2250 results about "High pressure homogenization" patented technology

The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted. (2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. Stabilizers may also be added or exchanged after homogenization. (3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization. (4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives. (5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.

The presence or absence of a high pressure condition in an implantable blood pump is determined at least in part based on a comparison between a determined amount of differential pressure across the pump and a pressure threshold value. The amount of differential pressure parameter may be determined based at least in part on a parameter related to flow, such as a parameter related to thrust on the rotor of the pump. In response to determining the presence of a high pressure condition, an updated speed of rotation of the rotor that is less than the rotor's initial speed may be determined. The rotor's speed may be increased when the flow rate of blood is determined to be at least equal to a flow recovery threshold value.

The invention relates to a process for preparing a novel formulation of an integrative traditional Chinese medicine and a production method thereof. Traditional Chinese medicine simple recipe, traditional Chinese medicine compound recipe, integrated Chinese and western medicine compound recipe and integrated Chinese and western medicine composition are prepared by utilizing a nanometer vector combination process. The production method comprises the following steps of extracting with alcohol-water, crushing and extracting in an ultrasonic manner, extracting in a microwave manner, decocting in water and condensing, spraying and drying, homogenizing under high pressure, grinding to be nanometer particles, preparing the nanometer particles and the like. The invention pays attention to the advantages of nanometer traditional Chinese medicine, such as multiple synergism, multiple targets and the like. After the novel formulation disclosed by the invention is produced in an industrial scale, the production cost can be greatly reduced, the quality of the product can be improved, and the target performance and the controlled release performance of the medicines are stronger.

The invention relates to a preparation method of a homogenized fine nano-cellulose fiber. The preparation method can solve the problems of uniform diameter distributor of biomass nano-cellulose prepared by the existing strong acid hydrolysis method and the high-strength mechanical shearing method, easy gathering among the nano-fiber and a narrow range of applications of the TEMPO catalytic oxidation method. The preparation method comprises the following steps: 1) extracting biomass fiber with benzyl alcohol solution; 2) carrying out treatment by using acidified sodium chlorite; 3) carrying out gradient treatment with alkaline liquor; 4) using TEMPO, sodium bromide and sodium hypochlorite for catalytic oxidation treatment; 5) using sodium chlorite for treatment; and 6) carrying out nano-scale processing by using the long-term stirring method, the ultrasonic method or the high-pressure homogenization method, drying, and then obtaining the homogenized fine nano-cellulose fiber. The fiber has the uniform diameter distribution, the diameter is 3-5nm, the length-diameter ratio is not less than 500, the fiber is mutually interwoven into a mesh snarling structure, and the method is applicable to preparing the nano-cellulose fiber by using wood pulp, paper-making pulp, wood, bamboo and crop straw.

The invention relates to a multifunctional compound fertilizer capable of killing pests, preventing diseases and increasing yield. The preparation method of the multifunctional compound fertilizer comprises the following steps: firstly, respectively preparing a component A, a component B and a component C, wherein the component A is a vegetable insecticide, thecomponent B is a vegetable bactericide, and the component C is a vegetable growth promoting and yield increasing agent; after the three components are prepared, adding the finished product of the component C into a synthesis kettle for heating; then, sequentially adding the liquid medicine of the component A and the liquid medicine of the component B for continuously stirring, and keeping constant temperature; adding a penetrating agent JFC and polyethylene glycol into the synthesis kettle for stirring; and finally, adding a buffering agent for stirring and mixing uniformly, and homogenizing the mixture by a high-pressure homogenizer to obtain the finished product of the multifunctional compound fertilizer. The multifunctional compound fertilizer of the invention has very high insecticidal and bactericidal efficiencies, smaller toxic side effects and safety to people and livestock, promotes the growth and the development of plants, increases the chlorophyll content, and greatly improves the crop yield.

The invention provides medicinal compositions of taxol medicaments and pharmaceutically acceptable biological carriers and preparation method thereof. The medicinal compositions of the taxol medicaments and carrier proteins are nano mixed suspensions prepared from the carrier proteins, organic phases, stabilizers, freeze drying protective agents and the taxol medicaments. The weight volume percentconcentration of the taxol medicaments is 0.075 to 1.0. The taxol medicament nano particles prepared by using high-pressure homogenization can reduce adverse reaction aroused by the taxol medicamentsand improve the safety of the clinical administration of the taxol medicaments. The preparation process of the nano mixed suspensions is simple and feasible and is suitable for large-scale preparation and industrial production.

The invention relates to high-content medium chain triglyceride powdered oil which is characterized by being prepared from the following raw materials in percentage by weight: 50%-80% of medium chain triglyceride, 10%-30% of grape syrup, 5%-26% of modified starch and the balance of auxiliary agents. The high-content medium chain triglyceride powdered oil disclosed by the invention is obtained by carrying out mirco-encapsulated embedding on medium chain triglyceride and achieving an oil powdered effect by adopting advanced process technologies, namely high-pressure homogenized emulsification, spray drying and the like, through formula design and process optimization, achieves the oil content as high as 80% and the oil embedding rate more than 98%, and has the advantages of good solubility and stability and convenience for transportation and storage. The product can be applied to multiple foods and health-care foods and is used for enhancing the nutrition value of the foods, improving the tissue structures, appearance quality and palatability of the foods and prolonging the quality guarantee period of a product.

The invention relates to a strong anti-oxidation DHA microcapsule. The microcapsule comprises the following components in percentage by weight: 10 to 30 percent of DHA fish oil, 0.02 to 0.2 percent ofantioxidant, 10 to 60 percent of wall material, and 5 to 30 percent of auxiliary wall material 5. The invention also relates to a method for preparing the strong anti-oxidation DHA microcapsule. On the basis of the prior process, the microcapsule is prepared by adding the antioxidant to oil phase and water phase respectively and performing emulsification, high-pressure homogenization, improved spray granulation and cold-air boiling-drying. The newly added antioxidant can produce better anti-oxidation effects and greatly improve the oxidation stability of the DHA microcapsule so as to prolongthe shelf life of products, and the improved spray granulation and the cold-air boiling-drying process can increase the yield of the DHA microcapsule. The DHA microcapsule can be used in the fields ofmedicines, foods, beverages and the like.

The present invention is linseed oil microcapsule powder and its preparation, and features that modified polysaccharide, sodium octyl alkenyl succinate starch, is used as capsule wall material for forming microcapsule in preparing linseed oil microcapsule powder. The preparation process includes adding linseed oil into the solution of sodium octyl alkenyl succinate starch, stirring to form homogeneous emulsion, high pressure homogenizing to obtain linseed oil emulsion of granularity smaller than 1000 nm, and final spray drying or freeze drying to obtain white linseed oil microcapsule powder with high stability and high flowability. The linseed oil microcapsule powder has high linseed oil activity, high stability and high bioavailability, and may be applied in food and health product.

The invention discloses a flaxseed oil microcapsule and a production method thereof. The core material of the flaxseed oil microcapsule is flaxseed oil, and the wall material is made of modified starch, maltodextrin and sodium caseinate. The production method comprises steps of adding the modified starch, the maltodextrin and the sodium caseinate to hot water with high-speed stirring until the the modified starch, the maltodextrin and the sodium caseinate are dissolved completely and forming a water phase; weighing and taking the flaxseed oil, adding vitamin E, rosemary and tea polyphenol step by step, stirring the mixture until the mixture is dissolved completely and forming an oil phase; conducting high-speed cutting for the obtained water phase by using a cutting machine, adding the obtained oil phase slowly and obtaining an emulsion; homogenizing the emulsion by using a high-pressure homogenizer; sterilizing the emulsion which is homogenized by using an ultra high-temperature sterilizing machine; and spraying and drying the sterilized and obtaining the flaxseed oil microcapsule. The embedding rate of the flaxseed oil microcapsule is more than 90%, the capacity of the flaxseed oil can reach 45%, the process is simple, the taste is special, the scent is obvious and the shelf life is long.

The invention discloses a method for preparing a water-oil repellent fluorine-containing textile finishing agent, comprising the following steps of: adding a fluorine-containing alkyl (methyl) acrylate monomer, a higher fatty alcohol (methyl) acrylate monomer, a cross-linking monomer, an emulsifying agent, a solvent, a chain transfer agent and the like into a container in sequence, dropwise adding deionized water at 30-80 DEG C, shearing at high speed for pre-emulsification, carrying out high-pressure homogenization or ultrasound on a pre-emulsified solution, adding an initiator, and polymerizing for 0.5-8h at 50-80 DEG C. The obtained finishing agent has small particle size, uniform polymer composition and favorable properties of mechanical stability, pH stability, chemical stability, dilution stability and storage stability, and contains no components such as PFOS/PFOA (Perfluorooctane Sulfonates/Perfluorooctanoic Acid) and the like harmful to human bodies, and textiles finished with the finishing agent have favorable water-oil repellent property and has lower cost in comparison with like products.

The invention provides a method for preparing nanometer graphene materials in a large scale mode through hydraulic shearing. The method includes the steps that graphite powder is added into liquid, a small number of oxidizing agents are added, oxidizing agent molecules rapidly and alternately enter graphite through a multifunctional grinding dispersion machine in an inserted mode, a high shear emulgator and a high-pressure homogenizer which are connected in series, and the materials are sheared and peeled under the hydraulic effect through continuous mechanical force, and are rapidly layered. The problem that graphene can not be prepared in a large scale mode with high quality and low cost at present is solved, it is guaranteed that the graphene structure is not damaged, and the obtained graphene can be widely applied to the lithium battery field, the super capacitor field, the polymer composite material field, the heat-conduction and heat-radiation film field, the functional coating field, the national-defense and military-industry field and the like.

A process for producing nanoparticles of paclitaxel and albumin having antitumor properties, by which a mixture obtained by adding paclitaxel in powder form to an aqueous solution of albumin with chloroform is subjected to high pressure homogenization treatment.

The invention relates to a method for preparing nano celluloses through high-pressure homogenizing and low-temperature cooling. The method comprises the following steps: dispersing the raw fibers in a sulfuric acid aqueous solution with the mass fraction of 10-20%, maintaining the raw fibers in the aqueous solution for 2-6 hours at 20-60 DEG C, adding a dispersing agent after dilution, centrifugal separation and cyclic dialysis, utilizing a high-pressure homogenizer for high-pressure homogenizing, simultaneously carrying out low-temperature cooling in the process of high-pressure homogenizingto obtain nano cellulose colloids and obtaining the nano celluloses through centrifugal separation and freeze drying, wherein the pressure is 1000-1200bar; and the cycle index is 4-16. The diameter and length of the obtained nano celluloses are respectively about 10-30nm and 300nm. The method has the beneficial effect of solving the following problems: the existing nano celluloses prepared by utilizing the homogenizers have wide and nonuniform diameter distribution; the fibers are interwoven in micron size; and the pressure and the temperature are raised in the process of high-pressure homogenizing.

The invention provides walnut powder and a production method thereof; walnut kernel is peeled by high pressure water spraying, bubble water stream impact and ultrasonic wave vibration after being soaked by compound alkaline liquid, and then second-grade cold pressing is carried out to the peeled walnut kernel after the peeled walnut kernel is dried and crushed, the walnut kernel is crushed, filtered, batched and colloid-milled to be refined, and then a complex stabilizer is added in the walnut kernel to be sterilized, concentrated, homogenized and dried to obtain the walnut powder. The method has low damage degree, can effectively prevent protein denaturation and reduce alkaline liquid amount; the second-grade cold pressing technology is adopted, the denaturation degree of the protein of the walnut cake is reduced, and the walnut powder is prepared by high-pressure homogeneity and spraying drying; the visual color and luster, solubility and the content of the protein and other indexes of the product are superior to the similar products in the current market. The invention realizes the comprehensive utilization of the walnut resource, the technology is advanced, simple and practical and is easy to popularize, thereby having good economic and social benefits.

The invention discloses an oil-in-water type vaccine adjuvant as well as a preparation method and application thereof. The oil-in-water type nano-emulsion vaccine adjuvant comprises the following components in percentage by mass: 0.1-10 percent of oil phase, 0.1-10 percent of emulsifier, 0.1-3 percent of stabilizer, 0.1-3 percent of complexing agent and 0.01-10 percent of immunopotentiator. The preparation method comprises the following steps: (1) uniformly dispersing the immunopotentiator, the stabilizer and the complexing agent in water, thereby obtaining an aqueous phase; (2) mixing an oil phase and an emulsifier, thereby obtaining an oil phase; (3) slowly adding the oil phase into the aqueous phase, and continuously stirring, thereby forming a stable emulsion; (4) regulating the pH value of the emulsion, and fixing the volume to obtain a primary emulsion; and (5) performing high-speed shearing and high-pressure homogenizing on the primary emulsion. The vaccine adjuvant provided by the invention is simple in preparation, convenient to use and small in side reactions, is used for diluting vaccines, particularly swine fever live vaccines and is high in stability and good in immune effect.

The invention relates to a green, economical and sustainable method for preparing nanocellulose fibrils. The preparation method comprises the following steps that 1, a cellulose raw material is added to a citric acid solution to be heated, stirred and hydrolyzed; 2, treated cellulose and hydrolysate are separated through methods of centrifugal sedimentation and the like, and precipitated cellulose is centrifugally washed with water multiple times and diluted into a cellulose suspension; 3, the separated hydrolysate can be directly recycled at least once, citric acid is recovered from the recycled hydrolysate, and the citric acid obtained through recovery can be recycled continuously; 4, the natural structure of the cellulose suspension obtained in the second step is further destroyed through a high pressure homogenizer or ultrasonication or physical mechanical treatment of a disc mill, and the colloidal nanocellulose fibrils are obtained. According to the method for preparing the nanocellulose fibrils, a catalyst is not adopted, the reaction condition is relatively mild, the reaction is easy to control, operation is easy, and the method is friendly to environment.

The invention relates to a preparation method for stable water soluble carotenoid dry powder, the organic solvent of acetone or isopropanol dissolved with carotenoid component is added into an aqueous phase solvent containing a surfactant and adjuvant-stabilization component to be sufficiently mixed under sufficient stirring, then the organic solvent in the mixed solvent is removed and an auxiliary forming accessory which is one to twelve times of the carotenoid component by mass is added to be evenly stirred and treated with sponging frying to obtain the powder product. The preparation method is simple and easy, complex operation such as high pressure homogenization is not needed, and the procedures are less, therefore, the method is applicable to various carotenoid components containing Beta-carotene, astaxanthin, lutein, corn pigment and lycopene, etc. The method has the advantages that the performance of the products is good, the grain diameter of the powder product can be in the range of 90 to 170 nm, and the product can be evenly dispersed in water and form a stable and transparent carotenoid water dispersoid solvent.

The invention discloses a black matte polyimide thin film and a preparation method thereof. The preparation method comprises the following steps that 1, black slurry is prepared, wherein a silane coupling agent is added to dimethylacetamide to be stirred to be uniform, black pigment is added, and the black slurry is obtained after high-pressure homogenization treatment is conducted; 2, inorganic filler dispersion liquid is prepared, wherein a matting agent and talcum powder are added to organic solvent and stirred to be uniform, and shear dispersion and ultrasonic dispersion treatment is conducted; 3, the black matte polyimide thin film is prepared, wherein diamine is dissolved in an organic solution, tetracarboxylic acid dianhydride with isoequivalent weight is added, PAA resin is obtained after a reaction is conducted, the PAA resin, the black slurry prepared in the first step and the inorganic filler dispersion liquid prepared in the second step are taken, mixed, stirred and defoamed, and the black matte polyimide thin film is obtained through two-way stretching and high-temperature imidization. The black matte polyimide thin film is low in light transmittance and lustrousness and excellent in mechanical property.

The invention discloses a preparation method of an extract of a traditional Chinese medicine composition with bacteriocidal function and application thereof in daily chemical products, relating to the technical field of traditional Chinese medicine formulations and the daily chemical field. The traditional Chinese medicine composition comprises the following traditional Chinese medicines in percentage by mass: 2-25 percent of honeysuckle, 2-10 percent of chrysanthemum indicum, 1-20 percent of taraxacum, 1-10 percent of liquorice, 1-20 percent of ginger, 2-20 percent of Chinese holly, 2-20 percent of herba andrographis, 2-20 percent of abelmoschus manihot, 1-20 percent of radix salviae miltiorrhizae, 2-30 percent of aloe and 2-20 percent of groundsel. The extract of the traditional Chinese medicine composition is prepared through measuring, mixing, pulverizing, extracting through high pressure homogenization and decoloring with active carbon. The extract of the traditional Chinese medicine composition does not contain chemically synthesized substances, has no toxicity or side effect, can effectively eliminate and kill bacteria on human skin and prevent the human skin from being infected by the bacteria at the same time and can be used for the daily chemical products, such as dandruff remover shampoo, antibacterial bath foam, antibacterial liquid soap, acne-removing cosmetics, antibacterial perfumed soap, and the like.

The present invention discloses a camellia oil microcapsule, its preparation method and application. Said camellia oil microcapsule (by 1000g prescription raw material) contains 20-90g of beta-cyclodextrin, 130-244g of malt dextrin, 6-14g of modified starch, 2-6g of monoglyceride and sucrose fatty ester compound emulsifying agent, 40-90g of camellia oil and the rest is water. Said camellia oil microcapsule can be used as general food, health-care food, medicine, food additive and feed additive. Besides, said invention also provides the concrete steps of its preparation method.

The invention relates to a thermal sublimation digital printing ink-jet ink and a preparation method thereof; the weight percentages of ink components are: (1) disperse dye: 1 to 10 percent; (2) dispersant: 1 to 10 percent; (3) organic solvent: 60 to 90 percent; (4) surfactant: 1 to 5 percent; (5) wetting agent: 1 to 5 percent; (6) defoamer: 1 to 5 percent. The preparation method comprises: (1) the disperse dye, the dispersant, the organic solvent, the wetting agent and the deformer are mixed at normal temperature, and a mixed solution can be obtained by stirring the mixture for 0.5 to 1 hour; (2) the mixed solution is homogenized for 0.5 to 5 hours under a high pressure homogenizer, and the stable-dispersed ink, the average particle size of the dispersed dye of which is 100 to 300 nanometers can be obtained; (3) the ink of magenta (M), cyan (C), yellow (Y), black (K), light cyan (Lc) or light magenta (Lm) can be obtained after the ink is filtered by a 2 microns filtering film and a 0.45 micron filtering film. The particle size of the thermal sublimation digital printing ink-jet ink of the invention is even in distribution and good in disperse stability and can be applied on the large scale piezoelectric type digital printing machines of the nozzles of XAAR and SPECTRA, etc and printed on polyester fabrics; ink jetting is smooth without blocking the nozzles; the thermal sublimation digital printing ink-jet ink can be stored for a long time; the patterns printed by the ink of the invention is colorful in color and the thermal sublimation digital printing ink-jet ink is good in color fixation rate, washing fastness and solarization fastness, is simple in the operation of the production method and is environment-friendly.

The invention relates to the filed of microalgae utilization engineering, in particular to a production method for fully utilizing oleaginous microalgae. The method is characterized in that the wall of the microalgae is broken by a high-pressure homogenization method, and the solid phase and liquid phase are separated out by an extraction kettle and a horizontal spiral centrifuge, and microalgae powder is made from the solid phase by a spray dryer. An oil phase and a water phase are separated from the liquid phase by an oil-water separator, and the oil phase is microalgae oil. A solid phase and a liquid phase are separated from the water phase by a vacuum concentration kettle, a salting-out kettle and a high-speed centrifugal filter, and microalgae protein is made from the solid phase by a freeze dryer or a spray dryer. A solid phase and a liquid phase are separated from the liquid phase by an alcohol precipitation kettle and the high-speed centrifugal filter, and microalgae polysaccharide is made from the solid phase by the freeze dryer or the spray dryer, and ethanol and microalgae liquid fertilizer are made from the liquid phase by an ethanol recovery tower. The invention is a good production method which requires low investment, has simple operation and can comprehensively use microalgae on a large scale, and can produce semi-finished products with high added value, such as the microalgae oil, the microalgae powder, the microalgae protein, microalgae polysaccharide, the microalgae liquid fertilizer, etc.