5 results about "Juglone" patented technology

The application discloses a nano-suspension preparation of juglone, which is mainly prepared from 5-15 parts of juglone and 1-20 parts of a stabilizer by weight. The application also adopts a reverse solvent method-high pressure homogenization method to establish a corresponding preparation method, which is simple in process and can obtain smaller drug particle size, thereby improving the drug bioavailability and enhancing the anti-tumor effect. Therefore, the application prepares a novel traditional Chinese medicine nano-preparation of juglone through the means of pharmacy, effectively improves the solubility and bioavailability of juglone. The in-vitro anti-tumor activity experimental results show that the nano-suspension preparation has significant inhibitory activity on the growth of various tumor cells, can be used for preparing drugs for preventing and treating related tumors, increases the targeting and bioavailability of the drug on tumors, reduces the toxicity, provides a new method and strategy for clinical treatment, and has good market prospect and high social value and economic value.

This invention belongs to the field of pharmaceutical technology, specifically relating to a naphthol glycoside compound, juglone-naphthol glycoside I, extracted and isolated from *Clerodendrum trichotomum*, its preparation method, and its application. The preparation method specifically includes the following steps: First, *Clerodendrum trichotomum* powder is extracted by heating and reflux with 70% ethanol. After filtration, 10% (w / v) CaCl2 powder is added to the extract, stirred thoroughly, and allowed to stand. The ethanol is recovered from the supernatant to obtain a concentrated extract. After water dispersion, the extract is extracted five times each with dichloromethane and n-butanol. The n-butanol layer is separated, and then subjected to reversed-phase silica gel column chromatography and recrystallization to obtain the target compound. The preparation method provided by this invention only requires salting out impurities, solvent extraction, reversed-phase column chromatography separation, and recrystallization, achieving efficient enrichment and separation of the target compound. The steps are simplified and easy to operate. Furthermore, the naphthol glycoside prepared by this invention has been shown in in vitro activity experiments to have good anti-ethanol-induced gastric ulcer damage, providing a valuable pharmacodynamic substance for the future development of novel anti-gastric ulcer drugs, with broad application prospects.

The invention relates to a new saccharomycetes, in particular to a pseudomonas putida RT12 strain and an application of the pseudomonas putida RT12 strain in degradation of juglone in walnut green seedcases. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on November 19, 2025, the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.36686. A strain of Pseudomonas putida RT12 is obtained through separation, screening and identification in Aksu Red-flag slope region in Xinjiang, and experiments on growth characteristics, physiology and biochemistry, ester production capability and tolerance of the strain verify that the strain has the activity of efficiently degrading juglone, which indicates that the Pseudomonas putida RT12 has a good application prospect, and can be used for preparing a high-efficiency degradation product of juglone. The method can be widely applied to the agricultural solid waste resource treatment industry.

The present application relates to the field of photocatalyst, discloses a carbon and nitrogen coated transition metal cluster photocatalyst and its preparation method and application, the method comprises the following steps: in the presence of organic solvent, mixing transition metal nitrate and diamino maleonitrile, then the mixture is hydrothermally reacted to obtain a solid product; the transition metal nitrate is selected from at least one of cobalt nitrate, iron nitate and copper nitrate; the molar ratio of transition metal nitrate and diamino maleonitrile is 1:1-3; the hydrothermal reaction conditions include: temperature is 120-140 DEG C, time is 8-15h; under the protection of inert gas, the solid product is calcined, and then the calcined product is pickled; the calcination conditions include: the temperature rising rate is 3-10 DEG C / min, the temperature is 450-700 DEG C, and the time is 1-4h. The photocatalyst obtained by the method can catalyze the production of hydrogen peroxide and catalyze 1,5-dihydroxynaphthalene oxidation to produce juglone, and the yield of the product is higher.

The present application belongs to the technical field of plant source pesticide, and relates to a preparation method of juglone solid pesticide and insecticidal activity of the same, in particular to a preparation method of juglone effervescent tablets and insecticidal activity of the same. The prescription composition of the juglone effervescent tablets is as follows in terms of mass percentage: 5-20% of juglone, 30-75% of effervescent agent, 5-25% of dispersing agent, 5-35% of inert carrier and 0-10% of lubricant. Compared with traditional chemical pesticides, the effervescent tablet of the present application belongs to 'green pesticide', has good chemical and physical stability, avoids decomposition of the original medicine, has no organic solvent and emulsifier compared with traditional pesticide dosage form, has good safety, small environmental pollution, is convenient to store, transport and use, has short disintegration and dispersion time, and has good insecticidal activity.