Preparation method of multilayer-embedded microcapsules

A microcapsule and single-layer technology, which is applied in the field of preparation of multilayer embedded microcapsules, can solve the problems of poor continuity and uniformity, long reaction time, etc., to improve continuity and uniformity, save cost and energy consumption, The effect of increasing the sustained release time

Active Publication Date: 2017-12-19
GUANGZHOU LIBY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems that the existing encapsulation technology has a long reaction time and is affected by various factors, needs to use toxic substances as curing agents for curing treatment or the continuity and uniformity of the formation of the second layer of shell is poor, etc., and provides a A new preparation method of multi-layer embedded microcapsules

Method used

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  • Preparation method of multilayer-embedded microcapsules
  • Preparation method of multilayer-embedded microcapsules
  • Preparation method of multilayer-embedded microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] This embodiment provides a method for preparing two-layer embedded microcapsules, comprising the following steps:

[0048] (1) material preparation

[0049] Take 0.05 g of water-soluble solid drug (cepiryl chloramine), 1 g of protective agent (olive oil), and add 1 g of emulsifier (equal amounts of tween80 and span80) as the total core material.

[0050] Take 1g of chitosan, 0.5g of modified starch, add 1ml of acetic acid (solvent) and 50ml of distilled water, stir and dissolve at 50°C, and use it as wall material A.

[0051] Take 1g of sodium lauryl sulfate, 3g of sodium tripolyphosphate, and 0.3g of sodium alginate and dissolve them in 100ml of distilled water at the same time as coagulation bath A.

[0052] Dissolve 0.1g of sodium alginate in 25ml of distilled water as wall material B.

[0053] Dissolve 0.5g of calcium chloride in 25ml of distilled water as coagulation bath B.

[0054] (2) Single layer wrapping

[0055] Wall material A is mixed with the total core ...

Embodiment 2

[0060] This embodiment provides a method for preparing two-layer embedded microcapsules, comprising the following steps:

[0061] (1) material preparation

[0062] Take 0.05 g of water-soluble solid drug (cepiryl chloride), 1 g of protective agent (soybean oil), and add 1 g of emulsifier (equal amounts of tween80 and span80) as the total core material.

[0063] Take 1g of chitosan, 0.5g of modified starch, add 1ml of acetic acid and 50ml of distilled water, stir and dissolve at 50°C, and use it as wall material A. Take 1g of sodium lauryl sulfate, 3g of sodium tripolyphosphate, and 0.3g of sodium alginate and dissolve them in 100ml of distilled water at the same time as coagulation bath A.

[0064] Take 0.5g chitosan and dissolve in 50ml distilled water as wall material B.

[0065] Coagulation bath A was reused as coagulation bath B.

[0066] (2) Single layer wrapping

[0067] After the wall material A is mixed with the total core material and homogenized by high-speed she...

Embodiment 3

[0073] This embodiment provides a method for preparing two-layer embedded microcapsules, comprising the following steps:

[0074] (1) material preparation

[0075] Total core material, wall material A, wall material B and coagulation bath B are consistent with embodiment 1.

[0076] Take 0.6g of sodium lauryl sulfate, 1.8g of sodium tripolyphosphate, and 0.3g of sodium alginate and dissolve them in 100ml of distilled water at the same time as the coagulation bath A.

[0077] (2) The steps of single-layer wrapping and double-layer wrapping are the same as in Example 1.

[0078] When the emulsion is squeezed through the orifice in the single-layer encapsulation step, the size of the microcapsules is controlled by selecting the size of the orifice used. The particle size distribution of the secondary embedding microcapsules prepared in this example is uniform, with an average particle size of 500 μm.

[0079] Observing the wrapping condition of the secondary embedding microcaps...

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Abstract

The invention relates to the technical field of encapsulation and in particular relates to a preparation method of multilayer-embedded microcapsules. According to the preparation method provided by the invention, reaction time for forming single-layer covering outside a core material and forming two-layer covering is short; a compound condensation bath A is formed by adopting sodium dodecyl sulfate, sodium tripolyphosphate and sodium alginate, so that the continuity and the uniformity of a microcapsule capsule film of each layer can be greatly improved; single-layer and multilayer capsule shells can be finished outside capsule cores of the microcapsules at the same time; a core material leakage phenomenon is not caused and core material leakage does not occur after the microcapsules are placed for long time; compared with a method for realizing a relatively high embedding rate through a plurality of times of random landfilling of wall materials, the loss amount of raw materials is reduced to the greatest extent and the cost is saved; in a multilayer embedding process, drying treatment does not need to be carried out and a glutaraldehyde toxic curing agent does not need to be used, so that the cost and the energy consumption are reduced and the safety of the microcapsules is also improved.

Description

technical field [0001] The invention relates to the technical field of encapsulation, in particular to a preparation method of multilayer embedded microcapsules. Background technique [0002] In recent years, encapsulation technology characterized by unique controlled release (sustained release), isolation of active ingredients, taste masking, and toxicity reduction has been more and more widely used in the fields of food, daily chemicals, medicine, and agriculture. The encapsulation technology here is mainly based on micro-packaging, that is, microcapsule technology, which means that active components are wrapped in microcapsules with certain surface characteristics. The active ingredient is gradually released from the microcapsules at a pre-desired rate. From a technical point of view, the encapsulation technology should meet two conditions in order to realize the above-mentioned needs: the active component must be able to be wrapped in the microcapsule; the microcapsule ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
CPCB01J13/02
Inventor 易丹陈伟才高南
Owner GUANGZHOU LIBY
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