290 results about "Methicillin resistant Staphylococcus" patented technology

The invention discloses a broad-spectrum antibacterial peptide SS-7 and application thereof, and belongs to the field of biological medicine. The amino acid sequence of the broad-spectrum antibacterial peptide SS-7 disclosed by the invention is VRRVRFVVLRRIKKWRRI, and the broad-spectrum antibacterial peptide SS-7 has a remarkable inhibition effect on various gram-positive bacteria and gram-negative bacteria such as drug-resistant strains such as methicillin-resistant staphylococcus aureus (ATCC43300) and shows low toxicity and no hemolytic toxicity on eukaryotic cells and red blood cells of mammals; lPS and lipoteichoic acid on the surfaces of bacteria can be combined to achieve the effect of neutralizing the bacteria, and a very good treatment and protection effect is achieved on animals infected by the bacteria. The antibacterial peptide SS-7 can be used for preparing an antibacterial agent and preparing a medicine for preventing or treating bacterial infection, has the advantages of being wide in antibacterial spectrum, low in drug-resistant mutation frequency, low in toxicity and low in production cost, can effectively solve the current bacterial drug resistance problem, and has wide application prospects and important clinical value.

The invention relates to a mouse anti-PBP2a hybridoma cell strain, a monoclonal antibody and application of the mouse anti-PBP2a hybridoma cell strain, staphylococcus aureus PBP2a protein is extracted as an antigen, after the high-purity antigen is obtained, a good immunoreaction is aroused in a mouse body, then a hybridoma technology is adopted, two cell strains with high affinity and specificity are screened, and the corresponding antibody is prepared; the two antibodies are used as a gold-labeled antibody and a coating antibody in a colloidal gold immunoassay kit, and the kit can be used for detecting PBP2a protein in methicillin-resistant staphylococcus aureus and can be used for developing related in-vitro diagnostic reagents.

The invention provides a test strip for rapidly detecting methicillin-resistant staphylococcus aureus and application of the test strip, and belongs to the technical field of biochemical detection. The test strip comprises a bottom plate, a sample pad, a combination pad, a detection pad and a water absorption pad, the two ends of the detection pad are in lap joint with the combination pad and the water absorption pad respectively, the detection pad is located on the lower portion, the sample pad is in lap joint with the combination pad, and the combination pad is located on the lower portion; a detection line and a quality control line are arranged on the detection pad, the detection line is arranged on one side close to the combination pad, and the quality control line is arranged on one side close to the water absorption pad; the detection pad is coated with a MoS2 nanosheet, the combination pad is coated with a penicillin binding protein 2a polyclonal antibody labeled by horse radish peroxidase, and the detection line is coated with a penicillin binding protein 2a monoclonal antibody; the quality control line is coated with goat anti-rabbit IgG (immunoglobulin G). The kit is high in sensitivity and wide in linear range, has good specificity, repeatability and stability, and can effectively detect MRSA in a clinical sample.

The invention is applicable to the technical field of polypeptides, and provides a novel antibacterial peptide GG25 and application thereof, and the amino acid sequence of the antibacterial peptide GG25 is as shown in SEQ ID No.1. The molecular weight of the novel antibacterial peptide GG25 is 2890.52 Da, and the novel antibacterial peptide GG25 has antibacterial activity on escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, enterococcus faecalis, salmonella typhimurium, methicillin-resistant staphylococcus aureus, staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes and bacillus subtilis; the hemolytic activity is low, the cytotoxicity is small, and the escherichia coli and methicillin-resistant staphylococcus aureus are not easily induced to generate drug resistance; in addition, the gelatin chitosan food coating containing GG25 also has a good beef preservation effect, and can be applied to the fields of food, animal husbandry, medicine and the like.

The invention relates to a double-probe detection reagent for detecting methicillin-resistant staphylococcus aureus and a preparation method, and belongs to the technical field of food safety. The double-probe detection reagent is composed of a magnetic separation probe reagent solution and a fluorescent nano-enzyme probe reagent solution; the magnetic separation probe reagent liquid is used for specifically binding methicillin-resistant staphylococcus aureus and carrying out separation and enrichment treatment on a detection sample; the blue fluorescent nano-enzyme probe reagent solution is used for specifically combining, separating and enriching the methicillin-resistant staphylococcus aureus and generating a concentration dependent colorimetric signal and a fluorescent signal of the methicillin-resistant staphylococcus aureus. The magnetic separation probe has high specific surface area and super-strong magnetism, the capture efficiency is enhanced, and the magnetic attraction time is shortened; according to the invention, mutual verification is carried out between dual-mode signals, an internal proofreading effect is achieved, and the accuracy of a detection result is improved; the detection time of the method is within 1 h, the detection time is short, the detection sensitivity is high, and the method has good specificity for common type strains.

The invention discloses an antibacterial peptide as well as a preparation method and application thereof. The antibacterial peptide has an amino acid sequence as shown in any one of SEQ ID NO: 1-11. The antibacterial peptide prepared by the scheme provided by the invention has very strong bacteriostasis and sterilization capabilities on methicillin-resistant staphylococcus aureus and multidrug-resistant escherichia coli, has application potential of becoming an antibacterial agent, a preservative or a disinfectant, and is not easy to generate drug resistance.

The invention discloses a phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative as well as preparation and antibacterial application thereof. According to the series of compounds, phenanthro [9, 10-d] imidazole quaternary ammonium salt derivatives which are novel in structure and good in antibacterial activity are prepared by taking phenanthro quinone as a lead compound and modifying the structure of phenanthro quinone, the structural general formula of the phenanthro [9, 10-d] imidazole quaternary ammonium salt derivatives is shown in the specification, and R is selected from H, C6-C14 alkyl or C3-C8 alkylene. The phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative prepared by the invention has a relatively good antibacterial effect on gram-positive bacteria such as staphylococcus aureus S.aureus ATCC 29213 and various clinical methicillin-resistant staphylococcus aureus (MRSA), meanwhile, the water solubility is improved, the biotoxicity of a parent body is reduced, and the phenanthro [9, 10-d] imidazole quaternary ammonium salt derivative has relatively high yield and is suitable for industrial production. The compound is expected to be further developed into a clinical candidate antibacterial drug. # imgabs0 #

The invention discloses an application of osmundone in preparation of a medicine for treating methicillin-resistant staphylococcus aureus infectious pneumonia. Experimental results of an MRSA mouse pneumonia infection model show that osmundone can significantly reduce the bacterial load in lung tissues, alleviate excessive inflammatory response caused by infection and effectively improve the survival rate of mice. In addition, the invention discloses that osmundone reduces the adhesion and invasion ability of bacteria, reduces the toxicity of the bacteria and plays an antibacterial role by inhibiting the protein activity of staphylococcus aureus Sortase A (SrtA). Different from traditional antibiotics, osmundone does not apply survival pressure to bacteria, so that generation of drug resistance is not easily induced. On the basis, osmundone shows a good application prospect in the aspect of research and development of safe and effective MRSA infectious pneumonia treatment drugs.

The invention discloses an application of an Mxene-Mo4VC4 new member nano platform with light-enhanced peroxidase activity in treatment of methicillin-resistant staphylococcus aureus infection so as to promote healing of infected wounds, and belongs to the field of two-dimensional nano material catalyst antibacterial research. The single-layer Mo4VC4 nanosheet is synthesized on the basis of Mo4AlVC4-MXene through a hydrofluoric acid etching method. The Mo4VC4 nanosheet shows activity similar to peroxidase, and can locally catalyze low-concentration hydrogen peroxide and generate hydroxyl radicals toxic to bacteria, so that methicillin-resistant staphylococcus aureus is effectively killed, and a biological membrane is removed. In addition, high photo-thermal conversion efficiency and photo-thermal stability are shown under irradiation of near-infrared light with low concentration (50 mu g / mL). The similar peroxidase activity is obviously amplified by the temperature rise caused by the photothermal effect of the Mo4VC4 nanosheet. And finally, rapidly eliminating methicillin-resistant staphylococcus aureus in deep infection and accelerating abscess regression by adopting a satisfactory photo-thermal amplification peroxidase strategy.

The invention discloses application of swertiflavin in preparation of a medicine for treating infectious pneumonia caused by methicillin-resistant staphylococcus aureus, and relates to the technical field of medicine. It is found for the first time that swertiflavin can significantly reduce the toxicity of staphylococcus aureus by inhibiting the activity of ClpP protein in MRSA. In addition, the swertiflavin shows a remarkable protection effect in the treatment of the MRSA infectious pneumonia. Specifically, the swertiflavin not only can relieve the injury degree of lung tissues, but also can reduce infiltration and aggregation of inflammatory cells in the lung. The discovery shows that the swertiflavin has potential application value in the field of anti-infection treatment. The invention provides a novel treatment strategy, namely, swertiflavin is used as an active ingredient for preparing the medicine for treating the staphylococcus aureus infectious pneumonia.

The invention relates to an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide is as shown in SEQ ID No. 1. The antibacterial peptide has excellent broad-spectrum antibacterial activity, for example, the antibacterial peptide has antibacterial activity on bacteria of the genus Staphylococcus (Staphylococcus), the genus Acinetobacter (Acinetobacter) and the genus Bacillus (Bacillus). Under the background that the global bacterial drug resistance problem is increasingly severe and traditional antibiotics gradually lose efficacy on multi-drug-resistant bacteria, a new treatment means is provided for treating bacteria such as methicillin-resistant staphylococcus aureus, carbapenem-resistant acinetobacter baumannii and bacillus subtilis which bring huge threats to public health. And a new possibility is provided for solving the problem that no medicine can be used clinically.

The invention provides a bridged triphenylamine-derived AIE type antibacterial photosensitizer, a preparation method and antibacterial application thereof, the bridged triphenylamine-derived AIE type antibacterial photosensitizer has the following structure: # imgabs0 is subjected to a cyclization reaction to form a bridged structure to limit bond rotation as a novel molecular design, and the photodynamic antibacterial effect of the AIE photosensitizer (PSs) can be effectively improved; and an AIE photosensitizer is combined with a donor-pi-receptor (D-pi-A) structure, so that a smaller singlet-triplet energy level difference (delta EST) is realized, and an intersystem crossing process is promoted. The mutual combination effect of the PSs and bacteria can be influenced by regulating and controlling the charge number of the PSs, so that effective bacteria recognition and selective antibacterial performance are realized. Experiments show that the AIE antibacterial photosensitizer based on bridged triphenylamine has a specific elimination effect on gram-positive bacteria; and the photodynamic antibacterial agent has a good photodynamic antibacterial effect on staphylococcus aureus and methicillin-resistant staphylococcus aureus.

The invention discloses a nano antibacterial material based on bisoxalate and hypericin as well as a preparation method and application of the nano antibacterial material, and belongs to the technical field of antibacterial agents. A supermolecule self-assembly method is used for organically combining a chemiluminescence agent CPPO and a photosensitizer hypericin, the chemiluminescence agent CPPO and the photosensitizer hypericin are tightly combined through chemical acting force, and the antibacterial nanometer material with the optimal size and dispersity is obtained by adjusting the ratio of the chemiluminescence agent CPPO and the photosensitizer hypericin. The antibacterial nano-material disclosed by the invention has excellent antibacterial biofilm performance generated by triple effects of deep permeation, production of active oxygen to kill bacteria and inhibition of H2S from damaging a self-defense mechanism of the bacteria, and still has a relatively good antibacterial effect on methicillin-resistant staphylococcus aureus at low concentration (2 mu g / mL).

The invention provides a red light carbon quantum dot as well as a preparation method and application thereof. The red light carbon quantum dot is prepared from fulvic acid and polyamine as raw materials through a hydrothermal reaction. The fulvic acid is used as a carbon source, the polyamine is used as a nitrogen source, the carbon quantum dots are prepared through a hydrothermal reaction, the obtained carbon quantum dots are small in size, and the particle size is 1-3 nm; the red light emission wavelengths are 680 nm and 720 nm, and the photoluminescence characteristic is irrelevant to the excitation wavelength; the prepared quantum dot has good biocompatibility, the quantum efficiency is greater than or equal to 20%, the prepared quantum dot has good bacteriostatic and antibacterial activity, and the inhibition rate on staphylococcus aureus, pseudomonas aeruginosa, enterobacter cloacae, escherichia coli, klebsiella pneumoniae or methicillin-resistant staphylococcus aureus under the concentration of 2 mu g / mL can reach 99.9%. Wide application prospects are realized in the aspects of antisepsis, anti-inflammation and wound healing promotion.

The invention relates to the technical field of biological medicine, in particular to cyclic cationic polyamino acid and a preparation method and application thereof, and the cyclic cationic polyamino acid has a structure as shown in a formula I. The cyclic cationic polyamino acid provided by the invention shows a good in-vitro sterilization effect on gram-positive bacteria, gram-negative bacteria and methicillin-resistant staphylococcus aureus, has high selectivity, can quickly sterilize, and is not easy to induce the bacteria to generate drug resistance. The synthesized cyclic antibacterial polyamino acid can destroy the integrity of bacterial cell membranes through physical action, has rapid bactericidal kinetics, can kill 99% or more of bacteria within 30 minutes, and is not easy to induce the bacteria to generate drug resistance.

The invention discloses a polyketone compound derived from actinomycetes as well as a preparation method and application thereof, and relates to the technical field of microbial natural product mining and biological medicine, and the key point of the technical scheme is that the invention discloses a novel polyketone compound Strepactone derived from actinomycetes Streptomyces sp. DP0001, and the molecular formula of the novel polyketone compound Strepactone is C25H38O5. The compound is obtained through strain fermentation, ethyl acetate extraction and multi-step chromatographic purification, and the structure is identified through ESI-MS, 1H NMR and 13C NMR. Experiments show that Strepactone has an inhibition effect on staphylococcus aureus and methicillin-resistant staphylococcus aureus and has remarkable inhibition activity on human non-small cell lung cancer A549 cells, the half inhibitory concentration IC50 of the Strepactone is 5.36 mu M, and the Strepactone has no obvious cytotoxic activity on human embryo kidney cells 293T cells at the concentration of 30 mu M. The compound provided by the invention can be used for preparing anti-drug-resistant bacteria drugs and anti-human non-small cell lung cancer drugs, and also provides a structural basis for the development of novel antibacterial and anti-tumor leading drugs.

The invention discloses a method for preparing a copper-based nanoparticle / attapulgite composite antibacterial material by using a red paeony root extract, which comprises the following steps: extracting active substances from a traditional Chinese medicinal material red paeony root as a reducing agent and a stabilizing agent, taking attapulgite as a carrier, and carrying out hydrothermal reaction to prepare the copper-based nanoparticle / attapulgite composite antibacterial material. Active ingredients such as flavone, terpenes, saponin, phenolic acid and polysaccharide in the red peony root extract synergistically play roles in reducing metal ions and stabilizing nanoparticles, hydrothermal treatment promotes generation of copper-based nanoparticles on the surface of attapulgite, and the cuprous oxide nanoparticles can be obtained by regulating and controlling the pH value of a reaction system. The prepared nano composite material has efficient antibacterial activity on methicillin-resistant staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase-producing escherichia coli (ESBLs-E. coli), and shows excellent photo-thermal antibacterial activity at the same time, and the prepared product can be applied to the fields of biological medicines and the like as a nano material for resisting drug-resistant bacteria.

The invention discloses a co-culture method of methicillin-resistant staphylococcus aureus and pseudomonas aeruginosa, and relates to the technical field of microbiology. Comprising the following steps: preparing materials: preparing methicillin-resistant staphylococcus aureus MRSA, pseudomonas aeruginosa PA and a culture medium; performing strain culture and activation, inoculating MRSA and PA, and performing subculture; preparing a bacterial suspension, and culturing MRSA and PA overnight; adding overnight culture bacterium liquid MRSA and PA into the culture medium, oscillating and uniformly mixing to prepare a bacterium suspension, and diluting for later use; the complete processes of strain preparation, bacterial suspension preparation, direct contact and indirect contact co-culture, drug sensitivity testing and the like are covered, and the interaction between MRSA and PA can be comprehensively researched; indirect contact co-culture is realized by adopting a Transwell insert, and a new method is provided for researching the interaction of two bacteria under the non-direct contact condition.

The invention discloses an antibacterial polypeptide AuGF and application of the antibacterial polypeptide AuGF in preparation of a medicine for treating and / or preventing bacterial infection. The amino acid sequence of the polypeptide is as follows: SEQ ID NO.1: GLFIKIIKIKIAKSF; the antibacterial polypeptide AuGF disclosed by the invention has broad-spectrum antibacterial activity, can effectively solve the problem of bacterial drug resistance, and has a remarkable bacteriostatic effect on various bacteria including staphylococcus aureus, streptococcus mutans, actinobacillus, methicillin-resistant staphylococcus aureus and the like; the compound provided by the invention has the advantages of simple preparation process and low cost, can play a significant role at low concentration, has low minimum inhibitory concentration on various pathogenic bacteria, has strong bacteriostatic ability, and is beneficial to reduction of side effects and improvement of drug safety; the antibacterial polypeptide AuGF can also be used as a bacteriostatic additive to be applied to articles of daily use, provides an effective bacteriostatic means for daily cleaning and skin care, and has a wide market application prospect.

Described herein are Staphylococcal toxins inspired peptides (STIPs) with antimicrobial activity, compositions and kits comprising the peptides, and use of the peptides to treat microbial infections. Also described are methods of inhibiting or preventing the growth of a microorganism, and methods of treating microbial infections such as bacterial infections including MRSA, and fungal infections including C. albicans.

This invention discloses the application of ferrous ions in the preparation of products for treating bacterial infections, belonging to the field of pharmaceutical technology. Antibacterial activity tests of ferrous ions against Staphylococcus aureus showed strong bactericidal effects, with a survival rate of less than 0.001% against Staphylococcus aureus and less than 0.01% against methicillin-resistant Staphylococcus aureus (MRSA). The use of ferrous ion-containing hydrogels in the treatment of keratitis and skin wound infections significantly reduced the risk of MRSA infection in the lungs and effectively prevented the proliferation and spread of microorganisms in the body, revealing that drugs containing ferrous compounds can be used to treat Staphylococcus aureus infections, including MRSA.

This invention discloses a method for preparing and applying a photothermal nanoreagent targeting bacteria. This invention utilizes Ti3C2T... x Using MXene as a matrix, a photothermal nanoreagent MXene@PDA@Peptide (MPP) was constructed by sequentially modifying the surface of Ti3C2Tx MXene with polydopamine and grafting it with the peptide CAEKA, which has the function of recognizing bacteria. Under the recognition of the peptide CAEKA, the photothermal Ti3C2Tx MXene was targeted. x MXene nanosheets are guided to the surface of bacterial cells, achieving effective sterilization at a relatively low overall temperature of around 50°C (or achieving more efficient sterilization at the same overall temperature level, exhibiting superior sterilization performance compared to pure Ti3C2Tx MXene). This makes them particularly suitable for the preparation of therapeutic drugs for subcutaneous abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) infection.

The application belongs to the field of antibacterial two-dimensional nanomaterial Mxene catalysts, and particularly relates to a monolayer W@MoS2 nanosheet as well as a preparation method and application thereof. The method comprises the following steps: 1) dissolving water-soluble molybdate and water-soluble tungstate in water to obtain a mixed solution; 2) adding a sulfur source and an organic solvent to the mixed solution, and then performing reaction after mixing, and drying to obtain a powder. The monolayer W@MoS2 nanosheet has a unique two-dimensional planar structure, a large specific surface area, and good optical and electronic properties, and has high light-heat absorption in the near-infrared two region, i.e., the light-heat conversion efficiency is improved. Meanwhile, the peroxidase-like activity of the monolayer W@MoS2 nanosheet material realizes efficient light-heat amplification, can treat methicillin-resistant Staphylococcus aureus infection, and avoids heat therapy damage to normal tissues.

The invention belongs to the technical field of natural antibacterial drugs, and discloses application of cyclovirobuxine D and pharmaceutically acceptable salts thereof in preparation of antibacterial drugs. The invention discloses the effect of cyclovirobuxine D in preparation of antibacterial drugs, and tests prove that cyclovirobuxine D has remarkable antibacterial activity in inhibition of gram-positive bacteria such as staphylococcus aureus, gram-negative bacteria such as escherichia coli and super drug-resistant bacteria such as MRSA (Methicillin Resistant Staphylococcus Aureus).

The invention discloses a method for rapidly and efficiently preparing a series of novel ester group facaplysin derivatives by combining EDCI and HOBT to react with carboxyl facaplysin and directly carrying out ester exchange reaction on an active ester intermediate and alcohol without separation. The invention also discloses application of the derivatives in resisting methicillin-resistant staphylococcus aureus and escherichia coli. The preparation method comprises the following steps that EDCI and HOBT are combined to activate carboxyl facaplysin for reaction, an activated ester intermediate is generated, the activated ester intermediate and alcohol are directly subjected to esterification reaction without separation, and a series of ester-based facaplysin derivatives are obtained. According to the preparation method, ester-based Fascaplysin derivatives with different structures can be rapidly and efficiently constructed, and compared with a traditional method that ester-based carboline derivatives are firstly synthesized and then high-temperature intramolecular cyclization is performed, the time and the raw material cost are greatly saved, the synthesis efficiency is improved, the reaction process is observable and controllable, and the yield is stable. And the synthesized ester group facaplysin derivative has excellent antibacterial activity on methicillin-resistant staphylococcus aureus and escherichia coli.

The invention relates to an artificial multienzyme nanoflower composite hydrogel wound dressing and a preparation method thereof. According to the preparation method of the artificial multienzyme nanoflower composite hydrogel wound dressing, the nanoflower loaded with glucose oxidase and hemoglobin and an NO donor are jointly doped into a matrix to prepare the artificial multienzyme nanoflower composite hydrogel wound dressing. According to the artificial multienzyme nanoflower composite hydrogel wound dressing, the diabetes wound microenvironment can be remodeled by reducing the local blood glucose concentration and pH, relieving oxygen deficit and removing excessive active oxygen; nO of different doses is released under different blood glucose levels to play the antibacterial and angiogenesis promoting functions, and then healing of methicillin-resistant staphylococcus aureus infected diabetes wounds is effectively promoted.

The invention belongs to the technical field of biology, and particularly relates to a method for screening methicillin-resistant staphylococcus aureus of oral samples of wild animals. The methicillin-resistant staphylococcus aureus is selectively cultured by adopting a culture medium composition with specific composition, and molecular biological detection is combined, so that the methicillin-resistant staphylococcus aureus is screened from a wild macaque oral cavity sample for the first time. According to the screening method, the screening efficiency of the methicillin-resistant staphylococcus aureus is greatly improved, the methicillin-resistant staphylococcus aureus can be rapidly, accurately and efficiently screened and enriched from a large number of samples, and technical support is provided for experimental research related to the methicillin-resistant staphylococcus aureus.

The invention belongs to the technical field of organic synthesis, and relates to an electron donor-double receptor type fluorescent compound as well as a preparation method and application thereof, the electron donor-double receptor type fluorescent compound has the following structural formula: # imgabs0 #, R1 is at least one of the following functional groups: # imgabs1 # R2 is H,-CH3,-COOCH2CH3,-COOCH3 or-NO2; x1 is a halogen ion; the preparation method comprises the following steps: # imgabs2: mixing a compound as shown in a formula 2, a compound as shown in a formula 3 and organic alkali, and carrying out a Knoevenagel reaction to obtain the electron donor-double receptor type fluorescent compound. Compared with the prior art, the photosensitizer structure disclosed by the invention can efficiently generate active oxygen and shows an efficient photodynamic killing effect on methicillin-resistant staphylococcus aureus and escherichia coli. Due to the characteristics, the donor-double acceptor pyridinium salt derivative has important application value in the development of novel antibacterial materials.

The present invention relates to the technical field of pharmaceutical compounds and specifically discloses a selenocyanine pregnenol ketamide compound having the following general structural formula: #imgabs0#. The selenocyanine pregnenol ketamide compound of the present invention exhibits strong inhibitory activity against human breast cancer cells, cervical cancer cells, ovarian cancer cells, and human liver cancer cells. Furthermore, the selenocyanine pregnenol ketamide compound of the present invention also exhibits strong inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The selenocyanine pregnenol ketamide compound of the present invention has low toxicity to humans and exhibits strong inhibitory effects against cancer cells and various drug-resistant bacteria at low concentrations. It can be used to prepare cancer treatment drugs and as an antibacterial agent against drug-resistant bacteria.

The application belongs to the technical field of medical materials, and particularly relates to a sonodynamic Ag2O / MoS2 nanocomposite material as well as a preparation method and application thereof. The Ag2O / MoS2 nanocomposite material is prepared by depositing Ag2O on the surface of MoS2 to construct a heterostructure under the catalysis of a surfactant CTAB. The inhibition rate of the Ag2O / MoS2 nanocomposite material prepared by the application to 10 6 CFU / mL of Staphylococcus aureus, Escherichia coli and methicillin-resistant Staphylococcus aureus reaches 95.98% or more.