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Polysaccharide SM-0.4M and anti-tumor product prepared from polysaccharide SM-0.4M

A technology of polysaccharides and products, which is applied in the field of polysaccharide SM-0.4M in raspberry polysaccharides and its preparation, can solve problems that have not been studied in depth, and achieve the effects of enhancing phagocytosis, promoting proliferation, and improving immunity

Active Publication Date: 2021-03-23
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, no in-depth research has been done on the specific components of raspberry polysaccharides. If the sugar chain structures of different components in raspberry polysaccharides can be clarified, it will be of great significance to the development of anti-tumor drugs and immune adjuvants of polysaccharides

Method used

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  • Polysaccharide SM-0.4M and anti-tumor product prepared from polysaccharide SM-0.4M
  • Polysaccharide SM-0.4M and anti-tumor product prepared from polysaccharide SM-0.4M
  • Polysaccharide SM-0.4M and anti-tumor product prepared from polysaccharide SM-0.4M

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Experimental program
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Embodiment 1

[0053] 1. Extraction of Raspberry Crude Polysaccharide

[0054] Dried raspberry frozen fruit, crushed and removed seeds, added 1-10 times of petroleum ether (boiling range 60-90°C) to degrease, added 85% ethanol at 50-70°C to reflux to remove monosaccharides and pigments, and Add 5-30 times of pure water to the filtered residue for ultrasonic extraction (power 50-70W, temperature: 50-90°C, processing time: 60min-100min), centrifuge to get the supernatant, extract the filter residue twice according to the original conditions, and combine the filtrate , concentrated under reduced pressure to 1 / 4 of the original volume, added 3 to 5 times the volume of 95% ethanol, stood at 4 degrees Celsius for 24 hours, filtered to collect the filter residue, and freeze-dried to obtain the raspberry crude polysaccharide.

[0055] 2. Separation and purification of raspberry homogeneous polysaccharide fraction

[0056] The DEAE Sepharose Fast Flow filler is used for polar separation of polysacch...

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Abstract

The invention discloses a polysaccharide SM-0.4M which is separated from raspberry polysaccharide. A specific sugar chain structure is identified, and tests prove that the polysaccharide SM-0.4M can promote macrophage proliferation, promote macrophage to release NO and up-regulate expression of TNF-alpha and IL-6, thereby enhancing phagocytic action of macrophage and improving immunity. The anti-tumor effect by themacrophages is facilitated, related products can be prepared, and reference is provided for further exploring the structure-activity relationship of the raspberry polysaccharide anddeveloping polysaccharide anti-tumor drugs and immunologic adjuvants.

Description

technical field [0001] The invention belongs to the technical field of natural products, and in particular relates to polysaccharide SM-0.4M in raspberry polysaccharide and its preparation method and application. Background technique [0002] Plant polysaccharides, also known as plant polysaccharides, are polysaccharides with a degree of polymerization of more than 10 produced by plant cell metabolism. Important biological macromolecules in living organisms are one of the basic substances to maintain the normal operation of life activities. [0003] At the same time, plant polysaccharides are recognized as natural macromolecules with various biological activities, and most plant polysaccharides have significant immunomodulatory and antitumor activities in vivo. They can not only directly affect the functions of various immune cells such as macrophages, T lymphocytes, B lymphocytes, and natural killer cells, but also regulate the production of related cytokines and complemen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K39/39A61P37/04A61K31/715A61P35/00
CPCA61K31/715A61K39/39A61K2039/55583A61P35/00A61P37/04C08B37/0003C08B37/006
Inventor 杨永晶田文慧尹星星王学红魏涛
Owner QINGHAI UNIVERSITY
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