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Medicine-carrying system of vitamin E-modified silicon-base hydrogel contact lens and preparation method of medicine-carrying system

A contact lens and silicon hydrogel technology, which is applied in the direction of medical formula, glasses/goggles, medical preparations with non-active ingredients, etc., can solve the problem of ofloxa in vitamin E modified silicon-based hydrogel contact lenses. Star loading research or reports and other issues, to achieve the effect of alleviating dry eye syndrome, good biocompatibility, and prolonging the sustained release time

Active Publication Date: 2017-10-20
南京美材科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no research or report on the use of vitamin E modified silicon-based hydrogel contact lenses for loading of ofloxacin

Method used

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  • Medicine-carrying system of vitamin E-modified silicon-base hydrogel contact lens and preparation method of medicine-carrying system
  • Medicine-carrying system of vitamin E-modified silicon-base hydrogel contact lens and preparation method of medicine-carrying system
  • Medicine-carrying system of vitamin E-modified silicon-base hydrogel contact lens and preparation method of medicine-carrying system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Step 1: Synthesizing a silicone prepolymer with a methacrylate end group, and curing it by a one-time compression molding method to obtain a silicon-based hydrogel.

[0064] Add GMA and KF8010 with a substance ratio of 1:1 into a 100ml flask and stir to mix evenly. 2 A drying tube was inserted on the flask to isolate moisture, and the prepolymer GKF8010 was obtained by stirring and reacting at 70°C for 5 hours. GKF8010, TRIS, Darocur1173 and 40% DMA were weighed and mixed in a 10ml beaker at a mass ratio of 28:28:6:38, and nitrogen gas was continuously injected into the beaker, and electric stirring was performed at room temperature for 9 hours. Drop the reacted mixture into the mold, press it tightly, irradiate with ultraviolet light for 5 minutes, soak the mold in distilled water overnight, and demould.

[0065] Step 2: Modification of silicon-based hydrogel contact lenses with vitamin E.

[0066] Take a piece of the prepared silicon hydrogel contact lens, soak it i...

Embodiment 2

[0070] Step 1: Synthesizing a silicone prepolymer with a methacrylate end group, and curing it by a one-time compression molding method to obtain a silicon-based hydrogel.

[0071] Add GMA and KF8010 with a substance ratio of 2:1 into a 100ml flask, stir and mix evenly, and fill with CaCl 2 A drying tube was inserted on the flask to isolate moisture, and the prepolymer GKF8010 was obtained by stirring and reacting at 80°C for 6 hours. Weigh GKF8010, TRIS, Darocur1173, and 40% DMA in a mass ratio of 28:29:5:38 and mix them uniformly in a 10ml beaker, continuously inject nitrogen gas into the beaker, and stir electrically at room temperature for 10 hours. Drop the reacted mixture into the mold, press it tightly, irradiate with ultraviolet light for 10 minutes, soak the mold in distilled water overnight, and demould.

[0072] Step 2: Modification of silicon-based hydrogel contact lenses with vitamin E.

[0073] Take a piece of the prepared silicon hydrogel contact lens, soak it...

Embodiment 3

[0077] Step 1: Synthesizing a silicone prepolymer with a methacrylate end group, and curing it by a one-time compression molding method to obtain a silicon-based hydrogel.

[0078] Add GMA and KF8010 with a substance ratio of 3:1 into a 100ml flask, stir and mix evenly, and fill with CaCl 2 A drying tube was inserted on the flask to isolate moisture, and the prepolymer GKF8010 was obtained by stirring and reacting at 90°C for 7 hours. GKF8010, TRIS, Darocur1173 and 40% DMA were weighed and mixed in a 10ml beaker according to the mass ratio of 29:29:4:38, and nitrogen gas was continuously injected into the beaker, and electric stirring was performed at room temperature for 11 hours. Drop the reacted mixture into the mold, press it tightly, irradiate with ultraviolet light for 15 minutes, soak the mold in distilled water overnight, and demould.

[0079] Step 2: Modification of silicon-based hydrogel contact lenses with vitamin E.

[0080] Take a piece of the prepared silicon h...

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Abstract

The invention discloses a medicine-carrying system of a vitamin E-modified silicon-base hydrogel contact lens as well as a preparation method and application of the medicine-carrying system. The preparation method comprises the following steps: (1) synthesizing an organosilicone prepolymer of a methacrylate terminal group through hydroxyl modification of the methacrylate terminal group, mixing reaction monomers, putting a mixture into a mold, and carrying out curing by virtue of a one-time mold pressing method, so as to obtain a silicon-base hydrogel contact lens; (2) soaking the prepared silicon-base hydrogel contact lens into a mixed solution of vitamin E and ethanol for modification, so as to obtain a vitamin E-modified silicon-base hydrogel contact lens; and (3) loading ofloxacin of different concentrations with the silicon-base hydrogel contact lens before being modified by vitamin E and the vitamin E-modified silicon-base hydrogel contact lens. The prepared medicine-carrying system of the vitamin E-modified silicon-base hydrogel contact lens is good in biocompatibility, high in light transmittance and relatively good in mechanical property and is capable of prolonging the drug release time.

Description

technical field [0001] The invention relates to the fields of hydrogel and biomedicine, in particular to a drug-loading system of a vitamin E-modified silicon-based hydrogel contact lens and a preparation method thereof. Background technique [0002] With the extensive use of electronic products in today's society, more and more people suffer from eye diseases. Contact lenses (also known as contact lenses) are widely used in vision correction and eye disease treatment. Contact lens is a medical device worn on the cornea to treat eye diseases and correct vision. It relieves fatigue, protects the cornea, and promotes treatment. According to the nature of the material, contact lenses can be divided into hard contact lenses and soft contact lenses. [0003] Since entering the 21st century, my country's contact lens market demand has grown rapidly. In order to meet the requirements of daily and clinical medicine for silicone hydrogel contact lenses, it is necessary to design id...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K47/22A61K31/5383A61P27/02G02C7/04
CPCA61K9/0002A61K9/0051A61K31/5383A61K47/22A61K47/34G02C7/049
Inventor 张小娟郝凌云蔡文斌魏显霁周智鹏张志颖张思源赵雪
Owner 南京美材科技有限公司
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