18 results about "AIDS disorders" patented technology

The invention discloses an AIDS treatment compliance intelligent image monitoring and intervention system and method, and belongs to the technical field of artificial intelligence and image processing, and the system comprises an image collection module, an image preprocessing module, a feature extraction module, an image sequence modeling module, a compliance evaluation module, a reminding strategy module and a notification execution module. The core innovation of the system lies in the image sequence modeling module, the module maps continuously collected medicine images to Riemannian manifold to form a medicine taking behavior track, accurate judgment of the medicine taking behavior is achieved through geodesic distance calculation and curvature tensor analysis, and the system particularly has outstanding advantages in the aspect of identifying false medicine taking behaviors, and has good application prospects. The medicine taking behavior recognition accuracy is improved to 93.1%, the false medicine taking behavior detection rate reaches 95.4%, and clinical application proves that the treatment compliance of AIDS patients can be improved to 91.6% from 72.3% by using the system, the treatment effect is remarkably improved, and the development of drug resistance is reduced.

Provided are an inhibitor containing a bicyclic derivative, a preparation method therefor and the use thereof. In particular, involved are a compound shown by general formula (I), a preparation method therefor, a pharmaceutical composition thereof, and the use thereof as an RET inhibitor in the treatment of cancers, inflammations, chronic liver diseases, diabetes, cardiovascular diseases, AIDS, and other related diseases, wherein each substituent in general formula (I) has the same definition as that given in the description.

The invention provides a synthesis method of an anti-AIDS drug, and belongs to the technical field of drug preparation, the synthesis method comprises the following steps: (1) reacting an SM1 compound with a Grignard reagent, and then reacting with an SM2 compound to obtain a compound shown in a formula III; (2) performing oxidation reaction on the compound in the formula III to obtain a compound in a formula II; (3) performing demethylation reaction on the compound in the formula II under the action of a demethylation reagent to obtain a compound in a formula I; (4) carrying out ethylation reaction on the compound shown in the formula I to obtain enovirin; the synthesis route effectively avoids the use of a highly toxic cyaniding reagent and an expensive heavy metal catalyst, and meanwhile, the route is simple and mild in reaction condition and high in yield, and has an extremely good industrial prospect.

Subject matter of the present invention is an angiotensin-receptor-agonist and / or a precursor thereof for use in the treatment of a disease in a subject, • wherein said disease is selected from the group comprising heart failure, chronic heart failure, acute heart failure (AHF), myocardial infarction (MI), stroke, liver failure, burn injuries, traumatic injuries, severe infection (microbial, viral (e.g. AIDS), parasitic diseases (e.g. Malaria)), SIRS or sepsis, cancer, acute kidney injury (AKI), CNS disorders (e.g. seizures, neurodegenerative diseases), autoimmune diseases, vascular diseases, hypotension and shock, and • wherein said subject has an amount of DPP3 protein and / or DPP3 activity in a sample of bodily fluid that is above a predetermined threshold.

The invention relates to an exemption treatment system for an AIDS patient, and the system comprises a patient information input module which is used for inputting basic information of the patient; the patient evaluation module is used for evaluating psychological, physical and social indexes of the patient according to the input information; the providing and processing module for formulating or adjusting a patient treatment scheme is connected with the patient evaluation module; and the AIDS patient intervention rehabilitation processing module is connected with the processing module for formulating or adjusting the patient psychological treatment scheme. The invention further relates to a corresponding method and device, a processor and a storage medium thereof. By adopting the system, the method and the device for the exemption treatment system evaluation and rehabilitation management for the AIDS patient, the processor and the storage medium thereof, an individualized, intelligent and convenient psychological treatment scheme is formulated and provided for the AIDS patient; therefore, psychological-physiological-social rehabilitation of AIDS patients can be realized to the greatest extent.

Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.

Described herein are methods, compositions, products, and processes that utilize bioceramics in traditional agricultural and hydroponic systems. The bioceramics are utilized in powder form, as films, as aerosols, as water based treatment systems, or in solid forms. The methods and bioceramic compositions described here are also used for growing a Cannabis plant. One or more cannabinoids within the plant can be used in therapeutic compositions for the treatment of glaucoma, AIDS wasting syndrome, neuropathic pain, cancer, multiple sclerosis, chemotherapy-induced nausea, and certain seizure disorders.

The utility model relates to the field of medical protection, and discloses an AIDS prevention and treatment blood sampling detection device which comprises a supporting plate for supporting, the top end of the supporting plate is fixedly connected with a blocking frame body, the left side of the blocking frame body is fixedly connected with a blocking curtain, the two sides of the interior of the blocking curtain are both fixedly connected with soft rubber rings, and the soft rubber rings are fixedly connected with the supporting plate. A patient hand probing notch is formed in the middle of the right side of the blocking frame body, a supporting frame is fixedly connected to the interior of the notch in the top end of the blocking frame body, and a blocking plate is installed in the notch in the top end of the blocking frame body and used for blocking blood. According to the blood sampling device, a doctor observes the interior of the blocking frame body through the observation transparent plate, so that blood sampling is carried out, harm caused by blood splashing is avoided, self protection of medical staff is improved, the downward pressing rubber mat and the installation rubber sleeve interact, a detection test tube is fixed, the installation stability of the test tube is improved, and the safety of the test tube in the transportation process is guaranteed.

The invention discloses a dynamic nursing scheme generation method and system oriented to AIDS disease course evolution, and belongs to the technical field of public health. The AIDS patient disease course characteristic data is classified and analyzed, key information is accurately extracted, the nonlinear mapping model is constructed by means of the recurrent neural network, the influence of each characteristic on disease course evolution is quantified, the individual difference of the patient is comprehensively and accurately reflected, a data basis is provided for disease course stage division, nursing strategy making and scheme generation, and the accuracy and the reliability of the system are improved. In the whole process from disease course stage division to nursing scheme adjustment, a dynamic monitoring and feedback mechanism is introduced, disease course stages are scientifically divided according to multi-dimensional information, a specific nursing strategy is formulated for each stage and continuously optimized, and meanwhile, based on patient data collected in real time, the nursing intervention is accurately matched with the disease condition development requirement of a patient. The disease course change is evaluated in time through the correlation model, the nursing scheme is dynamically adjusted, and the nursing service can respond to the dynamic evolution of the condition of the patient in real time.

The present invention provides for compounds of formula (I)wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

The invention provides a traditional Chinese medicine composition for treating spleen-kidney yang deficiency type acquired immune deficiency syndrome related diarrhea and application, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises the following components in parts by mass: 10-20 parts of common fenugreek seed, 4-8 parts of baked ginger, 5-15 parts of codonopsis pilosula, 4-8 parts of divaricate saposhnikovia root, 2-8 parts of elecampane, 2-6 parts of coptis chinensis, 4-8 parts of roasted rhizoma atractylodis macrocephalae, 2-8 parts of raw liquorice, 5-15 parts of nutmeg, 10-20 parts of salted semen plantaginis, 5-15 parts of scorched hawthorn fruit, 2-8 parts of honey-fried liquorice and 10-20 parts of dandelion. According to the traditional Chinese medicine composition, the content of inflammatory factors in intestinal flora and serum is adjusted, and the symptoms of spleen-kidney yang deficiency type AIDS related diarrhea patients can be remarkably improved.

The utility model relates to the technical field of AIDS (acquired immune deficiency syndrome) detection, in particular to an AIDS detection test paper storage box, which is provided with an accommodating mechanism which is supported upwards and is convenient to draw out in a single layer, and is more efficient in use and higher in practicability. Comprising an AIDS test paper containing box, a twisting outlet, a paper outlet, a first hinge, a box cover, a sliding sleeve, a sliding rod, a spring, a pulling piece and a pressing plate, the twisting outlet is formed in the rear side of the top end of the AIDS test paper containing box, the paper outlet is formed in the upper portion of the front side of the AIDS test paper containing box, and the right side of the AIDS test paper containing box is open. The rear end of the rear side of the AIDS test paper containing box is movably connected with the rear side end of the box cover through a first hinge, a locking mechanism is further arranged between the AIDS test paper containing box and the box cover, the bottom end of the sliding rod is connected with the middle of the top end of the pulling piece, and the outer side of the top end of the pulling piece and the outer side of a sliding sleeve at the bottom end of the AIDS test paper containing box are connected with springs. The top end of the sliding rod is connected with the middle of the bottom end of a pressing plate, and the pressing plate is movably arranged in the AIDS test paper containing box.

The present invention relates to methods for evaluating and / or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and / or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and / or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and / or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

The invention relates to the technical field of computers, discloses an internet-of-things-driven AIDS patient remote follow-up monitoring method and system, and aims to solve the problems that in the prior art, multi-source data fusion is insufficient, risk prediction precision is low, a model lacks self-adaptive ability, and intervention is disjointed from clinic. The method comprises the following steps: collecting physiological, medication and environmental data in real time through an Internet of Things terminal; cleaning, alignment and feature extraction are carried out through an edge gateway; the method comprises the following steps: fusing an electronic medical record at a cloud end, performing dynamic modeling by utilizing a hybrid model of a time sequence convolutional network and a long-short-term memory network, and generating an individualized health risk score through a cross-modal attention mechanism; and matching the three-level intervention rule base based on the score, and dynamically pushing follow-up or medical instructions. According to the technical scheme, high-precision risk early warning, minute-level continuous monitoring, low-delay response and personalized closed-loop intervention can be achieved, and the follow-up compliance rate and the clinical intervention efficiency are remarkably improved.

The present application relates to a kind of determination methods of the concentration of conazepam in blood plasma, belong to the technical field of drug concentration analysis.The determination method uses the way of adding internal standard working solution to the blood plasma sample to be measured to process clinical sample, the concentration of conazepam in blood plasma is determined using ultra-high performance liquid chromatography-tandem mass spectrometry, the clinical specific population including AIDS patients, chronic hepatitis patients and liver transplant patients.The determination method of the concentration of conazepam in blood plasma provided by the present application combines the diagnosis and treatment needs of clinical therapeutic drug monitoring, systematically completes the method linear range, sample stability verification, and special plasma matrix effect of chronic hepatitis, AIDS, liver transplant patients is investigated, significantly improves the detection accuracy and clinical adaptability, can accurately support the individualized dosing of conazepam and therapeutic drug monitoring, and the clinical popularization value is excellent.

The application provides a traditional Chinese medicine composition for treating AIDS combined with pneumocystis pneumonia, and belongs to the technical field of traditional Chinese medicines.The traditional Chinese medicine composition is prepared from the following raw medicinal materials in a proportion by weight: lily 10-16 parts, raw rehmannia 5-12 parts, prepared rehmannia 5-12 parts, ophiopogon 5-12 parts, licorice 2-6 parts, fried white peony root 2-6 parts, scrophularia 5-12 parts, platycodon 2-6 parts, angelica 5-12 parts, radix pseudostellariae 10-16 parts, astragalus 10-16 parts, and atractylodes 10-16 parts.It has been verified that the traditional Chinese medicine composition can obviously improve the effective treatment rate; when treating patients with AIDS combined with pneumocystis pneumonia, in addition to the conventional application of compound sulfamethoxazole (SMZ-TMP) and / or combined with lily solid gold soup oral treatment, the application of SMZ-TMP combined with the traditional Chinese medicine composition can effectively improve the symptoms, chest CT performance and other conditions of the patients, and can shorten the time of the uncomfortable symptoms of the patients.