Nano-magnetic medicinal microglobule, its preparation method and application

A nano-magnetic and nano-magnetic material technology, applied in the application field of medicine, can solve problems such as hindering application and low drug loading

Inactive Publication Date: 2005-10-26
SHENZHEN PEOPLES HOSPITAL
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In the above preparation method, the non-magnetic microspheres have a small particle size reaching nanoscale, but the drug loading capacity is not high. After adding magnetic powder, the particle size of the microspheres becomes very large, reaching hundreds of microns, thereby hindering further application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nano-magnetic medicinal microglobule, its preparation method and application
  • Nano-magnetic medicinal microglobule, its preparation method and application
  • Nano-magnetic medicinal microglobule, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0071] Implementation Proceeding 1: Take 34.8mg carbon-coated iron-ferromagnetic powder (produced by Shenzhen Zunye Nano Materials Co., Ltd., model is JY-FeC, average particle size is 25nm, maximum particle size is 60nm), magnetic carbon-coated iron powder transmission electron microscope See figure 1 . 32.4mg of doxorubicin (produced in Japan, provided by Shenzhen Wanle Pharmaceutical Co., Ltd., content 98.4%), 31.0mg chitosan (provided by Jinan Haidebei Marine Bioengineering Company, deacetylation degree > 95.7%) was dissolved in 3mlHAC ( 5%), ultrasonically mixed, placed to remove air bubbles, and then 0.6ml of 5% glutaraldehyde aqueous solution was added, ultrasonically mixed to form an aqueous suspension. Above-mentioned suspension is dripped in 30ml toluene, wherein comprises 12gAOT (the AOT of described, is aerosol OT, and molecular formula is C 20 h 37 NaO 7 S, the molecular weight is 444.56, purchased by Shanghai Jufeng Chemical Technology Co., Ltd., produced by J...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

A magnetic nanosphere of doxorubicin for treating cancer is prepared directly in the reverse-phase microemusion through one step. It has high carried medicine quantity (10%), half life of 7 days, and regulatable granularity.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to magnetic nano-medicine microspheres and a preparation method thereof, as well as pharmaceutical compositions and substances containing the nano-magnetic drug microspheres. Drug application in malignant tumors. Background technique [0002] Doxorubicin (English name is doxorubicin or adriamycin) is a broad-spectrum anticancer drug that hinders the synthesis of nucleic acids in cancer cells. It has potent anticancer activity, but it has a lot of toxic and side effects in clinical application, causing serious damage to normal tissues and organs (Omelyanenko V, Kopeckova P, Geniry C, et al. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J ControlRel, 1998, 53(1-3):25-37). In order to improve its drug effect and reduce its toxic and side effects, people explore its ultrafine particle controlled release and targeting system, and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16
Inventor 周汉新李富荣韩涛齐晖任莉莉
Owner SHENZHEN PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap