34 results about "Chloroacetamide" patented technology

The present disclosure relates to herbicidal combinations, compositions and methods for controlling weeds comprising the carbamate herbicide asulam and an additional herbicide selected from the group comprising cyclohexanedione oxime herbicides, pyrimidinylsulfonyhirea herbicides, triazolopyrimidine herbicides, imidazolinone herbicides, alkylazine herbicides, triketone herbicides, N-phenylimide herbicides or chloroacetamide herbicides. Specifically, the additional herbicide may be one of clethodim, chlorimuron, diclosulam, imazamox, imazethapyr, indaziflam, mesotrione, saflufenacil, tiafenacil or S-metolachlor.

The invention provides a method for synthesizing carboxymethyl cellulose by a slurry method based on a novel etherifying agent and an application, the method comprises the following steps: adding crushed cellulose into a reaction container filled with an organic solvent, stirring, continuously introducing nitrogen into the reaction container, and when the temperature of the reaction container reaches 25-35 DEG C, stirring for 2-3 hours; slowly dropwise adding a sodium hydroxide aqueous solution into the reaction container, keeping the temperature for a period of time, rapidly raising the temperature of the reaction container to 55 DEG C, slowly adding a novel etherifying agent into the reaction container, controlling the temperature of the reaction container to be kept at 55-75 DEG C, placing the reaction container at 65 DEG C after dropwise adding, and keeping the temperature for a period of time; wherein the novel etherifying agent is low-carbon alcohol chloroacetate or chloroacetamide, an acidic material is added into a reaction container to adjust the pH value of a reaction system to 6.5-7.5, washing liquid is used for multiple times to obtain carboxymethyl cellulose, and the novel etherifying agent is adopted to solve the problems of a traditional etherifying agent. And the high-quality and high-substitution-degree carboxymethyl cellulose is prepared.

The present invention is directed to a method for controlling weeds in the presence of a rice crop that has been wet-seeded comprising contacting the weeds or their locus with an agriculturally effective amount of a chloroacetamide, salts or stereoisomers thereof and an ALS inhibitor. The invention also covers tank mixtures and formulations for use in weeding wet-seeded rice crops.

The invention discloses a method for detecting residual chloroacetamide in piracetam. A sample to be detected is detected by adopting gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS / MS); the gas chromatography parameters are as follows: the temperature of a sample inlet is 245-255 DEG C; the heating procedure is as follows: the initial temperature is 45-55 DEG C, the temperature is raised to 275-285 DEG C at the heating rate of 35-45 DEG C / min, the post-operation temperature is 295-305 DEG C, and the post-operation time is 4.5-5.5 minutes; the mass spectrum parameters are as follows: the temperature of an ion source is 225-235 DEG C, the temperature of a quadrupole is 145-155 DEG C, and the temperature of a transmission line is 245-255 DEG C; the sampling mode is MRM, the solvent delay is 1.5-2.5 min, and the post-operation time is 2.00-5.00 min. The method disclosed by the invention is simple to operate and high in detection speed, and has the advantages of high sensitivity, high precision and high repeatability.

The invention discloses a novel methoxyimino acetate derivative containing a chloroacetamide structure as well as a preparation method and application of the novel methoxyimino acetate derivative. According to the invention, a methoxyimino acetate skeleton is used as a leading structure, and different pharmacophores are introduced on the basis of the leading structure, so that a series of novel methoxyimino acetate skeleton derivatives containing a chloroacetamide structure are synthesized. In-vitro tests of the compounds show that the compounds have excellent inhibition effects on plant pathogenic fungi such as fusarium graminearum, eggplant verticillium wilt, mango anthracnose pathogen, alternaria solani, sclerotinia sclerotiorum, muskmelon fusarium wilt pathogen and the like; the methoxyl acrylate derivative pesticide with high activity and novel action mechanism is expected to be developed.

The invention belongs to the field of genetic engineering and enzymology, and particularly relates to a deacetylase mutant and application thereof in clethodim synthesis, the deacetylase mutant is obtained by performing single-point mutation or multi-point mutation on the 272th site, the 92th site, the 203th site, the 304th site, the 305th site, the 306th site and the 270th site of an amino acid sequence shown in SEQ ID NO.1, and the mutant with improved specificity on a substrate chloroacetamide is obtained. The mutant Y305E, the mutant Y305E / G304L and the mutant Y305E / H306F can catalyze a substrate chloroacetamide to synthesize chloramine and are used for subsequent clethodim production, compared with a wild type, the relative enzyme activities of the mutants Y305E, Y305E / G304L and Y305E / H306F are improved by 7.8 times, 9.6 times and 10.3 times respectively, the catalytic efficiency of the Y305E is improved by 3.2 times compared with that of the wild type, and the catalytic efficiency of the Y305E / H306F is improved by 4.2 times compared with that of the wild type. When the deacetylase mutant provided by the invention is used for synthesizing chloramine, the reaction condition is mild, the deacetylase mutant is harmless to the environment, the reaction time is short, and the deacetylase mutant has the application prospect of large-scale production of chloramine and subsequent products.

The application discloses a series of evodiamine derivatives containing pyridine quaternary ammonium salt, a preparation method and antibacterial application thereof. The series of compounds are prepared by introducing a pyridine ring and then connecting with a chloroacetamide fragment based on a natural product evodiamine as a mother structure, so as to prepare a series of evodiamine derivatives containing pyridine quaternary ammonium salt, and the structural general formula is shown in the following formula (1). The series of compounds have strong in-vivo and in-vitro antibacterial activities on Staphylococcus aureus ATCC 29213 and clinically isolated Methicillin-resistant S. aureus (MRSA). The water solubility and antibacterial activity of the application are enhanced through further structure optimization, and the in-vivo and in-vitro toxicity, safe hemolytic activity and low drug resistance are low. Therefore, the evodiamine derivatives containing pyridine quaternary ammonium salt have the potential to be further developed as new antibacterial drugs.

The present invention relates to a method for controlling undesired vegetation in the crop by applying to the locus of the undesired vegetation an herbicidal mixture comprising an herbicidally effective amount of bifenox and an herbicidally effective amount of a chloroacetamide compound, wherein the chloroacetamide compound is selected from the group consisting of butachlor or pretilachlor.

The invention belongs to the technical field of organic synthesis route design and preparation of raw material medicines and intermediates, and particularly relates to a preparation method of Erdatinib and an intermediate compound used for the method. The present invention relates to a process for preparing Erdatinib using an intermediate compound II (2-{N-(3, 5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl) quinoxaline-6-yl] amino}-N-isopropylacetamide), and provides a process for preparing Erdatinib using a compound III (N-(3, 5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl) quinoxaline-6-yl] amino)-N-isopropylacetamide The invention relates to a method for preparing a compound II by carrying out nucleophilic substitution reaction on 2-(3, 5-dimethoxyphenyl)-3-(1-methyl-1H-pyrazol-4-yl) quinoxaline-6-amine) and N-isopropyl-2-chloroacetamide or N-isopropyl-2-bromoacetamide, and a method for preparing a compound III by using the compound VI (2-(3, 5-dimethoxyphenyl)-3-(1-methyl-1H-pyrazol-4-yl) quinoxaline-6-amine). The invention relates to a method for preparing a compound II by carrying out a coupling reaction on a compound I (2, 5-dimethoxyphenyl amino)-N-isopropylacetamide) and a compound VII (7-bromo-2-(1-methyl-1H-pyrazol-4-yl) quinoxaline). According to the present invention, the new synthesis technology is adopted, such that the side reaction is avoided through the amino group positioning and the timely conversion of the amide structure, the Erdatinib is conveniently and rapidly prepared, and the new way with the practical application value is provided for the industrial production of the Erdatinib bulk drug.

The application provides a preparation method of a modified cellulose buffer layer-based forward osmosis membrane and a product thereof, and comprises the following steps: 1) dispersing cellulose fibers into an aqueous sodium hydroxide solution to prepare an alkaline dispersion solution of the cellulose fibers; 2) adding 2-chloroacetamide into the alkaline dispersion solution of the cellulose fibers, and continuously heating and stirring to prepare modified cellulose fibers; 3) dissolving the modified cellulose fibers in a solvent to prepare a cellulose solution, and then coating the cellulose solution on the surface of a non-woven fabric; and 4) growing an ultrathin polyamide layer on the surface of the cellulose-non-woven fabric in situ by using m-phenylenediamine and 1,3,5-benzene tris-methyl chloride, so as to prepare the modified cellulose buffer layer-based forward osmosis membrane. The modified cellulose buffer layer-based forward osmosis membrane has excellent water flux and salt retention performance, has good stability of separation performance, has a simple preparation process, can reduce the amount of polyamide, is low in cost, and is suitable for large-scale production.

The invention provides a novel method for preparing an epinastine intermediate N-[2-(phenyl methyl) phenyl]-2-chloroacetamide. The method mainly comprises the following steps: by taking 2-aminobenzophenone as an initial raw material, firstly reducing and then acylating, and carrying out reduction reaction on carbonyl of 2-aminobenzophenone to methylene under the catalysis of RaneyNi by taking water as a proton source. The method has the advantages that RaneyNi is recycled and reused, the organic solvent can be recycled and reused, hydrogen and a hydrogenation kettle are not needed, introduction of a high-boiling-point solvent and a toxic reagent is avoided, and the method is easy and convenient to operate, mild in reaction condition, short in reaction time, low in cost, small in pollution, high in product yield and purity and suitable for industrial large-scale production.

The application discloses a benzothiazole compound containing an acetamide bond, named N-(4-methylbenzothiazole-2-yl)-2-(pyrrolidine-1-yl)acetamide. A preparation method comprises the following steps: first, preparing an N-(4-methylbenzo[d]thiazole-2-yl)-3-chloroacetamide compound; dissolving the N-(4-methylbenzo[d]thiazole-2-yl)-3-chloroacetamide compound and anhydrous potassium carbonate in dichloromethane to obtain a reaction solution; under the condition of an ice water bath and stirring, adding tetrahydropyrrole dropwise into the reaction solution; reacting at room temperature; monitoring the reaction progress by using TLC; after the reaction is completed, quenching the reaction solution by using water; adjusting the pH to neutral; obtaining a solid crude product; and purifying the solid crude product by recrystallization with ethanol to obtain the benzothiazole compound containing the acetamide bond. The compound can effectively inhibit monoamine oxidase and has low cytotoxicity.

The application provides a method for catalytic degradation of polyolefin plastic by using a eutectic solvent, comprising the following steps: placing polyolefin plastic particles, C4-C6 alkane, amide-AlCl3 eutectic solvent, initiator and polychloromethane in a reactor to perform a catalytic degradation reaction in a water-free and sealed environment to obtain a hydrocarbon product; wherein the C4-C6 alkane is added before the polyolefin plastic particles and the amide-AlCl3 eutectic solvent coexist in the reactor; the amide-AlCl3 eutectic solvent comprises an amide compound and AlCl3; the amide compound is selected from one or more of chloroacetamide, formamide, acetamide, N-methyl formamide, N-methyl acetamide, N,N-dimethyl acetamide, N,N-diethyl acetamide and N,N-dimethyl formamide; the application first applies the eutectic solvent to the catalytic degradation of the polyolefin plastic, and solves the problems of low efficiency and high cost of the traditional method at low temperature.

The present invention relates to a liquid herbicidal composition. In particular, the present invention relates to a liquid herbicidal composition comprising triazolone herbicide and at least one co-herbicide selected from triketone herbicide and chloroacetamide herbicide; a process for preparing said composition; and a method for controlling weeds using the same.

This invention provides a method for preparing high-strength straw-based mechanical pulp using chemically cross-linked fibers and the resulting product. The method comprises the following steps: (1) dispersing straw-based mechanical pulp fibers in water to prepare a straw-based mechanical pulp fiber dispersion; (2) adjusting the pH of the straw-based mechanical pulp fiber dispersion with sodium hydroxide solution; (3) adding 2-chloroacetamide to react and prepare an acetamide-modified straw-based mechanical pulp fiber dispersion; and (4) adding ethylene glycol to the acetamide-modified straw-based mechanical pulp fiber dispersion to perform a chemical cross-linking reaction, thereby obtaining high-strength straw-based mechanical pulp. This invention uses 2-chloroacetamide and ethylene glycol to chemically modify straw-based mechanical pulp fibers, constructing strong chemical cross-linking bonds between the straw-based mechanical pulp fibers, thereby improving the mechanical strength of the straw-based mechanical pulp fibers.

The invention discloses a chloroacetamide thioredoxin reductase inhibitor and application of the chloroacetamide thioredoxin reductase inhibitor in preparation of antitumor drugs. The structural formula of the chloroacetamide thioredoxin reductase inhibitor is # imgabs0 #. The chloroacetamide thioredoxin reductase inhibitor disclosed by the invention has a very good inhibition effect on proliferation of various cancer cell strains in vitro and can inhibit pure thioredoxin reductase and intracellular thioredoxin reductase, and the inhibition activity and selectivity of the inhibitor are superior to those of positive medicaments, namely Jinnofen, TRI-1 and TRI-2.

The present disclosure relates to a method for controlling weeds of Rottboellia genus with herbicidal combinations / compositions comprising chloroacetamide herbicides and dinitroaniline herbicide. The present disclosure further provides a method for controlling weeds using the herbicidal combination possessing enhanced efficacy over the individual herbicides.

This invention belongs to the fields of genetic engineering and enzymology, specifically relating to deacetylase mutants and their application in the synthesis of clethodim. The deacetylase mutants are obtained by single-point or multi-point mutations at positions 272, 92, 203, 304, 305, 306, and 270 of the amino acid sequence shown in SEQ ID NO.1, resulting in mutants with enhanced specificity for the substrate chloroacetamide. These mutants can catalyze the synthesis of chloroamines from chloroacetamide for subsequent clethodim production. Compared to the wild type, the relative enzyme activities of mutants Y305E, Y305E / G304L, and Y305E / H306F are increased by 7.8 times, 9.6 times, and 10.3 times, respectively. Specifically, the catalytic efficiency of Y305E is 3.2 times higher than that of the wild type, and the catalytic efficiency of Y305E / H306F is 4.2 times higher. When using the deacetylase mutant provided by this invention to synthesize chloroamines, the reaction conditions are mild, environmentally friendly, and the reaction time is short, making it promising for large-scale production of chloroamines and subsequent products.

The invention discloses application of a small molecule compound in preparation of a pyroptosis inhibitor. The chemical name of the small molecule compound is isopropyl-2-(2, 2-dichloroacetamido)-5-(diethylaminoformyl)-4-methylthiophene-3-carboxylic acid diethyl ester, and the short name is C9. According to the invention, the pyroptosis model for highly simulating the in-vivo environment is constructed, and the model can accurately reflect the biological change of the cells in the pyroptosis process. Through multiple rounds of screening and verification, the small molecule compound C9 is excellent in performance in a test and shows excellent pyroptosis inhibition performance. Through an MST experiment, it is clear that good affinity and high specificity exist between the ninth compound and the target protein.

The invention belongs to the technical field of environmental microorganisms, and particularly relates to a metolachlor anaerobic degradation strain SRB-9 and application thereof. According to the present invention, a strain SRB-9 capable of efficiently and anaerobically degrading metolachlor (MET) is separated from anaerobic sediments, and the morphological and molecular biological identification results show that the strain belongs to nitrate desulfurization vibrio, is named as Nitatidesulfurvibrio sp. SRB-9, is preserved in the China Center for Type Culture Collection (CCTCC), and has a preservation number of CCTCC M 20251781. The invention further provides a preparation method of the metolachlor-metolachlor anaerobic degradation strain SRB-9, and the metolachlor-metolachlor anaerobic degradation strain SRB-9 can be used for efficiently and anaerobically degrading metolachlor-metolachlor anaerobic degradation strain SRB-9, the bacterial strain can rapidly degrade MET under anaerobic conditions, and the degradation half-life period of the bacterial strain to MET with the concentration of 100 [mu] M is 9.6 d. And the strain can also be used for rapidly and anaerobically degrading five kinds of chloroacetamide herbicides such as alachlor, acetochlor, propisochlor, pretilachlor and butachlor. The strain disclosed by the invention is beneficial to repairing wastewater or soil polluted by various chloroacetamide herbicides, enriches a resource library of pesticide degrading bacteria, and has a good application prospect.

The invention belongs to the technical field of biology, and particularly relates to a metolachlor and chloroacetamide herbicide degrading bacterium, an enzyme and application. According to the present invention, the degrading bacterium Rhodococcus sp. L-9 capable of efficiently degrading metolachlor and other chloroacetamide herbicides is found through screening, and the degrading bacterium Rhodococcus sp. L-9 can be used for efficiently degrading metolachlor and other chloroacetamide herbicides. Furthermore, according to the invention, a gene cluster metABD for degrading the metolachlor and other chloroacetamide herbicides is cloned from a strain L-9, and the gene cluster metABD can encode three-component cytochrome P450 oxidase MetABD to catalyze the degradation of the metolachlor and other five chloroacetamide herbicides (alachlor, acetochlor, propisochlor, pretilachlor and butachlor); and enantiomer selectivity is achieved in catalysis of chiral herbicide metolachlor, and good social and economic benefits are achieved.

The invention belongs to the technical field of organic chemistry, and particularly discloses a polyamide-based disulfide ester compound as well as a preparation method and application thereof. The structural formula of the polyamide-based disulfide compound is shown in the specification. N is any integer between 2 and 500. The preparation method comprises the following steps: mixing sulfur, a dichloroacetamide compound, organic alkali and an organic solvent, carrying out a first reaction, adding dibromide after the first reaction is finished, and carrying out a second reaction to obtain the polyamide-based disulfide compound. The polymer provided by the invention has high molecular weight, good optical properties and excellent mechanical properties, large-batch preparation of polyamide-based disulfide compounds can be realized, and meanwhile, main chain editing of the polymer can be realized through ammonolysis reaction with diamine, so that the polymonothiooxamide compound with better thermal and mechanical properties can be obtained.

The invention provides a diluent for enhancing colloidal gold color development, a kit containing the diluent and a method for enhancing colloidal gold color development. Wherein the diluent comprises an enhancing reagent and an antigen stabilizing reagent, and the enhancing reagent is selected from one or more than two of 4-dimethylaminoantipyrine, p-acetamidophenol, gentamicin sulfate and 2-chloroacetamide. According to the method, by optimizing the diluent formula and increasing the copper ion deposition process, colloidal gold enhanced color development is achieved, and the sensitivity of the colloidal gold detection card is improved. Meanwhile, the method provided by the invention is relatively simple in use process, only one step of operation is added, the increased reaction time is also relatively short (1-5 minutes), and the operation complexity is not remarkably increased. Reagents used in the method are common chemicals, and special compounds do not need to be synthesized by themselves, so that the detection cost is not obviously increased.

The invention discloses a multifunctional auxiliary agent based on dual grafting, a preparation method and application in a sheet, and relates to the technical field of high polymer material modification.The preparation method of the auxiliary agent comprises the following steps that S1, 4, 4-dicarboxylic acid diphenyl ether is dissolved in N, N-dimethylformamide, and chloroacetamide and triethylamine are added into the solution; s2, glycerol triglycidyl ether and zinc acetylacetonate are added for a reaction; s3, after the reaction, acrylic acid (3, 4-epoxy cyclohexyl) methyl ester is added for continuous reaction, and a grafting auxiliary agent precursor is obtained; s4, uniformly mixing PBAT, an initiator and the grafting auxiliary agent precursor, and performing melt extrusion to obtain PBAT-g-TCOE; and S5, uniformly mixing PBAT-g-TCOE, an initiator and PBS, and carrying out melt extrusion to obtain the multifunctional auxiliary agent. The auxiliary agent provided by the invention is simple in synthesis process, can overcome the problems of low nucleation efficiency and poor compatibility with PLA / PBAT of the existing auxiliary agent, and can significantly improve the compatibility between PLA and PBAT, thereby enhancing the mechanical and thermal properties of the PLA / PBAT composite material.

The invention discloses a series of rutaecarpin derivatives containing pyridine quaternary ammonium salt as well as a preparation method and antibacterial application of the rutaecarpin derivatives. The series of compounds take a natural product rutaecarpin as a parent structure, a pyridine ring is introduced and then connected with a chloroacetamide fragment, so that a series of rutaecarpin derivatives containing pyridine quaternary ammonium salt are prepared, and the structural general formula of the rutaecarpin derivatives containing pyridine quaternary ammonium salt is as shown in formula (1). The series of compounds have relatively strong in vivo and in vitro antibacterial activity on Staphylococcus aureus ATCC 29213 and clinically isolated methicillin-resistant Staphylococcus aureus (Methicillin-Resistance S. aureus, MRSA), and can be used for preparing the antibacterial agent for treating the staphylococcus aureus, the antibacterial agent for treating the staphylococcus aureus, the antibacterial agent for treating the methicillin-resistant Staphylococcus aureus and the antibacterial agent for treating the methicillin-resistant Staphylococcus aureus, the antibacterial agent for treating the staphylococcus aureus, the antibacterial agent for treating the staphylococcus aureus and the antibacterial agent for treating the staphylococcus aureus. Through further structural optimization, the water solubility and antibacterial activity of the compound are enhanced, and the compound has relatively low in-vivo and in-vitro toxicity, safe hemolytic activity and low drug resistance. Therefore, the rutaecarpin derivatives containing the pyridine quaternary ammonium salt have the potential of being further developed into novel antibacterial drugs. # imgabs0 #

The invention belongs to the technical field of fine chemical engineering, and provides a cross-linked color fixing agent, a preparation method and application thereof, and a color fixing method. The preparation method comprises the following steps: carrying out dehydration treatment on hyperbranched polyethyleneimine, and carrying out nucleophilic substitution reaction on the dehydrated hyperbranched polyethyleneimine and N-hydroxymethyl chloroacetamide to obtain N-hydroxymethylated hyperbranched polyethyleneimine; and dissolving the N-hydroxymethylated hyperbranched polyethyleneimine in water, and adjusting the pH value of the system to 5-7 to obtain the cross-linked color fixing agent. According to the preparation method, primary amino on a hyperbranched polyethyleneimine molecular chain is used as a nucleophilic reagent and is subjected to nucleophilic substitution reaction with a carbon-chlorine bond in N-hydroxymethyl chloroacetamide, and nitrogen hydroxymethyl is introduced into the hyperbranched polyethyleneimine molecular chain; nitrogen hydroxymethyl forms a cross-linked network in two modes of self-condensation and etherification reaction with active hydrogen; then, residual amido on a hyperbranched polyethyleneimine molecular chain is converted into ammonium salt through neutralization, so that the electrostatic interaction between the hyperbranched polyethyleneimine molecular chain and anionic dye is improved, and finally, the color fixing effect is improved.

The invention discloses a multifunctional auxiliary agent based on double grafting, a preparation method and application in a sheet material, and relates to the technical field of polymer material modification. The method for preparing the auxiliary agent comprises the following steps: S1: dissolving 4,4-dicarboxylic acid diphenyl ether in N,N-dimethylformamide, and adding chloroacetamide and triethylamine to the solution; S2: adding glycerol triglycidyl ether and zinc acetylacetonate to carry out a reaction; S3: adding (3,4-epoxycyclohexyl) methyl acrylate after the reaction and continuing the reaction to obtain a grafting auxiliary agent precursor; S4: mixing PBAT, an initiator and the grafting auxiliary agent precursor, and then melt-extruding to obtain PBAT-g-TCOE; S5: mixing PBAT-g-TCOE, an initiator and PBS, and then melt-extruding to obtain the multifunctional auxiliary agent. The additive synthesis process of the present invention is simple, can overcome the problems of low nucleation efficiency and poor compatibility with PLA / PBAT of existing additives, and can significantly improve the compatibility between PLA and PBAT, thereby enhancing the mechanical and thermal properties of the PLA / PBAT composite material.

The application provides a preparation method of a 4-(2-aminoethyl)piperazine-2,6-dione derivative. Specifically, the method comprises the following steps: (1) a substitution reaction of a compound of formula e with chloroacetamide in a first solvent in the presence of an acid-binding agent to obtain a compound of formula a; (2) a substitution reaction of the compound of formula a with methyl chloroacetate in a second solvent in the presence of an acid-binding agent to obtain a compound of formula b; (3) ring closure of the compound of formula b under the action of sodium hydroxide to obtain a compound of formula c; and the method can further comprise the following step: (4) deprotection of the compound of formula c in a fourth solvent under the action of an acid reagent to obtain a compound of formula d; wherein PG is an amino protecting group. The method has the advantages of mild conditions, convenient operation, no need of high temperature and high pressure, and is more conducive to the synthesis of piperazine-2,6-dione derivatives with a protecting group; and the method has the advantages of high yield and high efficiency of the target compound.

The invention discloses a preparation method of a functional polycarboxylic acid water reducing agent suitable for underwater non-dispersible concrete, which comprises the following steps: (1) adding tetrabutylammonium bromide into ethylene glycol monovinyl polyethylene glycol ether, uniformly stirring, sequentially adding NaOH powder and 2-chloroacetamide, and heating to react to obtain modified EPEG; (2) uniformly mixing olefine acid, thiohydracrylic acid and water to form a mixed solution I; and then adding the modified EPEG and the modified nano silicon dispersion liquid into water, heating and stirring to form an emulsion. And then dropwise adding the mixed solution I and an initiator solution into the emulsion at the same time, heating and stirring to react, cooling after the reaction is completed, and then adjusting the system to be neutral or acidic to obtain the functional polycarboxylic acid water reducing agent. The problems of rheological contradiction and pumping difficulty caused by the fact that the traditional technology purely depends on improvement of static viscosity are effectively solved.