19 results about "Symbiotic bacterium" patented technology

The invention discloses klebsiella aerogenes HW2024 and application of the klebsiella aerogenes HW2024 in preparation of drugs for treating allergic rhinitis. The preservation number of the klebsiella aerogenes HW2024 is CCTCC NO: M 20252524. The Klebsiella aerogenes disclosed by the invention is a symbiotic bacterium, and is relatively safe and easy to obtain, so that the treatment cost of AR patients can be greatly reduced, and a new treatment choice is provided for AR treatment; the pharmaceutical preparation for treating allergic rhinitis is simple and convenient in administration route, easy to operate and convenient for patients to use.

Compositions for use in preventing or treating an infection of the nasal passages, sinuses, or both of a subject are described. The compositions include one or more peptoid compounds in an amount effective to prevent or treat the infection in the nasal passages, sinuses, or both. The compositions include the one or more peptoid compounds in an amount effective to inhibit one or more pathogenic bacteria, pathogenic fungus, or pathogenic virus in the nasal passages, sinuses, or both, while having relatively little or no activity against commensal bacterial species, commensal fungal species, commensal viral species, or any combination thereof, in the nasal passages, sinuses, or both of the subject.

The present application relates to the field of microbial technology, and particularly relates to a bacillus megaterium YBZ13 for preventing and treating walnut leaf scorching and application thereof. The bacillus megaterium YBZ13 is preserved in the China General Microbiological Culture Collection Center, and the preservation number is CGMCC No.28098. The bacillus megaterium YBZ13 is a walnut rhizosphere symbiotic bacterium, and the bacterial suspension has a significant prevention and treatment effect on walnut seedling leaf scorching.

The invention belongs to the technical field of application of microorganisms, and particularly relates to a strain of streptomyces endogenus WA10-1-8 in intestinal tracts of cockroaches and application of a metabolic secondary product streptopherol compound of the streptomyces endogenus WA10-1-8 in anti-MRSA (Methicillin Resistant Staphylococcus Aureus) drugs. The cockroach intestinal endophytic streptomyces WA10-1-8 provided by the invention has the taxonomic name of Streptomyces albovinaceus, is preserved in Guangdong Microbial Culture Collection Center on June 13, 2024, and has the preservation number of GDMCC No: 4.422; the streptomyces WA10-1-8 is a symbiotic bacterium which is separated and screened from intestinal tracts of insect cockroaches; a metabolic secondary product, namely a streptophezine compound, has a relatively strong inhibition effect on MRSA (Methicillin-Resistant Staphylococcus Aureus), and can be used for preparing a medicine for treating MRSA infection.

The present application belongs to the field of microbial technology. More particularly, it relates to a salt-tolerant Bradyrhizobium sp. strain RY15 and its application. The Bradyrhizobium sp. strain RY15 provided by the present application has excellent salt tolerance and can significantly promote the growth and development and nodule fixation ability of Desmodium velutinum. The pot experiment results prove that the application of the RY15 strain can significantly increase the fresh weight of the aboveground part, the fresh weight of the underground part and the number of nodules of Desmodium velutinum; in the saline soil field, the yield of the pasture is increased by 68.89% after the inoculation of the RY15 inoculant. The RY15 strain of the present application can be made into a liquid or solid microbial inoculant, which is suitable for seed dressing, root soaking or soil application, and is simple to operate, low in cost and easy to popularize. The RY15 strain of the present application is a natural symbiotic bacterium, is safe and non-toxic, can improve the nitrogen cycle of soil, expand the planting of high-quality leguminous forage in saline-alkali soil, and has good application prospect and application value.

The invention discloses a flora-friendly selective antifungal peptide HRI and application thereof, and belongs to the technical field of novel antibacterial materials. The antifungal peptide HRI provided by the invention can only selectively resist pathogenic fungi instead of bacteria and especially does not resist symbiotic bacteria on the premise of maintaining flora balance, has relatively high biological safety, and has a certain inhibition effect on matrix metalloproteinase (MMP-9).

The invention discloses an entomopathogenic nematode symbiotic bacterium and an application of the entomopathogenic nematode symbiotic bacterium in prevention and control of potato pests. The symbiotic bacterium is derived from heterorhabditis bacteroides HL6. The invention further discloses a preparation method of the entomopathogenic nematode symbiotic bacterium. Researches show that the symbiotic bacterium has obvious pathogenic and lethal activity on a plurality of important potato pests, and especially has an efficient insecticidal effect on underground pests grubs and potato tuber moths which are seriously damaged by storage and fields. The symbiotic bacteria or the fermentation product thereof can quickly cause death of pests by infecting insect body cavities, destroying tissue structures and inhibiting immune response. Compared with a traditional chemical pesticide, the entomopathogenic nematode symbiotic bacterium has the advantages of being natural in source, high in safety, environmentally friendly, not prone to generating resistance and the like, is suitable for preparing a biological prevention and control preparation and is used for green prevention and control of pests in the potato production process. The invention provides a new biological prevention and control resource and technical approach for sustainable prevention and control of potato pests, and has good application prospect and popularization value.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine cough-relieving anti-inflammatory formula based on compound synergy and a process thereof, and the formula is composed of lily, radix peucedani, poria cocos, honey-fried licorice root, schisandra chinensis, dried ginger, pinellia ternate, asarum, almond, fresh pear and honey. The preparation process comprises the following steps: constructing a natural gel matrix through directional gradient enzymolysis; carrying out molecular pre-assembly on part of the medicinal materials; carrying out pH gradient guided programmed coupling and refining; capturing volatile components at low temperature; and finally carrying out symbiotic bacterium system biotransformation. According to the method, a low-temperature process is adopted in the whole process, ordered combination of substance levels of all components is achieved through the steps of enzymolysis, molecular assembly, programmed coupling, bioconversion and the like, and the technical problems of loss of active components, poor stability and enrichment of irritant components caused by a traditional high-temperature process are solved. The obtained traditional Chinese medicine is high in active ingredient retention rate, good in stability and low in irritation, and the in-vitro anti-inflammatory activity is improved.

The invention relates to the technical field of rose green tea production, and discloses a unique fermentation process of rose tender shoot green tea. The unique fermentation technology of the novel rose tender shoot green tea comprises the following steps of raw material selection and treatment, core fermentation and post-treatment, green tea tender shoots are subjected to low-temperature pulse ultrasonic cleaning and vacuum gradient freeze-drying and matched with a tea polyphenol protective agent, and loss of core active ingredients is greatly reduced; rose axillary buds are subjected to photoperiod domestication and composite enzymolysis to break cell walls, conditions are created for release and fusion of flavor substances, and the problem of component fusion is solved; by matching with staged regulation and control of a double-bacterium symbiotic bacterium agent, infectious microbes are inhibited, theanine is improved, and characteristic fragrance is generated; multispectral irradiation promotes generation of rose characteristic aroma and slows down degradation of chlorophyll, and aroma-producing yeast is matched to enrich ester aroma, so that aroma coordination of rose and green tea is realized; the bamboo charcoal coating of the ceramic pot adsorbs foreign flavor, and flavor purity is improved.

The application discloses a Phaeoacremonium scolyti strain and application thereof. A laccar symbiotic bacterium is screened from laccar, and is identified as a strain of the Phaeoacremonium genus through morphology and molecular biology, and is named as Phaeoacremonium scolyti CX-2. The bacterium can utilize laccar powder after laccar is combined to carry out fermentation, and active substances are produced, and with the increase of the fermentation time, the laccar alcohol extract content, the laccar characteristic substance content and the laccar alcohol extraction antioxidant activity are significantly improved, so that the bacterium can produce sesquiterpenes and chromones by taking wood as raw material, and has a wide application prospect in the industrial production of laccar.

The application discloses a corynebacterium striatum phage and application thereof. The corynebacterium striatum phage is a corynebacterium striatum phage CSP1, the preservation number of which is CGMCC NO: 45598, and the preservation time is July 4, 2023. The corynebacterium striatum phage has strong tolerance, biological safety and carries site-specific recombination functional elements (integrase and recombination sites). Meanwhile, the corynebacterium striatum phage can lyse 20 strains of multi-drug resistant corynebacterium striatum, and lays a foundation for subsequent medical researches using the corynebacterium striatum phage as a test and treatment carrier, a targeted pathogenic bacterium or symbiotic bacterium, and an immune regulator inducer.

A genetically modified strain of commensal bacteria Staphylococcus epidermidis is provided which produces a material with UV absorbing properties. The material with UV absorbing properties may be a mycosporine-like amino acid such as shinorine.

The invention provides application of lactobacillus plantarum YMJK-001 in fermented plant beverages and traditional Chinese medicines, and belongs to the technical field of functional microorganism fermentation and application. The lactobacillus plantarum YMJK-001 is obtained through self-screening, the preservation number of the lactobacillus plantarum YMJK-001 is CGMCC No.36695, a heat-resistant symbiotic bacterium system needing to be inactivated at the temperature of 100 DEG C for 60 minutes is formed when the lactobacillus plantarum YMJK-001 is subjected to symbiotic fermentation with lactobacillus casei ATCC393 and lactobacillus acidophilus ATCC4356, and the heat-resistant symbiotic bacterium system needs to be inactivated at the temperature of 100 DEG C for 60 minutes; the mixed bacterium retains high activity and does not need an embedding process. Meanwhile, the feed additive has extremely high transformation capacity on traditional Chinese medicine and plant beverages, debitterizing, sweetening and flavor reconstitution are realized, and the palatability is remarkably improved without addition. By applying a fermentation system containing the strain, the process can be simplified, the production cost can be reduced, the commercialization path of functional fermented drinks can be expanded, and the method has extremely high popularization value.

A genetically modified strain of commensal bacteria Staphylococcus epidermidis is provided which produces a material with UV absorbing properties. The material with UV absorbing properties may be a mycosporine-like amino acid such as shinorine.

The application discloses screening and synthesis of an antibacterial peptide CR24 and antibacterial application of the antibacterial peptide CR24. The antibacterial peptide CR24 is screened from a whole genome of a sheep intestinal symbiotic bacterium Bacillus haynesii strain B1, and is obtained through artificial synthesis. Experiments show that the antibacterial peptide CR24 is an antibacterial peptide, has extremely low cytotoxicity and hemolytic activity, does not produce drug resistance, and is excellent in safety. The antibacterial peptide CR24 has broad-spectrum antibacterial activity on various pathogenic bacteria, can exert bactericidal activity by damaging a cell membrane of Staphylococcus aureus, and can promote skin wound healing caused by Staphylococcus aureus infection in in-vivo application. In a word, the antibacterial peptide CR24 provided by the application is an antibacterial peptide which is small in molecular weight, easy to artificially synthesize, strong in antibacterial activity, safe and non-toxic, and can be used for preparing feed additives, anti-infection drugs, food preservatives and the like, and has a wide application prospect.

Disclosed herein are processes for the manufacture of a new topically adherent selective bactericide and products resulting therefrom. More specifically a method for producing a complexed stable microbiome regulating protein configured for topical application and use of that product as a medicament, effective for therapeutic effect against pathogenic bacteria, but not commensal bacteria.

The invention discloses an application of a skin symbiotic bacterium staphylococcus epidermidis fermentation broth and / or a lipopeptide 78 component thereof in preparation of a medicine for preventing and / or treating light aging and natural aging of skin. The staphylococcus epidermidis as a skin symbiotic bacterium has a certain anti-inflammatory effect, and the skin can generate senescence-related secretion phenotypes in the senescence process. The staphylococcus epidermidis fermentation liquor (the molecular weight of the component is less than 10kDa) and / or the component lipopeptide 78 of the staphylococcus epidermidis fermentation liquor are / is injected or smeared into the skin of UV-induced photoaged mice and old mice, so that the expression of UV-induced aging marker genes, IL-6 and the like in the skin of the mice can be obviously inhibited; dNA damage in the skin of a photoaged mouse is relieved, ROS accumulation and collagen degradation are reduced, and expression of an aging marker gene in the skin of an aged mouse is reduced. In addition, when the staphylococcus epidermidis fermentation liquor and / or the component lipopeptide 78 of the staphylococcus epidermidis fermentation liquor are / is added into photoaging keratinocytes, secretion of SASPs can be inhibited, and therefore aging of fibroblasts induced by the SASPs is inhibited.

The application discloses a friendly-bacterial flora type selective antifungal peptide HRI and application thereof, and belongs to the technical field of antibacterial new materials. The antifungal peptide HRI can selectively resist pathogenic fungi but not bacteria, especially not symbiotic bacteria, under the premise of maintaining bacterial flora balance, has high biological safety, and has a certain inhibitory effect on matrix metalloproteinase (MMP-9).