447 results about "Pathogenic fungus" patented technology

The invention relates to the technical field of microorganisms, and particularly discloses a saline-alkaline tolerant bacillus deserticola BW-13 with biocontrol and growth promoting functions and application thereof. The bacillus safensis BW-13 is preserved in the China Center for Type Culture Collection on January 13, 2025, the classification name of the bacillus safensis BW-13 is bacillus safeensis, and the preservation number of the bacillus safensis BW-13 is CCTCC NO: M 2025108. The strain BW-13 has relatively high salt tolerance, and still keeps good resistance under various stress conditions; meanwhile, the plant growth promoting agent has various plant growth promoting characteristics including nitrogen fixation, phosphorus solubilization and cellulase and protease secretion capacity, and pot experiment verifies that the plant growth promoting agent can improve the salt resistance of cucumber seedlings and promote plant growth; the strain has an antagonistic effect on a plurality of phytopathogens, and especially has a remarkable prevention and treatment effect on plant diseases such as apple ring spot, polygonatum kingianum anthracnose, pear tree rot and tomato gray mold caused by ascomycophyta pathogenic fungi.

The invention discloses paenibacillus sp. H31, which is preserved in the China Center for Type Culture Collection (CCTCC), the preservation number is CCTCC NO: M 20252669, and the preservation date is November 24, 2025. The invention further discloses a preparation method of the paenibacillus sp. The paenibacillus H31 disclosed by the invention not only has broad-spectrum disease-resistant activity on pathogenic fungi of various plants, but also has a remarkable growth-promoting effect on pepper, so that the paenibacillus H31 can be widely applied to prevention and treatment of agricultural diseases and insect pests, and sustainable development of green agricultural production is promoted. In addition, the paenibacillus H31 also has the effects of hydrolyzing proteinase and cellulose and decomposing ferritin, so that the paenibacillus H31 also can be applied to the scenes of industrial production and the like.

The invention discloses a salt-tolerant brevibacillus for promoting growth and preventing and controlling plant diseases and application of the salt-tolerant brevibacillus. The brevibacillus halotolerans T101 is preserved in the Guangdong Microbial Culture Collection Center (GDMCC) on July 23, 2025, and the preservation number of the brevibacillus halotolerans T101 is GDMCC No: 66731. The brevibacillus halotolerans T101 is preserved in the Guangdong Microbial Culture Collection Center (GDMCC) on July 23, 2025. The strain T101 disclosed by the invention can effectively antagonize plant pathogenic fungi peronophythora litchii and plant pathogenic bacteria such as pseudomonas syringae, xanthomonas campestris, citrus canker pathogen and ralstonia solanacearum, can generate siderophores and plant growth hormone IAA, and can remarkably promote the growth of tomato root systems in a pot experiment. Therefore, the strain T101 can be used for preparing microbial preparation products for preventing and treating plant diseases and promoting plant root growth, and has important application potential in the aspects of microbial agents, biological fertilizers and the like for promoting plant growth and development.

The invention discloses bacillus tequilensis 83IBC04-2 and application thereof, the bacillus tequilensis 83IBC04-2 comes from a deep sea hydrothermal zone and is preserved in China Center for Type Culture Collection on October 15, 2025, and the preservation number is CCTCC NO: M20252212. The compound has a remarkable antagonistic effect on a plurality of important pathogenic fungi such as tomato gray mold, tomato early blight, rice blast and wheat scab, can be used for preparing a broad-spectrum and high-efficiency biological bactericide, effectively reduces the use amount of chemical pesticides, and reduces pesticide residues and environmental pollution.

The invention discloses a novel application of massinia phosphate solubilizing C22 in prevention and treatment of fungal diseases of plants, and belongs to the technical field of agricultural biology, and particularly relates to a novel application of massinia phosphate solubilizing C22 in prevention and treatment of fungal diseases of plants. The known strain C22 has a remarkable antagonistic effect on pathogenic bacteria fusarium pseudograminearum of wheat stem rot, and the plate inhibition rate reaches 36.79%. Potting and field tests prove that wheat basal stem rot can be effectively prevented and treated by applying the C22 fungicide, the morbidity in the seedling stage is reduced by 21.64%, the morbidity in the adult-plant stage is reduced by 55.06%, the DON toxin content in plants can be remarkably reduced by 68.26%, and the pathogenic bacterium load can be remarkably reduced. According to the invention, the potential of the phosphorus-solubilizing massinia sp. C22 in the aspect of biological control is disclosed for the first time, and a new core microbial resource and a technical scheme are provided for developing a green biological pesticide for controlling wheat stem rot.

The present invention belongs to the field of biotechnology. Disclosed are a plant immunity-inducing protein CcHE1 and a use thereof. The disclosed plant immunity-inducing protein CcHE1 secreted by a plant pathogenic fungus has an amino acid sequence shown as SEQ ID NO.2, and a nucleotide sequence of the gene encoding CcHE1 shown as SEQ ID NO.1. The present invention provides a novel plant immunity-inducing protein CcHE1, capable of inducing plant resistance and immune defense responses, significantly enhancing plant disease resistance, effective at low concentrations, and exhibiting remarkable disease-resistance effects. CcHE1 activates the plant's own immune system, providing a new approach to improving plant resistance, and has broad application prospects in areas such as green control of forest diseases.

The invention discloses bacillus velezensis as well as a compound medicament and application thereof, and belongs to the technical field of plant disease control. In order to solve the problems of easy generation of drug resistance, influence on ecological environment, residue of forbidden pesticide, excessive pesticide and the like in the existing chemical control method for cowpea fusarium wilt, the invention screens out a bacillus velezensis T9 with a relatively good inhibition effect on pathogenic bacteria of cowpea fusarium wilt; experiments find that the strain T9 has an obvious inhibition effect on various plant pathogenic fungi, and a bacterial solution of the strain T9 can effectively prevent and treat cowpea fusarium wilt and can effectively promote cowpea growth; besides, the compound medicament prepared from prochloraz and bacillus velezensis T9 bacterial liquid is used for irrigating cowpea seedlings, and the compound medicament is found to have a good control effect on cowpea fusarium wilt, can effectively reduce the use amount of chemical medicaments, and also has a certain growth promoting effect on cowpea plants.

The invention belongs to the field of microorganisms, and discloses bacillus velezensis and application thereof in prevention and treatment of plant fungal diseases. The bacillus velezensis disclosed by the invention is bacillus velezensis YC46, is preserved in the China General Microbiological Culture Collection Center (CGMCC), and has the preservation number of CGMCC No.33975. The bacillus velezensis can grow by taking leftovers in an aquatic product processing process as a unique nutrient source, and has the advantages of high yield, low cost and the like. The bacillus subtilis has the antibacterial activity on plant pathogenic fungi such as fusarium oxysporum, botrytis cinerea, alternaria alternata, colletotrichum gloeosporioides and penicillium, thalli or fermentation products of the thalli can be used as active ingredients for preparing biocontrol microbial agents or bacteriostatic agents for preventing and treating plant fungal diseases, and the bacillus subtilis has good application value and ecological environmental protection value.

The invention discloses a novel leuconostoc screening method and an antibacterial mechanism of leuconostoc on leaf mold of zanthoxylum bungeanum, and relates to the technical field of pathogenic bacteria experiment and analysis. The novel leuconostoc screening method comprises the following steps that S1, materials are prepared, specifically, rotten Chinese prickly ash tree plants are selected, and tested strains in the Chinese prickly ash tree plants comprise plant pathogens of alternaria alternata, fusarium solani, fusarium layered, fusarium oxysporum, fusarium syphilis and colletotrichum pini, and are stored in a refrigerator of a laboratory at the temperature of 4 DEG C for standby application; in the invention, the leuconostoc also has an efficient inhibition effect on field crop pathogenic fungus alternaria alternata, and the research expands the biocontrol spectrum of lactic acid bacteria. Meanwhile, the invention discloses a molecular mechanism that the Leuconostoc suionicum HJ-L synergistically regulates and controls the synthesis of antibacterial substances through lipid metabolism, an ABC transport system and an autophagy pathway, and a theoretical basis and a practical basis are provided for the application of the strain in green prevention and control of the leaf mold of Chinese prickly ash.

The application discloses application of Trichoderma asperellum strain YN4 and fungicides in prevention and treatment of plant fungal diseases. The application research shows that the Trichoderma asperellum strain YN4 has a good inhibitory effect on pepper anthracnose, rubber anthracnose, mango anthracnose, soybean anthracnose and the like. Further, compared with the single use of fungicides or the Trichoderma asperellum strain, the inhibitory effect of the combination of the two is better. Under certain conditions, the Trichoderma asperellum strain is combined with 10% difenconazole water dispersible granules, 70% thiophanate-methyl wettable powder or 450g / L prochloraz emulsion in water, and has a synergistic effect. Not only can the use amount of fungicides be greatly reduced, but also the inhibitory effect on plant pathogenic fungi can be further improved, the incidence can be reduced, the inhibition on pathogenic bacteria can be enhanced, the use and residue of chemical pesticides can be reduced, and technical support is provided for the selection of fungicides for pepper anthracnose and the like and the combination of bacteria and drugs.

Provided are a non-ribosomal antifungal peptide MaAFP1, a preparation method therefor and a use thereof. The molecular formula of the antifungal peptide MaAFP1 is C41H74N18O12, wherein an amino acid sequence from the N-terminus to the C-terminus is (D)Arg-(L)Arg(OH)-(D)Orn-(L)Thr-(D)Orn-(L)Arg(OH)-(D)Tyr. Fermentation is performed by using Metarhizium anisopliae CQMa421, a fermentation broth is collected, and separation and purification are performed by means of ion exchange chromatography and high performance liquid chromatography so as to obtain the antifungal peptide MaAFP1. The structure of MaAFP1 is analyzed by comprehensively using an Edman degradation method, mass spectrometry, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and circular dichroism spectroscopy. By performing an in vitro bacteriostatic test, it is found that MaAFP1 has a good inhibitory effect on a variety of animal and plant pathogenic fungi, and has the value of the development of a novel antibacterial drug.

Novel strains of the insect-pathogenic fungus, Metarhizium var. anisopliae fungal strain BNL 101 deposited in the CABI UK Centre, United Kingdom, having IMI CC Number 506833; or BNL 102 deposited in the CABI UK Centre, United Kingdom, having IMI CC Number 506834; or a culture having the identifying characteristics thereof, are disclosed. The present invention also discloses methods of using the fungal strains, and spores obtained therefrom, to control insects, and provides a natural pest control preparation. The preparations and compositions comprise several unique and desirable features, such as a wide host range or alternatively a selective host range, and a consistent pathogenicity. The preparations and compositions have a high virulence (insecticidal activity), that is 2 times to 3 times, or greater, mor virulent (insecticidal) than compositions or preparations that do not contain the preparation or composition, and especially that do not contain the BNL 101 or BNL 102 fungal strain, or spores therefrom. The fungal strains also provide for a high spore yield in production, and possess a high stability in the field.

The application relates to the field of agricultural disease control technology, and particularly relates to the use of indole compounds and pharmaceutically acceptable salts, solvates, crystal forms, prodrugs, stereoisomers and tautomers thereof for preparing a medicine for inhibiting pathogenic key protein kinase CgSlt2 of pathogenic fungi. The application first proposes a new type of CgSlt2-targeted inhibitor, specifically, indole compounds ((S)-N-(1-(1H-indol-3-yl)-4-(methylamino)-4-oxobutan-2-yl)-8-bromo-1,6-naphthyridine-2-carboxamide) and ((S)-N-(2-((1H-indol-3-yl)-1-(methylamino)-1-oxopropyl)-8-bromo-1,6-naphthyridine-2-carboxamide) are used as CgSlt2 inhibitors, have the characteristics of high target specificity and high activity, and exhibit excellent pathogenicity inhibition of a strain of the complex group of Colletotrichum gloeosporioides.

The present application relates to the application of allantoin in the prevention and treatment of fungal diseases of grain crops. The present application finds that allantoin can inhibit the growth of pathogenic fungi of grain crops, especially inhibit the infection of pathogenic fungi of grain crops to host cells or inhibit the expansion of pathogenic fungi of grain crops in host cells, thus indicating that allantoin can be used as a pesticide to prevent and treat pathogenic fungi of grain crops, especially Magnaporthe oryzae, Cochliobolus miyabeanus and Ustilaginoidea virens.

The invention relates to the technical field of biological prevention and control, and discloses application of a bacillus velezensis P15 fungicide in preservation of harvested strawberries, and the application comprises the step of applying the bacillus velezensis P15 fungicide to the harvested strawberries so as to prevent and control strawberry postharvest diseases caused by pathogenic fungi. The preservation number of the bacillus velezensis P15 is CGMCC (China General Microbiological Culture Collection Center) NO.31995. The bacillus velezensis P15 microbial inoculum is used for preservation of picked strawberries, can efficiently inhibit more than 90% of picked pathogenic bacteria such as botrytis cinerea and the like, has a control effect superior to that of prochloraz, and does not enable the pathogenic bacteria to resist drugs after being used for a long time; the strawberry preservative is harmless to human, animals, plants and the environment, has no microbial agent residue, can be used for fresh keeping of green and organic strawberries, solves the food safety problem of chemical preservative residue, and improves the acceptability of consumers.

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The application discloses a marine source penicillium and a fermentation method and application thereof. The marine source penicillium is named Penicillium sp. DSF059, and the preservation number is CCTCC NO: M 20232310. Penicilliu The application optimizes the culture condition of the strain, selects a culture medium and culture condition with high yield of antibacterial active compounds to carry out fermentation, so that more target products can be obtained, the operation is simple, the cost is low, and meanwhile, the marine source penicillium Penicilliu Penicillium sp. DSF059 can provide an excellent strain for new drug development of resisting plant pathogenic fungi such as coffee leaf blight, coffee brown spot disease, grape gray mold disease, Chinese cinnamon brown spot disease, citrus black rot disease, pepper late blight, hickory leaf blight, coffee black spot disease and four pathogenic fungi separated from coffee leaf diseases and Staphylococcus aureus, and has a good application prospect for preventing and treating the plant pathogenic fungi and Staphylococcus aureus.

The invention discloses a (-)-menthol group-containing nicotinamide derivative with antifungal activity as well as a preparation method and application thereof, and relates to the technical field of synthesis of agricultural chemicals. The derivative has a structure as shown in a general formula (I), in the formula, n is an integer from 1 to 5, and R1, R2, R3 and R4 are specific substituent groups. Through a molecular hybridization strategy, the (-)-menthol, the N-fatty acyl piperazine bridge and the nicotinamide fragment are covalently linked, and a compound with a brand new structure is created. A biological activity test shows that the series of compounds have remarkable inhibitory activity on various plant pathogenic fungi, especially sclerotinia sclerotiorum and valsa mali of apple trees, and are low in cytotoxicity. Molecular docking research proves that the action target of the gene is succinate dehydrogenase (SDH). The invention provides a valuable leading structure for developing novel SDHI bactericides.

The embodiment of the application discloses a biocontrol streptomyces and application thereof, and relates to the technical field of microorganisms. The biocontrol streptomyces is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC No: 68067, and the preservation date is April 10, 2026. The biocontrol streptomyces has a significant prevention and treatment effect on postharvest mango anthracnose, and has a broad-spectrum antagonistic effect on various pathogenic fungi. The strain has a fast growth speed, a wide growth temperature adaptation range, and can grow well under high-temperature conditions, and the antagonistic effect on anthracnose is outstanding, thereby providing a new idea for the research and development of a postharvest disease biological control of mango and a new green control agent.

The present application relates to a kind of fungicide composition;Also related to the application of the fungicide composition in the field of agriculture, forestry or horticulture in preventing or preventing plant pathogenic fungi from infecting plants.The fungicide composition comprises active ingredient A and active ingredient B, the active ingredient A is formula (I) compound, the active ingredient B is bronopol, kasugamycin, the mass ratio of the active ingredient A and active ingredient B is 1:24-60:1.The fungicide composition of the present application has good control effect on bacterial diseases, especially on cucumber bacterial angular spot disease, and shows significant synergistic effect, which can effectively reduce the amount of drug, reduce agricultural input cost, and delay the resistance of plant pathogenic fungi.

The invention belongs to the technical field of pesticide chemistry, and particularly relates to an application of a substituted phenylhydrazine copper salt complex as an agricultural fungicide, the structural general formula of the substituted phenylhydrazine copper salt complex is [Cu (ArNHNH2) 2] Xn, Ar is selected from 3-chlorphenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, 2, 4-dichlorophenyl-, the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl, and the compound is prepared from 2, 6-dichlorophenyl, p-trichloromethoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-bromophenyl, 4-nitrophenyl, 4-cyanophenyl and 4-carboxyphenyl. X is selected from SO4 <->, Cl <-> and NO3 <->; n is equal to 1-2. The substituted phenylhydrazine copper salt complex disclosed by the invention has remarkable inhibitory activity on plant pathogenic bacteria, has very high inhibition rate on three plant pathogenic fungi, namely fusarium graminearum, rhizoctonia solani and sclerotium rolfsii, can be used as a safe and efficient novel bactericide, and is applied to prevention and treatment of various crop diseases.

The application discloses a preparation method of a diphenylmethyl quinoxaline ketone derivative, and belongs to the technical field of biological medicines. The structure of the diphenylmethyl quinoxaline ketone derivative is shown in the specification. The application adopts a cross dehydrogenative coupling strategy, realizes quinoxaline ketone 3-alkylation through direct activation of an alkane and accompanying hydrogen atom transfer, and has the advantages of mild reaction conditions, cheap and easily available reagents, and higher efficiency and environmental friendliness. The diphenylmethyl quinoxaline ketone derivative has high-efficiency and broad-spectrum antifungal activity, shows inhibitory effects on a plurality of common plant pathogenic fungi, and can be developed into a product for treating plant fungal infections.

The application provides application of a bacillus subtilis K8 nano-seleniumized active bacterium agent in prevention and treatment of plant pathogenic bacteria, and belongs to the technical field of biological prevention and treatment of plant diseases. Bacillus subtilis The bacillus subtilis K8 nano-seleniumized active bacterium agent is obtained by fermenting and culturing bacillus subtilis K8 in a fermentation medium containing sodium selenite. Bacillus subtilis The bacillus subtilis K8 nano-seleniumized active bacterium agent has a strong prevention and treatment effect on cucumber fusarium wilt, cucumber botrytis blight, tomato early blight and tomato root rot, provides an efficient, safe and practical method for prevention and treatment of plant fungal diseases, has low cost, simple preparation process, is convenient for industrialization, and has good development value and market prospect.

The present invention provides a method for detecting fungal DNA in a turf grass sample with a loop-mediated isothermal amplification (LAMP) assay which contains primers for fungal DNA of at least one turf pathogenic fungi selected from Sclerotinia homoeocarpa, Rhizoctonia solani spp., Pythium aphanidermatum, Gaeumannomyces graminis spp., Microdochium nivale spp., Magnaporthe poae, Colletotrichum graminicola, Colletotrichum cereale and Pythium ultimum var. ultimum, comprising: subjecting the turf sample to a LAMP reaction wherein the LAMP reaction uses a primer set of four or more nucleic acid sequences with each primer in the set having from 15 to 50 nucleic acids The primers useful in the present method are selected from specifically selected internal transcribed spacer regions or genes of the target fungi to provide improved assay results.

The present application relates to the technical field of pesticide chemistry and medicinal chemistry, and particularly relates to a substituted pyrazole-containing ortho-hydroxy aryl formamide derivative, a preparation method and application thereof. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative is prepared from a 5-amino pyrazole intermediate (I) and a different substituted ortho-hydroxy aryl formic acid (II) as raw materials through an amide condensation reaction. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative prepared by the present application has a broad-spectrum inhibitory activity on plant pathogenic fungi, and particularly has excellent inhibitory activity on Valsa mali, Sclerotinia sclerotiorum and Botrytis cinerea, and is expected to be developed into a new type of green fungicide with high efficiency, safety, economy and environmental friendliness.

The invention relates to the field of biological medicine, in particular to vortioxetine and application of pharmaceutically acceptable salts, solvates, crystal forms and prodrugs of vortioxetine to preparation of drugs for preventing or treating pathogenic fungal infection. The application reveals that the antidepressant vortioxetine (vortioxetine) and hydrobromide thereof (vortioxetine. HBr) which are sold on the market have measurable in-vitro inhibitory activity on various clinical common pathogenic fungi for the first time, so that the pharmacological action spectrum of the compound is expanded, and a new candidate direction is provided for research and development of antifungal drugs; the application not only overcomes the defects of existing antifungal drugs in the aspects of drug resistance, biological membranes and safety, but also opens up a brand new application direction of mental small molecule drugs in the anti-infection field, and has remarkable technical innovation, social value and industrial popularization prospect. The application also provides a theoretical basis for establishing a'multi-modal micromolecular antifungal library ', and can promote the development of pharmacological mechanism research and fungal infection precise treatment.

The application discloses a compound with antifungal activity and a preparation method and application thereof, and discloses a compound targeting AAA ATPase and a preparation method and application thereof. The compound targeting AAA ATPase has the following formula (I) or formula (II) structure, and tests show that three compounds, namely, AH-003, AH-006 and AH-008, have the activity of inhibiting the growth of plant pathogenic fungi.

The present application belongs to the field of agricultural fungicides, and particularly relates to a fungicidal composition and application thereof.The composition comprises two active components A and B, the weight ratio of the active component A to the active component B is 1:99-99:1; the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof, and the active component B is selected from one fungicide.The fungicidal composition is particularly suitable for preventing and treating various plant pathogenic fungi and bacterial diseases.

The invention discloses paenibacillus FHY1 and application thereof, and belongs to the field of microorganisms. A strain of paenibacillus FHY1 is screened from Xinjiang populus euphratica juice, and experimental verification shows that a liquid culture of the paenibacillus FHY1 strain provided by the invention has a remarkable inhibition effect on magnaporthe oryzae, the bacteriostasis rate can reach 84%, and the inhibition rate on magnaporthe oryzae spore germination is 92%. And the rice growth can be promoted under the conditions of 150mM NaCl and 250mM NaCl. Meanwhile, the strain also has a good inhibition effect on pyricularia grisea, fusarium oxysporum, fusarium graminearum, sclerotinia sclerotiorum and colletotrichum gloeosporioides. Therefore, the invention provides a new strain with a good control effect on pathogenic fungi, and meanwhile, the growth and development of rice are remarkably promoted in a salt stress environment.

The present application provides a novel structure of thiophene compound, the compound has significant inhibitory effect on spore germination and appressorium formation of various plant pathogenic fungi and oomycetes (such as Pyricularia oryzae, Colletotrichum gloeosporioides, Gibberella, Phytophthora, Phytophthora capsici), which can be used for preventing and treating plant diseases caused by fungi and / or oomycetes.