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Application of juglone for adjusting immune states of mice and oxidizing reactions

A technology of oxidation reaction and jugone quinone, applied in the field of pharmacodynamics research, can solve the problems of immune regulation and oxidation reaction, which are rarely studied.

Inactive Publication Date: 2012-12-19
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, although there are many studies on the anti-tumor activity of juglone, there are few studies on the immune regulation and oxidation reaction of different immune states in mice

Method used

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  • Application of juglone for adjusting immune states of mice and oxidizing reactions
  • Application of juglone for adjusting immune states of mice and oxidizing reactions
  • Application of juglone for adjusting immune states of mice and oxidizing reactions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1. Regulatory effect of juglone on the immune status of mice

[0009] 1.1 Experimental animals

[0010] KM mice, male, 4-6 weeks old, weighing 18-22 g, SPF grade. Provided by the Department of Laboratory Animal Science, Peking University Health Science Center, license number: SCXK (Beijing) 2006-0008. Adaptive feeding for 3 days before the experiment. The ambient temperature is controlled at 22-25°C, humidity > 60%, natural light (12 hours / day), free access to water, and feeding with standard pellet feed.

[0011] 1.2 Test materials

[0012] 1.2.1 Drugs and main reagents

[0013] 1) Drugs: juglone, provided by Beijing Bailingwei Technology Co., Ltd.; dexamethasone sodium phosphate injection, provided by Tianjin Jinyao Amino Acid Co., Ltd.; cyclophosphamide, provided by Jiangsu Hengrui Medicine Co., Ltd.

[0014] 2) Reagents: sheep red blood cells, provided by Guangzhou Ruite Biotechnology Co., Ltd.; glacial acetic acid, provided by Beijing Chemical Factory....

Embodiment 2

[0051] Example 2 Effect of juglone on the antioxidant capacity of mice

[0052] 2.1 Experimental animals

[0053] KM mice, male, 4-6 weeks old, weighing 18-22 g, SPF grade. Provided by the Department of Laboratory Animal Science, Peking University Health Science Center, license number: SCXK (Beijing) 2006-0008. Adaptive feeding for 3 days before the experiment. The ambient temperature is controlled at 22-25°C, humidity > 60%, natural light (12 hours / day), free access to water, and feeding with standard pellet feed.

[0054] 2.2 Test materials

[0055] 2.2.1 Drugs and main reagents

[0056] 1) Drugs: juglone, provided by Beijing Bailingwei Technology Co., Ltd.; dexamethasone sodium phosphate injection, provided by Tianjin Jinyao Amino Acid Co., Ltd.; cyclophosphamide, provided by Jiangsu Hengrui Medicine Co., Ltd.

[0057] 2) Reagents: sheep red blood cells, provided by Guangzhou Ruite Biotechnology Co., Ltd.; glacial acetic acid, provided by Beijing Chemical Factory.

[...

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PUM

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Abstract

The invention relates to the technical field of medicines, discovers an application of juglone for adjusting immune states of mice and oxidizing reactions, and mainly researches medicinal composition juglone. A chemical name of the juglone is 5-hydroxy-1,4-naphthoquinone and 5-hydroxy-1,4-naphthalene diketone. An English name of the juglone is Juglone, walnuts quinine, 5-hydroxy-1,4-naphthoquinone and 5-hydroxynaphthalene, regianin, Nucin. A molecular formula of the juglone is C10H6O3. A relative molecular weight is 174.15. An immunocompromised model is built through systematic pharmacological tests and by using KM mice and adopting dexamethasone sodium phosphate injecta, a mouse immunostimulation model is built by using sheep red blood cells (SRBC) to induce the mice to produce SRBC immune bodies and cyclophosphamide, a fact that the juglone can recover low immunologic functions to a normal level is proved, the immunostimulation states are improved, self stability of an organism is maintained, and both-way immunoregulation functions are displayed. The juglone displays functions of adjusting organism immune system functions by adjusting oxidative stress reactions in the organism.

Description

[0001] 【Field】 [0002] The invention relates to the use of juglone, a pharmacodynamic component, for regulating the immune state and oxidation reaction of mice, and belongs to the field of pharmacodynamic research. 【Background technique】 [0003] Juglans is a plant of Juglandaceae Juglans, which has high medicinal value. It tastes bitter, pungent, and cold in nature. Juglone belongs to naphthoquinone components, and exists in the root bark, bark, green fruit peel (Qinglongyi) and leaves of Jugland mandshurica Maxim and walnut (Juglans regia L). There are research reports at home and abroad that juglone has a wide range of pharmacological effects and has potential application value in medicine and agriculture. Juglone not only has anti-tumor effect, but also has biological activities such as anti-fungal, anti-chlamydia, anti-HIV virus, hypoglycemic and insecticidal, and has been paid more and more attention by people. Juglone can significantly increase the membrane fluidity ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P37/02A61P37/04A61P39/06
Inventor 李岩郭楠马晓科董继锐付振平赵剑璞夏雨
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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