135 results about "Chloroacetamide" patented technology

The present invention relates to the field of pesticide herbicides, and discloses a herbicide composition and a herbicide containing the herbicide composition, the herbicide composition comprises a component A and a component B, the component A is a triketone compound shown as formula (I), and the component B is at least one selected from the group consisting of triazine herbicides, hydroxybenzonitrile herbicides, triazolinone herbicides, diphenyl ether herbicides, pyridinecarboxylic acid herbicides, phenoxycarboxylic acid herbicides, benzoic acid herbicides, pyridine herbicides, chloroacetamide herbicides, sulfonylurea herbicides, triazolopyrimidine herbicides, bentazone, mesotrione and topramezone. The herbicide composition can broaden the herbicidal spectrum and can improve the controleffect and retard the occurrence of weed drug resistance and anti-drug property.

The invention provides a new amide compound shown as structural formula (I) and application thereof in preparing monoamine oxidase inhibitor. The invention takes phenols compound shown as formula (II) and 2-chloroacetamide shown as formula (III) as reaction substrate, reaction is taken place to obtain amide compound shown as the formula (I), and then fluorescence detection method is used for detecting monoamine oxidase inhibition activity. The method has simple operation process, raw materials are available, and the obtained monoamine oxidase inhibitor has stable properties, and purity is high (more than 99%); compared with the previously researched method of monoamine oxidase inhibitor, the sieved novel amide monoamine oxidase inhibitor has simple structure, and inhibition activity and selectivity on MAO-A and MAO-B are all greatly improved.

An emulsifiable pesticide suspension composition is provided, the composition contains (a) a pesticide-effective amount of a liquid pesticide with low solubility in water, such as a chloroacetamide herbicide such as acetochlor, (b) a pesticide-effective amount of Solid granular pesticides, especially salt-forming pesticides, such as glyphosate herbicides, which are dispersed in the form of solid particles in liquid pesticides, (c) a stabilizing amount of a suspending aid, (d) an emulsifier, and An amount sufficient to emulsify the concentrated composition in an appropriate amount of water to form a diluted sprayable composition, and (e) zero to assay adjusting amount of an inert liquid in which the liquid pesticide is soluble or miscible . The concentrate composition is substantially anhydrous. Liquid pesticides and solid pesticides should be selected to be chemically compatible with each other. According to the present invention, by substantially avoiding the use of water and inert organic solvents, it is possible to provide suspension compositions containing extremely high concentrations of active ingredients.

The invention discloses a synthesis method of epinastine. The synthesis method is implemented by taking 2-aminobenzophenone as a raw material and comprises the following steps of: reacting the 2-aminobenzophenone with a silane agent to obtain 2-benzylaniline; then, carrying out acylation reaction on the 2-benzylaniline and 2-chloroacetyl chloride to obtain N-(2-benzyl phenyl)-2-chloroacetamide; carrying out acidamide dehydration and cyclization on the N-(2-benzyl phenyl)-2-chloroacetamide under the action of a dehydrating agent to obtain 6-(chloromethyl)-11H-dibenzo[b,e] azepine; carrying out azidation reaction on the 6-(chloromethyl)-11H-dibenzo[b,e] azepine to obtain 6-(azido-methytbiphenyl)-11H-dibenzo[b,e] azepine; carrying out reduction on the 6-(azido-methytbiphenyl)-11H-dibenzo[b,e] azepine to obtain 6-(aminomethyl)-6,11-dihydro-1H-dibenzo[b,e] azepine; and finally, carrying out cyclization on the 6-(aminomethyl)-6,11-dihydro-1H-dibenzo[b,e] azepine and cyanogen bromide to obtain the epinastine. The synthesis method disclosed by the invention avoids the application of expensive and flammable lithium aluminium hydride and aluminium hydride as well as hypertoxic sodium cyanide, so that the operation is safer in industrial production, and the cost is reduced. The method is simple in process and high in yield, requires mild conditions, and is suitable for industrialized production.

The invention discloses a fluorescence probe based on 1, 3, 4-oxadiazole derivative, and a synthetic method and applications thereof. Chemical formula of the fluorescence probe is represented in the invention. The synthetic method comprises following steps: N-[2-(5-phenyl-1, 3, 4-oxadiazole-2-yl)phenyl]-2-chloroacetamide, di-(pyridylmethylene)amine, N, N-diisopropylethylamine and potassium iodide are added into acetonitrile so as to obtain a mixture; the mixture is stirred, and is subjected to heating reflux under protection of nitrogen; solvent removing is realized via reduced pressure distillation, and obtained residues are subjected to column chromatography for separation so as to obtain the fluorescence probe N-[2-(5-phenyl-1, 3, 4-oxadiazole-2-yl)phenyl]-2-di(2-pyridylmethylene) acetamide. The raw materials are easily available; the synthetic method is simple; product separation and purification processes are easy; and the fluorescence probe possesses excellent water solubility, can be used for Zn<2+> monitoring analysis and tracer analysis in water environmental systems and biological cell systems, and possesses excellent sensitivity and relatively strong anti-interference capability on detection of Zn<2+>.

The invention provides a method for preparing Oxiracetam, which comprises the following steps: performing alkaline treatment of 4-hydroxy-2-pyrrolidone under a water-free condition; reacting the treated 4-hydroxy-2-pyrrolidone with 2-chloroacetamide in an organic solvent in the presence of a catalyst; and after the reaction is finished, performing filtration, distillation and recrystallization to obtain the Oxiracetam. In the method, the final product can be obtained by a one-step reaction, the operation is simple and convenient, and large scale production can be realized. The invention also provides the Oxiracetam obtained by the method, which has the characteristics of high yield, high purity and good treatment effect. The invention also provides the use of the Oxiracetam obtained by the method in the preparation of medicaments for treating brain dysfunction, impaired memory and senile dementia.

The invention discloses a relay-type multifunctional fluorescent probe, and a preparation method and application thereof, belonging to the field of functional materials. The preparation method comprises the following steps: adding N-[2-(5-phenyl-1,3,4-oxadiazolyl-2-yl)phenyl]-2-chloroacetamide, di-(pyridylmethylene)amine, N,N-diisopropylethylamine and potassium iodide into acetonitrile, and stirring and heating under reflux in a nitrogen protective atmosphere; and after the reaction finishes, distilling under reduced pressure to remove the solvent, carrying out column chromatography separation on the residues to obtain the fluorescent probe N-[2-(5-phenyl-1,3,4-oxadiazolyl-2-yl)phenyl]-2-di(2-pyridylmethyleneamino)acetamide. The fluorescent probe has excellent water solubility, can be used for monitoring analysis and tracing of zinc ions, pyrophosphate and sulfur ions in a water environment system, and has favorable determination sensitivity for target ions.

The invention relates to a preparation method of Pramiracetam sulfate. The preparation method comprises the steps of using N, N-diisopropylethanolamine as a starting raw material, and conducting chlorination and ammonolysis to obtain an intermediate N, N- diisopropylethylene diamine; then conducting acylation, substitution, salt forming and refining to obtain the Pramiracetam sulfate. The preparation method of the Pramiracetam sulfate has the characteristics that the reaction process is safe and controllable, the cost of used raw materials and solvent is low and the raw materials and the solvent are easy to obtain; organic solvent is very easy to recycle, the emission of organic matters is greatly reduced, and the environmental friendliness is improved; since the intermediate N-[(2-diisopropyl amino) ethyl]-chloroacetamide is not separated and purified, the reaction equipment is simplified, and the operation process is enabled to be more high-efficient.

The invention provides chloridized 1-vinyl-3-amino-formyl methyl-imidazole bifunctional ionic liquid and a synthetic method thereof. The chloridized 1-vinyl-3-amino-formyl methyl-imidazole bifunctional ionic liquid is obtained by taking 1-vinylimidazole and 2-chloroacetamide as raw materials, acetone as a solvent and phenol as a polymerization inhibitor, and reacting at 45-55 DEG C. The synthesized ionic liquid enriches the variety of polymerizable ionic liquid, and provides more selections for the application of the ionic liquid in the fields of functional materials, catalysis, separation and the like. Besides, the synthetic method is simple in step, does not need special equipment and is lower in cost.

The invention discloses a chloroacetamide herbicide degrading strain, a bacterium produced thereby and application thereof. The chloroacetamide herbicide degrading strain, rhodococcus sp. AC-1, is preserved in China General Microbiological Culture Collection Center under CGMCC No.10778 on 30th April, 2015. The chloroacetamide herbicide degrading strain AC-1 is suitable for use in degrading chloroacetamide herbicides, preferably in degrading chloroacetamide herbicides in soil; by directly applying a degrading strain product, residue of the chloroacetamide herbicides (specifically alachlor, acetochlor and butachlor) in the soil can be decreased by above 85%, the problem that the residue of the alachlor, acetochlor and butachlor in agricultural production is out of limits is solved, and chemical damage caused by herbicide residue to crops is prevented.

The invention discloses alkannin acetyl glucose and a preparation method and an application thereof. The method comprises the following steps: adding 1 mol of 1- trichloroacetamido-acetyl glucose and 1-2 mol of alkannin into dichloromethane solution, and reacting at the temperature of minus 20-minus 40 DEG C under the existence of 4angstrom of molecular sieve and boron trifluoride diethyl etherate, thus obtaining alkannin acetyl glucose. The alkannin acetyl glucose is used for the medicines with tumor activity resistance and drug resistance. In the invention, the alkannin acetyl glucose is prepared simply and effectively by four steps of reaction, the tumor activity resistance and drug resistance of the alkannin acetyl glucose are inspected, therefore, the alkannin acetyl glucose which has strong inhibiting action to the tumor cell lines is showed, and the good drug resistance of the alkannin acetyl glucose are also proved, and the alkannin acetyl glucose is a prospecting medicine for resisting tumor.

The invention discloses an aminothiazole alkyl xanthate derivative as well as a preparation method and application of the aminothiazole alkyl xanthate derivative. The aminothiazole alkyl xanthate derivative is obtained by a reaction of alkyl xanthate and 2-(chloracetamido)thiazole. The technology conditions adopted in the preparation method are mild, and yield is high; the aminothiazole alkyl xanthate derivative has a chemical structure formula as shown in a general formula (I), wherein in the formula, R is a C3-30 branched chain or linear chain alkyl; and the aminothiazole alkyl xanthate derivative used as an environment-friendly lubricating oil addictive can improve extreme-pressure wear-resistant property of lubricating oil which takes liquid paraffin as base oil.

The present invention is a herbicidal composition containing glyphosate or glufosinate-ammonium, a chloroacetamide, and a triazine, wherein the composition has an aqueous phase, an oil phase, and is dispersed in the aqueous phase and / or particles in the oil phase and are stabilized by a stabilizing amount of one or more emulsifiers.

The invention discloses a benzothiazole derivative multifunctional lubricating oil additive, a preparation method and application thereof. The preparation method specifically includes: firstly subjecting alkylamine and chloroacetyl chloride to amidation reaction to obtain alkyl chloroacetamide, then reacting 2-mercaptobenzothiazole with carbon disulfide and alkyl chloroacetamide to obtain the benzothiazole derivative multifunctional lubricating oil additive with a structure shown as general formula I. The benzothiazole derivative multifunctional lubricating oil additive has the characteristicsof simple preparation method, mild process conditions, easily available raw material, low synthesis cost, high synthesis yield and the like, can be used as an extreme pressure, antiwear, antifrictionand corrosion resistant additive of lubricating oil, can obviously improve the bearing capacity of base oil and improve the wear resistance and antifriction performance, and is an environment-friendly multifunctional lubricating oil additive.

The invention provides a synthesis method of 2,3-dichloro-5-methylpyridine. The method comprises following steps: taking N-propylidene benzylamine as the primary raw material, carrying out acylation reactions between the N-propylidene benzylamine and chloroacetyl chloride in the action of an acid binding agent at the temperature of minus 10 DEG C to 60 DEG C so as to obtain N-benzyl-N-propenyl-alpha-chloroacetamide, and then carrying out cyclization reactions between the N-benzyl-N-propenyl-alpha-chloroacetamide and (dichloromethylene)dimethylammonium chloride at the temperature of 20 DEG C to 120 DEG C so as to obtain 2,3-dichloro-5-methylpyridine. Compared to the conventional methods, the synthesis method has the advantages of little raw material toxicity, high yield, low cost, mild reaction conditions, and little waste water, waste gas, and waste solid, and has an industrial application value.

The invention relates to a ratio-dependent florescent probe for identifying Zn<2+> and S<2-> in a relayed manner. The ratio-dependent florescent probe has a structure formula described in the specification. The ratio-dependent florescent probe is synthesized by adopting the specific steps of: with DMF (Dimethyl Formamide) as a solvent, stirring raw materials, namely N-(2-(1H-benzimidazoly)phenyl)-2-chloroacetamide and bis-(pyridylmethylene) amine, according to a molar ratio of 1: 2-1: 4 at room temperature for reaction for 7-10 hours to obtain a solution; and adding distilled water to the solution, adjusting pH of the solution to 6-7 by using diluted hydrochloric acid, filtering to collect generated precipitate, and recrystallizing by using acetonitrile to obtain the florescent probe N-(2-(1H-benzimidazoly)phenyl)-2-bis(2-pyridylmethylene) acetamide. The ratio-dependent florescent probe has the advantages of favorable sensitivity, strong antijamming capability and friendliness to environment in the process of carrying out monitoring analysis and tracing on Zn<2+> and S<2-> in a water environment system and a biological cell system.

The binary compound herbicide as one kind of agricultural chemicals contains one kind of diphenyl ether herbicide, one kind of chloroacetamide herbicide and assistant. It has the advantages of both diphenyl ether herbicide and chloroacetamide herbicide, their synergistic and cooperative effect, wide herbicidal spectrum and raised herbicidal effect. Once application can ensure no weed damage in the whole growth period of crop. It has high safety to water melon. It has low cost, convenient use, less residue and environmental pollution.

The invention relates to a preparation method of glycyl-tyrosine, which comprises the following steps: using L-tyrosine, toluene and water raw material, adding chloroacetamide and sodium hydroxide drop by drop under certain condition, adding hydrochloric acid drop by drop to control the pH value after reacting, then carrying out an aminolysis at normal pressure, heating and concentrating, washing and centrifuging to obtain the glycyl-tyrosine crude product, dissolving, filtering, crystallizing, carrying out pumping filtration and drying to obtain glycyl-tyrosine. The glycyl-tyrosine crystal prepared by the preparation method has high purity, and is beneficial to further purifying and refining glycyl-tyrosine.

The invention relates to a cephamycin intermediate compound and a preparation method thereof. The cephamycin intermediate compound has a structure of formula (I), and is prepared by directly reacting 7beta-chloroacetamide-7alpha-methoxy-3-(1-methyl-1H-tetrazole-5-thiomethyl)-3-cephem-4-carboxylic acid and dicyclohexylamine in a specific solvent to form a salt and crystallizing. The cephamycin intermediate compound has the characteristics of high purity, high stability and the like, is conductive to improving the purity of cephamycin final products such as cefminox sodium, cefmetazole sodium and cefotetan disodium, and is beneficial to large-scale production and application.

The invention discloses a preparation method of X-ray contrast agent ioversol intermediate, belonging to the technical field of organic compound preparation. The chemical name of the intermediate is 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method utilizes 5-amino-2,4,6-triiodo-1,3-phthalic acid to react with thionyl chloride, and then reacts withchloroacetic chloride to obtain 5-chloroacetamide-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride, finally reacts with 3- amino-1,2- propylene glycol to obtain the 5-chloroacetamide-N,N'-bi(2,3-dyhydroxyl propyl)-2,4,6-triiodo-1,3-benzenedicarboxamide. The method has simple synthesis process route, shortened reaction steps, mild reaction condition, security and reliability, stable quality, high yield, low cost and less equipment investment, thereby being applicable to large-scale industrial production.

The invention discloses a synthesizing method for a chloroacetamide compound. In a reaction kettle, a secondary amine compound is dissolved in an organic solvent, the mixture is heated for reflux, chloroacetyl chloride is added into the mixture, a reflux reaction is conducted for 0.5-20 hours, and the chloroacetamide compound is obtained. According to the synthesizing method for the chloroacetamide compound, an acid binding agent is not used, discharging of wastewater in the after-treatment process is reduced, by keeping the reflux state of the system, hydrogen chloride gas generated from thereaction is exhausted out of the system and absorbed by water outside the system, high-purity hydrochloric acid is obtained, the waste is turned into wealth, the method comes up to the production standard of safety and environment protection, and discharging of waste gas, waste water and waste residues is reduced; according to the synthesizing method for the chloroacetamide compound, few operationsteps are utilized, the reaction speed is high, the product yield is high, the purity is high, the production cost is low, and the method is safe, friendly to the environment and suitable for industrial large-scale production.

The invention relates to a novel compound 1-[2-(2,4-dimethylphenylthio)phenyl]-2-oxopiperazine and its preparation method and use in vortixetine synthesis. 2-(2,4-dimethylthiophenyl)aniline and chloroacetyl chloride as initial raw materials undergo a synthesis reaction to produce N-2-(2,4-dimethylphenylthio)phenyl-chloroacetamide and the N-2-(2,4-dimethylphenylthio)phenyl-chloroacetamide undergoes a classical Mitsunobu ring closing reaction to produce 1-[2-(2,4-dimethylphenylthio)phenyl]-2-oxopiperazine. The preparation method needs a low reaction temperature and prevents side reactions caused by ring closing high temperature conditions of other routes. The novel compound is used for vortixetine synthesis and has the advantages of simple processes, easy acquisition of raw materials, low cost, mild reaction conditions, safety, environmental friendliness, short reaction time, simple processes and after-treatment, high yield, high product purity and industrial production feasibility.

The invention relates to a magnetic particle reagent and a kit for chemiluminescence immunodetection. The magnetic particle reagent comprises magnetic particles coated by 0.5-1.5mg / mL streptavidin oranti-fluorescein isothiocyanate antibody, 0.5-5mg / mL protein, 0.5-10mg / mL chloroacetamide type protein protection agent, 1-10mg / mL preservative, 5-10mg / mL polyol compound and 1-5mg / mL buffer solutionof surfactant, wherein the polyol compound is polyol or polysaccharide, and the surfactant is at least one of Brij35, TX-100 and peregal O-20. The magnetic particle reagent can disperse the magnetic particles uniformly and stably for a long time and can maintain activity and stability of streptavidin or anti-fluorescein isothiocyanate antibody and protein in unfavorable environment like high temperature, so that chemiluminescence immunoassay is large in chemiluminescence value, high in repeatability and small in background value.

The invention discloses a biodegradable alkyl acetamidobenzotriazole derivative lubricating oil additive which does not contain sulfur, phosphorus, halogens and metal elements as well as a preparation method and application thereof. The preparation method comprises the following steps: under the action of alkali, performing amidation on alkyl amine and chloroacetyl chloride to obtain alkyl chloroacetamide; and then performing a nucleophilic substitution reaction with benzotriazole to obtain a target compound of a formula I. The preparation method disclosed by the invention is simple in preparation method, mild in process condition, easily available in raw material, low in preparation cost and high in synthetic yield. The novel alkyl acetamidobenzotriazole derivative can be independently used as an extreme pressure anti-wear corrosion-resistant additive of lubricating oil, also can be used with other lubricating oil additives in a compound manner, also can be used in common working conditions and high-temperature working conditions, can improve the bearing capacity of basic oil obviously and improve the anti-wear performance, and is the lubricating oil additive which is environmentally friendly and multi-functional. The formula I is as shown in the specification.

The invention discloses O-acetamide chitosan Schiff-base and a preparation method thereof. The preparation method includes: benzaldehyde chitosan Schiff-base is allowed to have nucleophilic substitution reaction with chloroacetamide so as to prepare the O-acetamide chitosan Schiff-base. The O-acetamide chitosan Schiff-base has the advantages that the O-acetamide chitosan Schiff-base is definite in modification position, high in purity and good in flocculation and sterilizing effect, and chitosan amino protection is achieved through the Schiff-base reaction to allow hydroxyl to have a fixed-position modification effect.

The invention discloses an excited state intramolecular proton transfer regulation based fluorescence probe, and a synthetic method and applications thereof. The structural formula of the fluorescence probe is shown in the patent specification of the invention. Specific synthetic steps are as following: DMF is taken as a solvent; molar ratio of N-(2-(1H-benzimidazolyl)phenyl)-2-chloroacetamide to picolylamine, which are used as raw materials, is 1:1.5-1.3; the mixture is stirred at room temperature for 5 to 10 h; the mixture is diluted with distilled water, pH value of the mixture is adjusted to 6.5 to 7.5 with dilute hydrochloric acid, the mixture is filtered, produced sediment is collected and is recrystallized with acetonitrile, so that the fluorescence probe N-(2-(1H-benzimidazolyl)phenyl)-2-(2- picolylamine)acetamide is obtained. Advantages are that: synthesis is simple; water solubility is high; the fluorescence probe is friendly to the environment, and can be used for monitoring, analyzing and tracking Zn<2+> and S<2-> in water environment system and biological cell system; sensitivity is high, and anti-interference capability is excellent.

The invention discloses a lignin-based polyurethane chain extender as well as a preparation method and an application thereof, methylene diphenylamine of the lignin-based polyurethane chain extender is shown as a formula I. The preparation method comprises the following steps: carrying out a hydroxyalkylation reaction on a lignin cracking monomer compound II and a carbonyl compound to obtain a compound III; performing an ammonification reaction on the compound III and chloroacetamide to obtain a compound IV, and performing a Smiles rearrangement reaction on the compound IV to obtain the lignin-based polyurethane chain extender methylene diphenylamine shown in the formula I. According to the invention, green and sustainable lignin is used as a raw material, the carcinogenic potential risk of 2-chloroaniline as a raw material required for producing MOCA is avoided, the dependence on fossil resources is reduced, and the product as a chain extender enhances the thermal stability, mechanical properties and aging resistance of a polyurethane material.

The present invention relates to an inhibitor for tobacco axillary bud growth, the inhibitor comprising, as an active ingredient, one or more kinds of very-long chain fatty acid synthesis inhibitors such as a chloroacetamide-based herbicide, fentrazamide, cafenstrole or indanofan; an inhibitor for tobacco axillary bud growth, the inhibitor comprising the aforesaid very-long chain fatty acid synthesis inhibitor together with clorthal-dimethyl or an aliphatic alcohol having 6 to 20 carbon atoms; and a method for inhibiting tobacco axillary bud growth which comprises applying the inhibitor for tobacco axillary bud growth. The inhibitor for tobacco axillary bud growth of the present invention shows sustained drug efficacy at a low concentration, induces neither chemical injury nor disease, and can contribute to the improvement in labor productivity.

The invention relates to a selenium nano-sensing material and a preparation method thereof and belongs to the field of preparation of silicon dioxide nanometer materials. According to the selenium nano-sensing material, an N-phenyl-2-(4'-methyl-2'-formyl)-phenoxyl acetamide compound serving as a selenium fluorescence detection probe is embedded into silicon dioxide nano-particles, so that the embedded selenium (Se) nano-sensing material is formed. The preparation method comprises three steps of synthesizing N-phenyl-2-chloroacetamide, synthesizing N-phenyl-2-(4'-methyl-2'-formyl)-phenoxyl acetamide and preparing the embedded selenium nano-sensing material. The preparation method is simple and safe in operation and high in repeatability; the defects of toxicity, poor optical chemical stability and the like caused by that the traditional organic matter directly serves as a sensor are overcome; the Se element under the inorganic environment can be detected; and the Se in the organism can be subjected to imaging research.