126 results about "Ofloxacin" patented technology

The invention discloses a surface defect and oxygen doping co-modified pore-rich g-C3N4 nano material as well as preparation and application thereof. The preparation method comprises the following steps: mixing a white viscous melamine-cyanuric acid suspension with an oxalic acid solution to obtain a melamine-cyanuric acid-oxalic acid suspension solution, carrying out hydrothermal treatment to obtain a hydrogen bond connected self-assembled supramolecular aggregate, and finally carrying out thermal polycondensation on the self-assembled supramolecular aggregate and formaldehyde to obtain the surface defect and oxygen doping co-modified porous g-C3N4. The surface defect and oxygen doping co-modified g-C3N4 nano material with different morphologies and physicochemical properties is obtained. The preparation method is simple in process flow, efficient, low in cost and suitable for large-scale production, and the synthesis process meets the green chemical requirement; the obtained nano material has a higher specific surface area and more active sites, and has higher catalytic reaction and adsorption performance on organic pollutants, namely levofloxacin, ciprofloxacin and tetracycline hydrochloride, in a water body.

The invention relates to a method for detecting six second-line antituberculous drugs by high performance liquid chromatography. The method comprises the following steps: providing an internal standard stock solution and a standard stock solution of six second-line antituberculosis drugs; preparing an internal standard working solution and a standard curve working solution by utilizing the diluent; preparing a solution of a product to be detected by using the Tianlongitudinal sample extraction liquid TZ-002; a liquid chromatograph is used for detection, and the conditions are as follows: a mobile phase A is a Tianlongitudinal sample releasing agent TZ-D004; a mobile phase B is acetonitrile; a mobile phase C is water; and gradient elution. According to the method, the plasma concentration of the second-line antituberculous drug taken by a tuberculosis patient is measured by applying the reversed-phase high-performance liquid chromatography, the cost is relatively low, the analysis time is short, the sensitivity is high, and the accuracy is high. The kit can be used for simultaneously detecting the blood concentration of six second-line antituberculosis drugs such as isopropylthioamide, levofloxacin, linezolid, moxifloxacin, deramanib and bedaquiline in human serum, and is expected to provide a more reliable basis for clinicians to adjust the dosage of the antituberculosis drugs.

The invention relates to the technical field of animal disease models, and discloses a construction method of an intraocular hypertension animal model, comprising the following steps: step A, selecting an experimental animal; step B, preparing experimental instruments and reagents; c, in an anesthesia mode, deep anesthesia is carried out on the animal, and subsequent deep anesthesia is carried out; d, intraocular pressure measurement, wherein the basic intraocular pressure value is measured through anterior chamber injection. Step E, performing anterior chamber injection, and using ofloxacin antibiotic oculentum to prevent infection after an operation; and F, intraocular pressure measurement: measuring the change of the intraocular pressure value after the anterior chamber injection. According to the method, the natural pathological process of open-angle glaucoma is simulated by injecting IFN-beta into the anterior chamber, the situation that acute intraocular pressure rise is caused mainly by blocking an aqueous humor flow outlet channel like other models is avoided, and the method can better reflect the real situation of glaucoma diseases; in addition, the model avoids intraocular pressure change caused by anatomical structure change, so that the accuracy and reliability of the model are improved.

This invention belongs to the field of environmental chemical catalytic water treatment technology and discloses a method for preparing a Cu2O / black phosphorus catalyst for removing antibiotics from water. Using Cu2O and black phosphorus (BP) as precursor reactants, a series of Cu2O / BP composite photocatalysts were prepared. The BP catalyst was prepared by a simple hydrothermal method. Then, Cu(NO3)2·3H2O and BP were calcined in varying proportions to form the composite Cu2O / BP photocatalysts. Analysis revealed that the Cu2O was loaded onto the BP layer, forming a composite structure. The prepared catalysts were used to degrade levofloxacin hydrochloride under visible light, and the catalytic activity of the composite photocatalysts was evaluated. Results showed that among the photocatalysts with varying Cu2O / BP loadings, 3% and 4% Cu2O / BP exhibited the best photocatalytic degradation performance, achieving a degradation rate of 89% in 3 hours, 2.83 times that of pure BP. This demonstrates the successful preparation of highly efficient composite catalysts.

The invention discloses a blue fluorescent carbon dot as well as a preparation method and application thereof, and belongs to the technical field of drug monitoring. The carbon dot is a boron-nitrogen co-doped carbon dot, a carbon source is citric acid, a nitrogen source is p-phenylenediamine, and a dopant is boric acid; wherein the mass ratio of the citric acid to the boric acid to the p-phenylenediamine is (10-13): (12-15): (11-14). The preparation method comprises the following steps: mixing citric acid, boric acid and p-phenylenediamine, adding ethanol, carrying out ultrasonic treatment, heating at 150-200 DEG C for 20-60 minutes, cooling to room temperature, and purifying and drying supernate to obtain the blue fluorescent carbon dots. The blue fluorescent carbon dot provided by the invention is simple in preparation method, easily available in raw materials and suitable for industrial production, and the prepared fluorescent carbon dot can be used for drug monitoring of vancomycin and is also suitable for detecting ofloxacin and / or levofloxacin in food.

The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative. The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative thereof, for use in a method for the treatment of conjunctivitis and for the prevention or treatment of inflammation or prevention of infection after cataract surgery in a subject, according to a dosage regimen that improves patient compliance and tolerability and enables the prevention and treatment of intermediate / antibiotic-resistant infections.

According to the method, melamine and urea are used as carbon and nitrogen sources, hollow tubular phosphorus-doped carbon nitride is constructed by adopting a sodium polyphosphate-assisted hydrothermal-thermal polymerization method, molybdenum disulfide is loaded on the surface of P-TCN in a hydrothermal in-situ growth mode, and the hollow tubular phosphorus-doped heterojunction photocatalyst is obtained. The hollow tubular phosphorus-doped heterojunction photocatalyst P-TCN / MoS2 is prepared; the catalyst disclosed by the invention shows excellent degradation performance on ciprofloxacin, levofloxacin, rhodamine B and methylene blue under an illumination condition. The catalyst disclosed by the invention is simple in preparation method, low in cost and easily available in raw materials, and has a wide application prospect in the field of photocatalytic treatment of antibiotic and dye wastewater.

The invention belongs to the technical field of acoustic catalysis composite materials, and particularly relates to a molybdenum disulfide / zirconium dioxide composite acoustic catalyst and a preparation method and application thereof. According to the preparation method disclosed by the invention, through a two-step method, zirconium dioxide is firstly prepared, and then MoS2 / ZrO2 is synthesized through a solvothermal synthesis method. According to the method, the influence on the ofloxacin degradation effect is researched from factors such as different compound proportions and addition amounts of MoS2 / ZrO2, the initial concentration and pH value of an ofloxacin solution, ultrasonic time and the like, the feasibility of the technology is comprehensively verified, and the degradation rate of the finally synthesized MoS2 / ZrO2 catalyst on ofloxacin under the ultrasonic condition can reach 80% or above.

The present application belongs to the technical field of water pollution treatment, and particularly relates to a kind of constructed wetland coupled microbial fuel cell and a kind of water pollution treatment method.The modified iron-carbon material in the present application can reduce the inhibitory effect of antibiotics on device electricity generation, well maintain the activity of electricity-generating bacteria, and maintain stable electricity generation of the system;The modified iron-carbon material in the present application not only has efficient electron transport capacity, strengthens electron transfer, but also has a large number of active adsorption sites, can effectively remove ofloxacin, and is helpful for denitrification;At the same time, the surface area of the modified iron-carbon material is huge, and the surface is loaded with Fe, which can improve the removal capacity of phosphorus.The present application realizes efficient degradation of ofloxacin and conventional pollutants by reasonably constructing a constructed wetland coupled microbial fuel cell, and has higher electricity generation performance.

The invention discloses a Co3O4-Cu2-xS composite photo-thermal catalyst as well as a preparation method and application thereof. The composite photo-thermal catalyst is prepared by taking a surfactant as a bridge and compounding Co3O4 and Cu2-xS. The composite photo-thermal catalyst has a reduced band gap width, can effectively promote migration and separation of photon-generated carriers, enhances the absorption efficiency of visible light-near infrared light, and shows excellent photo-thermal conversion performance. The composite photo-thermal catalyst can be used for constructing a Co3O4-Cu2-xS + PMS + NIR catalytic system, and peroxymonosulfate is activated under the irradiation of near-infrared light so as to degrade antibiotics in water. Experiments prove that the Co3O4-Cu2-xS + PMS + NIR system disclosed by the invention can achieve the degradation rate of 99% on levofloxacin within 20 minutes, and the generation efficiency of active species is remarkably improved through the synergistic effect of a photothermal effect and interface activation. The catalyst has broad-spectrum degradation activity on various antibiotics, keeps efficient and stable catalytic performance in a wide pH range, and shows excellent ion interference resistance and adaptability to various water bodies.

The present invention provides an isopsoralen chalcone-curcumin derivative, its preparation method and application, and an antibacterial pharmaceutical preparation, belonging to the field of pharmaceutical chemistry technology. The isopsoralen chalcone-curcumin derivative of the present invention is based on the isopsoralen chalcone and curcumin structural framework. In vitro antibacterial experiments have shown that it has excellent broad-spectrum antibacterial activity, especially against drug-resistant Staphylococcus aureus (MRSA), with antibacterial activity that is more than 1,000 times that of the positive drug ofloxacin. At the same time, the isopsoralen chalcone-curcumin derivative has high biosafety.

The invention belongs to the technical field of environmental functional material preparation, and discloses a method for preparing a Cu-coated Cu2O-coated C net by an ethanol-assisted combustion method and molecular oxygen activation application of the Cu-coated Cu2O-coated C net. The cleaned copper net is soaked in ethyl alcohol and then calcined, and the Cu-coated Cu2O-coated C net is obtained after repeated soaking and calcination. According to the optimized net, the local O2 enrichment concentration of the net in an aqueous solution is 2.3 times of the oxygen content in a normal aqueous solution, and the degradation rate constant of ofloxacin reaches 0.178 min <-1 >, which exceeds that of traditional photocatalysis and Fenton-like systems. In addition, the net exhibits gt; gt; gt; gt; gt; the degradation efficiency is 95%, and the method has the feasibility of pilot scale (the cost is 0.001 dollar per liter when 144 L of wastewater is treated), and provides a sustainable example for on-site water remediation. The preparation method disclosed by the invention is simple and easy to implement, relatively short in process and suitable for industrial production and use.

The utility model discloses a levofloxacin hydrochloride tablet preparation raw material quick mixing device, including frame, the frame top is provided with removal subassembly, the frame inside is provided with mixing box through removal subassembly, the both sides of mixing box are provided with guide component, and guide component is connected with the frame, the mixing box top is provided with drive assembly, the mixing box is provided with the pivot through drive assembly in the inside, the pivot is rotatably connected with mixing box, the pivot surface fixed mounting has the stirring rod. This kind of stirring and shaking combined mode can make raw materials flow and mix in multiple dimensions, can effectively avoid the situation that raw materials are not mixed sufficiently in local area, significantly improve the uniformity and effect of mixing, apply force to raw materials from different directions, speed up the mutual blending and diffusion between raw materials, can reach the ideal mixing state in shorter time, thereby improve the overall mixing efficiency, save production time.

The invention belongs to the technical field of adsorption materials, and discloses a hydrothermal carbon loaded cuprous oxide adsorbent as well as a preparation method and application thereof. The preparation method of the hydrothermal carbon loaded cuprous oxide adsorbent comprises the following steps: (1) mixing corn straw powder with a solvent, and carrying out hydrothermal reaction to prepare hydrothermal carbon; and (2) mixing the hydrothermal carbon, copper chloride, sodium dodecyl benzene sulfonate and alkali liquor, and carrying out heating reaction to prepare the hydrothermal carbon loaded cuprous oxide adsorbent. The adsorption mechanism of the hydrothermal carbon loaded cuprous oxide adsorbent is that efficient adsorption of fluoroquinolone antibiotic levofloxacin or tetracyclines is realized through electrostatic interaction, pi-pi accumulation, hydrogen bonds, pore filling and hydrophobic interaction.

The present invention provides a raspberry-shaped iron-cobalt nanooxide material, its preparation method, and application, belonging to the technical field of nanomaterial preparation. The present invention uses iron salt, cobalt salt, urea, and sodium lauryl sulfate as raw materials, and uses a hydrothermal method to prepare a cobalt-iron nanooxide precursor. The precursor is then calcined at high temperature in a tubular furnace to obtain the raspberry-shaped iron-cobalt nanooxide material. The present invention has the advantages of a simple synthesis method and low production cost. The resulting raspberry-shaped iron-cobalt nanooxide material is applied to an enzyme-free antibiotic fluorescence sensor, which has the advantages of high sensitivity, rapid detection, certain selectivity, and good stability, and is suitable for detecting ciprofloxacin and ofloxacin.

The application discloses a flagellum inhibiting peptide of pseudomonas aeruginosa and a preparation method and application thereof, and the sequence of the flagellum inhibiting peptide is Lys-Ile-Gly-Leu-Phe-Arg-Trp-Arg. The synthetic inhibiting peptide has a time-dependent self-assembly ability, can gradually evolve from scattered granular into filamentous structure, and finally forms a stable net-like morphology. The synthetic inhibiting peptide can significantly inhibit the flagellum motility of PAO1 and other strains of pseudomonas aeruginosa, and has synergistic antibacterial activity when combined with allicin, ciprofloxacin, meropenem, levofloxacin, polymyxin B and the like. Moreover, the synthetic inhibiting peptide has obvious bacteriostatic and healing-promoting effects on burn wound infection.

The invention discloses a GSH (glutathione) response type nano-drug carrier as well as a preparation method and application thereof, the nano-drug carrier is a levofloxacin loaded BSA (bovine serum albumin) and PAMAM (polyamidoamine) compound, and is obtained by coupling BSA to a levofloxacin loaded PAMAM nano-drug by a disulfide bond-containing compound; the invention further discloses application of the levofloxacin loaded BSA and PAMAM compound in an antibiotic controlled release drug delivery system. According to the present invention, the drug can be effectively sealed, the non-specific release of the drug under the normal physiological condition can be prevented, the controllable release of the drug can be initiated in the presence of the GSH, the on-demand drug delivery can be achieved, and the drug delivery scheme can be optimized;

The invention discloses a medical dressing capable of absorbing moisture and releasing sweat and a preparation method of the medical dressing, and relates to the technical field of medical dressings, the medical dressing comprises a polyurethane copolyester nanofiber membrane, and the preparation method of the polyurethane copolyester nanofiber membrane comprises the following steps: pouring non-isocyanate polyurethane copolyester, levofloxacin and polyacrylonitrile into hexafluoroisopropanol, and stirring uniformly; carrying out electrostatic spinning; and spin-coating a chitosan-gelatin-glycerol mixed solution, and spin-coating a spermidine cross-linking agent to obtain the polyurethane copolyester nanofiber membrane. By introducing the polyglycolic acid-based non-isocyanate polyurethane copolyester and the levofloxacin, the levofloxacin is uniformly dispersed and embedded into a fiber network, so that uniform dispersion and controllable release of an antibacterial drug are realized, growth and reproduction of bacteria at a wound are effectively inhibited, and the problems of wound infection and slow healing are solved; the healing speed is increased; and the complication risk is reduced.

The invention belongs to the technical field of coordination polymers, and particularly relates to a zinc coordination polymer as well as a preparation method and application thereof in fluoroquinolone antibiotic detection. The structural formula of the zinc coordination polymer is [Zn (mu3-L ') (H2O)] n, wherein L' 2-is generated by hydrolyzing 5-((4 '-cyanobenzyl) oxygen) isophthalic acid (H2L) in the reaction process. The zinc coordination polymer is prepared by the following steps: adding Zn (NO3) 2.6 H2O and 5-((4 '-cyanobenzyl) oxygen) isophthalic acid into a mixed solvent containing acetonitrile and water, and carrying out solvothermal reaction. The zinc coordination polymer has a one-dimensional structure, has good fluorescence selectivity detection performance on fluoroquinolone antibiotics in an aqueous solution, such as ofloxacin, levofloxacin and norfloxacin, and can be used as a fluorescence sensor for efficiently detecting the fluoroquinolone antibiotics.

The present invention discloses a visible light responsive photocatalyst capable of activating persulfate, and its preparation and application. The photocatalyst is added to a high-salt wastewater system containing antibiotic pollutants. After adsorption equilibrium is achieved in the dark under a water bath at 20-35°C, persulfate is added, and the antibiotic pollutants in the high-salt wastewater system are synergistically removed under visible light illumination. The photocatalyst is an Ag-doped asymmetric mesoporous TiO2 catalyst. The present invention deposits Ag inside the novel spirally stacked asymmetric TiO2 pores to obtain a composite catalyst with visible light response, and due to the Ti in the composite catalyst, the 3+ / Ti 4+ There is a coupling system that can effectively activate persulfate and utilize photocatalysis and persulfate activation to form abundant active groups such as photogenerated holes, sulfate radicals and hydroxyl radicals, which effectively improves the removal effect of the catalyst on ofloxacin antibiotics in the wastewater system.

The invention provides a macrolide compound and a preparation method and application of an intermediate compound of the macrolide compound, and belongs to the field of organic synthesis. The macrolide compound provided by the invention has the following chemical structure. The macrolide compound prepared by the invention is a compound with a 19-membered lactone ring structure, has a [5, 6]-tetrahydroindene ring structural unit and a (Z, E, Z) conjugated triene unit, and has a chemical structure completely different from that of MRSA drug-resistant bacterium antibiotics clinically used at present, such as polypeptide drugs (vancomycin and the like) and quinolone drugs (ofloxacin and the like), and the MRSA drug-resistant bacterium antibiotics can be used in clinical application. The macrolide is proved to have new drug-resistant bacterium resisting action targets and mechanisms. The macrolide compound provided by the invention has strong anti-MRSA activity, the minimum inhibitory concentration (MIC) is 1-2mg / mL and is equivalent to the anti-MRSA activity of vancomycin, and based on the strong anti-drug-resistant bacterium activity, the macrolide provided by the invention can be developed into a novel anti-drug-resistant bacterium drug. # imgabs0 #

Naphthoquinone derivatives of Lawsone have been found to be effective against Staphylococcus aureus and methicillin resistant Staphylococcus aureus (MRSA). Such compounds generally contain a substituent group at the 3-position of a specific naphthoquinone compound, i.e. 2-hydroxy-1,4-naphthoquinone. One of these derivatives referred to as compound 6c in the series exhibits potent antimicrobial activity that is comparable to that of the two commercial antibiotics ofloxacin and ciprofloxacin against the two strains of methicillin sensitive Staphylococcus aureus (MSSA; ATCC 29213 and ATCC 6538). In the case of two strains of MRSA (ATCC BAA-44 and ATCC BAA-1717) that have developed drug resistance to both ofloxacin and ciprofloxacin, the antimicrobial activity of 6c can almost rival that of vancomycin and daptomycin. Furthermore, 6c is also effective against vancomycin-intermediate and daptomycin non-susceptible strain of MRSA (ATCC 700699). Besides the efficacy, 6c has a much improved drug resistance profile in comparison with the conventional antibiotics.

The invention relates to a fumaric acid metal organic framework for treating eye germ infection and application of the fumaric acid metal organic framework in treating eye germ infection. The fumaric acid metal organic framework is Zr / Fe-coated FA MOFs, metal coordination ions are Zr (IV) and Fe (III), and a ligand is fumaric acid. The Zr / Fe-coated FA MOFs has excellent anti-biofilm activity, and the effect of the Zr / Fe-coated FA MOFs can be greatly improved when the Zr / Fe-coated FA MOFs is combined with levofloxacin; besides, the invention further provides a packaged microneedle system Zr / Fe-FA MNs, MOFs can be directly delivered to a bacterial microcolony focus area in a 3D limited microenvironment through the precise penetrating capacity of a microneedle, and the effectiveness of the medicine in biological membrane eradication is remarkably enhanced. Zr / Fe-coated FA MNs not only can overcome the limitation of traditional eye drops in the aspect of cornea permeability, but also can realize long-acting treatment through the sustained release characteristic of MOFs and the sustained release characteristic of microneedles.

The present invention relates to a fumarate metal-organic framework for treating ocular bacterial infections, and also relates to its use in treating ocular bacterial infections. The fumarate metal-organic framework is Zr / Fe@FA MOFs, the metal coordination ions are Zr(IV) and Fe(III), and the ligand is fumaric acid. The Zr / Fe@FA MOFs have excellent anti-biofilm activity, and their effect can be greatly improved when used in combination with levofloxacin. In addition, the present invention also provides an encapsulated microneedle system, Zr / Fe@FA MNs, which can deliver MOFs directly to bacterial microcolony lesion areas in 3D confined microenvironments through the precise penetration ability of microneedles, significantly enhancing the effectiveness of drugs in biofilm eradication. Zr / Fe@FA MNs can not only overcome the limitations of traditional eye drops in corneal permeability, but also achieve long-term treatment through the sustained release of MOFs and the slow-release properties of microneedles.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

The invention provides a local external medicine composition for treating acne as well as a preparation method and application of the local external medicine composition. The pharmaceutical composition disclosed by the invention is prepared from ozlafloxacin, adapalene, a solubilizer, a surfactant and a solvent, wherein the solubilizer is an alcohol compound and / or an ester compound, the hydrophilic-lipophilic balance value of the surfactant is 20-30, and the pH value of the pharmaceutical composition is 4s < 10 >. According to the pharmaceutical composition disclosed by the invention, the ozlafloxacin and adapalene can be effectively released, and in a stability experiment, the content of the ozlafloxacin and adapalene can be kept stable, obvious degradation does not occur, and the particle size distribution is not obviously changed.

The invention is applicable to the technical field of nano material preparation, and provides a preparation method and application of a Mn < 2 + >-MoS2-Ag surface enhanced Raman spectrum substrate, the method comprises the following steps: synthesizing a Mn < 2 + >-doped MoS2 nano material through a hydrothermal method, and loading Ag nano particles on the surface of the Mn < 2 + >-doped MoS2 nano material by using an ultrasonic-assisted chemical reduction method to obtain the Mn < 2 + >-MoS2-Ag surface enhanced Raman spectrum substrate. The substrate combines a chemical enhancement effect brought by Mn < 2 + > doping and an electromagnetic enhancement effect provided by Ag nanoparticles to form a synergistic enhancement system. When being applied to SERS (Surface Enhanced Raman Scattering) detection of trace ofloxacin in a water environment, the sensor shows excellent sensitivity and specificity, and the detection limit can reach 10 <-11 > M. The method is simple in preparation process and mild in condition, the prepared substrate is good in stability and remarkable in enhancement effect, and an effective tool is provided for rapid and high-sensitivity detection of antibiotic pollutants in the environment.

A method for degrading levofloxacin in wastewater based on a visible light-driven CMP (Chemical Molecular Polymer) photocatalytic system is disclosed. This invention aims to address the problems of most existing photocatalysts being only responsive to ultraviolet light, having limited solar energy utilization efficiency, being highly susceptible to the influence of wastewater turbidity and color, and exhibiting low degradation efficiency for norfloxacin. The method comprises: 1. Synthesizing a conjugated microporous polymer; 2. Performing photocatalytic degradation under visible light irradiation. This invention aims to achieve efficient solar energy utilization by utilizing the excellent photogenerated charge generation and transport efficiency of conjugated microporous polymers for the efficient degradation of levofloxacin. This provides a mild, efficient, and environmentally friendly green method for degrading the novel pollutant levofloxacin, offering a new option for treating complex industrial wastewater.

The invention relates to a pH responsive hydrogel drug delivery system for corneal neovascularization treatment, which is a composite hydrogel LEV-DG-HPMC formed by forming LEV-DG nano-micelles from drugs levofloxacin and dipotassium glycyrrhizinate by a film dispersion method, then heating and self-assembling to form LEV-DG hydrogel, and introducing hydroxypropyl methylcellulose as a tackifier. The drug delivery system disclosed by the invention has unique pH response characteristics, can accurately identify the alkali burn microenvironment and control the release of drugs, and obviously prolongs the cornea residence time. Through the synergistic effect of DG and LEV, the vicious circle of infection-inflammation-neovascularization is effectively blocked. Experiments show that the system can significantly reduce the corneal neovascularization area and accelerate epithelium repair, has good biocompatibility and treatment effect, and provides a new solution for treatment of corneal alkali burn.

The invention discloses a CoMoO4 / BiVO4 nano material, a preparation method and application, CoMoO4 and BiVO4 are used as raw materials, CoMoO4 and BiVO4 are mixed according to a certain mass, and the CoMoO4 / BiVO4 nano material is successfully prepared through a hydrothermal reaction and calcination treatment. When the CoMoO4 / BiVO4 nano material is used as a photocatalyst for degrading levofloxacin hydrochloride in antibiotic wastewater, the CoMoO4 / BiVO4 nano material shows excellent visible light absorption performance and photocatalytic oxidation activity, so that the CoMoO4 / BiVO4 nano material can be used for photocatalytic degradation of levofloxacin hydrochloride pollutants. In addition, the preparation method has the characteristics of simple process, easy operation, easily available raw materials and the like, and is suitable for industrial production and popularization.