15 results about "Juglone" patented technology

The invention belongs to the technical field of veterinary treatment medicines, and relates to a compound ivermectin juglone liniment as well as a preparation method and application thereof. The compound ivermectin juglone liniment is prepared from the following components in percentage by weight: 0.2 percent to 0.7 percent of juglone, 0.3 percent to 0.7 percent of ivermectin, 0.8 percent to 1 percent of tween-80, 0.1 percent to 0.15 percent of butylated hydroxytoluene, 0.2 percent to 5 percent of azone, 0.05 percent to 5 percent of menthol, 1 percent to 12 percent of isopropyl myristate and the balance of medium chain triglyceride, the compound ivermectin juglone liniment can be used for effectively removing parasites of animals, and is non-toxic and low in toxicity.

The invention provides a multi-color plant hair dyeing cream and a preparation method thereof. The hair dyeing cream contains a water phase, an oil phase and an active phase, and is prepared by taking sodium alginate as a thickening agent / film-forming agent, sorbitol as a humectant / stabilizer, juglone as a color fixing agent, indigo blue, carmine, curcumin and sodium chlorophyllin as plant pigments, cationic guar gum, ferrous sulfate and tannic acid as a color fixing enhancer and absolute ethyl alcohol and deionized water as solvents. After a water phase, an oil phase and an active phase are respectively prepared, the water phase, the oil phase and the active phase are fully mixed, and the composite material is prepared. The multi-color plant hair dyeing cream prepared by the invention does not contain phenylenediamine and other components, and shows better multi-color dyeing effect and color stability.

The invention provides juglone derivatives and application thereof, and belongs to the technical field of medicines. A series of juglone derivatives are designed and synthesized, and the juglone derivatives can target the HuR protein, inhibit the binding activity of the HuR protein and mRNA and have an obvious inhibiting effect on brain glioma cells. Data of the embodiment shows that the juglone derivative disclosed by the invention has relatively good anti-glioma activity and relatively good safety, the activity of the juglone derivative disclosed by the invention is superior to that of a positive control drug, and the juglone derivative can be used for developing a novel anti-tumor drug and has a relatively good application prospect.

The application discloses a nano-suspension preparation of juglone, which is mainly prepared from 5-15 parts of juglone and 1-20 parts of a stabilizer by weight. The application also adopts a reverse solvent method-high pressure homogenization method to establish a corresponding preparation method, which is simple in process and can obtain smaller drug particle size, thereby improving the drug bioavailability and enhancing the anti-tumor effect. Therefore, the application prepares a novel traditional Chinese medicine nano-preparation of juglone through the means of pharmacy, effectively improves the solubility and bioavailability of juglone. The in-vitro anti-tumor activity experimental results show that the nano-suspension preparation has significant inhibitory activity on the growth of various tumor cells, can be used for preparing drugs for preventing and treating related tumors, increases the targeting and bioavailability of the drug on tumors, reduces the toxicity, provides a new method and strategy for clinical treatment, and has good market prospect and high social value and economic value.

The invention belongs to the technical field of medicines, and particularly relates to a naphthol glycoside compound walnut naphthol glycoside I extracted and separated from cortex juglandis mandshuricae as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: firstly, taking juglans regia powder, adding 70% ethanol, heating, refluxing and extracting, filtering, adding 10% (W / V) CaCl2 powder into an extracting solution, fully stirring, standing, recovering ethanol from supernate to obtain a concentrated extract, dispersing with water, respectively extracting with dichloromethane and n-butyl alcohol for five times, respectively taking an n-butyl alcohol layer, and drying to obtain the juglans regia extract. According to the preparation method provided by the invention, efficient enrichment and separation of the target object are realized only through the processes of salting-out impurity removal, solvent extraction, reversed-phase column chromatography separation and recrystallization, the steps are simple, and the operation is easy; meanwhile, in-vitro activity experiment research shows that the juglans regia naphthol glycoside provided by the invention has good resistance to gastric ulcer injury caused by ethanol, provides a valuable drug effect substance for developing novel anti-gastric ulcer drugs in the future, and has a wide application prospect.

The invention relates to the technical field of catalyst preparation, in particular to a juglone-TiO2 catalyst as well as a preparation method and application thereof. The method comprises the following steps: carrying out a hydrothermal reaction on an aqueous solution of tetra-n-butyl titanate to obtain an amorphous TiO2 precursor, and calcining the amorphous TiO2 precursor to obtain spherical-like granular nano anatase type TiO2; the preparation method comprises the following steps: mixing juglone, spherical-like granular nano anatase type TiO2 and a solvent, and loading the juglone on the surface of the spherical-like granular nano anatase type TiO2, so as to obtain the juglone-TiO2 catalyst. According to the juglone-TiO2 catalyst disclosed by the invention, high stability of TiO2 and excellent light absorption performance of juglone are integrated, so that the photocatalytic activity and the photoresponse range are remarkably improved, and hydrogen peroxide can be efficiently produced by utilizing water and air under the photocatalytic condition; meanwhile, the spectral response range of TiO2 is expanded, and the charge separation efficiency of TiO2 is improved.

The application discloses a use of a combination of juglone and solanum aviculare in preparation of a medicine for inducing tumor cell ferroptosis. The juglone and the solanum aviculare form a quinone-amine free radical (ESR g≈2.004) under a tumor microenvironment, and induce ferroptosis by synergistically inhibiting GPX4 and DHODH. 50 =15.8 μM, CI=0.58 (strong synergy), and the inhibition rate is 78%. The tumor / normal tissue distribution ratio is greater than 5:1. The combination can be used for treating triple-negative breast cancer.

This invention belongs to the field of pharmaceutical technology, specifically relating to a naphthol glycoside compound, juglone-naphthol glycoside I, extracted and isolated from *Clerodendrum trichotomum*, its preparation method, and its application. The preparation method specifically includes the following steps: First, *Clerodendrum trichotomum* powder is extracted by heating and reflux with 70% ethanol. After filtration, 10% (w / v) CaCl2 powder is added to the extract, stirred thoroughly, and allowed to stand. The ethanol is recovered from the supernatant to obtain a concentrated extract. After water dispersion, the extract is extracted five times each with dichloromethane and n-butanol. The n-butanol layer is separated, and then subjected to reversed-phase silica gel column chromatography and recrystallization to obtain the target compound. The preparation method provided by this invention only requires salting out impurities, solvent extraction, reversed-phase column chromatography separation, and recrystallization, achieving efficient enrichment and separation of the target compound. The steps are simplified and easy to operate. Furthermore, the naphthol glycoside prepared by this invention has been shown in in vitro activity experiments to have good anti-ethanol-induced gastric ulcer damage, providing a valuable pharmacodynamic substance for the future development of novel anti-gastric ulcer drugs, with broad application prospects.

The invention provides a conductive coordination nano-enzyme and a preparation method and application thereof, the conductive coordination nano-enzyme has a core-shell structure, metal ions and 1, 5-naphthalenediol are coordinated to form a core crystal structure, and the metal ions and a particle size regulator are coordinated to form a shell amorphous structure; the metal ions comprise any one or a combination of at least two of Cu < 2 + >, Fe < 3 + >, Mn < 2 + >, Co < 2 + >, Fe < 2 + >, Ni < 2 + >, Pt < 2 + >, Ag < + >, Au < 3 + > or Ga < 3 + >; the particle size regulator comprises any one or a combination of at least two of cysteine, lipoic acid, glutathione, mercaptoethanol, mercaptoacetic acid, mercaptopropionic acid, formic acid, acetic acid, benzoic acid, trifluoroacetic acid, citric acid, oxalic acid, maleic acid or salicylic acid. The conductive coordination nano-enzyme provided by the invention can stimulate a tumor site to continuously generate hydroxyl radicals to kill tumors, oxidize DHN to be converted into juglone, and specifically induce pyroptosis of tumors.

The invention relates to a new saccharomycetes, in particular to a pseudomonas putida RT12 strain and an application of the pseudomonas putida RT12 strain in degradation of juglone in walnut green seedcases. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on November 19, 2025, the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.36686. A strain of Pseudomonas putida RT12 is obtained through separation, screening and identification in Aksu Red-flag slope region in Xinjiang, and experiments on growth characteristics, physiology and biochemistry, ester production capability and tolerance of the strain verify that the strain has the activity of efficiently degrading juglone, which indicates that the Pseudomonas putida RT12 has a good application prospect, and can be used for preparing a high-efficiency degradation product of juglone. The method can be widely applied to the agricultural solid waste resource treatment industry.

The invention provides a supported catalyst as well as a preparation method and application thereof. The supported catalyst can cover a light absorption band of 300-600 nm, the light energy utilization efficiency is improved, and the juglone compound can be prepared with high selectivity, high yield, low catalyst consumption and high reaction rate.

The invention discloses a composition for increasing solubility of quinone compounds and application thereof, and belongs to the technical field of pharmaceutical preparations, the composition comprises insoluble quinone compounds, amphiphilic phospholipids or derivatives thereof and / or amphiphilic stabilizers, and the insoluble quinone compounds are benzoquinone and naphthoquinone compounds; wherein the benzoquinone compound is selected from idebenone, coenzyme Q10, 2, 6-dimethoxy-1, 4-benzoquinone, 2-methoxy-6-pentyl-1, 4-benzoquinone, 2, 3-dimethoxy-5-methyl-6-decaisopentenyl-1, 4-benzoquinone and creptyquinone, and the benzoquinone compound is selected from idebenone, coenzyme Q10, 2, 6-dimethoxy-1, 4-benzoquinone, 2, 3-dimethoxy-5-methyl-6-decaisopentenyl-1, 4-benzoquinone, 2, 3-dimethoxy-5-methyl-6-decaisopentenyl-1, 4-benzoquinone and creptyquinone. The naphthoquinone compound is selected from alkannin and derivatives thereof, juglone, blue snow quinone and isoalkannin. The composition has the advantages of strong solubilizing ability and good stability, and when the drug concentration is greater than 0.5%, the phenomenon of drug crystallization and precipitation does not occur within 6 months in an acceleration test at 40 DEG C and under the condition that the composition is diluted by 50 times. The composition can be used for preparing a preparation for topical administration through skin or mucous membranes or systemic administration through injection and gastrointestinal tracts.

The present application relates to the field of photocatalyst, discloses a carbon and nitrogen coated transition metal cluster photocatalyst and its preparation method and application, the method comprises the following steps: in the presence of organic solvent, mixing transition metal nitrate and diamino maleonitrile, then the mixture is hydrothermally reacted to obtain a solid product; the transition metal nitrate is selected from at least one of cobalt nitrate, iron nitate and copper nitrate; the molar ratio of transition metal nitrate and diamino maleonitrile is 1:1-3; the hydrothermal reaction conditions include: temperature is 120-140 DEG C, time is 8-15h; under the protection of inert gas, the solid product is calcined, and then the calcined product is pickled; the calcination conditions include: the temperature rising rate is 3-10 DEG C / min, the temperature is 450-700 DEG C, and the time is 1-4h. The photocatalyst obtained by the method can catalyze the production of hydrogen peroxide and catalyze 1,5-dihydroxynaphthalene oxidation to produce juglone, and the yield of the product is higher.

The invention discloses juglone-amino-acid ester derivatives, a synthetic method thereof and application of the juglone-amino-acid ester derivatives in biological antibacterial agents, the synthetic method comprises the following steps: taking natural amino acid as a raw material, preparing a series of amino acid methyl esters through esterification and deacidification reaction, and then carrying out double-bond reaction on the amino acid methyl esters and 5-hydroxynaphthalene-1, 4-diketone (juglone) to obtain the juglone-amino-acid ester derivatives. And preparing different juglone-amino-acid ester derivatives. In addition, the invention also provides an application of the juglone-amino-acid ester derivative in an antibacterial agent, the juglone derivatives of valine methyl ester, leucine methyl ester and threonine methyl ester have certain antibacterial activity on escherichia coli and staphylococcus aureus, and the growth inhibition effect on the staphylococcus aureus is more prominent.

The present application belongs to the technical field of plant source pesticide, and relates to a preparation method of juglone solid pesticide and insecticidal activity of the same, in particular to a preparation method of juglone effervescent tablets and insecticidal activity of the same. The prescription composition of the juglone effervescent tablets is as follows in terms of mass percentage: 5-20% of juglone, 30-75% of effervescent agent, 5-25% of dispersing agent, 5-35% of inert carrier and 0-10% of lubricant. Compared with traditional chemical pesticides, the effervescent tablet of the present application belongs to 'green pesticide', has good chemical and physical stability, avoids decomposition of the original medicine, has no organic solvent and emulsifier compared with traditional pesticide dosage form, has good safety, small environmental pollution, is convenient to store, transport and use, has short disintegration and dispersion time, and has good insecticidal activity.