584 results about "Infectious Disorder" patented technology

The invention relates to a respiratory infectious disease transmission risk assessment method based on a multi-person dynamic scene. The method sequentially comprises the steps of building models of a risk assessment object and a research area, setting analysis parameters according to infection source characteristics, setting crowd movement parameters, carrying out numerical simulation aiming at diffusion of infectious substances, calculating a personnel exposure level and carrying out infectious disease infection risk comprehensive assessment. Building models of the risk assessment object and the research area, to be specific, building a calculation area of a multi-person dynamic scene where the respiratory infectious disease occurs, and performing calculation grid division on the area to build a calculation model; analysis parameters are set according to characteristics of infection sources, release characteristics of the infection substances from different areas of the respiratory system of a patient are considered, different infection source types and exhalation characteristics are set according to different scenes, then the process of exhalation of the infection substances and aerodynamic characteristics of the process are simulated, and a result with universality is constructed to serve as an input module.

The present disclosure is directed to compounds of Formula (I):which modulate PD-1 / PD-L1 protein / protein interaction, compositions, and methods of treating various diseases, including infectious diseases and cancer.

The invention discloses a preparation method of a protein halo-coated silicon-coated gold nanorod and a PCR amplification method and kit based on the protein halo-coated silicon-coated gold nanorod, and belongs to the technical field of PCR detection. The photo-thermal nano material is composed of an AuNR coated SiO2 core-shell structure and an external protein halo layer, the protein halo layer avoids inhibition of AuNR on a PCR reaction system, meanwhile, adsorption of AuNR on biological small molecules is effectively reduced, non-specific amplification is reduced, and normal amplification of PCR reaction is guaranteed; and the protein halo layer is used as a thermal insulation layer to optimize heat exchange and maintain the temperature uniformity of the reaction liquid. When the kit is applied to a photo-thermal PCR detection reagent, DNA of a pathogen to be detected can be efficiently and stably amplified and detected within 10 minutes, the kit has huge application potential in the fields of early screening of infectious diseases, food safety detection and the like, collaborative optimization of photo-thermal conversion efficiency, biocompatibility, detection sensitivity and operation convenience is achieved, and the kit has a wide application prospect. And an efficient solution is provided for prevention and control of infectious diseases, food safety monitoring and biomedical research.

The invention discloses a respiratory infectious disease multi-pathogen nucleic acid detection kit based on a fluorescent PCR detection technology and application of the respiratory infectious disease multi-pathogen nucleic acid detection kit. The invention provides two detection kits aiming at 20 and 6 respiratory tract detection, the two kits can specifically detect respiratory tract pathogens, the detection sensitivity is high, the whole detection system is short in time consumption and simple and convenient in use process, and detection results of 20 pathogenic microorganisms can be reported within 40 min at the shortest; the whole set of detection kit and the detection method are high in sensitivity and good in specificity; the normal-temperature storage and transportation of the reagent can be realized.

The invention relates to the field of pathogen detection, in particular to a primer probe group, a gene chip and a kit for detecting seven waterfowl infectious disease pathogens and application. The primer probe group provided by the invention can be used for simultaneously detecting the goose parvovirus, the duck viral enteritis virus, the muscovy duck parvovirus, the duck hepatitis A virus type 1, the duck hepatitis A virus type 3, the duck tembusu virus and the novel duck reovirus, and is strong in specificity and high in sensitivity. Furthermore, a gene chip prepared by using the primer probe group provided by the invention not only has strong specificity and high sensitivity (1.0 * 100 copies / [mu] L), but also has good repeatability and stability, can be stably stored within at least 180 days, has sensitivity superior to that of a standard fluorescent quantitative PCR method, can rapidly and efficiently detect main epidemic disease pathogens of waterfowl together, and has good application prospects. The method can be used for epidemiological investigation and disease diagnosis of waterfowls.

The invention relates to the technical field of nucleic acid on-site rapid visual detection, in particular to a one-pot rapid nucleic acid detection system based on an SfaTnpB combined isothermal amplification technology and application of the one-pot rapid nucleic acid detection system. According to the invention, an RAA isothermal amplification technology and an LAMP isothermal amplification technology are respectively combined with SfaTnpB nuclease, and finally, an RAA-SfaTnpB one-pot method system and an LAMP-SfaTnpB one-pot method system are successfully established. The one-pot system established by the invention has the advantages of high sensitivity, high specificity, fast reaction, strong accuracy and no need of complex equipment, the detection result can be visually interpreted by naked eyes, the system has high convenience and practicability, the adaptability and practicability of the system are further improved, and the rapid detection requirements in various scenes can be flexibly met. The system has a wide application prospect in the fields of rapid pathogen detection, genotype detection, early diagnosis of infectious diseases and the like.

The invention provides a solid-phase agglutination detection test paper card and a detection method thereof. A reaction area of the solid-phase agglutination detection test paper card comprises a reaction film, the reaction film is coated with captured protein and can enrich to-be-detected antibodies in a to-be-detected sample, and the captured protein is combined with the to-be-detected antibodies and then subjected to agglutination reaction with granular antigens in a detection reagent to form an agglutination compound. And the agglutination compound is intercepted in the reaction film for color development. The granular antigen is a cell carrying a specific antigen or a conjugate formed by coupling the specific antigen and an inert carrier, and the granular antigen can be colored or has a luminescence property in various modes. The solid-phase agglutination detection test paper card provided by the invention has the advantages of simple detection steps, short detection time, high sensitivity, accurate detection result, strong specificity and the like, can be used for detecting various diseases and monitoring antibody level, and also has important significance in the fields of infectious disease prevention and control, medical diagnosis and the like.

Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and / or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and / or adaptive immune response), and are useful in treating and / or preventing a disease, as adjuvants in a vaccine for the disease. (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

An infectious disease infection prediction method and device based on macrograph-micrograph fusion, and a storage medium. The method comprises: acquiring macrographs of a plurality of first areas and micrographs of second areas in a certain set time period; respectively inputting the macrographs and the micrographs into a first graph convolutional neural network and a second graph convolutional neural network to respectively obtain a first hidden layer vector and a second hidden layer vector, and fusing the first hidden layer vector and the second hidden layer vector to obtain fused hidden layer information of each first area; performing temporal calculation on the fused hidden layer information to obtain temporal hidden layer information of each first area, and separately inputting the temporal hidden layer information into two prediction networks to obtain two prediction results; and performing fusion calculation on the two prediction results to obtain a final infectious disease prediction result for each first area.

The present invention relates to the protein for treatment of infectious disease caused by Coronaviridae. In particular, the invention relates to a recombinant Sclerotium rolfsii lectin for use in the treatment, reduction in progression and curing of SARS-COV2 disease in a subject in need thereof. Pharmaceutical compositions comprising said recombinant Sclerotium rolfsii lectin are also described. The recombinant Sclerotium rolfsii lectin protein may comprise an amino acid sequence having at least 70% homology to SEQ ID NO: 1.

The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

The present disclosure relates to compositions and methods, including Trim / inhibitors that find use in the treatment of disease, such as therapies for cancer, including cancers that are resistant to anti-checkpoint agents, infectious diseases and inflammatory diseases.

The invention provides a bacillus thuringiensis strain, a fermentation culture method and application of the bacillus thuringiensis strain. The strain is preserved in the China Center for Type Culture Collection on September 28, 2011, the preservation address is No. 299 on eight road, Wuchang District, Wuhan City, Hubei Province, the preservation number is CCTCC No: M 2011334, and the preservation date is September 28, 2011. The strain cultured by the fermentation method has efficient, specific and stable insecticidal activity on culex, aedes and other mosquitoes, has the advantages of low preparation cost, environmental friendliness and the like, can be developed into a biological insecticide for preventing and killing mosquitoes and preventing and controlling malaria, dengue fever, chikungunya and other mosquito-borne infectious diseases, and meets the requirements of green and safe prevention and control in China.

Provided herein are compounds, crystalline forms, and pharmaceutical compositions of Compound 1 and / or Compound 2. Also provided are methods of treating a disease or disorder such as a cancer or infectious disease that comprises administering to a subject in need thereof one or more of the compounds or compositions of the present disclosure.

The present invention relates to a WKYMVm peptide analog comprising an amino acid sequence of Trp (W)-Lys (K)-Tyr (Y)-Met (M)-Val (V)-D-Met (m), in which at least one amino acid residue selected from the group consisting of Lys (K), Tyr (Y), and Met (M) in the amino acid sequence is substituted with a β3-amino acid residue or a peptoid residue, and a use thereof. The WKYMVm peptide analogs of the present invention has effects of increasing stability by increasing in vivo degradation half-life and of promoting activation of innate immune responses by neutrophils through activation of formyl peptide receptors, and thus can be effectively used in preventing or treating a disease that is be prevented or treated by formyl peptide receptors, especially an infectious disease or inflammatory disease.

The invention provides a solid-phase agglutination detection test paper card directly marked by antigens and a detection method thereof. A reaction area of the solid-phase agglutination detection test paper card comprises a reaction film, the reaction film is coated with captured protein and can enrich to-be-detected antibodies in a to-be-detected sample, and the captured protein is combined with the to-be-detected antibodies and then subjected to agglutination reaction with granular antigens in a detection reagent to form an agglutination compound. And the agglutination compound is intercepted in the reaction film for color development. The granular antigen is a conjugate formed by coupling a specific antigen and an inert carrier, the specific antigen is not a protein, and the specific antigen is specifically combined with an antibody to be detected. The solid-phase agglutination detection test paper card provided by the invention has the advantages of simple detection steps, short detection time, high sensitivity, accurate detection result, strong specificity and the like, can be used for detecting various diseases and monitoring antibody level, and also has important significance in the fields of infectious disease prevention and control, medical diagnosis and the like.

The invention provides detection test paper and a detection kit for detecting an IgG / IgM antibody. The detection test paper comprises a marking pad, a sample pad, a detection pad and a water absorption pad which are adhered to a bottom card and are sequentially overlapped from upstream to downstream, the detection pad is coated with an IgG detection line and an IgM detection line, and the IgG detection line is located at the upstream of the IgM detection line; during detection, the sample reaches the detection line of the detection pad before the marker. The detection test paper is simple in structure, convenient to use, high in anti-interference capacity and high in detection sensitivity, and the detection kit can improve the accuracy, early diagnosis and early treatment of early diagnosis of diseases such as infectious diseases, so that transmission of the infectious diseases is reduced.

The invention relates to the technical field of infectious disease detection, and discloses a new respiratory infectious disease early warning method, which comprises the following steps: S1, specimen collection and data collection: collecting biological samples of new respiratory infectious disease virus infected individuals and other respiratory infectious disease virus infected individuals, the biological sample comprises a blood sample and a swab sample; meanwhile, basic information of the individuals is collected, wherein the basic information comprises gender, age and respiratory symptom duration; s2, quantitative detection: the biological sample is subjected to quantitative detection by adopting reagents of various respiratory infectious disease viruses, the detection content comprises antigens and antibodies, and the antibodies comprise an I gM antibody, an I gG antibody and an I gA antibody; according to the invention, basic information of individuals and antigen-antibody detection reagent resources of various respiratory infectious disease viruses are deeply integrated, so that the recognition capability of new respiratory infectious disease virus infected individuals is effectively improved.

The invention discloses a rapid detection and intelligent early warning system for port concerned infectious diseases, and relates to the field of customs quarantine, and the system comprises a target selection unit, a construction unit, a modification unit, an amplification unit, a purification unit, a determination unit and a detection unit. According to the invention, through systematic improvement in the aspects of multi-primer design and modification, amplification system optimization, product purification, multi-dimensional scoring decision and the like, many defects in the aspects of multi-pathogen detection, dimer interference suppression, detection efficiency and sensitivity improvement in the prior art are overcome; rapid, efficient and intelligent screening and real-time early warning of port concerned infectious diseases are realized.

Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

The invention belongs to the field of poultry infectious diseases, and particularly relates to a riemerella anatipestifer phage mutant strain and a method for quickly mutating riemerella anatipestifer phage. Escherichia coli bacteriophage, riemerella anatipestifer bacteriophage and corresponding host bacteria are mixed, the infection complex number is made to be larger than 100, after culture, supernate is taken and then mixed with the host bacteria for culture, a bacteriophage mutant strain is separated from a secondary culture solution, the phage spectrum of the bacteriophage mutant strain is detected, and the mutant strain with the broadened phage spectrum is screened. At present, no report for widening the bacteriophage spectrum of the riemerella anatipestifer based on similar principles is found, and the research can fill the blank in the related research field.

A method for treatment or prophylaxis of a disease in a subject involving administering to the subject a vaccine composition including non-immunomodulating, engineered, plant-derived extracellular vesicles (EVs), is provided. The Evs are loaded with an exogenous nucleic acid molecule encoding a protein antigen. The disease is an infectious disease or cancer. A method for the preparation of the vaccine composition, which makes use of one or more polycationic substances and one or more sugar molecules is also provided.

The present invention relates to vaccines based on viral vectors for delivery of antigens against infectious diseases. In particular, the present invention relates to a recombinantly modified vaccinia virus Ankara (MVA) encoding EBV antigens that elicit infectious mononuclear hyperplasia (IM) and different cancer types. The invention also relates to medical application of the recombinant MVA in prevention of diseases caused by EBV (Epstein-Barr Virus).

T cell responses are exquisitely antigen-specific and directed against peptide epitopes displayed by human leukocyte antigen (HLA) on the surface of presenting cells. In particular, class II HLA (HLA-II) is remarkably polymorphic, which allows for presentation of diverse peptide antigens to T cells, but also forms the basis for genetic associations with diverse immunopathologies across the spectrum of infectious disease and autoimmunity. Here, Applicants employ monoallelic immunopeptidomics to retrieve over 200,000 unique peptides presented by 41 HLA-II heterodimers covering major alleles across diverse ancestries. Applicants leveraged this expansive dataset to develop computational models that predict peptide antigens based on HLA-II binding properties and infer informative features of the protein antigens from which these peptides derive. Combining both peptide and (contextual) protein features, Applicants develop Context Aware Predictor of T cell Antigens (CAPTAn) to discover novel T cell epitopes from prokaryotes in the human microbiome and the viral pandemic pathogen SARS-COV-2.

Antibody molecules that specifically bind to LAG-3 are disclosed. The anti-LAG-3 antibody molecules can be used to treat, prevent and / or diagnose cancerous or infectious disorders.

The present invention relates to specific binding molecules which bind to the HLA-E restricted peptide RLPAKAPLL (SEQ ID NO: 1) derived from Mycobacterium tuberculosis enoyl-ACP reductase. Said specific binding molecules may comprise CDR sequences embedded within a framework sequence. The CDRs and framework sequences may correspond to a T cell receptor (TCR) variable domain and may further comprise non-natural mutations relative to a native TCR variable domain. The specific binding molecules of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of infectious disease.

Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and / or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime / boost vaccination strategy.

The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of infectious diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.

Provided are novel antibodies and antigen-binding fragments thereof that bind interleukin-18 receptor beta (IL-18Rβ), along with conjugates thereof, nucleic acids encoding the same, compositions comprising the same, and methods of producing and using the same, including in the treatment of various diseases and conditions, such as inflammatory bowel disease, and other immune-mediated diseases, autoimmune diseases, inflammatory diseases, cancers, and infectious diseases.

The invention discloses a sheep infectious disease number zero individual tracing method and system based on a group interaction network, particularly relates to the technical field of agricultural informatization, and is used for solving the problem of number zero individual misjudgment caused by neglecting group dynamic behaviors in an existing static network model. The method comprises the following steps: dividing a continuous time window to construct a time sequence interaction network by acquiring dynamic contact data and high-risk medium use data of a sheep flock; virtual edges are added to individuals with the use interval smaller than the pathogen survival time of the same high-risk medium; calculating a node behavior mode mutation degree based on a medium using interval variance, and analyzing propagation fluctuation in combination with an input / output propagation flow ratio standard deviation; identifying nodes of which behavior mutation exceeds a threshold value, propagation fluctuation continuously exceeds the threshold value and output propagation flow suddenly drops as an abnormal propagation source; and extracting a first window associated sub-network, and judging the node which has the highest behavior mutation degree and uses a high-risk medium in the sub-network as a zero individual, thereby realizing accurate tracing of the sheep infectious disease source and providing a basis for accurate prevention and control of a farm.