38 results about "Peptoid" patented technology

Disclosed herein are a peptoid compound and a peptoid conjugate such as a peptoid-lipid conjugate, and preparation methods therefor and the use thereof in a small molecule drug and nucleic acid delivery. Further disclosed herein are a lipid particle containing the peptoid-lipid conjugate, such as a liposome and a lipid nanoparticle, and a small molecule drug and / or a nucleic acid delivery composition containing the peptoid-lipid conjugate or the lipid particle. The peptoid-lipid conjugate, lipid particle, and small molecule drug and / or nucleic acid delivery composition that can be used for the small molecule drug and nucleic acid delivery of the present invention enable highly efficient compounding, protection, intracellular and targeted delivery and release of the small molecule drug and biomolecules, such as nucleic acids, in tissues and organs both in vitro and in vivo.

Lipopolysaccharide-binding peptoids, and compositions and methods of use thereof, are described.

Methods of using peptoid compounds for preventing or treating an infection of a virus of the Filoviridae family are described.

Compositions for use in preventing or treating an infection of the nasal passages, sinuses, or both of a subject are described. The compositions include one or more peptoid compounds in an amount effective to prevent or treat the infection in the nasal passages, sinuses, or both. The compositions include the one or more peptoid compounds in an amount effective to inhibit one or more pathogenic bacteria, pathogenic fungus, or pathogenic virus in the nasal passages, sinuses, or both, while having relatively little or no activity against commensal bacterial species, commensal fungal species, commensal viral species, or any combination thereof, in the nasal passages, sinuses, or both of the subject.

The application relates to the technical field of medical materials, and discloses an antibacterial coating containing a peptide-like substance and a preparation method thereof, which comprises the following steps: step 1, preparing an antibacterial solution containing a peptide-like substance; step 2, cleaning and drying the surface of a medical material; step 3, immersing the medical material treated in step 2 in the antibacterial solution in step 1 and standing, then taking out and drying the medical material, and preparing the antibacterial coating on the surface of the medical material; the antibacterial solution containing the peptide-like substance comprises the following raw material components according to 100% by mass: 0.1-2% of a peptide-like substance, 5-20% of tannic acid, 0.5-2% of hydrochloric acid, and the rest is an organic solvent; the peptide-like substance has the following structure. In the application, the peptide-like substance compound with excellent antifungal effect is used in cooperation with natural plant polyphenol tannic acid, the hydrogen bond and the pi-pi stacking between the tannic acid and the peptide-like substance are used together, a hydrophobic antibacterial coating with excellent antibacterial effect, stable adhesion and uniformity is formed on the surface of the medical material.

The present disclosure is directed to peptoids and peptoid multimers that inhibit IL-15 and their use in treating autoimomune / inflammatory diseases.

Broad spectrum peptoids for treatment or prevention of oral infections, and compositions and methods of use thereof, are described.

The present invention relates to the field of antimicrobial peptoids. Especially, the present invention relates to a terpolymer of formula (I), or a pharmaceutically acceptable salt and / or solvate thereof, wherein Rinit, X, A, B, C, Rter, x, y, z and m are as defined in the claims. The present invention also relates to the process for manufacturing said terpolymer, the pharmaceutical composition including said terpolymer and its uses in the treatment and / or prevention of microbial infections.

The present invention discloses a class of cationic symmetrical bacteria-induced antibacterial self-assembling peptoids, whose structure has the following general formula: #imgabs0# The primary structure of this type of molecule is different from that of natural polypeptides. It not only has linear symmetry, but also has antibacterial effects and can also serve as an antibacterial adjuvant for sensitizing antibiotics.

The present invention relates to a pharmaceutical composition for the treatment or prevention of breast cancer / mammary carcinoma, in particular locally recurrent or metastatic breast cancer, in a patient or patient group suffering from or suspected of suffering from breast cancer, comprising: at least 4 to 8 HLA-A tumor antigen peptides corresponding to MHC class I complexes and at least 2 tumor antigen peptides corresponding to MHC class II complexes, wherein the HLA tumor antigen peptides are tumor specific or tumor associated HLA antigen peptides and are directed against at least one MHC complex, including combinations thereof; a pharmaceutical composition, a kit (or parts thereof); a method for determining class I and / or class II HLA peptides; a method for the manufacture of a pharmaceutical composition according to the invention; and the use of a pharmaceutical composition according to the invention for the manufacture of a pharmaceutical composition for the treatment of malignancies, leukemias and tumors.

Broad spectrum peptoids for treatment or prevention of wound infections, and compositions and methods of use thereof, are described.

The invention relates to the technical field of nano materials, in particular to a preparation method of a light response type ultrathin organic vesicle. The structural formula of the amphiphilic peptoid molecule is as shown in formula I: # imgabs0 #; and the light response type ultrathin organic vesicle prepared by self-assembling the amphiphilic peptoid molecule has excellent light response characteristic, so that the amphiphilic peptoid molecule has wide application prospect in preparation of a catalyst carrier.

The application provides a kind of poly-peptide containing functionalized diphenylamine group and its preparation method.The preparation method includes: N-thiocarboxylic anhydride containing bromine phenyl group is subjected to ring-opening polymerization under the action of initiator, and poly-peptide containing bromine phenyl group is obtained; in the presence of inorganic base, palladium catalyst and ligand, the raw material system including poly-peptide containing bromine phenyl group and aromatic amine derivative occurs amination coupling reaction, and poly-peptide containing functionalized diphenylamine group is obtained, as shown in formula (I), wherein R1 is any one of n-hexyl, benzyl, neopentyl, methoxy polyethylene glycol group;R2 is any one of hydrogen atom, alkyl, alkoxy, phenyl, triphenylvinyl, diazene phenyl;N is an integer between 10 and 100;X is 1 or 2.The preparation method is simple and easy to operate, with the advantages of high efficiency and strong universality, and is suitable for wide application.

Lipopolysaccharide-binding peptoids, and compositions and methods of use thereof, are described.

The present application relates to the technical field of bioengineering, and particularly relates to application of a collagen peptoid in preparation of a vascularized culture system. It is found for the first time that the electrically neutral collagen peptoid containing GER with high GPO monomer proportion has a stable 3D vascularized structure, can be effectively combined with a biomimetic gel component, and is helpful to formation of organoid vascularization. The collagen peptoid has a good industrialization prospect and has a wider application value in the field of medical regeneration.

The present application relates to the technical field of bioengineering, in particular to a collagen peptoid and a preparation method and application thereof. The present application provides a method different from conventional solid-phase synthesis of collagen peptoids. The preparation method of the collagen peptoid provided only needs two-step reactions of polymerization (random polycondensation) and hydrogenation catalysis, and the reactions are carried out in a homogeneous solution, so that the preparation method is simple and suitable for large-scale industrialized preparation. Moreover, the structure of the collagen peptoid provided can be flexibly changed according to needs on the basis of different monomer proportions, and the target peptoid can be quickly prepared.

The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The peptoid polymers and peptoid-peptide hybrids provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.

The present invention relates to the prevention and treatment of disease like cancer. The inventors have previously characterized MELOE-1 antigen as an IRES dependent, melanoma specific translation product from a lncRNA mainly transcribed in the melanocytic lineage. MELOE-1 contains numerous class II epitopes and one HLA-A*0201-restricted CD8 epitope eliciting a frequent repertoire of high avidity T cells. They designed various synthetic long peptide (SLPs) comprising a CD4 epitope coupled to the CD8 epitope by a serie of linkers of 4 to 6 aa and studied the efficacy of T cell clone activation by SLP-loaded DC in vitro. Particularly, they evaluated the ability of a few selected SLPs to stimulate specific T cells proliferation of PBL from healthy donors in vitro and finally, they explored the vaccination potential of their best SLP candidate in vivo in an HLA*A0201 / HLA-DRB0101 transgenic mouse. Thus, the present invention relates a SLP comprising a CD4 class II peptide linked to a CD8 class I peptide by a specific linker and its use in the treatment of disease like cancers.

The present disclosure provides delivery vehicle compositions comprising hydroxyalkyl-capped cationic peptoids, such as 2-aminopropane-1,3-diol-capped cationic peptoids, and complexes of the delivery vehicles with polyanionic compounds, such as nucleic acids. The disclosure further provides methods of making and using the delivery vehicle compositions and complexes, such as for the delivery polyanionic compounds (e.g., nucleic acids) to cells. The disclosure also provides methods of eliciting an immune response with the delivery vehicle complexes of the disclosure.

Broad spectrum peptoids for treatment or prevention of oral infections, and compositions and methods of use thereof, are described.

The invention discloses an application and a method of hydrogel in vascularization culture of organoids, in the application, the hydrogel is prepared from a precursor composition, the precursor composition is an aqueous solution, and the precursor composition comprises, by weight, 10-20% of an aqueous solution, and 10-20% of an aqueous solution. W / v: the concentration of the norbornene modified heparin is 0.2-2%, the concentration of the norbornene modified gelatin is 0.5-5%, the concentration of the sulfydryl four-arm polyethylene glycol is 0.3-3%, the concentration of the photoinitiator is 0.01-0.1%, the concentration of the matrix metal protein peptidomimetic MMP is 0.05-0.5%, the sequence of the matrix metal protein peptidomimetic MMP is shown as SEQ ID NO.3, the norbornene modified heparin is obtained by modifying a heparin raw material, and the thickness of the matrix metal protein peptidomimetic MMP is 0.5-1 mm. The norbornene modified gelatin is obtained by modifying a gelatin raw material. According to the invention, the vascularization culture of the tumor-like organs is realized, and the large-scale vascularization culture of the tumor-like organs is facilitated.

Compositions are provided which feature mixtures of at least a first and second peptoid. The second peptoid has a terminal aliphatic moiety, while the first peptoid lacks a terminal aliphatic moiety. These compositions have various end uses, including the treatment of various cancers and tumors and the treatment of bacterial, fungal, microbial or parasitic infections.

The present invention relates to a novel peptoid derivative, which is a partially modified adiponectin receptor peptide and has higher stability and superior p-AMPK activity than existing adiponectin receptor peptides, and has the advantage of being advantageous for drug formulation due to improved physical properties and activity. Therefore, the peptoid derivative of the present invention can be used for preventing or treating skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, and for preventing or improving aging, sensitive skin, wrinkles, or moisture.

Methods of using peptoid compounds for preventing or treating an infection of a virus of the Filoviridae family are described.

The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.

Provided are a polypeptide compound, and a complex and use thereof, specifically relating to the technical field of pharmaceutical chemistry. The polypeptide compound is shown as formula I. Compared with the prior art, the provided peptoid compound can target integrin proteins such as αvβ5, α5β1, and αvβ3, is enriched in tumor cells having high integrin expression, and has an important function in diagnosis and / or treatment of tumors.

The application relates to the field of biological medicine, and discloses an antibacterial hydrogel containing a peptoid as well as a preparation method and application thereof, the preparation method comprising the following steps: step 1, adding a catalyst and dopamine hydrochloride into a hyaluronic acid solution to prepare a hyaluronic acid-dopamine precursor solution through reaction; and step 2, mixing a peptoid solution with the precursor solution, and constant-temperature solidification to obtain the antibacterial hydrogel; the structural formula of the peptoid is as follows. In the application, the hyaluronic acid is modified and grafted by using dopamine, and the benzene rings of dopamine and the benzene rings in the peptoid are used to form a multi-component crosslinking network through the joint action of pi-pi stacking and hydrogen bonding, so that a high-stability hydrogel is prepared. The hyaluronic acid is covered on the hydrogel to have excellent biological functionality, the peptoid is covered on the hydrogel to have excellent antibacterial property, the preparation method is simple, raw materials are easy to obtain, and the hydrogel can be applied to the preparation of medical materials for treating wound infection and chronic wound treatment.

Disclosed are compounds having a linker for increasing trans-cyclooctene stability. The linker of the invention is a three-arm linker. In some embodiments, one arm of the linker is attached to a trans-cyclooctene moiety, another arm is attached to a compound selected from the group consisting of antibodies, proteins, peptides, and peptoids, and the third arm extends into the solution.

This invention relates to the field of organoid culture technology, specifically to the application of a collagen peptide in the preparation of organoid culture systems. This invention discovers that a GER-containing, electrically neutral collagen peptide with a GPO monomer content as high as 40-80% can significantly promote organoid growth, exhibiting a marked promoting effect on organoid proliferation and differentiation. It can effectively combine with biomimetic gels to form organoid culture systems, promoting organoid formation. This invention has good industrialization prospects and broader application value in the field of medical regeneration.

Broad spectrum peptoids for treatment or prevention of wound infections, and compositions and methods of use thereof, are described.