53 results about "Macrophage proliferation" patented technology

Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.

Methods for modulating macrophage proliferation in an individual afflicted with or at risk for an ocular disease such as ARMD are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including ARMD. The invention also provides methods for aiding diagnosis and monitoring therapy of an ocular disease such as ARMD.

The invention relates to an organism modified preparation method for improving the activity of lily polysaccharides, belonging to the field of agricultural-product functional ingredient preparation technologies. Lily polysaccharides (403.3kDa) are subjected to organism modification (namely enzyme-method controllable degradation) by adopting a compound enzyme (beta-mannanase and beta-glucanase) method. After the modification, the lily polysaccharides are subjected to separation and purification, and the molecular weight of product lily polysaccharides is 8.0-70.0kDa. The in-vitro immunoregulation activity of the lily polysaccharides and modified products of the lily polysaccharides is subjected to model research by adopting in-vitro macrophages RAW264.7. The activity of the modified lily polysaccharides is improved remarkably, and the macrophage proliferation activity is increased by 40.5-77.2% compared with a substrate. The activity of the lily polysaccharides is relatively low no matter the molecular weight of the lily polysaccharides is too high or too low. The method for improving the immunocompetence of the lily polysaccharides is created, and the biologically modified lily polysaccharides have great application values in the fields of medicines and functional foods.

The invention discloses a polysaccharide SM‑0.2M, which is separated from raspberry polysaccharides, and its specific sugar chain structure is identified. It is verified by experiments that the polysaccharide SM‑0.2M can promote the proliferation of macrophages, and can promote macrophages The cells release NO, up-regulate the expression of TNF-α and IL-6, and then enhance the phagocytosis of macrophages, improve immunity, and help macrophages play an anti-tumor effect, which can be used to prepare related products, and to further prove The structure-activity relationship of raspberry polysaccharides and the development of polysaccharide antitumor drugs and immune adjuvants provide reference.

The invention discloses a Mycoplasma bovis Mbov_0475 gene mutant strain, which belongs to the technical field of prevention and treatment of animal infectious diseases. The mutant strain is named as Mycoplasma bovis (Mycoplasma bovis) T9.55, and is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2020082, the nucleotide sequence of the Mbov_0475 gene is shown in SEQ ID NO: 1. The strain can induce the proliferation of macrophages and improve the viability of macrophages. Since bovine macrophages are important immune cells for the host to resist pathogenic infection, the mutant strain is expected to play an important role in the field of immune prevention and treatment of Mycoplasma bovis.