86 results about "Pathogenic fungus" patented technology

The application relates to the field of agricultural disease control technology, and particularly relates to the use of indole compounds and pharmaceutically acceptable salts, solvates, crystal forms, prodrugs, stereoisomers and tautomers thereof for preparing a medicine for inhibiting pathogenic key protein kinase CgSlt2 of pathogenic fungi. The application first proposes a new type of CgSlt2-targeted inhibitor, specifically, indole compounds ((S)-N-(1-(1H-indol-3-yl)-4-(methylamino)-4-oxobutan-2-yl)-8-bromo-1,6-naphthyridine-2-carboxamide) and ((S)-N-(2-((1H-indol-3-yl)-1-(methylamino)-1-oxopropyl)-8-bromo-1,6-naphthyridine-2-carboxamide) are used as CgSlt2 inhibitors, have the characteristics of high target specificity and high activity, and exhibit excellent pathogenicity inhibition of a strain of the complex group of Colletotrichum gloeosporioides.

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The embodiment of the application discloses a biocontrol streptomyces and application thereof, and relates to the technical field of microorganisms. The biocontrol streptomyces is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC No: 68067, and the preservation date is April 10, 2026. The biocontrol streptomyces has a significant prevention and treatment effect on postharvest mango anthracnose, and has a broad-spectrum antagonistic effect on various pathogenic fungi. The strain has a fast growth speed, a wide growth temperature adaptation range, and can grow well under high-temperature conditions, and the antagonistic effect on anthracnose is outstanding, thereby providing a new idea for the research and development of a postharvest disease biological control of mango and a new green control agent.

The application discloses a preparation method of a diphenylmethyl quinoxaline ketone derivative, and belongs to the technical field of biological medicines. The structure of the diphenylmethyl quinoxaline ketone derivative is shown in the specification. The application adopts a cross dehydrogenative coupling strategy, realizes quinoxaline ketone 3-alkylation through direct activation of an alkane and accompanying hydrogen atom transfer, and has the advantages of mild reaction conditions, cheap and easily available reagents, and higher efficiency and environmental friendliness. The diphenylmethyl quinoxaline ketone derivative has high-efficiency and broad-spectrum antifungal activity, shows inhibitory effects on a plurality of common plant pathogenic fungi, and can be developed into a product for treating plant fungal infections.

The application provides application of a bacillus subtilis K8 nano-seleniumized active bacterium agent in prevention and treatment of plant pathogenic bacteria, and belongs to the technical field of biological prevention and treatment of plant diseases. Bacillus subtilis The bacillus subtilis K8 nano-seleniumized active bacterium agent is obtained by fermenting and culturing bacillus subtilis K8 in a fermentation medium containing sodium selenite. Bacillus subtilis The bacillus subtilis K8 nano-seleniumized active bacterium agent has a strong prevention and treatment effect on cucumber fusarium wilt, cucumber botrytis blight, tomato early blight and tomato root rot, provides an efficient, safe and practical method for prevention and treatment of plant fungal diseases, has low cost, simple preparation process, is convenient for industrialization, and has good development value and market prospect.

The present application relates to the technical field of pesticide chemistry and medicinal chemistry, and particularly relates to a substituted pyrazole-containing ortho-hydroxy aryl formamide derivative, a preparation method and application thereof. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative is prepared from a 5-amino pyrazole intermediate (I) and a different substituted ortho-hydroxy aryl formic acid (II) as raw materials through an amide condensation reaction. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative prepared by the present application has a broad-spectrum inhibitory activity on plant pathogenic fungi, and particularly has excellent inhibitory activity on Valsa mali, Sclerotinia sclerotiorum and Botrytis cinerea, and is expected to be developed into a new type of green fungicide with high efficiency, safety, economy and environmental friendliness.

The present application provides a novel structure of thiophene compound, the compound has significant inhibitory effect on spore germination and appressorium formation of various plant pathogenic fungi and oomycetes (such as Pyricularia oryzae, Colletotrichum gloeosporioides, Gibberella, Phytophthora, Phytophthora capsici), which can be used for preventing and treating plant diseases caused by fungi and / or oomycetes.

Compositions for use in preventing or treating an infection of the nasal passages, sinuses, or both of a subject are described. The compositions include one or more peptoid compounds in an amount effective to prevent or treat the infection in the nasal passages, sinuses, or both. The compositions include the one or more peptoid compounds in an amount effective to inhibit one or more pathogenic bacteria, pathogenic fungus, or pathogenic virus in the nasal passages, sinuses, or both, while having relatively little or no activity against commensal bacterial species, commensal fungal species, commensal viral species, or any combination thereof, in the nasal passages, sinuses, or both of the subject.

The present application relates to the technical field of pesticides, and discloses a chromene aryl hydrazide derivative, a preparation method and application thereof, a structural general formula of the chromene aryl hyydrazide derivative is as formula (I); the preparation method is as follows: taking p-hydroxybenzaldehyde as raw material, and obtaining the chromene aryl hydrazide compound through substitution reaction, cyclization reaction, oxidation reaction, acylation reaction and hydrazinolysis reaction. The chromene aryl hydrazide compound is used for preparing an agricultural bacteriostatic agent. The present application combines aryl hydrazine and chromene skeleton by using the pharmacophore splicing principle in medicinal chemistry, and designs and synthesizes a series of chromene aryl hydrazide compounds. The bacteriostatic activity test result shows that the compounds have excellent bacteriostatic activity, and can be used as active ingredients for preparing a plant pathogenic fungus fungicide.

The application discloses a synthesis method of C3-substituted quinoxaline ketone derivatives and application thereof. A series of C3-substituted quinoxaline ketone derivatives with both terpene and quinoxaline ketone biological activity skeletons are obtained by using N-alkoxy phthalimide and quinoxaline ketone as starting substrates, under the catalysis of a photocatalyst and visible light irradiation, and at a temperature of 55-65 DEG C for 10-15 h. The application has the advantages of stable and easy-to-prepare raw materials, mild reaction conditions, simple experimental operation, good chemical selectivity and functional group tolerance, and is a green chemical synthesis method with good application prospect. The activity experiment results show that the synthesized C3-substituted quinoxaline ketone derivatives have good inhibiting effect on the growth of plant pathogenic fungi.

This application discloses a strain of *Priestia taiwanensis* W178 and its application in controlling soil-borne fungal diseases. This strain was deposited at the China Center for Type Culture Collection (CCTCC) on December 29, 2025, with accession number CCTCC NO:M 20253047. The strain exhibits significant antagonistic activity against 11 soil-borne pathogenic fungi, including *Sclerotinia sclerotiorum* and *Fusarium graminearum*, with an inhibition rate reaching up to 91.10%. This application also establishes a fermentation process for this strain, resulting in a spore count of 19.3 × 10⁻⁶ after fermentation. 8 CFU / mL. Pot experiments showed that the fermentation broth, diluted 10 times, was significantly effective in controlling rapeseed sclerotinia stem rot and could effectively inhibit the spread of lesions. This application is the first to discover the broad-spectrum biocontrol potential of *Priscilla taiwanensis* and provides an active strain and its fermentation product that can be developed into microbial agents, bio-organic fertilizers, or compound microbial fertilizers, suitable for the green control of various soil-borne fungal diseases such as rapeseed sclerotinia stem rot and wheat stem rot.

This invention belongs to the field of agricultural microbiology technology and relates to a strain of Bacillus velezensis S-34 and its application in controlling mango leaf anthracnose. It was isolated from the rhizosphere soil of the anthracnose-resistant mango variety 'Jinhuang' and deposited at the China Center for Type Culture Collection (CCTCC) on May 29, 2025, with accession number CCTCC No. M 20251225. The Bacillus velezensis S-34 provided by this invention not only controls mango leaf anthracnose but also exhibits good antagonistic effects against various mango leaf pathogenic fungi. Furthermore, Bacillus velezensis S-34, its sterile fermentation broth, and volatile gases can inhibit the germination and epidermal penetration of Anthracnose spores, thereby inhibiting the infection process of Anthracnose spores on plants. This invention provides a new biocontrol agent and preparation method for the efficient control of mango leaf anthracnose and other foliar diseases in agricultural production, which is beneficial to the green and healthy development of the mango industry.

The present application belongs to the technical field of biological control, and particularly relates to a microbial agent for preventing and treating gray mold of crops, and a preparation method and application thereof. The present application provides a microbial agent for preventing and treating gray mold of crops, which comprises a microbial strain and / or a fermentation broth of the microbial strain; the microbial strain comprises one or more of Bacillus subtilis JD-L9, Pseudomonas lundensis DS-PZ-P18 and Pseudomonas chlororaphis HQ-CZ-P12; wherein the Pseudomonas chlororaphis HQ-CZ-P12, the Pseudomonas lundensis DS-PZ-P18 and the Bacillus subtilis JD-L9 have a good inhibition rate on the pathogenic fungus of gray mold, and after being compounded into a compound microbial agent, the compound microbial agent is sprayed on seedlings of medicinal materials, so that the incidence of gray mold during seedling raising is significantly reduced, pesticide residues of the medicinal materials are reduced, and the safety of the medicinal materials is improved.

The present application belongs to the field of microorganisms and biological control technology, and particularly relates to Burkholderia cenocepacia Tzs39 and application thereof in preventing and treating plant pathogenic fungi. The present application provides a Burkholderia cenocepacia Tzs39, and the preservation number of the Burkholderia cenocepacia Tzs39 is CGMCC No.30082. The antagonistic bacteria Tzs39 in the present application is isolated from rhizosphere soil of continuously cultivated Radix Pseudoginseng, has a good rhizosphere colonization effect and is safe and reliable, and can be used for preventing and treating or alleviating soil-borne disease problems of continuously cultivated medicinal plants, preventing and treating root rot in the process of continuously cultivating medicinal plants. The results of the embodiments show that the antagonistic bacteria Tzs39 can effectively inhibit the growth of Fusarium oxysporum and Trichoderma.

This invention relates to the field of microbial technology and discloses a biocontrol strain for controlling peanut stem rot, wherein the biocontrol strain is *Bacillus pilaris* (…). Paenibacillus peoriae This invention also provides a biocontrol agent containing this strain and its preparation method. Genomic analysis revealed that this strain contains gene clusters encoding active substances such as fusarium and polymyxin, exhibiting significant antagonistic activity against peanut stem rot fungus, and broad-spectrum inhibitory activity against various plant pathogenic fungi, including wheat stem base rot fungus and rapeseed sclerotinia. Furthermore, this strain possesses the ability to secrete auxin, produce proteases, and produce cellulases. The prepared inoculum, applied through root irrigation, can construct a preventative biological barrier in the rhizosphere, providing both disease prevention and growth promotion effects. This invention provides a highly efficient germplasm resource for the green control of crop diseases.

The application belongs to the technical field of agricultural microorganisms, and particularly relates to a plant endophytic Paenibacillus polymyxa and application thereof in preventing and treating plant diseases. Paenibacillus polymyxa The plant endophytic Paenibacillus polymyxa has the strain number PP8, the classification name Paenibacillus polymyxa, the preservation number CGMCC No. 36638, and is preserved in the China General Microbiological Culture Collection Center on November 17, 2025. The Paenibacillus polymyxa has broad-spectrum inhibitory activity on pathogenic fungi, oomycetes and bacteria, and can produce significant inhibitory effect on plant pathogenic microorganisms through multiple action mechanisms. In addition, the Paenibacillus polymyxa PP8 has the ability to colonize in the internal tissue of plant roots, can exist in the plant body and play the disease-inhibiting effect, thereby further enhancing the prevention and control effect on soil-borne diseases and improving the persistence and stability of the biological control effect.

The application discloses a thiazolidine-2,4-dione derivative containing a thioamide and a piperidine structure and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis and application. The thioamide with excellent activity and the thiazolidine-2,4-dione structure are combined through a piperidine pharmacophore to synthesize a series of thiazolidine-2,4-dione derivatives containing a thioamide and a piperidine structure. Through the plant pathogenic fungus activity test of the synthesized derivatives, it is found that the thiazolidine-2,4-dione derivative containing a thioamide and a piperidine structure synthesized by the application can effectively inhibit plant pathogenic fungi, especially the rice sheath blight fungus.

The application discloses a Robbauera fungus derived from a rainforest and an application thereof, and relates to the technical field of microorganisms. Robbauera albescens The Robbauera fungus is named 1-F6 and has a preservation number of CGMCC No.42326, and has antibacterial property. The Robbauera fungus provided by the application has significant inhibitory activity on various plant pathogenic fungi, and exhibits good prevention and control activity. Meanwhile, metabolites produced by the Robbauera fungus under the condition of industrial culture medium have a high efficient lethal effect on nematodes. In addition, the Robbauera fungus also has the effect of promoting the growth of cowpea root systems.

The application discloses a method for observing infection of wheat leaf by Erysiphe graminis. The back of the wheat leaf is fixed on an acrylic plate, and the spores of Erysiphe graminis are inoculated uniformly; the epidermis of the back of the leaf is torn and immersed in a phosphate buffer solution; the buffer solution is absorbed, a cell component eluent is added for elution, and then the phosphate buffer solution is replaced; the phosphate buffer solution is absorbed, and a coomassie brilliant blue solution is added for staining, so as to obtain a plant sample for observation. The method can greatly save the experimental time, the reagents used do not contain toxic reagents, the structure, edge and infection point of each period of pathogen infection are clearer, and the background color is uniform and clear. The method can be used for rapid observation of the infection of cereal crops by powdery mildew, and is also suitable for the observation of the infection of other plant pathogenic fungi.

The invention belongs to the technical field of organic synthetic chemistry and agricultural chemicals, and particularly relates to an imidazo aza-aryl oxazoline compound as well as a preparation method and application thereof. The imidazo aza-aryl oxazoline compound provided by the invention has a structure as shown in a formula 1, comprises substituted imidazo aza-aryl and substituted oxazoline substructures, has a remarkable inhibition effect on various plant pathogenic fungi, and can be used as a novel bactericide candidate compound or directly used as a bactericide; the compound also has an inhibiting effect on various harmful mites or aphids, and can be used as an acaricide. The imidazo nitrogen heteroaryl oxazoline compound provided by the invention has positive significance in discovery of innovation of new drugs. Formula 1.

This invention discloses a strain of Bacillus subtilis FHY1 and its applications, belonging to the field of microbiology. The present invention obtained a strain of Bacillus subtilis FHY1 from the juice of Populus euphratica in Xinjiang. Experimental verification shows that the liquid culture of the Bacillus subtilis FHY1 strain provided by this invention has a significant inhibitory effect on rice blast fungus, with an inhibition rate of 84% and an inhibition rate of 92% on rice blast fungus spore germination. It can promote rice growth under conditions of 150mM NaCl and 250mM NaCl. Simultaneously, this strain also has good inhibitory effects on rice blast fungus, Fusarium oxysporum, Fusarium graminearum, Sclerotinia sclerotiorum, and Anthracnose fungus. Therefore, this invention provides a new strain with good control effect against pathogenic fungi, and significantly promotes rice growth and development under salt stress.

The application discloses use of an extract of black tiger in preparation of a fungicide for preventing and treating plant diseases caused by pathogenic fungi and oomycetes. The black tiger extract has the effects of inhibiting spore germination, germ tube growth or zoospore formation, and vegetative hypha growth of the fungi and oomycetes, can effectively prevent growth of the pathogenic fungi and infection on host plants, and has certain prevention and treatment effects on rice rice blast, rice rice smut, potato late blight, cucumber anthracnose, grape anthracnose, corn ear rot, pepper blight and camphor blight, and provides a possibility for development of a plant source fungicide with diversified effective components, high prevention and treatment efficiency and a wide spectrum of prevention and treatment objects.

This invention discloses a myxobacterium resistant to plant pathogenic fungi and bacteria. The strain is named *Myxococcus sp.* R23, with accession number GDMCC No: 63212. The methanol extract of the fermentation supernatant of *Myxococcus sp.* R23 inhibits the growth of *Rhizoctonia solani* Kühn GDMCC 3.513, which causes rice sheath blight. Furthermore, this strain can prey on *Ralstonia solanacearum* GIM 1.70, which causes bacterial wilt in tomatoes, demonstrating its application value in the biological control of plant diseases.

The present application relates to the field of microbiological technology, and particularly relates to a walnut decay disease biocontrol bacterium Achromobacter insuavis P52 and application thereof.The Achromobacter insuavis is Achromobacter insuavis P52, which is preserved in the China General Microbiological Culture Collection Center, and the preservation number is CGMCC No.28849.A strain of Achromobacter insuavis is isolated from a pot seedling of Populus trichocarpa, and the strain has a significant antagonistic effect on a walnut decay disease pathogenic fungus Cytospora chrysosperma, with an inhibition rate of 62.4%, and an in-vitro prevention and treatment effect on walnut branch decay disease of 76%.The Achromobacter insuavis in the present application has a significant prevention and treatment effect on walnut decay disease, and has a good application prospect.

The present application belongs to the technical field of tobacco planting, and particularly relates to a method for targeted removal of pathogenic bacteria in continuous tobacco field, which comprises the following steps: S1, land preparation: removing field residues and weeds before transplanting flue-cured tobacco seedlings; S2, pesticide application: applying base fertilizer and removal agent to the tobacco ridge area of the tobacco field; S3, ridging: loosening and ridging the soil where the removal agent is applied; S4, film mulching and sealing: mulching after ridging, and sealing the tobacco ridge; S5, film breaking and air release: breaking the film at the interval of the tobacco seedling nest distance and releasing the air in the film; S6, trial planting and verification: planting 3-5 tobacco seedlings or vegetable seedlings per mu, watering and observing, and then transplanting after no abnormality of the plants; S7, transplanting tobacco seedlings; in use, the inhibition rates of Fusarium, Pseudomonas and Pythium in the continuous tobacco field are all above 86%, the comprehensive removal rate of pathogenic bacteria is greater than or equal to 86%, the incidence of tobacco seedlings is reduced from 36.8% to less than 7%, the frequent occurrence of soil-borne diseases is solved from the source, the bacteria are targetedly inhibited, no fallow is needed, and the cost is low.

The application discloses a benzisothiazole carboxamide compound and application thereof. The benzisothiazole carboxamide compound has the characteristics of high specificity and high activity as an inhibitor of myosin motor domain, and can significantly inhibit the growth and development process and pathogenicity of pathogenic fungi, especially Pyricularia oryzae.

This invention discloses a compound seed treatment agent containing metalaxyl-M and tebuconazole, its preparation method, and its uses, belonging to the technical field of seed treatment agents. The suspension of this invention uses metalaxyl-M, tebuconazole, and sodium selenite as the main components, supplemented with emulsifying and dispersing agents, wetting and dispersing agents, antifreeze agents, suspending agents, film-forming agents, and warning colors, and is prepared by adding deionized water to a sufficient volume. Metalaxyl-M targets and inhibits ribosomal RNA polymerase I of oomycete pathogens, while tebuconazole targets and inhibits sterol 14α-demethylase. The two have complementary fungicidal spectra, synergistically controlling maize stalk rot and maize head smut. Sodium selenite, by inhibiting the oxidative stress defense system of pathogenic fungi involving glutathione and thioredoxin, promotes the effects of the two main components and simultaneously remediates selenium-deficient soils. This invention is suitable for the green and efficient control of maize stalk rot and head smut, and also has the function of ecological restoration of selenium-deficient soils.

The application discloses application of a broad-spectrum antibacterial biocontrol Cytospora fungus F-XTBG8 in preparation of antifungal active substances. Chaetomella raphigera The application of the broad-spectrum antibacterial biocontrol Cytospora fungus (F-XTBG8) is applied in preparation of antifungal active substances. The strain has obvious antagonism to more than 100 environmental fungi and plant pathogenic fungi including Pyricularia oryzae (Monascus oryzae), Mycosphaerella fijiensis (Mycosphaerella fijiensis), Alternaria tenuissima (Alternaria tenuissima), Fusarium graminearum (Fusarium graminearum), Fusarium oxysporum (Fusarium oxysporum) and Fusarium verticillioides (Fusarium verticillioides), and fermentation liquor of the strain can significantly reduce occurrence of corn large spot, tobacco black spot and sclerotinia rot. Magnaporthe oryzae Setosphaeria turcica Alternaria tenuissima Fusarium graminearum Fusarium oxysporum Fusarium concentricum The application provides an excellent biocontrol strain for development and research of microbial source pesticides and provides a new idea for green prevention and control of plant diseases.​​​​​

The application belongs to the field of agricultural microbial technology, and particularly relates to a plant endophytic Bacillus safensis and application thereof in plant disease prevention and treatment. The plant endophytic Bacillus safensis has a strain number of BSA15, a classification name of Bacillus safensis Bacillus safensis , a preservation number of CGMCC No. 36637, and is preserved in the China General Microbiological Culture Collection Center on November 17, 2025. The Bacillus safensis has a broad-spectrum inhibitory activity on pathogenic fungi and oomycetes, and can produce a significant inhibitory effect on plant pathogenic microorganisms through multiple mechanisms. In addition, the Bacillus safensis BSA15 can be stably colonized in the plant body as an endophyte, further enhancing the disease prevention and control effect. Using the strain for disease prevention and treatment can significantly reduce the use amount of chemical pesticides, reduce pesticide residues and environmental pollution, and meet the requirements of green agriculture and sustainable development.

The application discloses a wheat rhizosphere growth promoting composite microbial agent and a preparation method and application thereof, and belongs to the technical field of agricultural microorganisms.The wheat rhizosphere growth promoting composite microbial agent has the functions of nitrogen fixation, phosphorus dissolution and IAA production, and is beneficial to nutrient utilization of wheat; after wheat seedlings are connected with the wheat rhizosphere growth promoting composite microbial agent, the nitrogen absorption efficiency can be significantly improved, and the growth of the wheat is promoted, so that the purpose of reducing fertilizer and increasing efficiency is achieved; moreover, the wheat rhizosphere growth promoting composite microbial agent has an antagonistic effect on multiple pathogenic fungi such as false smut fungus, fusarium graminearum, fusarium solani and the like, and can be used for biological control of wheat.