1477results about How to "Strong interaction" patented technology

A wireless gateway is provided that connects mobile and remote assets or employees to business enterprise users through multiple wireless networks and the Internet by using web served applications. The central core of the gateway is a location aware business component that sends and receives location based information to and from remote and mobile assets and applies business logic to the location data to enhance and automate business applications run by the enterprise user. This functionality considerably exceeds that of a traditional wireless gateway, which simply manages messages passed through multiple wireless networks but does nothing with the content of the messages. The business logic component provides a common interface and protocol for handling location information and allows applications that follow the protocol to interface with the gateway to take advantage of location information by using location data to trigger events or to tag events, messages, or other data.

A wireless gateway is provided that connects mobile and remote assets or employees to business enterprise users through multiple wireless networks and the Internet by using web served applications. The central core of the gateway is a location aware business component that sends and receives location based information to and from remote and mobile assets and applies business logic to the location data to enhance and automate business applications run by the enterprise user. This functionality considerably exceeds that of a traditional wireless gateway, which simply manages messages passed through multiple wireless networks but does nothing with the content of the messages. The business logic component provides a common interface and protocol for handling location information and allows applications that follow the protocol to interface with the gateway to take advantage of location information by using location data to trigger events or to tag events, messages, or other data.

Mono- and diimide perylene and naphthalene compounds, N- and core-substituted with electron-withdrawing groups, for use in the fabrication of various device structures.

Provided is a method, system, and program for managing access to resources. Encryption keys are exchanged among a first entity, second entity, third entity, and a fourth entity. Each entity has one relationship with one other entity and the encryption keys are exchanged pursuant to the relationships. Electronic messages are encrypted with the encryption keys concerning digital enrollments to provide to the first entity. The digital enrollment is associated with at least one digital ticket that authorizes access to a resource managed by the fourth entity. Presentation of the digital enrollment causes the presentation of one digital ticket associated with the digital enrollment to authorize the first entity to access the resource.

A microfluidic device comprising a set of one or more, preferably more than 5, covered microchannel structures manufactured in the surface of a planar substrate. The device is characterized in that a part surface of at least one of the microchannel structures has a coat exposing a non-ionic hydrophilic polymer. The non-ionic hydrophilic polymer is preferably attached covalently directly to the part surface or to a polymer skeleton that is attached to the surface.

This invention relates to a method and device for separating charged particles according to their diffusivities in a separation medium by means of a spatially and temporally varying electric potential. The method is particularly suited to sizing and separating DNA fragments, to generating DNA fragment length polymorphism patterns, and to sequencing DNA through the separation of DNA sequencing reaction products. The method takes advantage of the transport of charged particles subject to an electric potential that is cycled between an off-state (in which the potential is flat) and one or more on-states, in which the potential is preferably spatially periodic with a plurality of eccentrically shaped stationary potential wells. The potential wells are at constant spatial positions in the on-state. Differences in liquid-phase diffusivities lead to charged particle separation. A preferred embodiment of the device is microfabricated. A separation medium fills physically defined separation lanes in the device. Electrodes deposited substantially transverse to the lanes create the required electric potentials. Advantageously, injection ports allow sample loading, and special gating electrodes focus the sample prior to separation. The effects of thermal gradients are minimized by placing the device in contact with a thermal control module, preferably a plurality of Peltier-effect heat transfer devices. The small size of a microfabricated device permits rapid separation in a plurality of separation lanes.

The current landscape for preparative chromatographic RNA purification uses reversed phase HPLC, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short RNAs. The invention provides preparative purification of RNA (e.g., mRNA) using ion (e.g., anion) exchange chromatography that allows for separation of longer RNAs up to 10,000 nucleotides in length via a scalable method. This method avoids problems with current techniques by using low pressure chromatography that is agreeable with existing equipment in cGMP commercial facilities, that uses aqueous-bases solutions as the mobile phase (rather than flammable of greater than 10 mg RNA / mL resin (e.g., using larger pore sorbents, >500 Angstroms, that display greater mRNA binding capacities), and that yields desired RNA salt forms for downstream formulation with no additional manipulation necessary (unlike ion pair reverse phase techniques).

The invention relates to a method for preparing graft modification protein adhesives, belonging to the adhesive technical field. The method obtains the graft modification protein adhesives by adopting redox system initiator to react for a period of time at a certain temperature and linking vinyl monomer branched chains on a protein trunk chain. During the production and use processes, substances such as formaldehydes and so on are not released, thereby the method is favorable for environmental protection; and simultaneously the method can increase the added value of protein products and has important economic value. Because more hydrophobic groups are linked on the protein trunk chain, the interaction between the graft modification protein adhesives obtained and molecular groups on the wood surface is stronger and the adhesives are difficult to damage by water molecules, thereby the graft modification protein adhesives have good bonding strength and superior water resistance. The method widens the application environment and solves the problem which disturbs actual application of the protein adhesives for a long time, consequently having obvious technical advance.

Mono- and diimide perylene and naphthalene compounds, N- and core-substituted with electron-withdrawing groups, for use in the fabrication of various device structures.

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. The methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to and agonize EphA2, thereby increasing EphA2 phosphorylation and decreasing EphA2 levels in cells which EphA2 has been agonized. The invention also encompasses antibodies that preferentially bind an EphA2 epitope exposed on cancer cells but not non-cancer cells. The invention also provides pharmaceutical compositions comprising one or more EphA2 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.

The invention provides, in some aspects, a system for rendering images, the system having one or more client digital data processors and a server digital data processor in communications coupling with the one or more client digital data processors, the server digital data processor having one or more graphics processing units. The system additionally comprises a render server module executing on the server digital data processor and in communications coupling with the graphics processing units, where the render server module issues a command in response to a request from a first client digital data processor. The graphics processing units on the server digital data processor simultaneously process image data in response to interleaved commands from (i) the render server module on behalf of the first client digital data processor, and (ii) one or more requests from (a) the render server module on behalf of any of the other client digital data processors, and (b) other functionality on the server digital data processor.

Methods of reversal of the binding between a biotin compound and a biotin-binding compound are disclosed. A method of reversibly releasing a biotinylated moiety from a streptavidin (or avidin) coated support is shown as an example. The strong interaction between streptavidin or avidin-biotin is made much weaker by using a combination of modified streptavidin or avidin and modified biotin like desthiobiotin or a derivative thereof like DSB-X Biotin. A protein, such as an antibody may be biotinylated with the modified biotin. When this protein is isolated by binding the modified biotin to the modified streptavidin or avidin bound to an solid surface, it may be released under very gently and very rapid conditions by addition of free biotin. In contrast to proteins obtained by the prior art release methods the protein obtained using the previously available release methods, the proteins obtained using the methods disclosed herein will maintain their native conformation. Uses of the methods in various procedures including cell detachment procedures and techniques of detection, identification, determination, purification, separation and / or isolation of target proteins or nucleic acid molecules are also described.

In an interface unit, an input section obtains an input signal of user's speech or the like and an input processing section processes the input signal and detects information relating to the user. On the basis of the detection result, a response contents determination section determines response contents to the user. While, a response manner adjusting section adjusts a response manner to the user, such as speech speed and the like, on the basis of the processing state of the input signal, the information relating to the user detected from the input signal, and the like.

An approach for stabilizing the interactions between a plasma and the generator powering the plasma is provided. Reactive elements disposed between the power generator and plasma operate to modify the apparent impedance characteristics of the plasma such that the trajectory of the plasma load impedance as a function of power is substantially aligned locally with the contours of constant power output in impedance space. In this way, instabilities in the generator and plasma system are avoided because reinforcement or amplification of fluctuations in plasma impedance due to interactions between the generator and the plasma are reduced or eliminated. The reactive elements may be variable in order to align plasma trajectories and generator power contours under a range of process conditions.

The invention discloses a man-machine interaction method and device based on an emotion system, and a man-machine interaction system. The method comprises following steps of collecting voice emotion parameters, expression emotion parameters and body emotion parameters; calculating to obtain a to-be-determined voice emotion according to the voice emotion parameters; selecting a voice emotion most proximate to the to-be-determined voice emotion from preset voice emotions as a voice emotion component; calculating to obtain a to-be-determined expression emotion according to the expression emotion parameters; selecting an expression emotion most proximate to the to-be-determined expression emotion from preset expression emotions as an expression emotion component; calculating to obtain a to-be-determined body emotion according to the body emotion parameters; selecting a body emotion most proximate to the to-be-determined body emotion from preset body emotions as a body emotion component; fusing the voice emotion component, the expression emotion component and the body emotion component, thus determining an emotion identification result; and outputting multi-mode feedback information specific to the emotion identification result. According to the method, the device and the system, the man-machine interaction process is more smooth and natural.

A system, method, and apparatus for stabilizing interactions between an electrical generator and a nonlinear load are described. One illustrative embodiment includes an impedance element that is coupled to an output of the generator and a power source coupled to the impedance element. The power source applies power to, or across, the impedance element so as to reduce energy loss that would ordinarily occur due to energy dissipation by way of the impedance element. In many variations, the power source operates within a defined bandwidth so that a stabilizing effect is achieved outside of this bandwidth.

A composite Mn-Ce oxide catalyst for oxidizing the form-aldehyde into CO2 and H2O is prepared through adding soluble manganese nitrate in the solution of potassium permanganate and cerium ammonium nitrate while stirring, adding potassium hydroxide, stirring to obtain deposit, filtering, washing, drying at 80-120 deg.C and calcining.

Disclosed herein are compositions and methods for the isolation and purification of antibodies from a sample matrix. In particular, the present invention relates to compositions and methods for isolating and purifying antibodies exhibiting low or high binding capacity for Protein A resin. In certain embodiments, the methods herein employ a kosmotropic salt solution, an affinity chromatographic step, and may include one or more additional chromatography and / or filtration steps to achieve the desired degree of purification. The present invention is also directed toward pharmaceutical compositions comprising one or more antibodies purified by a method described herein.

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye.

Disclosed herein are compositions and methods for the isolation and purification of antibodies from a sample matrix. In particular, the present invention relates to compositions and methods for isolating and purifying antibodies exhibiting weak binding strength and low binding capacity for Protein A resin. In certain embodiments, the methods herein employ a kosmotropic salt solution, an affinity chromatographic step, and may include one or more additional chromatography and / or filtration steps to achieve the desired degree of purification. The present invention is also directed toward pharmaceutical compositions comprising one or more antibodies purified by a method described herein.

The invention discloses a microwave electric field intensity meter based on a cold Rydberg atom interferometer and a measuring method thereof. The microwave electric field intensity meter comprises: a vacuum system, which is used for cooling and trapping atom to generate a cold atom cloud for preparing a Rydberg state and generating an interference effect so as to generate a phase difference by coherent atomic states; a laser, which is used for generating coupling light and detection light and exciting the cold atom in the vacuum system from a ground state to the Rydberg state coherently; a photoelectric detector, which is used for detecting an interference fringe generated by two beams of cold atom clouds due to coherence; and a microwave source, which is used for generating a microwave electric field. According to the invention, when the microwave electric field intensity meter is applied to the evolution process of coherent beam splitting and combination, the atom cloud in the Rydberg state interacts with a to-be-measured microwave electric field, thereby generating an alternating-current stark effect; and the to-be-measured microwave electric field intensity is associated with a phase generated by the an alternating-current stark, thereby realizing precise measurement of the microwave electric field.

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and agonize EphA4. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and inhibit cancer cell colony formation in soft agar or tubular network formation in three-dimensional basement membrane or extracellular matrix preparation. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that preferentially binds to an EphA4 epitope that is exposed on cancer cells but not non-cancer cells. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 with a very low Koff to reduce EphA4 expression and, thereby, inhibit tumor cell growth and / or metastasis. The invention also provides pharmaceutical compositions comprising one or more EphA4 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.

A modified emulsion asphalt compounded by inorganic nano-particles and polymer contains 200-700 parts by weight of asphalt, 2-80 parts by weight of modified inorganic nano-particles, 5-50 parts by weight of styrene-butadiene rubber latex, and 170-793 parts by weight of water, wherein the modified inorganic nano-particles is prepared by mixing 95-98 parts by weight of inorganic nano-particles with 2-5 parts by weight of coupling agent, and each components are mixed, followed by normal emulsion treatment to get the emulsion asphalt. The invention utilizes unique surface effect, small size effect and macroscopic quantum tunneling effect etc. of the inorganic nano-particles to give the product comprehensive properties, such as good wear resistance, intensity sum, anti-aging property and fine waterproof effect etc. Using the invention can increase the road maintenance cycle and decrease the cost. Furthermore, the water-proof cost of construction industry is greatly decreased.

A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC group; a 3-branched asparagine-linked oligosaccharide derivative which contains at least one fucose in N-acetylglucosamine on the nonreducing terminal side of the asparagine-linked oligosaccharide of the derivative; asparagine-linked oligosaccharides and oligosaccharides thereof wherein Q is a lipophilic protective group, biotin group or FITC group.

The invention provides, in some aspects, a system for rendering images, the system having one or more client digital data processors and a server digital data processor in communications coupling with the one or more client digital data processors, the server digital data processor having one or more graphics processing units. The system additionally comprises a render server module executing on the server digital data processor and in communications coupling with the graphics processing units, where the render server module issues a command in response to a request from a first client digital data processor. The graphics processing units on the server digital data processor simultaneously process image data in response to interleaved commands from (i) the render server module on behalf of the first client digital data processor, and (ii) one or more requests from (a) the render server module on behalf of any of the other client digital data processors, and (b) other functionality on the server digital data processor.

The invention provides a dual-rotational-flow inspirator, which comprises a top cover, a nozzle, an upper bottom, a middle bottom, a gas whirlcone and an inspirator cavity, wherein the inspirator cavity is a barrel-shaped hollow cylinder; a fuel cavity is formed between the top cover and the upper bottom of the inspirator; a gas oxidizing agent cavity is formed between the upper bottom and the middle bottom of the inspirator; a water cavity is formed between the middle bottom of the inspirator and the base of the inspirator; an inner nozzle passes through mounting holes in the upper bottom, the middle bottom and the inspirator cavity and is fixedly arranged on the upper bottom via a thread; the gas whirlcone is installed on the nozzle by a thread; water nozzles are water holes evenly distributed on the circumstance on the base of the inspirator. The inspirator provided by the invention has the characteristics of simple structure, low cost, good atomization performance and stable flame.

We report a heteroatom-doped carbon framework that acts both as conductive network and polysulfide immobilizer for lithium-sulfur cathodes. The doped carbon forms chemical bonding with elemental sulfur and / or sulfur compound. This can significantly inhibit the diffusion of lithium polysulfides in the electrolyte, leading to high capacity retention and high coulombic efficiency.

The invention provides, in some aspects, a system for rendering images, the system having one or more client digital data processors and a server digital data processor in communications coupling with the one or more client digital data processors, the server digital data processor having one or more graphics processing units. The system additionally comprises a render server module executing on the server digital data processor and in communications coupling with the graphics processing units, where the render server module issues a command in response to a request from a first client digital data processor. The graphics processing units on the server digital data processor simultaneously process image data in response to interleaved commands from (i) the render server module on behalf of the first client digital data processor, and (ii) one or more requests from (a) the render server module on behalf of any of the other client digital data processors, and (b) other functionality on the server digital data processor.

Organic / inorganic nanocomposites and methods for their preparation are disclosed. In one embodiment, the method comprises the steps of providing an organic / inorganic concentrate and processing the concentrate with a polymer resin. In a preferred embodiment the organic / inorganic concentrate and polymer resin are processed by extrusion using a single-screw extruder. In another embodiment, the method further comprises surface modifying an inorganic additive, mixing the modified additive with a polymer solution to produce an organic / inorganic solution, and removing solvent from the organic / inorganic solution to produce the organic / inorganic concentrate. Processing of the organic / inorganic concentrate with a polymer resin produces a homogeneous nanocomposite with superior mechanical and thermal properties.

The invention provides a high temperature self-repairing conductive silver adhesive. The high temperature self-repairing conductive silver adhesive is prepared from the following raw constituents by parts: 100 parts of epoxy resin, 10-30 parts of curing agent, 10-40 parts of epoxy diluent, 240-990 parts of silver pieces, 3-20 parts of coupling agent and 5-20 parts of self-repairing microcapsule; wherein the self-repairing microcapsule is composed of the following raw constituents by parts: 100 parts of epoxy resin, 8-20 parts of latent curing agent, 30-60 parts of diluents, 0.5-2.5 parts of emulsifying agent, 500-800 parts of nano silver wires, 5-16 parts of coupling agent, 60-120 parts of capsule wall material, 0.5-2 parts of antifoaming agent and 150-900 parts of deionized water. The invention also provides a preparation method of the high temperature self-repairing conductive silver adhesive. The high temperature self-repairing conductive silver adhesive has the positive effects that the repairing efficiency is high, the repairing effect is expanded on the basis of the original conductive network, crack-conductive network double repairing is realized, and the long-term using effect of the conductive adhesive is guaranteed, the cost is saved, and the reliability and service life of the conductive adhesive in high temperature working environment are improved.