6results about How to "Enhance cellular immunity" patented technology

The invention provides a varicella-zoster virus mRNA (messenger Ribonucleic Acid) vaccine and application thereof. The invention firstly provides an mRNA molecule, a coding region sequence of the mRNA molecule comprises a nucleotide sequence for coding an amino acid sequence as shown in SEQ ID NO: 1, and the coding region sequence preferably comprises a nucleotide sequence as shown in any one of SEQ ID NO: 2 to SEQ ID NO: 11, or a nucleotide sequence which has at least 93% similarity with the nucleotide sequence as shown in any one of SEQ ID NO: 2 to SEQ ID NO: 11 and codes the same amino acid sequence. When the mRNA molecule is used for preparing the vaccine, the production cost of the vaccine can be reduced, the physicochemical property of the vaccine is stable, the protein expression is improved to enhance the immune effect of the vaccine, and the humoral immunity and cellular immunity effects of the VZV-gE specificity are enhanced.

The invention relates to a mycobacterium tuberculosis vaccine, in particular, the vaccine comprises an immune composition, and the immune composition comprises an antigen component and a granular protein component. The granular protein component comprises nano-granular protein, and the antigen component and the granular protein component are covalently bound through a binding peptide 1 and a binding peptide 2 to form an immunogenic complex. The cell immunogenicity and the antibody immunogenicity of the vaccine are excellent. The invention also discloses a preparation method of the mycobacterium tuberculosis vaccine.

The invention belongs to the field of vaccines, and provides an adjuvant composition containing MF59 and CpG. The invention discloses a full-liquid preparation RSV vaccine containing the adjuvant composition. The vaccine contains RSV pre-F protein. The preparation method of the all-liquid preparation RSV vaccine comprises the operation of carrying out compatibility on the RSV pre-F protein and the adjuvant composition. According to the adjuvant composition and the full-liquid preparation RSV vaccine based on the adjuvant composition, the conformation of pre-F protein before fusion can be kept stable in a liquid dosage form, the preparation cost of the vaccine can be greatly reduced, and meanwhile the cellular immune effect and the humoral immune effect of the vaccine are improved.

The present invention provides a desensitized lactoglobulin peptide, which is prepared by placing lactoglobulin in an extremely strong magnetic field. The polypeptide provided by the present invention removes the allergenicity of lactoglobulin and has the ability to improve immunity. It has been verified by a mouse model that it can improve the cellular immunity and humoral immunity of mice, and can be used to prepare functional foods or medicines for improving immunity.

The invention belongs to the field of medicines, and particularly relates to a vaccine adjuvant and application thereof. And the adjuvant contains one or more of total saponins of Hylocereus undatus, a saponin component HA and a saponin component HB. The total saponin and the monomer saponin with immunologic adjuvant activity are separated from the Honeysuckle flower, and the total saponin and the monomer saponin can non-specifically change or enhance immune response reactions of various vaccines including influenza vaccines, so that not only can humoral immunity of influenza vaccine immunized mice be enhanced, but also cellular immunity of the influenza vaccine immunized mice can be enhanced.

This invention relates to the application of microalgae polysaccharides in enhancing intestinal immunity in dairy cows, belonging to the field of feed technology. The microalgae polysaccharides prepared by this invention are used to increase the secretion of IgA, IgG, and IgM by the intestinal mucosa. This invention uses a specific ratio of kelp buds, Dunaliella salina, and Haematococcus pluvialis for pre-enzymatic hydrolysis using trypsin and nattokinase for a certain period of time, followed by enzymatic hydrolysis using hemicellulase and pectinase for a certain period of time. The resulting microalgae polysaccharide product has excellent effects in promoting the secretion of immunoglobulins in the dairy cow intestine, significantly increasing the content of IgA, IgG, and IgM in the dairy cow intestine, thereby enhancing intestinal immunity. It can serve as a highly effective alternative component for improving the intestinal immune function of dairy cows.