47 results about "Ofloxacin" patented technology

The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative. The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative thereof, for use in a method for the treatment of conjunctivitis and for the prevention or treatment of inflammation or prevention of infection after cataract surgery in a subject, according to a dosage regimen that improves patient compliance and tolerability and enables the prevention and treatment of intermediate / antibiotic-resistant infections.

According to the method, melamine and urea are used as carbon and nitrogen sources, hollow tubular phosphorus-doped carbon nitride is constructed by adopting a sodium polyphosphate-assisted hydrothermal-thermal polymerization method, molybdenum disulfide is loaded on the surface of P-TCN in a hydrothermal in-situ growth mode, and the hollow tubular phosphorus-doped heterojunction photocatalyst is obtained. The hollow tubular phosphorus-doped heterojunction photocatalyst P-TCN / MoS2 is prepared; the catalyst disclosed by the invention shows excellent degradation performance on ciprofloxacin, levofloxacin, rhodamine B and methylene blue under an illumination condition. The catalyst disclosed by the invention is simple in preparation method, low in cost and easily available in raw materials, and has a wide application prospect in the field of photocatalytic treatment of antibiotic and dye wastewater.

The present application belongs to the technical field of water pollution treatment, and particularly relates to a kind of constructed wetland coupled microbial fuel cell and a kind of water pollution treatment method.The modified iron-carbon material in the present application can reduce the inhibitory effect of antibiotics on device electricity generation, well maintain the activity of electricity-generating bacteria, and maintain stable electricity generation of the system;The modified iron-carbon material in the present application not only has efficient electron transport capacity, strengthens electron transfer, but also has a large number of active adsorption sites, can effectively remove ofloxacin, and is helpful for denitrification;At the same time, the surface area of the modified iron-carbon material is huge, and the surface is loaded with Fe, which can improve the removal capacity of phosphorus.The present application realizes efficient degradation of ofloxacin and conventional pollutants by reasonably constructing a constructed wetland coupled microbial fuel cell, and has higher electricity generation performance.

The invention discloses a Co3O4-Cu2-xS composite photo-thermal catalyst as well as a preparation method and application thereof. The composite photo-thermal catalyst is prepared by taking a surfactant as a bridge and compounding Co3O4 and Cu2-xS. The composite photo-thermal catalyst has a reduced band gap width, can effectively promote migration and separation of photon-generated carriers, enhances the absorption efficiency of visible light-near infrared light, and shows excellent photo-thermal conversion performance. The composite photo-thermal catalyst can be used for constructing a Co3O4-Cu2-xS + PMS + NIR catalytic system, and peroxymonosulfate is activated under the irradiation of near-infrared light so as to degrade antibiotics in water. Experiments prove that the Co3O4-Cu2-xS + PMS + NIR system disclosed by the invention can achieve the degradation rate of 99% on levofloxacin within 20 minutes, and the generation efficiency of active species is remarkably improved through the synergistic effect of a photothermal effect and interface activation. The catalyst has broad-spectrum degradation activity on various antibiotics, keeps efficient and stable catalytic performance in a wide pH range, and shows excellent ion interference resistance and adaptability to various water bodies.

The invention belongs to the technical field of environmental functional material preparation, and discloses a method for preparing a Cu-coated Cu2O-coated C net by an ethanol-assisted combustion method and molecular oxygen activation application of the Cu-coated Cu2O-coated C net. The cleaned copper net is soaked in ethyl alcohol and then calcined, and the Cu-coated Cu2O-coated C net is obtained after repeated soaking and calcination. According to the optimized net, the local O2 enrichment concentration of the net in an aqueous solution is 2.3 times of the oxygen content in a normal aqueous solution, and the degradation rate constant of ofloxacin reaches 0.178 min <-1 >, which exceeds that of traditional photocatalysis and Fenton-like systems. In addition, the net exhibits gt; gt; gt; gt; gt; the degradation efficiency is 95%, and the method has the feasibility of pilot scale (the cost is 0.001 dollar per liter when 144 L of wastewater is treated), and provides a sustainable example for on-site water remediation. The preparation method disclosed by the invention is simple and easy to implement, relatively short in process and suitable for industrial production and use.

The utility model discloses a levofloxacin hydrochloride tablet preparation raw material quick mixing device, including frame, the frame top is provided with removal subassembly, the frame inside is provided with mixing box through removal subassembly, the both sides of mixing box are provided with guide component, and guide component is connected with the frame, the mixing box top is provided with drive assembly, the mixing box is provided with the pivot through drive assembly in the inside, the pivot is rotatably connected with mixing box, the pivot surface fixed mounting has the stirring rod. This kind of stirring and shaking combined mode can make raw materials flow and mix in multiple dimensions, can effectively avoid the situation that raw materials are not mixed sufficiently in local area, significantly improve the uniformity and effect of mixing, apply force to raw materials from different directions, speed up the mutual blending and diffusion between raw materials, can reach the ideal mixing state in shorter time, thereby improve the overall mixing efficiency, save production time.

The application discloses a flagellum inhibiting peptide of pseudomonas aeruginosa and a preparation method and application thereof, and the sequence of the flagellum inhibiting peptide is Lys-Ile-Gly-Leu-Phe-Arg-Trp-Arg. The synthetic inhibiting peptide has a time-dependent self-assembly ability, can gradually evolve from scattered granular into filamentous structure, and finally forms a stable net-like morphology. The synthetic inhibiting peptide can significantly inhibit the flagellum motility of PAO1 and other strains of pseudomonas aeruginosa, and has synergistic antibacterial activity when combined with allicin, ciprofloxacin, meropenem, levofloxacin, polymyxin B and the like. Moreover, the synthetic inhibiting peptide has obvious bacteriostatic and healing-promoting effects on burn wound infection.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

The invention provides a local external medicine composition for treating acne as well as a preparation method and application of the local external medicine composition. The pharmaceutical composition disclosed by the invention is prepared from ozlafloxacin, adapalene, a solubilizer, a surfactant and a solvent, wherein the solubilizer is an alcohol compound and / or an ester compound, the hydrophilic-lipophilic balance value of the surfactant is 20-30, and the pH value of the pharmaceutical composition is 4s < 10 >. According to the pharmaceutical composition disclosed by the invention, the ozlafloxacin and adapalene can be effectively released, and in a stability experiment, the content of the ozlafloxacin and adapalene can be kept stable, obvious degradation does not occur, and the particle size distribution is not obviously changed.

The invention is applicable to the technical field of nano material preparation, and provides a preparation method and application of a Mn < 2 + >-MoS2-Ag surface enhanced Raman spectrum substrate, the method comprises the following steps: synthesizing a Mn < 2 + >-doped MoS2 nano material through a hydrothermal method, and loading Ag nano particles on the surface of the Mn < 2 + >-doped MoS2 nano material by using an ultrasonic-assisted chemical reduction method to obtain the Mn < 2 + >-MoS2-Ag surface enhanced Raman spectrum substrate. The substrate combines a chemical enhancement effect brought by Mn < 2 + > doping and an electromagnetic enhancement effect provided by Ag nanoparticles to form a synergistic enhancement system. When being applied to SERS (Surface Enhanced Raman Scattering) detection of trace ofloxacin in a water environment, the sensor shows excellent sensitivity and specificity, and the detection limit can reach 10 <-11 > M. The method is simple in preparation process and mild in condition, the prepared substrate is good in stability and remarkable in enhancement effect, and an effective tool is provided for rapid and high-sensitivity detection of antibiotic pollutants in the environment.

A method for degrading levofloxacin in wastewater based on a visible light-driven CMP (Chemical Molecular Polymer) photocatalytic system is disclosed. This invention aims to address the problems of most existing photocatalysts being only responsive to ultraviolet light, having limited solar energy utilization efficiency, being highly susceptible to the influence of wastewater turbidity and color, and exhibiting low degradation efficiency for norfloxacin. The method comprises: 1. Synthesizing a conjugated microporous polymer; 2. Performing photocatalytic degradation under visible light irradiation. This invention aims to achieve efficient solar energy utilization by utilizing the excellent photogenerated charge generation and transport efficiency of conjugated microporous polymers for the efficient degradation of levofloxacin. This provides a mild, efficient, and environmentally friendly green method for degrading the novel pollutant levofloxacin, offering a new option for treating complex industrial wastewater.

The invention relates to a pH responsive hydrogel drug delivery system for corneal neovascularization treatment, which is a composite hydrogel LEV-DG-HPMC formed by forming LEV-DG nano-micelles from drugs levofloxacin and dipotassium glycyrrhizinate by a film dispersion method, then heating and self-assembling to form LEV-DG hydrogel, and introducing hydroxypropyl methylcellulose as a tackifier. The drug delivery system disclosed by the invention has unique pH response characteristics, can accurately identify the alkali burn microenvironment and control the release of drugs, and obviously prolongs the cornea residence time. Through the synergistic effect of DG and LEV, the vicious circle of infection-inflammation-neovascularization is effectively blocked. Experiments show that the system can significantly reduce the corneal neovascularization area and accelerate epithelium repair, has good biocompatibility and treatment effect, and provides a new solution for treatment of corneal alkali burn.

This invention discloses a compound ointment for protecting the nasal mucosa and repairing skin damage, and its preparation method, belonging to the field of pharmaceutical technology. The compound ointment is formulated with Sophora japonica fruit extract, erythromycin ointment, vitamin B6, levofloxacin hydrochloride tablets, loratadine tablets, fluticasone propionate nasal spray, sesame oil, and honey in specific weight proportions. The components work synergistically, providing protection for the nasal mucosa, treatment of rhinitis, reduction of cold air and external pollutant intrusion, and prevention of colds. It can also treat hemorrhoids, scars, eczema, and other skin damage, achieving "one medicine for multiple uses." This compound ointment has a stable dosage form, is convenient to use, has high utilization rate, high safety, and no obvious side effects, making it suitable for various populations and possessing good industrialization prospects.

The invention discloses a pharmaceutical composition and a nano preparation, a preparation method and application thereof, and relates to the technical field of biomedicine.The pharmaceutical composition comprises gallium salt and levofloxacin, the molar ratio of the gallium salt to the levofloxacin is 4: 1-300: 1, and the nano preparation comprises a polyphenol compound and the pharmaceutical composition. The gallium salt and the polyphenol compound are coordinated and complexed to form a network structure, and levofloxacin is loaded; the preparation method is a fractional step method or a one-pot synthesis method. The medicine for treating pseudomonas aeruginosa infection, which is prepared from the nano preparation, is delivered to the lung in an atomization administration manner; the invention has the following beneficial effects: the synergistic antibacterial activity is significantly enhanced; the drug stability and bioavailability are improved; and a stable platform is provided for subsequent surface targeted modification.

The invention discloses catalytic sludge biochar for strengthening iron-nitrogen anchoring through spatial constraint as well as a preparation method and application of the catalytic sludge biochar, and belongs to the technical field of organic solid waste recycling. The preparation method comprises the following steps: mixing an iron source, sludge and urea according to a certain mass ratio, adjusting the water content to 7-25%, and extruding, granulating and molding into granules with compact structures in a specific manner; and then pyrolyzing in an inert atmosphere to prepare the catalytic sludge biochar. The preparation method provided by the invention can effectively inhibit the volatilization loss of nitrogen element in the pyrolysis process and promote the reaction of iron and nitrogen, so that a rich FexN active structure is efficiently and directionally generated under the extremely low level that the use amount of urea is only 1-12% of the mass of sludge. The catalytic sludge biochar disclosed by the invention is excellent in performance, and the degradation removal rate of levofloxacin is as high as 98.94%. The method is simple in process and low in cost, and a brand new technical scheme is provided for high-value resource utilization of the sludge and efficient and economic treatment of the antibiotic wastewater difficult to degrade.

The invention provides a temperature-sensitive hydrogel for resisting bacteria and promoting repair and a preparation method thereof, the temperature-sensitive hydrogel comprises PEG-NB, a matrix metalloproteinase degradable peptide cross-linking agent, gelatin, indocyanine green and levofloxacin, and the temperature-sensitive hydrogel is prepared by photo-crosslinking. According to the temperature-sensitive hydrogel provided by the invention, the structure and the performance of the hydrogel are optimized through the synergistic effect of the gelatin and the PEG-NB, and the mechanical strength, the biocompatibility, the degradability and the like of the hydrogel are remarkably improved; meanwhile, the photo-thermal antibacterial function of the photo-thermal agent indocyanine green and the chemical antibacterial function of levofloxacin are integrated, and near-infrared light irradiation is combined, so that the antibacterial and skin repair promoting effects of the hydrogel are synergistically improved.

The invention relates to a nitrogen-sulfur co-doped metal-free carbon material catalyst as well as a preparation method and application thereof. The preparation method comprises the following specific steps: firstly, adding dopamine hydrochloride into an alkali modified ethanol solution, magnetically stirring, dropwise adding acetone, standing and settling, centrifugally collecting a precipitate, and carrying out vacuum drying and freeze drying to obtain PDA; carrying out high-temperature calcination on PDA in an inert atmosphere, cooling, washing, and drying to obtain PDAC; and mixing and stirring the PDAC and a sulfate compound, carrying out vacuum drying, grinding, carrying out secondary high-temperature calcination in an inert atmosphere, cooling, washing, and drying to obtain the novel catalyst (PDACS). The catalyst can efficiently activate peroxymonosulfate (PMS) and selectively degrade ofloxacin (OFX) in water through a non-free radical reaction path, and is low in cost, high in stability, free of metal leaching risk and high in repeated utilization rate.

The invention provides enterococcus faecalis bacteriophage vBEfaS-1017 and application thereof, the enterococcus faecalis bacteriophage vBEfaS-1017 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.46182, and the preservation time is September 6, 2024. The bacteriophage vBEfaS-1017 is high in specificity, short in incubation period and ultrahigh in stability, and has activity under the conditions of extreme pH, high temperature and ultraviolet radiation; by evaluating the in-vitro bactericidal efficacy of the bacteriophage vBEfaS-1017, it is determined that the bacteriophage vBEfaS-1017 can effectively remove a biological membrane formed by host bacteria Ef 10-17, the removal rate is as high as 90%, and the bacteriophage vBEfaS-1017 is expected to become a scavenger for solving the biological membrane. Further experiments prove that the bacteriophage vBEfaS-1017 has in-vivo and in-vitro safety. Through combined use of the bacteriophage and different antibiotics, it is found that combined use of the bacteriophage vBEfaS-1017 and the antibiotic levofloxacin can effectively treat bacteremia of mice, the treatment time after infection can be prolonged by using the bacteriophage in advance, and the bacteriophage has a good application prospect in the aspect of preventing and treating enterococcus faecalis.

The invention discloses a sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst and a preparation method and application thereof.The sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst is a sulfur-doped cobalt cerium composite oxide, and in the sulfur-doped bi-metal cobalt cerium oxide Fenton-like catalyst, the Co element content is 20-24 wt%, the Ce element content is 50-56 wt%, the O element content is 20-22 wt%, and the balance is a carrier. The content of the S element is 1-4 wt%. According to the sulfur-doped bimetallic cobalt cerium oxide Fenton-like catalyst disclosed by the invention, peroxyacetic acid is activated to generate organic oxygen free radicals, and 90.5% of moxifloxacin can be degraded within 15 minutes; and the composite material has a good degradation effect on pollutants of polycyclic aromatic compounds such as ofloxacin, gatifloxacin, norfloxacin, tetracycline, o-nitrophenol, naproxen and the like.

The invention provides a preparation method and application of a near-infrared response carbon dot composite bismuth vanadate / nickel oxide heterojunction photocatalyst. According to the material, levofloxacin is taken as a precursor, nitrogen-fluorine-doped carbon dots with an up-conversion characteristic are synthesized through a hydrothermal method, and the nitrogen-fluorine-doped carbon dots are compounded with a NiO nanosheet and a BiVO4 precursor which are prepared in advance by adopting a one-step hydrothermal strategy. Due to the up-conversion characteristic of the carbon dots, near-infrared light can be converted into visible light, spectral response is widened, and light capture efficiency is improved; meanwhile, the electron transmission capability of the material is cooperated with the built-in electric field of the BiVO4 / NiO p-n heterojunction, a multi-dimensional transmission channel is constructed, and carrier recombination is inhibited, so that the generation efficiency of active oxygen is remarkably improved, and the photocatalytic material with near-infrared light response characteristics, excellent antibiotic degradation performance and high stability is finally obtained.

The invention relates to the technical field of advanced oxidation, and discloses a preparation method and application of a tungsten anchored g-C3N4 photocatalyst. The preparation method of the tungsten-anchored g-C3N4 photocatalyst comprises the following steps: preparing a yellow g-C3N4 block by taking melamine as a raw material, mixing and grinding the g-C3N4 block, NaOH and WCl6 under an infrared lamp, then adding ultrapure water, performing ultrasonic treatment, drying, and calcining in a nitrogen atmosphere to obtain the tungsten-anchored g-C3N4 photocatalyst. The prepared tungsten anchored g-C3N4 photocatalyst shows efficient performance of photoactivated peroxymonosulfate for degrading ofloxacin, meanwhile, the preparation process is safe, simple, convenient and efficient, and the tungsten anchored g-C3N4 photocatalyst has potential environment purification application prospects.

The present invention relates to a storage-stable pharmaceutical composition for ophthalmic administration in the form of an aqueous solution comprising a therapeutically effective amount of antibiotic levofloxacin or a pharmaceutically acceptable salt or derivative thereof, as a first active ingredient, and a therapeutically effective amount of non-steroidal anti-inflammatory and analgesic ketorolac or a pharmaceutically acceptable salt or derivative thereof, as a second active ingredient, wherein said first active ingredient is from about 0.4 to about 0.9% w / v and said second active ingredient is from about 0.4 to about 0.9% w / v, wherein the weight / volume percentages are expressed as g / 100mL units, in order to prevent the precipitation and improve the stability of the product.

A method for preparing organometallic complexes Zn-L based on amidated bisbenzimidazole groups, this invention relates to a method for preparing organometallic complexes Zn-L, using Zn 2+ Using a central ion and amidated bisbenzimidazole as a ligand, a zero-dimensional zinc metal complex (Zn-L) was synthesized via a solvothermal method. The prepared fluorescent probe exhibited excellent selectivity and sensitivity for fluoroquinolone antibiotics, and the hierarchical clustering analysis (HCA) platform enabled accurate identification of structurally similar fungible quantifiers (FQs). Compared to other fluorescent probes for detecting Ofloxacin, it had a similar or lower limit of detection (LOD). The detection limit of this fluorescent probe for Ofloxacin reached LOD = 0.0514 μM, indicating that the Zn-L complex is a fluorescent sensor with excellent application value for the rapid detection of fluoroquinolone drugs.

The invention relates to the field of biomedical materials, and discloses a bionic multilayer dressing for chronic diabetic wounds and a preparation method. The dressing adopts a sequential coaxial electrostatic spinning technology to construct a three-layer composite fiber structure: a long-term response layer (PLGA (85: 15) / EGF / anti-scar medicine), a medium-term response layer (PLGA (50: 50) / bFGF / VEGF) and a quick response layer (PVA / levofloxacin / GM6001), and after glutaraldehyde steam crosslinking and curing, a composite fiber membrane with a stable structure is formed. According to the invention, through the combination of three polymer materials with different degradation characteristics, precise time sequence controlled release of rapid release of antibiotics for resisting infection, promotion of angiogenesis through medium-term release of growth factors and promotion of epithelialization through long-term release of epidermal growth factors is realized, and the natural healing process of wounds is effectively simulated and guided; the technical problems that a traditional dressing is single in function, and drug release and healing stages are not matched are solved, and the healing quality and efficiency of diabetic chronic wounds are remarkably improved.

The invention relates to a ternary organic-inorganic hybrid material for adsorbing antibiotics in a water body and a preparation method, and belongs to the technical field of water treatment. The preparation method comprises the following steps: dissolving a certain amount of chitosan quaternary ammonium salt in water, and uniformly mixing to obtain a solution A; dissolving tannic acid in water, and uniformly mixing to obtain a solution B; dissolving zirconium chloride in water, and uniformly mixing to obtain a solution C; adding the solution A into the solution B, and uniformly mixing; slowly dropwise adding the solution C, quickly stirring and uniformly mixing, and reacting at room temperature; precipitating the reacted sample with ethanol and washing to obtain a gelatinous solid sample; and drying the sample in an electrothermal constant-temperature blast drying box. The material can efficiently adsorb three antibiotics in a water body, including ofloxacin, tetracycline and erythromycin; the preparation process is green and mild, short in period, low in energy consumption and good in chemical stability.

The application relates to the technical field of water treatment, in particular to application of a multiple synergistic photocatalyst in photoelectric synergistic catalytic degradation of levofloxacin and drug-resistant bacteria in water. In water containing levofloxacin and drug-resistant bacteria, the multiple synergistic photocatalyst is added and placed in an activated carbon fiber electrode, and photoelectric synergistic catalytic treatment is carried out under the conditions of natural light irradiation and an applied voltage.

The invention discloses a method for detecting the concentration of eight second-line antituberculous drugs based on HPLC-MS / MS. The eight second-line antituberculous drugs are divided into two groups for detection, one group takes levofloxacin as an internal standard substance, and an internal standard stock solution is prepared; the method comprises the following steps: detecting by taking standard substances of levofloxacin, ciprofloxacin and gatifloxacin as target substances; and in the other group, albendamide, deramanib, pritomanib, clarithromycin and azithromycin are used as target objects for detection. According to the method, the detection time is short, only 5 min is needed, and the detection time is saved; meanwhile, according to the method disclosed by the invention, the consumption of an organic solvent is reduced, so that the pollution to the environment is reduced, and the method has the characteristics of high accuracy and good precision, and provides the fastest and effective basis for clinical treatment.

The invention provides a copper molybdate composite material, a preparation method thereof and a method for photodegrading levofloxacin hydrochloride, and belongs to the technical field of environmental chemical engineering photocatalytic water treatment.The method comprises the steps that biogas residues obtained from a sewage plant are dried and roasted, and biochar is obtained; and mixing Cu (NO3) 23H2O, Na2MoO4, water, ethylene glycol, glycerol and biochar, performing ultrasonic treatment, firing, and drying to obtain the CuMoO4 / BC composite material. The roasting temperature in the step S1 is 500 to 520 DEG C; the firing temperature in the step S2 is 180 to 200 DEG C. According to the copper molybdate-biochar composite material provided by the invention, the high specific surface area and rich functional groups of the biochar can effectively disperse copper molybdate particles, construct an efficient electron transport channel and remarkably inhibit carrier recombination, and meanwhile, the practical application potential of the material is improved due to the characteristics of low cost and easiness in preparation of the biochar, so that the bottleneck of a traditional material is comprehensively broken through; the method is an LVFX degradation technology with environmental friendliness and practical application potential.

The invention discloses a multi-drug resistant pseudomonas aeruginosa PAS57 strain and an application of the multi-drug resistant pseudomonas aeruginosa PAS57 strain. The preservation number of the pseudomonas aeruginosa PAS57 is GDMCC No: 67235. The pseudomonas aeruginosa PAS57 can be used for preparing a bacterial strain. According to the application disclosed by the invention, a KirbyBauer (KB) drug sensitivity experiment shows that the PAS57 is resistant to the levofloxacin, the ciprofloxacin, the meropenem, the imipenem and the tobramycin. The strain disclosed by the invention can be used for screening a novel antibacterial drug which is effective to the multi-drug-resistant pseudomonas aeruginosa, and a new way is provided for development of drugs for treating diseases caused by the pseudomonas aeruginosa.

The invention discloses a sulfur-containing cobalt monatomic loaded photo-self-Fenton catalyst as well as a preparation method and application thereof, and relates to the technical field of advanced oxidation treatment. The preparation method of the photo-self-Fenton catalyst comprises the following steps: calcining dicyandiamide in a heating device, naturally cooling to obtain a product, and grinding the product to obtain BCN; the preparation method comprises the following steps: mixing and grinding BCN, thiourea and cobalt acetylacetonate to obtain mixed powder, putting the mixed powder into a heating device for heating reaction, and then naturally cooling to obtain a product; and stirring and mixing the obtained product with an acid solution to form a mixed solution, then standing to obtain a layered mixed solution, removing a supernatant, centrifuging the residual substance, and washing and drying the solid substance obtained by centrifuging to obtain the sulfur-containing cobalt monatomic loaded photo-self-Fenton catalyst. The photo-auto-Fenton catalyst prepared by the invention shows efficient photo-auto-Fenton degradation performance on ofloxacin under the condition of visible light, meanwhile, the preparation process is safe, simple, convenient and efficient, and the photo-auto-Fenton catalyst has potential environment purification application prospects.