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Nano-magnetic medicinal microglobule, its preparation method and application

A nano-magnetic and nano-magnetic material technology, applied in the application field of medicine, can solve problems such as hindering application and low drug loading

Inactive Publication Date: 2005-10-26
SHENZHEN PEOPLES HOSPITAL
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Problems solved by technology

[0014] In the above preparation method, the non-magnetic microspheres have a small particle size reaching nanoscale, but the drug loading capacity is not high. After adding magnetic powder, the particle size of the microspheres becomes very large, reaching hundreds of microns, thereby hindering further application

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  • Nano-magnetic medicinal microglobule, its preparation method and application
  • Nano-magnetic medicinal microglobule, its preparation method and application
  • Nano-magnetic medicinal microglobule, its preparation method and application

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Embodiment Construction

[0071] Implementation Proceeding 1: Take 34.8mg carbon-coated iron-ferromagnetic powder (produced by Shenzhen Zunye Nano Materials Co., Ltd., model is JY-FeC, average particle size is 25nm, maximum particle size is 60nm), magnetic carbon-coated iron powder transmission electron microscope See figure 1 . 32.4mg of doxorubicin (produced in Japan, provided by Shenzhen Wanle Pharmaceutical Co., Ltd., content 98.4%), 31.0mg chitosan (provided by Jinan Haidebei Marine Bioengineering Company, deacetylation degree > 95.7%) was dissolved in 3mlHAC ( 5%), ultrasonically mixed, placed to remove air bubbles, and then 0.6ml of 5% glutaraldehyde aqueous solution was added, ultrasonically mixed to form an aqueous suspension. Above-mentioned suspension is dripped in 30ml toluene, wherein comprises 12gAOT (the AOT of described, is aerosol OT, and molecular formula is C 20 h 37 NaO 7 S, the molecular weight is 444.56, purchased by Shanghai Jufeng Chemical Technology Co., Ltd., produced by J...

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Abstract

A magnetic nanosphere of doxorubicin for treating cancer is prepared directly in the reverse-phase microemusion through one step. It has high carried medicine quantity (10%), half life of 7 days, and regulatable granularity.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to magnetic nano-medicine microspheres and a preparation method thereof, as well as pharmaceutical compositions and substances containing the nano-magnetic drug microspheres. Drug application in malignant tumors. Background technique [0002] Doxorubicin (English name is doxorubicin or adriamycin) is a broad-spectrum anticancer drug that hinders the synthesis of nucleic acids in cancer cells. It has potent anticancer activity, but it has a lot of toxic and side effects in clinical application, causing serious damage to normal tissues and organs (Omelyanenko V, Kopeckova P, Geniry C, et al. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J ControlRel, 1998, 53(1-3):25-37). In order to improve its drug effect and reduce its toxic and side effects, people explore its ultrafine particle controlled release and targeting system, and...

Claims

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Application Information

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IPC IPC(8): A61K9/16
Inventor 周汉新李富荣韩涛齐晖任莉莉
Owner SHENZHEN PEOPLES HOSPITAL
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