67% or above), the yield loss caused by diseases is effectively reduced, the use amount of chemical pesticides is reduced, the development requirement of green agriculture is met, and the method is worthy of popularization and application. The method has important practical application value and popularization prospect.

The invention relates to the technical field of high polymer materials, in particular to a preparation method and application of a high-water-absorptivity anti-freezing water-retaining agent with a urea slow release function. The preparation method comprises the following steps: adding a cross-linking agent, a catalyst, urea, a photoinitiator and a polysaccharide solution into an aqueous solution of potassium acrylate and acrylamide, stirring, and carrying out photo-initiation polymerization to prepare the water-retaining agent with excellent water absorption, water retention, cycle stability, soil freezing resistance and slow release performance by a one-pot method, and the water-retaining agent has a wide application prospect in the field of agriculture.

The invention relates to the technical field of biomedical materials, in particular to iodinated oil emulsion gel with a slow release function and a preparation method of the iodinated oil emulsion gel. The invention provides iodinated oil emulsion gel with a slow release function, the iodinated oil emulsion gel comprises an oil phase, a water phase and magnetic response amphiphilic particles, the oil phase is prepared by compounding oleic acid modified magnetic nanoparticles and iodinated oil; the water phase is prepared by dissolving a medicine in deionized water; the magnetic response amphiphilic particles are prepared by carrying out amination modification treatment on magnetic nanoparticles. The preparation method comprises the following steps: preparing oleic acid modified magnetic nanoparticles, compounding the oleic acid modified magnetic nanoparticles with iodinated oil to obtain magnetic iodinated oil, synthesizing magnetic response amphiphilic particles through multiple steps, and matching the magnetic response amphiphilic particles with a drug-containing aqueous phase and a gel agent to successfully prepare iodinated oil emulsion gel with a slow release function, and the iodinated oil emulsion gel has good centrifugal stability.

The invention discloses a polydopamine (PDA)-coated polylactic acid-glycolic acid (PLGA) targeted sustained release microsphere (Hep-coated PLGA-PDA MPs) loaded with heparin sodium, which is characterized in that the polylactic acid-glycolic acid microsphere (Hep-coated PLGA-PDA MPs) loaded with the drug heparin sodium is an inner core microsphere, and the outer part of the microsphere is also coated with a PDA layer. The invention also discloses a preparation method of the Hep-coated PLGA MPs, the microspheres have no burst release phenomenon within 2 hours of drug release, the release proportion of heparin sodium is 45.7-57.2% in 24 hours, and the microspheres have the characteristic of slow release. The microsphere disclosed by the invention can be used for developing an intravenous injection sustained-release agent for targeted therapy of thrombus.