25results about How to "Low affinity" patented technology

The invention belongs to the technical field of biomedical materials, and particularly relates to a carboxymethyl chitin composite material for an articular cavity and a preparation method of the carboxymethyl chitin composite material. The carboxymethyl chitin composite material for the articular cavity is prepared by selecting carboxymethyl chitin, hyaluronic acid, sodium alginate and chitosan which are good in biocompatibility as raw materials and performing functional modification treatment respectively, and through the synergistic effect of all the components, the elasticity modulus of the composite material is effectively improved, the swelling rate is reduced, and the joint cavity is more stable. And meanwhile, the composite material also has proper viscosity and degradation performance, and can meet application requirements.

The invention relates to a high-temperature resistant brazed die-casting aluminum alloy and a preparation method and application thereof. The alloy comprises Si: 0.05-0.8wt%; Fe: 0.8-3.0wt%; Ni: 0.005-1.5wt%; Mn: 0.3-1.5wt%; Mg: 0.005-2.50wt%; Zn: 0.005-3.0wt%; Cu: 0.005-1.0wt%; Ce: 0.005-0.20wt%; Cr: 0.01-0.5wt%; Ti: 0.01-0.25w%; B: 0.001wt%-0.1wt%; the sum of the weight percentages of other impurities is controlled to be less than 0.5wt%, and the remainder is Al; and the mass ratio P value of Fe to (Ni+Mn+Cr) is controlled to be 0.3-3:1. Compared with the prior art, the die-casting aluminum alloy prepared by the present invention has excellent die-casting property, high temperature resistance and brazing property.

This invention relates to the field of polymer materials technology, specifically disclosing a flame-retardant thermoplastic elastomer compound and its preparation method. The flame-retardant thermoplastic elastomer compound comprises 50-80 parts SEBS, 10-30 parts PP, 5-15 parts compatibilizer, 10-30 parts composite flame retardant, 3-10 parts plasticizer, 0.2-1 parts antioxidant, and 0.1-0.5 parts lubricant. The composite flame retardant is prepared by reacting and mixing an intumescent flame retardant, barium metaphosphate, boron nitride, triallyl isocyanurate, and SEBS. The flame-retardant thermoplastic elastomer compound of this application possesses good flame retardancy, mechanical properties, and water resistance stability.

The present invention provides a tight junction protein antibody H04 and its application, wherein the antibody H04 is a single-domain antibody, and the heavy chain variable region of the single-domain antibody includes CDR1, CDR2 and CDR3; the amino acid sequence of the CDR1 includes SEQ ID NO.1; the amino acid sequence of the CDR2 includes SEQ ID NO.2; and the amino acid sequence of the CDR3 includes SEQ ID NO.3. The tight junction protein antibody H04 obtained by the present invention has a higher affinity for CLDN6 and a lower affinity for CLDN9, that is, it has a higher specificity for CLDN6, and at the same time, the tumor killing effect of ADCC and CAR-T mediated by it is better, and the chimeric antigen receptor molecule constructed based on it can better mediate immune cell killing of tumors.

The present invention provides a special optoelectronic composite cable for use in extremely cold weather, belonging to the technical field of optoelectronic composite cable preparation; it comprises a cable core, a water-blocking layer, a cold-resistant reinforcement layer, and a cold-resistant sheath layer. The present invention effectively prevents moisture intrusion through the water-blocking layer, the cold-resistant reinforcement layer provides additional mechanical strength, and the cold-resistant sheath layer fully protects the internal structure of the optoelectronic composite cable. This multi-level and multi-functional structural design enables the optoelectronic composite cable in extremely cold weather to better meet the complex use requirements in extremely cold environments, and provides a reliable solution for communications and energy transmission in cold areas.

The present invention provides a polyamic acid film, a rod-shaped silver powder / polyimide composite film and a preparation method thereof, and relates to the field of antistatic materials. The preparation method first prepares a polyamic acid solution and a first silver powder, and then successively coats the first silver powder with vinyl triacetoxysilane and 12-hydroxystearic acid to obtain a second silver powder; finally, the second silver powder is added to the aforementioned polyamic acid solution, a film is formed by a casting method, and then heat-treated to obtain a polyamic acid film with processability. The film is treated in a vacuum environment of 280-300°C for 4-5h to obtain a rod-shaped silver powder / polyimide composite film, the bottom of the composite film is uniformly precipitated and enriched with rod-shaped silver powder, and the silver powders overlap each other to form a three-dimensional mesh conductive structure, so that the upper and lower surfaces of the film have different surface resistances, and the composite film can be applied to electrostatic dissipation or electrostatic conduction according to the surface resistance of the silver powder enriched surface.

The present invention discloses a tetrahydro(iso)quinoline or indoline derivative, a composition and its application. The derivative is a compound having a general structural formula (I) or a pharmaceutically acceptable salt thereof; the composition comprises a tetrahydro(iso)quinoline derivative or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers. The present invention also provides the application of a tetrahydro(iso)quinoline derivative or a pharmaceutically acceptable salt thereof or a pharmaceutical composition in the preparation of a drug for preventing or treating a neuropsychiatric disease, wherein the neuropsychiatric disease is schizophrenia. The derivative has small extrapyramidal side effects; its application in the treatment of schizophrenia has the potential to improve the positive symptoms of schizophrenia, and can improve the therapeutic efficacy of negative symptoms and cognitive impairment, so as to meet the needs of clinical medication.

The present invention relates to an interleukin-2 (IL-2) mutant and an application thereof. Key sites were selected by means of computer-aided molecular design, and an IL-2 mutant phage display library was constructed based on synthetic biology techniques and combined with forward and reverse screening strategies to screen for a biased IL-2 mutant. Compared with wild-type IL-2, the IL-2 mutant of the present invention has reduced IL-2Rα receptor affinity and increased or equivalent IL-2Rβ receptor affinity, and can activate effector T cells, activate NK cells, and stimulate the release of interferon γ in a biased manner. Also provided in the present invention are a nucleic acid encoding the novel IL-2 mutant and a vector and a host cell comprising the nucleic acid, and further provided are a method for preparing the novel IL-2 mutant, a pharmaceutical combination comprising the novel IL-2 mutant, and a therapeutic use of the novel IL-2 mutant.

This invention discloses a class of polypeptide ligands that can specifically bind to and / or significantly promote the assembly of Holliday linkers and their applications, belonging to the field of biomedical technology. The general formula for the amino acid sequence of the polypeptide ligand is: AX₄BQX₃CXn, where A and B are each independently selected from any one of phenylalanine, tryptophan, tyrosine, lysine, and arginine; C is selected from any one of arginine and lysine; X represents any amino acid; and n is an integer ranging from 0 to 4. The advantages of this invention are: the polypeptide provided by this invention has a high affinity for Holliday linkers (HJs), a strong ability to promote HJ formation, and exhibits certain antitumor activity against human liver cancer cells A549.

The present disclosure relates to detection of a target nucleic acid sequence using a tag oligonucleotide comprising a synthetic unnatural base. The protocol of the present disclosure increases a target signal by improving the binding affinity or specificity of the hybridization between the target-dependent fragment and the fragment-hybridizing oligonucleotide, and thus it is possible to detect the target sequences with more improved sensitivity.

The present invention belongs to the field of medicine, and specifically relates to the use of fructose-1,6-diphosphate in the preparation of drugs for preventing and treating herpes simplex virus type 1 infection. Fructose-1,6-diphosphate (FBP) can inhibit the replication of RNA and DNA viruses both in vitro and in vivo. Experiments have shown that this inhibitory effect is largely independent of type I interferon-mediated innate immunity, but occurs through HMGB1. After viral infection, FBP reduces the protein level of HMGB1 by promoting lysosomal degradation of HMGB1. In addition, FBP can also directly inhibit the binding of HMGB1 to the viral genome, thereby inhibiting viral replication. The present invention highlights the key role of FBP in inhibiting viral replication and proposes potential targets for controlling viral infection.

The invention relates to the technical field of textile printing and dyeing, and particularly discloses a golden yellow dye and a synthesis method thereof. According to the golden yellow dye provided by the invention, the structure of each group of the dye is stable and not twisted under the induction of low-energy light waves through the arrangement of the whole structure, excellent color stability is obtained, and the golden yellow dye has non-photosensitivity and excellent low affinity so as to show excellent soaking-resistant soap water fastness; the dye can be effectively used as a non-photosensitive dye to be applied to outdoor or anti-solarization brocade / spandex fabrics.

The utility model discloses a plastic model scribing cutter which comprises a cutter body and a cutting edge, the cutter body is fixedly connected with the cutting edge, the cutting edge is positioned at one end of the cutter body in the cutting direction, and the cutting edge is made of superhard materials. The cutting edges made of different materials are fixed in the cutting direction of the cutter body, and the cutting edges are made of super-hard materials, so that the advantages that the affinity of super-hard materials and plastic resin is low, cuttings easily flow out, and the quality of the cutting surface is good are fully played in the cutting and scribing process of a plastic (plastic cement) model; and the cutting quality and the model making and transforming efficiency of a user are greatly improved. Meanwhile, the existing mature ultra-high hardness material cutting edge is welded and fixed, so that the cutting edge, the knife body and the knife handle are separately manufactured, the knife handle and the knife body can be made of materials with lower technical requirements and lower cost, such as domestic conventional tungsten steel, and double effects of high-quality cutting and scribing and low-cost manufacturing can be realized.

The present disclosure relates to a positive electrode active material, a battery, and a method for manufacturing a positive electrode active material. The positive electrode active material includes an olivine-type phosphate compound including at least one selected from lithium manganese phosphate and lithium manganese iron phosphate, and a coating that coats at least a portion of a surface of the positive electrode active material and includes carbon and iron.

The application discloses an integrated composite acid emulsion applied to fracturing fluid and acid liquid and a preparation method thereof, and belongs to the technical field of oil and gas field exploitation. The preparation steps of the emulsion are as follows: S1, organic solvent and composite emulsifier are mixed, stirred, dispersed and uniformly distributed to obtain an oil phase; S2, quaternary ammonium salt unsaturated monomer, sodium benzenesulfonate unsaturated monomer, methacryloyloxyethyl phosphate and a complexing agent are added into water, mixed uniformly and adjusted to have a pH value of 7-9 to obtain an aqueous phase; S3, under the condition of stirring, the aqueous phase is added dropwise into the oil phase to form a water-in-oil emulsion; S4, after nitrogen is passed through the water-in-oil emulsion to remove oxygen, an initiator is added, the temperature is increased to 40-60 DEG C, and stirring reaction is carried out for 4-8 h to obtain the integrated composite acid emulsion. The composite acid emulsion prepared by the inverse emulsion polymerization method has the characteristics of strong thickening, high resistance, high temperature resistance, crosslinking and on-line viscosity change when applied to water and acid liquid, and is an integrated composite acid thickening agent emulsion suitable for fracturing fluid and acid liquid.

The present invention relates to a glycosylated Fc variant with improved selective binding affinity to FcγRIIIa. Novel human antibody Fc domain variants of the present invention have reduced binding affinity to FcγRIIIb, which is an immuno-inhibitory receptor, compared to antibodies approved as conventional antibody therapeutic agents, and have improved binding affinity to FcγRIIIa (an increase in the A / I ratio), which is an immuno-activating receptor, and thus have a significantly improved ability to induce ADCC, and have the effect of maximizing the immune action mechanism of therapeutic protein drugs, and thus can be effectively used as antibody drugs.

This invention discloses an organofluorosilicone emulsion deepening agent, which is made from the following raw materials in parts by weight: 3-9 parts of hexamethylcyclotrisiloxane, 2-4 parts of trifluoropropylmethylcyclotrisiloxane, 1-3 parts of hexamethyldisiloxane, 3-9 parts of vinyldisiloxane, 1-3 parts of emulsifier, 0.1-0.6 parts of catalyst, and 2-6 parts of acrylate monomer. The organofluorosilicone monomer is prepared by ring-opening reaction of hexamethylcyclotrisiloxane, trifluoropropylmethylcyclotrisiloxane, and hexamethyldisiloxane under the action of trifluoromethanesulfonic acid catalyst. Then, the emulsifier is used to emulsify the monomer to obtain organofluorosilicone emulsion I. This invention has a simple preparation method, can reduce dye affinity, and inhibit dye migration. Furthermore, by changing the amount of emulsifier, the particle size of the emulsion can be adjusted, and emulsions of different particle sizes can be mixed together to form a film with different roughness, thus achieving a deepening effect.

The invention belongs to the field of activated carbon material modification, and relates to a preparation method and application of nitrogen-doped-thermal-activated composite hydrophobic modified activated carbon. The method comprises the following steps: pretreating activated carbon; then carrying out dipping treatment on the pretreated activated carbon by using urea dipping liquids with different concentrations, and drying to obtain nitrogen-doped activated carbon; and then carrying out thermal activation on the nitrogen-doped activated carbon in an oxygen-free environment at 500-700 DEG C, and cooling to obtain the nitrogen-doped-thermal-activated composite hydrophobic modified activated carbon. Test data shows that when the relative humidity of the gas is 80%, the saturation adsorption time of the composite hydrophobic modified activated carbon to dichloromethane in the gas can be prolonged by 44.83% compared with unmodified activated carbon, the saturation adsorption capacity is 53.7 mg / g and is increased by 66.65% compared with the unmodified activated carbon, and the composite hydrophobic modified activated carbon can be used for adsorbing dichloromethane in the gas. Active carbon composite hydrophobic modification is beneficial for improving the adsorption selectivity of the adsorbent on VOCs under a high-humidity condition.

The invention discloses a low-resistance ultrasonic laser film and a preparation method thereof.The low-resistance ultrasonic laser film comprises a base layer and developing layers coated on the front face and the back face of the base layer, and raw materials of the developing layers comprise, by weight, 10-30 parts of adhesive; 2 to 10 parts of a tackifier; 0.2 to 2 parts of hydrophobic spherical micro powder; 0.1-1 part of a wear-resistant agent; 2-10 parts of a developer; 0.3-2 parts of a wetting agent; and 0.2-1 part of a leveling agent. According to the low-resistance ultrasonic laser film disclosed by the invention, the affinity between powder particles and the developing layer is weakened by the hydrophobic spherical powder added in the developing layer, and the powder particles exist on the surface of the developing layer in a suspended embedded form, so that the motion resistance of the hydrophobic spherical powder particles is reduced, and sliding between the films is realized; therefore, frictional resistance between the films is reduced, and self-service printing of the double-sided ultrasonic laser films is achieved.

The invention relates to a gel ink ballpoint pen follow-up sealant using a modified SEEPS-OH elastomer as a thickening agent and a preparation method of the gel ink ballpoint pen follow-up sealant. A polar group modified SEEPS-OH elastomer is adopted as a thickening agent of the follow-up sealant, the affinity with ink is properly improved while the stability of a grease system is not damaged, and the polar group of the SEEPS-OH modified elastomer weakens the affinity between the follow-up sealant and the inner wall of a refill oil tube. Under the combined action of the two, the follow-up sealant has good follow-up performance. The polar groups of the end group of the modified SEEPS-OH elastomer are distributed in a dotted mode on the inner wall of the oil pipe, the affinity of the follow-up sealant and the whole oil pipe is not damaged, good follow-up performance is achieved, meanwhile, the anti-falling performance is guaranteed, and the contradictory problem of the anti-falling performance and the follow-up performance is solved.

The invention provides a tight junction protein antibody D03 and application thereof, the antibody D03 is a single-domain antibody, and a heavy chain variable region of the single-domain antibody comprises CDR1, CDR2 and CDR3; the amino acid sequence of the CDR1 comprises SEQ ID NO. 1; the amino acid sequence of the CDR2 comprises SEQ ID NO. 2; the amino acid sequence of the CDR3 comprises SEQ ID NO. 3. The closely connected protein antibody D03 has higher affinity to CLDN6 and lower affinity to CLDN9, that is, the closely connected protein antibody D03 has higher specificity to CLDN6, meanwhile, the tumor killing effect of ADCC and CAR-T mediated by the closely connected protein antibody D03 is better, and a chimeric antigen receptor molecule constructed on the basis of the closely connected protein antibody D03 can better mediate immune cells to kill tumors.

The invention belongs to the technical field of nitrogen making equipment, and particularly relates to a zero-gas-consumption PSA nitrogen making device which comprises a fixing frame, the upper portion of the fixing frame is fixedly connected with a purification part, and the purification part can compress, filter and purify input air so as to remove impurities in the air; the purification part is connected with an adsorption part, and the adsorption part can filter the pumped air, so that oxygen, carbon dioxide and moisture in the air are adsorbed, and nitrogen is left; the adsorption part is connected with a buffer part, and the buffer part can collect nitrogen generated by the adsorption part; the adsorption part comprises at least two reaction tanks, the reaction tanks are connected through a pipeline with a valve, and the lower ends of the reaction tanks are fixedly connected with the fixing frame. According to the invention, by optimizing the adsorption circulation and desorption processes, the nitrogen flowing in the system is utilized for regeneration, and the situation that additional nitrogen or other gases are needed for regeneration in the traditional PSA system is avoided, so that zero gas consumption is realized.

The invention relates to a method for separating vanadium, iron and phosphorus in an acidic vanadium-containing solution by using an ion exchange method. According to the technical scheme, the method comprises the following steps: enabling an acidic vanadium-containing solution to flow into an ion exchange column at a flow rate of 1-1.5 BV / h until resin filled in the ion exchange column is adsorbed to be saturated, so as to obtain loaded resin and adsorption residual liquid; the pH value of the acidic vanadium-containing solution is 0-2.5. Enabling 5-10BV deionized water to reversely flow through the loaded resin in the ion exchange column at the flow rate of 2-5BV / h to obtain resin to be desorbed and washing wastewater; then, a desorption agent of 0.2-0.5 BV reversely flows through the resin to be desorbed in the ion exchange column at the flow rate of 0.2-0.5 BV / h for desorption, and desorbed resin and vanadium-rich liquid are obtained. The method has the characteristics of wide pH application range, good vanadium and iron phosphorus separation effect and low medicament consumption.

A filler of the novel paper comprises an insoluble organic acid calcium salt and calcium carbonate, and the amount of the insoluble organic acid calcium salt is 0-30 wt% of the total mass of the calcium carbonate and the insoluble organic acid calcium salt, and is not 0. The invention further discloses a preparation method and application of the novel paper. Insoluble organic acid calcium salt is added in the paper manufacturing process, the particle size distribution of the insoluble organic acid calcium salt is required to be the same as that of calcium carbonate, and the insoluble organic acid calcium salt replaces a part of calcium carbonate to serve as a filler. The ash coagulation index can be obviously reduced, and smoke components and sensory quality are not obviously changed. On the premise of not changing other design parameters, the cigarette paper can be directly used instead of conventional cigarette paper.