245results about How to "Long release time" patented technology

The present invention relates to pharmaceutical compositions for the sustained release of pharmacologically active compounds and methods of their manufacture and use. Sustained release times of 10-12 days have been achieved with the present invention. The present invention provides microcrystal compositions. The microcrystals comprise pharmacologically active compounds and are contained within a phospholipid layer which contains a unique combination of phospholipids. The present invention may be applied to a wide range of pharmaceutical compositions which may be rendered suitable for injection. The microcrystals are of varying sizes. At least 50 percent of the microcrystals are from 0.5 mum to about 3.0 mum in diameter, at least ten percent of the microcrystals are from about 3.0 mum to about 10 mum in diameter, and the composition contains microcrystals which are greater than 10 mum in diameter. In preferred embodiments, at least about 1% of the microcrystals are greater than 10 mum in diameter. The compositions and methods are useful for treating respiratory diseases, infections, inflammation, and pain in a variety of mammals. The compounds and methods are also able to sharply reduce the toxicity of drug compounds.

A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed herein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

A MEMS microphone structure, comprising a semiconductor substrate having a cavity, a first dielectric layer having a through-hole communicating with the cavity, a lower diaphragm electrode formed above the through-hole and at least partially attached to the upper surface of the first dielectric layer, and an upper electrode structure with an insulating layer. The upper electrode structure comprises an annular supporter, a back plate having multiple holes, and an upper electrode connection. At least a part of the annular supporter extends downwardly to the lower diaphragm electrode while the rest of the annular supporter extends downwardly to the substrate. The back plate is suspended above the lower diaphragm electrode by the annular supporter, forming an air gap therebetween. An upper electrode is embedded in the insulating layer at the back plate and is lead out by the upper electrode connection.

The invention relates to a quercetin nanoparticle and a preparation method thereof. The quercetin nanoparticle is prepared by using one or two selected from the group consisting of a nanometer precipitation process and a high pressure homogenization process. According to the invention, quercetin is used as a bulk drug, TPGS (vitamin E polyethanediol succinate) is used as a main stabilizing agent, and a mass ratio of the bulk drug to the carrier stabilizing agent is 1: 20 to 10: 1. The prepared quercetin nanoparticle has a small particle size and a high drug loading rate, and when a drug-carrier ratio is 5: 1, the average particle size of the quercetin nanoparticle is 173.21 nm and the drug-loading rate is about 80%; moreover, the prepared quercetin nanoparticle has good stability, the drug exists in crystal form in the nanoparticle, and an obvious slow release effect in vitro is obtained. The quercetin nanoparticle with a high drug loading rate and a small particle size can be prepared by using TPGS, shows obvious slow release effect in vitro, overcomes the problem of poor water-solubility and has good application prospects.

The invention relates to a preparation method of a bone restoration material containing multiple drug-loaded slow release systems, and belongs to the field of biomaterials. The preparation method comprises the following steps: adding an antibacterial medicine and halloysite nanotubes loaded with an osteogenesis promoting medicine through intracavity loading and tube outside grafting to main raw materials comprising biocompatible degradable aliphatic polyester and natural polymer, and carrying out an electrospinning technology to prepare the bone restoration material. The material has the advantages of excellent biocompatibility, controllable and long-term drug release performance, bone defect restoration promotion effect, no secondary surgery, and inhibition of bacterial infection and inflammations easily appearing after the defect.

The invention belongs to the technical field of composite medicine materials as well as a preparation method and application thereof, more particularly discloses a nanoparticle for embedding medicinal Adriamycin. The nanoparticle has a core-shell type structure with an inner core embedded by an outer shell, wherein the inner core is embedded medicinal adriamycin, and the material for the outer shell is silicon dioxide; and the preparation method of the nanoparticle comprises the following steps of: evenly mixing cyclohexane, a surfactant and n-hexylalcohol, adding a sodium fluoride solution into the mixed solution after being evenly mixed to form a reverse-phase microemulsion; adding adriamycin and tetraethoxysilane into the reverse-phase microemulsion, and reacting to obtain a nanoparticle microemulsion system for embedding the adriamycin; adding a silylanization reagent containing functional groups into the microemulsion system, stirring for reacting, adding ethanol and demulsifying, centrifuging and then preparing the nanoparticle for embedding the medicinal adriamycin and modifying the functional groups. The nanoparticle embedding for the adriamycin has good stability, good biocompatibility, long slow-release time, large drug-loading rate, high medicine packaging rate, and the like, and has application prospect in the fields of tumor imaging and treatment.

The invention provides a synthetic method of N-2-hydroxypropyl trimethyl ammonium chloride chitosan and a preparation method of Newcastle disease attenuated live vaccine-loaded nanoparticles of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan, relating to a synthetic method of chitosan and a preparation method of vaccine-loaded nanoparticles of the chitosan. The synthetic method comprises the following steps of: deacelation of the chitosan; dip-treatment of the chitosan; crude preparation of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan; and refined preparation of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan. The preparation method comprises the following steps of: adding a Newcastle disease virus solution into an N-2-hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain a solution A; adding sodium tripolyphosphate, PBS (phosphate buffer solution) and span-80 into the solution A to obtain a solution B; and centrifuging the solution B to obtain a deposit, adding PBS for suspension, adding mycose skimmed milk, and performing freeze drying to finish the preparation. The nanoparticles prepared by using the method has the advantages of easiness in control of particle size, small particle size of drug-loaded nanoparticles, high entrapment efficiency, large drug-loading quantity, mild preparation conditions, low drug toxic or side effect, long slow release time, simple preparation process, lower production cost and easiness in large-scale production.

The invention discloses a spinning solution, nuclear shell nanofiber as well as a preparation method and application thereof. A hydrophobic drug and polyvinyl alcohol (PVA)/polyethylene glycol-b-poly(p-dioxanone) (PEG-b-PPDO) are blended to obtain a spinning solution system, and the nuclear shell nanofiber is directly formed by utilizing a single-axis spinneret under a high-voltage electrostatic effect. The preparation method disclosed by the invention has the advantages of simple equipment, mild conditions, simple flow and low energy consumption, can be used for achieving the aims of high-efficiency embedding of the hydrophobic drug, controllable drug release speed and long sustained release time, and is very suitable for industrial production.

The invention discloses an ultrasonic preparation method of casein-polysaccharide nanogel and application of functional food, and relates to the technical field of functional food microcapsules. The casein-polysaccharide nanogel is prepared from the following raw materials in parts by weight: 2-40 parts of sodium caseinate and 2.5-25 parts of sodium alginate. The sodium alginate is added in the sodium caseinate, the advanced structure of the sodium caseinate is changed, the structure of the sodium caseinate is opened to expose an active group, meanwhile, protein and polysaccharides form small aggregates, and therefore, the various aggregates are promoted to form gel under the hydrophobic interaction so as to lay a foundation for embedding of bioactive components. In a process of embedding beta-carotene by using sodium caseinate-sodium alginate composite gel, the protein and the polysaccharides are promoted to be crosslinked to obtain the aggregates by a frequency sweeping ultrasonic treatment technology or a multi-mode ultrasonic technology through an ultrasonic physical force, the various aggregates are promoted to form gel through the hydrophobic interaction, and a foundation is laid for embedding of the bioactive components.

The invention discloses a preparation method of a novel polyether-synthesis slow-release-type polycarboxylic acid water reducer. The method comprises the following steps that S1, a polyether macromonomer and deionized water are added into a reaction kettle, stirred at the normal temperature and dissolved, and a small unsaturated acid or anhydride monomer and a small unsaturation esters monomer aremixed in water to obtain an A solution; a reduction agent, a chain transfer agent and water are sufficiently mixed to obtain a B solution for use; S2, a certain amount of A solution is added to a macromonomer aqueous solution obtained in the step S1, and even stirring is conducted; S3, an oxidizing agent is added to the mixture obtained in the step S2 in advance, then the B solution is dropwise added, the A solution is dropwise added after the B solution is dropwise added for 2-10 min, and after drip addition is completed, heat preservation is conducted for 0.5 h; S4, after a reaction is completed, an alkaline solution is added for neutralization, the product is poured out, and the slow-release-type polycarboxylic acid water reducer is obtained. The obtained slow-release-type polycarboxylic acid water reducer has the advantages that the slow release time is long, the slump degree can be maintained for a long time, and the slump result is excellent.

The invention discloses an ultrasonic preparation method of a peanut protein/polysaccharide composite particle and functional food application, and relates to the technical field of functional food microcapsules. The peanut protein/polysaccharide composite particle is prepared from the following raw materials in parts by weight: 1-10 parts of peanut protein, and 1-15 parts of carrageenan. The carrageenan is added into the peanut protein, the advanced structure of the peanut protein is changed, the structure of the peanut protein is opened, an active group is exposed, and besides, the protein and the polysaccharide form a small aggregate, so that various aggregates form the composite particle through hydrophobic interaction, and the foundation is provided for embedding a biological active ingredient. In the process of embedding a tea polyphenol by using the peanut protein/polysaccharide composite particle, the sweep frequency ultrasonic processing technique or the multi-mode ultrasonic technique is used, the physical force of the ultrasonic wave promotes the crosslinking of the protein and the polysaccharide to form the aggregate, so that the various aggregates are promoted to form the composite particle through hydrophobic interaction, and the foundation is provided for embedding the biological active ingredient.

A magnetic nanosphere of doxorubicin for treating cancer is prepared directly in the reverse-phase microemusion through one step. It has high carried medicine quantity (10%), half life of 7 days, and regulatable granularity.

The invention discloses a frequency-sweeping ultrasonic preparation method of rapeseed protein-chitosan nanoparticles, and relates to the technical field of composite nanoparticles of functional food. The rapeseed protein-chitosan nanoparticles are prepared from the following raw materials in parts by weight: 2-10 parts of active rapeseed protein and 1-2.5 parts of chitosan. The chitosan is added into the active rapeseed protein to change the advanced structure of the active rapeseed protein, so that the structure thereof is opened to expose active groups; meanwhile, the protein and polysaccharide form small aggregates, so that formation of the nanoparticles by the aggregates through hydrophobic interaction is promoted, and a foundation is laid for embedding a bioactive component. In the preparation process of the curcumin-embedded active rapeseed protein-chitosan composite nanoparticles, by a frequency-sweeping ultrasonic processing technology, cross-linking of the protein and the polysaccharide into the aggregates is promoted through the physical force of ultrasonic, so that the formation of the nanoparticles by the aggregates through the hydrophobic interaction is promoted and the foundation is laid for embedding the bioactive component.

The invention relates to a chlorine dioxide slow-release device and its replenishment liquid, in particular to a chlorine dioxide slow-release device and its replenishment liquid for epidemic prevention and disinfection, food antisepsis and air purification. The device includes three parts: a container, a container cover, and a strip-shaped volatile matter. The supplement liquid includes the following parts by weight: 1-15 parts of sodium chlorite, 1-15 parts of activator, 1-10 parts of thickener, 1-5 parts of stabilizer, 0.5-2 parts of air barrier agent, 53-5 parts of purified water 95.5 servings. The beneficial effect of the device is to stably preserve the activated chlorine dioxide liquid, and to control the amount of moisture and air in contact with the strip-shaped volatiles by increasing and/or reducing the total area exposed to the strip-shaped volatiles in the air. Control the amount of chlorine dioxide released. According to the scale prompt on the container, when the chlorine dioxide liquid drops to a certain level, open the container cover, add replenishing liquid, and it can be recycled. It has the advantages of simple preparation process, low cost, convenient use and environmental protection.

The invention relates to the fields of medicines and medical instruments, and particularly relates to a preparation method for a gel scaffold for repairing articular cartilage injuries. The preparation method specifically comprises the following steps: (1) modifying sodium hyaluronate; (2) dissolving PLGA nano-particles of a controlled-release small molecular compound in the sodium hyaluronate modified in the step (1), and then adding with a photoinitiator to obtain a controlled-release small molecular compound-sodium hyaluronate gel compound system; and (3) injecting/filling the controlled-release small molecular compound-sodium hyaluronate gel compound system to the articular cartilage injuries to be repaired for being irradiated by an ultraviolet point light source, so as to obtain the gel scaffold for repairing articular cartilage injuries. The gel scaffold provided by the invention is high in plasticity, and capable of being randomly shaped according to the shapes of cartilage defects; harmful substances are not introduced in the whole process, and the gel scaffold can be used in vivo.

The invention discloses an apigenin polylactic acid sustained release microsphere and a preparation method of the apigenin polylactic acid sustained release microsphere. The preparation method comprises the following steps: dissolving hydroxyl-terminated racemic polylactic acid and soybean lecithin in an organic solvent; stirring the liquid, and slowly adding the apigenin mixed liquid subjected to ultrasonic treatment in an emulsifier aqueous solution to be emulsified; reducing the pressure, removing the solvent with steam, concentrating the volume; centrifuging at high speed, washing and drying the obtained mixed liquid to prepare the polylactic acid entrapped apigenin acid sustained release microsphere, wherein the microsphere particle size is 1-5 microns, the drug loading ratio is larger than 25%, the encapsulation efficiency is larger than 79%, and the sustained release time is more than 550 hours. According to the polylactic acid with good biocompatibility and biodegradability is taken as a clad material to prepare the apigenin polylactic acid sustained release microsphere, so that the microsphere is uniform in shape, smooth and adhesion-free on the surface, uniformly distributed in the particle size, and good in slow-release effect, can keep continuous release time in vitro 550 h above, conquers the defects that the drug is poor in water solubility and fat solubility, improves the oral administration availability, prolongs the drug action time and improves the drug therapeutic effect.

The invention relates to a method for preparing potato starch medicament carrier microspheres, which comprises the following steps: (1) mixing potato native starch with water to form a starch emulsion with the emulsion concentration of 3.5 to 5.0g/100ml, and adjusting the pH value to between 8 and 11; (2) performing constant temperature gelatinization on the starch emulsion to obtain a gelatinized starch emulsion; (3) adding edible oil and an emulsifying agent into the starch emulsion respectively to prepare a reversed phase emulsion; and (4) adding a crosslinking agent, sodium bisulfite and ammonium persulfate into the reversed phase emulsion respectively to perform reactions, adjusting the pH to between 8 to 11, then standing the mixture, removing the supernatant fluid, washing, drying and crushing the mixture, and passing the powder through a sieve of 80 meshes. The method has a simple production process and simple operation and is easy to grasp, the production cost is low, the pollution is less, and the potato starch medicament carrier produced by the method has a long slow-release time and a high slow-release rate.

The invention relates to the field of preparation of medicines and particularly relates to ropivacaine nano particles, a preparation method thereof and an optimizing experimental method of effects of the ropivacaine nano particles. The preparation method comprises following steps: (A) dissolving ropivacaine free alkali and polylactic acid-polyglycollic acid segmented copolymer in dichloromethane to form an organic phase while a polyvinyl alcohol solution is employed as an aqueous phase; (B) performing evaporation to a white emulsion at 30-40 DEG C to remove the organic phase to obtain a pale blue opalescence suspension liquid; and (C) performing centrifugal separation to the pale blue opalescence suspension liquid to obtain a precipitate, washing the precipitate, and performing ultrasonic dispersion and a vacuum freeze-drying process to obtain the ropivacaine nano particles. By means of the prepration method of the ropivacaine nano particles, an in-vitro releasing research proves that the ropivacaine nano particles has a releasing rate being about 73% in 96 h, a slow-releasing effect is quite good and a pain-relieving requirement on acute pains, such as post-operation pain and the like, can be satisfied just through one-time dosing.

The invention discloses a preparation method of water-soluble polyaniline nano particles serving as a corrosion inhibitor. The preparation method comprises the following steps: adding deionized water into a template agent; completely dissolving the template agent under the action of ultrasonic; adding aniline into the completely dissolved template agent, and carrying out uniform stirring at the room temperature to obtain a solution I; adding an oxidizing agent into the solution I to ensure that aniline participates an oxypolymerization reaction under the action of the oxidizing agent, wherein the reaction temperature is 0 to 2 DEG C; after the reaction is finished, carrying out refining and drying to obtain the final product, namely the polyaniline nano particles. Compared with the prior art, the corrosion inhibitor contains no nitrite, is simple to use, and can be used as long as being diluted with water, thereby being safe and environmentally friendly. The corrosion inhibitor obtained according to the preparation method is used after being diluted by 50 to 300 times of water; when the concentration of the corrosion inhibitor is 0.5 g/L, the corrosion inhibiting effect on carbon steel reaches up to 95.6 percent.

The invention relates to a gentamicin sulfate wrapped in polylactic acid/nano-hydroxyapatite composite microspheres, which comprises the following components in parts by weight: 1-10 parts of nano-hydroxyapatite, 1 part of gentamicin sulfate, 12.5-25 parts of polylactic acid and 1-17 parts of methyl cellulose. The invention further discloses a preparation method. The prepared gentamicin sulfate has the advantages of high drug loading, high entrapment efficiency, long-term sustained release and biodegradability.