615 results about "Immunopotency" patented technology

The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.

The invention relates to a biological fermentation composition with an anti-cancer effect. The biological fermentation composition is prepared by using a method comprising the following steps: a, preparing a culture medium mixed solution; b, sterilizing; c, cooling; d, inoculating to obtain a fermentation solution; and e, standing to obtain the biological fermentation composition with the anti-cancer effect. The composition disclosed by the invention can be used for improving the in-vivo micro-ecological environment, balancing and regulating effective microbial communities in intestinal canals, repairing damaged cells, replenishing various in-vivo active bio-enzymes, amino acids, nucleic acids, trace elements and the like, improving the immunity of a human body, preventing diseases, effectively inhibiting cancer cells and stopping the dispersion and development of the cancer cells. Meanwhile, the biological fermentation composition can be used for improving an acidic physique to be a weak alkaline physique, is particularly suitable for the cancer crowd, the crowd with hypertension, hyperlipidemia and hyperglycemia and the fat crowd, can be prepared into various dosage forms such as pills, paste, aqueous solutions and the like, and has favorable supportive therapeutic effects on cancer, diabetes, digestive system diseases and the like.

The invention discloses a safe compound feed of juvenile prawn of penaeus vannamei boone, which consists of bean pulp, pea albumen powder, fish powder, blood cell albumen powder, cuttlefish powder, shrimp shell powder, double-low rapeseed meal, cotton pulp, monocalcium phosphate, No. 1 flour, gluten powder, 50% choline chloride, complex vitamin for shrimp, microelement additive for shrimp, bacillus licheniformis, decorticating element, lower polyxylose, fermented peptide for aquatic product, gene recombinant protein growth promoter, nutrition immunology aquatic product food attractant, phospholipids oil and fish oil. With the gene recombinant protein growth promoter, the nutrition immunology aquatic product food attractant, and the high antibacterial peptide-containing fermented peptide, the safe compound feed can effectively restrain various enteropathogenic bacteria, improves the digestibility of the nutrition constituent of the feed, promotes the growth of the penaeus vannamei boone, can improve the organism immunity of the penaeus vannamei boone, and can obviously improve the survival rate of the penaeus vannamei boone.

The invention discloses a new class of propylene glycol derivatives represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing them, and their use as medicines, especially immunomodulatory medicines. This kind of compound with excellent curative effect and low toxicity can be used for immune disorder and immunosuppression; and can be used for treatment and/or low immunity, rejection after organ transplantation and autoimmune disease. General formula (I)

Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective immunity has waned comprise one or more purified immunogenic proteins from Mycobacterium tuberculosis from a group of 30 proteins that stimulate T cell immunity and interferon-γ secretion. A preferred protein is Ag85A, the secreted product (SEQ ID NO:31) of the Rv3084c gene. Also disclosed are methods for boosting immunity in such BCG-vaccinated subjects comprising administering an effective amount of the above vaccine composition.

The invention provides veterinary compound acanthopanax granules with immunopotentiation, which is prepared from the following Chinese medicament raw materials by weight percentage: 70 to 60 percent of acanthopanax and the balance of astragalus root, wherein 100 grams of granules contain 100 grams of crud drugs. The compound acanthopanax granules produced by the method have good stability and safety, are mainly applied to strengthening the immunological effect of a vaccine and strengthening the immunity of organisms and the anti-stress efficacy clinically, and is applied to treating various immunosuppressive diseases of chickens and other animals and birds, strengthening the immunological effect, and treating symptoms of hypoimmunity, inappetence and the like caused by transportations, groups changes, abrupt climate changes and the like.

The invention discloses a synbiotics composition having an immunity enhancing function. The synbiotics composition comprises prebiotics and probiotics with a weight ratio being 1-10:1-10. The invention also discloses a preparation of the synbiotics composition having the immunity enhancing function, and powder, tablets, a particulate agent and capsules prepared by pharmaceutically acceptable accessories are added in the synbiotics composition. The invention also discloses an application of the synbiotics composition in preparation of a drug or a health food for preventing/treating hypoimmunity. The synbiotics composition combines a plurality of probiotics and prebiotics according to a ratio, and is helpful for inhibiting harmful pathogen reproduction and recovering the pH value of intestinal tract, by simulating an immunization function in the intestinal tract, immunocompetence can be regulated to a normal state, ecological balance of the human body can be kept, so that function healthof human body can be effectively promoted, human body immunity can be enhanced, and pathogenic bacteria invasion can be prevented.

Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.

The present invention is one kind of feed additive for strengthening immunity and promoting growth. The feed additive is prepared with soybean residue, wheat bran, corn protein powder, corn starch, alcohol dreg, tropina powder, waste molasses and/or starch, and through inoculating probiotics seed and solid fermentation. It has total immune polysaccharide content not less of 0.3-1.0 %, immune energy matter content 0.3-1.0 %, lysine content not less than 4.0 %, amino nitrogen content 0.5-1.0 %, total nitrogen content not less than 10.0 %, and water not more than 12.0 %. The feed additive can raise the immunity of animal obviously, raise the speed of synthesizing protein, promote the growth of animal, appetize, promote the absorption of animal body on mineral elements, regulate physiological activity and improve nutritious condition.

The invention relates to the field of immunology, in particular to a method for amplifying and activating a natural killer (NK) cell into a lymphokine-activated killer (LAK) cell by using a CD8 alpha-interleukin 21-CD137 compound. The method disclosed by the invention comprises the following steps of: forming the CD8 alpha-interleukin 21-CD137 compound by using CD8 alpha, interleukin 21 and a CD137 functional polypeptide, making an exogenous expression vector enter a host K562 cell, then activating a promoter and culturing a cell to obtain a cell for expressing a transmembrane interleukin 21-CD137 compound; and purifying the compound in the conventional way, and amplifying and activating a lymphocyte by using the purified compound to generate the LAK cell. The method has the advantage that: the LAK cell cultured and amplified by using the transmembrane interleukin 21-CD137 compound and a small dose of interleukin 2 is used for enhancing the immunity of a patient to help the patient resist tumors, viruses and bacteria. The method has a wide clinical using prospect.

The invention discloses the little molecule biological activity peptide, which is from the mixture of soy protein, lactalbumin, egg and milk. The molecular weight of 90% of the little molecule biological activity peptide is less 5KDa. The invention also provides the preparing method. The invention also provides the composition of biological activity peptide, which comprises the said little molecule biological activity peptide and carriers of pharmacy and foodstuff. The little molecule biological activity peptide can improves the immunity, promote wound healing and enhance health.

The invention provides an application of lactobacillus rhamnosus in regulating immunity. The lactobacillus rhamnosus is preserved in China General Microbiological Culture Collection Center on August 10, 2017, has the preservation number of CGMCC No.14511, and is classified and named as lactobacillus rhamnosus. The lactobacillus rhamnosus has good immunoregulatory effect on a body, has the inhibiting effect on the expression of inflammatory factors, the promotion effect on the anti-inflammatory factors and the promotion effect on lymphocyte proliferation significantly better than those of conventional commercial lactobacillus rhamnosus strains, and has immunoregulatory function on the body significantly better than that of the conventional lactobacillus rhamnosus strains.

The invention discloses a rabbit triple inactivated vaccine, a preparation method and the application thereof; the rabbit triple inactivated vaccine is formed mainly by rabbit hemorrhagic disease virus liquid which is inactivated and detoxified, rabbit pasteurella multocida liquid and rapid A type clostridium perfringens liquid which have 1:1:2 volume ratio; in the invention, by optimizing culture technology, concentration technology and immunizing dose and other measures, the rabbit triple inactivated vaccine which has good immunity effect and safety is obtained and can effectively control the rabbit hemorrhagic disease, the pasteurella multocida disease and the pasteurella multocida disease (A type) and reduce vaccine injection times of farmers, so as to reduce the stress reaction of animals and improve the production performance. The clinical application proves that the immunization effect of the rabbit triple inactivated vaccine is ideal, each rabbit is vaccinated with 2ml and has immunity after 5-7 days, the immune period is at least 180 days, and the immune safety is good without toxic and side effect.

The invention belongs to the field of tumor biotherapy, and relates to a preparation method and an application of a NK cells-cytokines mixture prepared by using an activation method for NK cells. NK cells obtained according to the invention are tumor-killing cells which are cultured in vitro, activated and amplified and has a cytotoxic effect, and can directly kill tumor cells and enhance immunity after being fed back to the bodies of patients; NK cell culture supernatant prepared according to the invention and freeze-dried powder preparations prepared by freeze-drying and concentrating the NK cell culture supernatant contain a series of natural cytokine mixtures with bioactivity, and the mixture of natural cytokines has good antitumor activity in anti-tumor treatment.

The invention relates to the field of proteins and specifically relates to a milk-derived bioactive polypeptide with in-vitro antioxidant activity and capability of enhancing immunity. The amino acid sequence is Gln-Glu-Pro-Val. In-vitro anti-oxidation experiments and in-vitro immune function promotion experiments verify that the polypeptide QEPV has better antioxidant bioactivity and activity of promoting cellular immunity; on the one hand, free radicals in an organism can be cleared, and the harm of the free radicals to a human body can be reduced; and on the other hand, the bioactive polypeptide QEPV can enhance the immunity, enhance the multiplication capacity of lymphocytes and macrophages, increase the induction quantity of nitrogen oxide from the macrophages, promote the secretion of cell factors by the macrophages, improve the capability of resisting external pathogen infection of the organism, reduce the disease incidence of the organism and realize the great significance for developing milk products, health care products and medicaments with anti-oxidation function and immunity-enhancing function.