714 results about "Methoxypolyethylene glycol" patented technology

The invention discloses a preparing method of graft copolymerization carboxylate high-performance dehydragent belonging to dehydragent domain, which comprises the following steps: choosing methoxy carbowax with molecular weight distributing between 1000-2000 and acroleic acid or methacrylic acid as main raw material; adopting total acid method esterified priority method; preparing intermediate (big monomer) with polymerization activity; adding third monomer into polymerization reaction; adjusting polymerization activity of copolymerization system; proceeding technique route synthesis of main chain polymerization in the water solution. The getting big monomer possesses merits of high conversion rate, short reacting time, simple process flow and strong controlling property.

The invention belongs to the field of pharmaceutical agents, relates to a polymer micelle lyophilized agent encapsulating an insoluble antitumor drug as well as a preparation method and an application thereof. The polymer micelle lyophilized agent is prepared by carrying out molecular self-assembly on a methoxy poly(ethylene glycol) 2000-polyester block copolymer to form micelles, and then encapsulating the insoluble antitumor drug in a hydrophobic core formed by the polyester. The lyophilized agent has high encapsulation rate, high drug loading and small particle size, can significantly improve the water solubility of the insoluble drug and result in passive targeting of more antitumor drugs to concentrate in the tumor tissues, thus improving an anti-tumor treatment effect and reducing the toxic and side effects of drugs, and can be used to prepare the drugs used for the treatment of lung cancer, intestinal cancer, mammary cancer, ovarian cancer, etc. The lyophilized agent can also be quickly dissolved and dispersed to form a transparent micellar solution after water for injection, normal saline solution and the like are added, and is used for the preparation of the drugs for treating primary intestinal cell carcinoma.

The invention relates to a synthesis method of a crude oil desalting demulsifying agent. The method specifically includes the steps of firstly, conducting p-nitrophenyl ester modification on methoxypolyethylene glycol; secondly, preparing glycidyl dimethyl alkyl ammonium chloride; thirdly, preparing quaternized carboxy alkyl chitosan; fourthly, making the modified methoxypolyethylene glycol react with quaternized carboxy alkyl chitosan to obtain a product, namely polyethylene glycol questin grafted quaternized carboxy alkyl chitosan. A chitosan type natural high-molecular compound serves as the raw material and has the advantages of being wide in resource, natural, free of toxin, sustainable, good in product biocompatibility, degradable and the like; The prepared demulsifying agent is good in demulsifying dewatering effect; meanwhile, due to the fact that lots of carboxy alkyl groups and quaternary ammonium salt groups are contained in demulsifying agent molecules and have strong binding capacity with metal cations, naphthenic acid radicals and other ions with negative charges and particles with surface electronegativity, the oil-soluble salt removing capacity is achieved during demulsifying.

The invention relates to a preparation method of a polyelectrolyte-type crude oil-desalting demulsifier. The preparation method comprises the following specific steps: (1) performing amination modification on methoxypolyethylene glycol; (2) preparing glycidyl dimethyl alkyl ammonium chloride; (3) preparing quaternized carboxyalkyl chitosan; (4) carrying out a reaction between the modified methoxypolyethylene glycol and the quaternized carboxyalkyl chitosan to obtain a target product methoxypolyethylene glycol-grafted quaternized carboxyalkyl chitosan. The polyelectrolyte-type crude oil-desalting demulsifier takes a natural macromolecule chitosan compound as a raw material, and has the advantages of wide sources, naturalness, non-toxicity, sustainability, good product biocompatibility, biodegradability and the like. The prepared demulsifier has good demulsifying and dehydrating effects; a demulsifier molecule contains a large number of carboxyalkyl groups and quaternary ammonium groups, which have very strong capacity of bonding metal cations, negatively-charged ions such as naphthenic acid radicals, and particles with negative charges on the surfaces, so that besides the demulsifying capability, the demulsifier also has the capability of removing oil-soluble salts.

The invention relates to a high performance early-strength polycarboxylate water reducer and a preparation method thereof, which pertains to the water reducer field. The early-strength water reducer is prepared mainly based on graft copolymeric carboxylic polymer and compounded with a preferred early strength component; wherein, the copolymeric carboxylic polymer refers to the polymer polymerized by methoxy polyethylene glycol acrylate and acrylic acid / methyl acrylic acid through a free radical initiator in water. The high performance early-strength polycarboxylate water reducer prepared by the invention is characterized by small doping, low alkaline content, no chloride ion and no sulfate, etc., and does not result in the corrosion and alkali aggregate reaction, etc., of the steel bars in the concrete structure, which is helpful for guaranteeing the duration of the concrete structure. The high performance early-strength polycarboxylate water reducer manufactured by the invention can be widely applied to the construction of various concrete projects and the construction of concrete at low temperature, and is particularly suitable for the low energy consumptive production technique of prefabricated concrete members and has a promising application prospect.

Derivatives useful in the protection of living organisms against damage due to free radical reactions derived from methoxypolyethylene glycols (MPEG), which are modified by chemically attaching chelating groups in an amide or amine linkage to the nonmethyl end of the polymer. Such chelating groups include ethylene-diamine tetraacetic acid (EDTA), diethylene triamine pentaacetic acid (DTPA), and ethylene glycol aminoethyl ether tetraacetic acid (EGTA), and pharmacologically acceptable salts or esters thereof.

The invention discloses a model releasing agent containing fluorine. The model releasing agent comprises the following components : (a) (methyl) crylic acid C1-C10 alkyl ester or (methyl) acrylic acid fluoro C1-C10 alkyl ester, (b) (methyl) acrylic ester or methoxyl group polyethylene glycol monomethacrylate containing two or three (methyl) acrylic ester groups, (c) fluoro epoxide resin, (d) evocating agent, and (e) cross linker. The invention also discloses a piece of releasing paper which is formed by base paper 1 as well as a bottom coating 2 and a releasing coating 3, wherein the bottom coating 2 and the releasing coating 3 are sequentially attached to the base paper 1, and the releasing coating is formed by solidifying the coating of the model releasing agent containing fluorine. The releasing paper has moderate hardness, stable releasing property, frequent use as well as favorable performances of solvent durability and high-temperature durability.

The invention provides an all-solid-state polymer electrolyte for a solid lithium ion battery and a preparation method of the all-solid-state polymer electrolyte. The polymer refers to a complex formed by polymerizing a methacrylic acid methoxypolyethylene glycol monomer, polydimethylsiloxane and an inorganic oxide, and an organic lithium salt is doped into the polymer. The method comprises the following steps: separating and performing vacuum drying on inorganic acid alkyl ester sol containing silicon or titanium group, monomers polyoxyethylene methyl methacrylate and polydimethylsiloxane and an initiator, thereby obtaining a PEGMEM-co-PDMS-inorganic oxide nanocrystal; adding an organic lithium salt into an organic solvent 3, performing film forming on turbid liquid in a film casting mode, removing the solvent 3, and performing vacuum drying, thereby obtaining the all-solid-state polymer electrolyte. Compared with the prior art, the all-solid-state polymer electrolyte prepared by a chemical grafting method disclosed by the invention has excellent conductivity and battery performance.

The invention discloses a preparation method for a polyocarboxy acid water reducing agent for precast units, which belongs to the field of water reducing agent. Under the action of a persulphate initiator, methoxypolyethylene glycol acrylate, acrylic acid, unsaturated sulfonic acid or a salt monomer b thereof, unsaturated amide or a salt monomer c thereof are copolymerized in an aqueous solution; a terminator is used to process the rest initiator of the reaction at a later polymerization stage; and finally alkaline solution is used for neutralization and the water reducing agent is obtained. The methoxypolyethylene glycol with high polymerization degree is introduced as a grafting side chain, thereby making the prepared water reducing agent effectively shorten the concrete coagulation time without reducing the concrete initial fluidity and improving the concrete compression strength. The early strength type polyocarboxy acid high performance water reducing agent can be widely applied to the construction of various concrete projects with a low temperature or early strength requirements, in particular to the low energy consumption production process of precast concrete units. The water reducing agent has wide generalization space.

The invention relates to a composite polymer electrolyte for a lithium ion battery and a preparation method thereof. The electrolyte takes a polymer as a matrix, and an organic-inorganic composite polymer electrolyte formed by modified nano fillers is uniformly dispersed in the matrix; the modified nano fillers comprise nano oxides, ferroelectric powder or lithium-containing compounds, and the mass of the modified nano fillers accounts for 0.5%-30% of that of the polymers; and the polymers comprise polyoxyethylene, polyacrylonitrile, polymethylmethacrylate, polyvinylidene fluoride and polyvinylidene fluoride-hexafluoropropylene copolymer and a blending and copolymerization system thereof. In the invention, methoxylpolyethylene glycol acrylate is adopted to modify the nano fillers, and the surface modification improves the dispersing performance of a polymer system, therefore, the aggregation of nano particles in the polymer system is restrained, the function of the nano particles for promoting the dissociation of lithium salt in the polymer electrolyte is better exerted, a fast ion conduction channel of the fillers / polymer interface is formed and forms dispersive stress of a three-dimensional network with the polymeric matrix. Therefore, the mechanical property of the whole polymer system is improved.

The invention relates to a cation-nonionic mixed aqueous polyurethane emulsion and a preparation method thereof. The emulsion is aqueous polyurethane which has a cation hydrophilic group and a nonionic hydrophilic side chain. The preparation method comprises the steps of firstly introducing the nonionic hydrophilic side chain by using a specific nonionic hydrophilic chain extender; and introducing the cation hydrophilic group by using a cation hydrophilic chain extender, wherein the amounts of the nonionic hydrophilic chain extender and the cation hydrophilic chain extender respectively account for 1-10 percent and 1-8 percent according to the total weight of the raw materials, and the specific nonionic hydrophilic chain extender is 3-(N,N-dihydroxyethyl) amino-propionic acid polyethyleneglycol monomethyl ether ester which is prepared by heating and reacting methoxy polyethylene glycol single methyl acrylate and diethanol amine in a molar ratio of 1:1. By using the emulsion, the defect of the existing emulsion is overcome, and the requirement of zinc-plating steel plate chromium-free passivation pretreatment on aqueous polyurethane resins are met, so that the cost is reduced.

The objective of the present invention is to provide a new antifeedant. The other objective of the present invention is to provide a NMU derivative showing a high antifeedant activity even in common administration forms such as peripheral administration. A neuromedin U derivative wherein a methoxypolyethylene glycol is bound via a linker having a specific structure to a polypeptide which contains at least 8 amino acids of the C-terminus of an amino acid sequence of neuromedin U and which consists of the same or substantially the same amino acid sequence as the amino acid sequence of neuromedin U.

The present invention provides a low dusting joint compound comprising a filler, a binder, a thickener and one or more synthetic polymeric waxes that are at least slightly soluble in water and are solid at room temperature. Preferably the wax includes a high molecular weight polyethylene glycol or methoxy polyethylene glycol having an average melting point of from about 80.degree. F. (27.degree. F.) to about 150.degree. F. (80.degree. C.). These additives impart low dusting properties without a sticky or oily feel. High molecular weight synthetic waxes also act as an internal binder to hold the joint compound together and improves paint gloss retention. The invention results in a joint compound with improved properties for drywall finishing.

The invention discloses an amphiphilic copolymer brush with pH responsiveness and a preparation method thereof. Particularly, the invention discloses an amphiphilic copolymer brush with pH responsiveness comprised of a block, which is formed by the copolymerization of a hydrophobic group and a pH response group, and a hydrophilic brush-shaped block. In the invention, a copolymer of a hydrophobic monomer and a pH response functional monomer is obtained by atom transfer radical polymerization (ATRP), then the copolymer is used as a macromolecular initiator to perform the ATRP polymerization of monomethoxypoly (ethylene glycol) methacrylate (PEGMA) which is a hydrophilic macromolecular monomer, and finally, a selective hydrolysis reaction is performed to prepare the amphiphilic copolymer brush with pH responsiveness. The preparation method of the invention has the advantages of simple process and high yield. The synthesized amphiphilic copolymer brush with pH responsiveness has a novel structure and an adjustable functional group proportion, and is suitable to be used in the transmission of entrapped insoluble medicaments.

The invention relates to a green preparation method of a slow-release polycarboxylic-acid high-performance water reducing agent, which comprises the following steps: firstly, dissolving unsaturated polyethenoxy ether in water, adding an oxidant solution, and evenly stirring; then, respectively and dropwisely adding a reducer / chain-transfer agent mixed solution and a comonomer solution, and polymerizing; and finally, adding an alkaline regulator to neutralize and age the solution, thereby obtaining the slow-release polycarboxylic-acid high-performance water reducing agent. In the invention, hydrogen on the terminal hydroxyl group of the original unsaturated polyethenoxy ether is substituted by an allyl group containing unsaturated bond, so that the terminal group of methoxypolyethylene glycol is converted from the original active hydroxyl group into the inert methoxy group at present; and thus, the byproducts of the copolymerization product are greatly reduced, and the molecular weight distribution is narrow, so that the synthesized water reducing agent has the advantages of high water reduction rate and slump resistance. The redox system with low activation energy is used for initiating the monomer copolymerization, so that the polymerization can be implemented at normal temperature, thereby implementing the production of the product by a no heat source method, simplifying the production equipment and lowering the energy consumption and cost.

The invention relates to a novel amphiphilic-block-copolymer-based pro-camptothecin drug, which is a compound of methoxy polyethylene glycol- polylactic acid and camptothecin derivatives (mPEG-X-PLA-T), wherein, mPEG refers to methoxy polyethylene glycol; X refers to linking group, for example, succinic acid; PLA refers to polylatic acid; T refers to drug molecule, that is, camptothecin derivatives such as, camptothecin, 10-hydroxycamptothecine, 7-ethyl-10- hydroxycamptothecine. Polylactic acid is connected with camptothecin derivatives through ester bond.

The invention discloses a preparation method for a high-slump-retention polycarboxylate water reducer. The preparation method comprises the following steps of: esterifying methoxylpolyethylene glycol monomethyl ethers with different molecular weights with methacrylic acid and a mixed polymerization inhibitor for a period of time under the action of a catalyst and at a certain temperature, then adding allyl alcohol in one time, further esterifying in the same conditions to obtain an esterified macromonomer MP containing crosslinking monomer allyl methacrylate; then performing aqueous solution polymerization on the MP, unsaturated sulfonate, (meth)acrylate unsaturated monomers and a chain transfer agent in a low-temperature condition and within a redox initiation system; and finally adding caustic soda liquid to neutralize, so as to obtain the polycarboxylate water reducer with a certain concentration. The high-slump-retention polycarboxylate water reducer prepared by the preparation method disclosed by the invention is a high-performance water reducer which is prepared at a low temperature by virtue of a molecular structure design, as well as is high in slump retention, excellent in dispersing performance, good in adaptability, simple in process, pollution-free, low in energy consumption, and easy to realize industrialized production.

The invention relates to exenatide joined with polyethylene glycol. The structural general formula of exenatide is (I), mPEG represents residue of methoxy polyethylene glycol, the selected value of n is 0-3, R represents an exenatide molecule from which an amino is removed, the amino is of lysine residue or of N-end histidine residue in the exenatide molecule, and the molecular weight of the exenatide joined with polyethylene glycol is 9,800-110,000. The invention further relates to a preparation method of the compound and application of the compound in preparing medicines for curing type 2 diabetes mellitus. The exenatide joined with polyethylene glycol has the advantages of being long in half-life period and good in stability and hypoglycemic effect.

The invention discloses a preparation method of a novel polycarboxylic acid type water-reducer. The novel polycarboxylic acid type water-reducer is prepared by the following steps: 1) a unsaturated acid monomer and an amine unsaturated monomer react under the action of a chain transfer agent, an initiator and a reducing agent to obtain a copolymer containing an amino group; 2) excessive diisocyanate is dropwise added into methoxy polyethylene glycol to react under the action of a catalyst so as to obtain methoxypolyethylene glycol mono-isocyanate; 3) the copolymer containing the amino group is added into the methoxypolyethylene glycol mono-isocyanate to react and then pH value is adjusted so as to obtain a novel polycarboxylic acid water-reducer. According to the method, product performance is adjusted by controlling molecular structure / molecular weight of the amine copolymer and molecular weight of methoxy polyethylene glycol. Reactions are fast and efficiency is high. In addition, no organic solvent is used; the water-reducer is nontoxic and pollution-free; and operation is simple. The polycarboxylic acid type water-reducer prepared by the method is a functional polycarboxylic acid type high-efficiency water-reducer, and product performance is stable.

The invention relates to a bifunctional polyethylene glycol and adriamycin conjugate and a preparation method thereof. The bifunctional polyethylene glycol and adriamycin conjugate is prepared in the following steps: modifying methoxy polyethylene glycol which serves as a raw material through hydroformylation, carrying out a reductive amination reaction on the modified methoxy polyethylene glycol and disulfide-bond containing dihydrazide to generate terminal-hydrazide polyethylene glycol, and carrying out a reaction on the terminal hydrazide of the terminal-hydrazide polyethylene glycol and the ketone carbonyl of the adriamycin to generate a hydrazone bond to obtain the bifunctional polyethylene glycol and adriamycin conjugate. The bifunctional polyethylene glycol and adriamycin conjugate provided by the invention can adapt to the reductive acidic environment in a cancer cell to release drugs rapidly to improve the cancer treatment effect and reduce the drug resisting possibility of the cancer cell, and in addition, the bifunctional polyethylene glycol and adriamycin conjugate can be self-assembled into a nano particle in a water phase to be able to circulate for a long time in blood to improve the pharmacokinetics of the doxorubicin. The method for preparing the bifunctional polyethylene glycol and adriamycin conjugate has the advantages of simple process, mild reaction conditions, high drug carrying rate and low cost, and the raw materials are easy to obtain. The bifunctional polyethylene glycol and adriamycin conjugate has potential application values in the aspects of targeted delivery of drugs, controlled release of drugs and improvement of clinical cancer resisting and treating effects.

The invention discloses full-solid-state multi-arm star-shaped block polymer based electrolyte. The preparation of the multi-arm star-shaped block polymer based electrolyte has the technical characteristics that a multi-arm star-shaped block polymer is synthesized by a core-first and arm-second method; a core of the multi-arm star-shaped block polymer is a hyperbranched polymer; each arm of the multi-arm star-shaped block polymer is composed of a rigid chain segment and a polymethoxyl polyethylene glycol acrylate chain segment; the rigid chain segment provides the mechanical strength and a polyethylene oxide (PEO) side chain can be used for dissolving salt and can be used as an ionic conduction base body. The polymer electrolyte does not contain any combustible and volatile solvent and a film can be formed by a solution pouring method; the room-temperature conductivity is close to 10<-4>s / cm. The polymer electrolyte has potential applications on electrochemical devices including lithium ion secondary batteries, ultra-capacitors, electronic sensors, electrochromism devices and the like.

The invention discloses a preparation method of polycarboxylic acids high efficiency water reducer, which includes steps of firstly synthesizing methoxypoly(ethylene glycol) monomethyl ether acrylate large monomer from methoxypoly(ethylene glycol) monomethyl ether and crylic acid which are used as raw materials, then copolymerizing the esterified large monomer and the acrylic acid to prepare the polycarboxylic acids high efficiency water reducer. In the synthesis of the esterified large monomer, hydroquinones and hydroquinone monomethyl ether are employed to coordinatedly blocking polymerization, thereby reducing failure ratio of unsaturated double bond, increasing effective content of the synthesized water reducer, increasing concrete water reducing ratio, and increasing slump retaining performance.

The present invention discloses a multifunctional down finishing agent, belonging to an adjuvant for treating down in the preparation process of down products. said down finishing agent composition contains (by weight portion) 0.5-2.5 portions of anti-bacterial anti-mildew agent, 0.5-2.5 portions of moth-proofing agent, 0.5-5 portions of film-forming agent, 1-8 portions of cross-linking agent, 20-90 portions of non-ionic surface active agent and 20-60 portions of water. The above-mentioned anti-bacterial anti-mildew agent is 2,4,4'-trichloro-2'-hydroxydiphenyl ether, the optimum moth-proofing agent is permethrin, the film-forming agent is acrylic composite resin, the cross-linking agent is melamine resin and / or dimethylol dihydroxy-ethylene urea and the described non-ionic surface active agent is methoxy polyethylene glycol and / or polyethylene glycol.

The invention discloses a synthetic method for maleic polycarboxylic water reducer. The method is characterized in that: maleic anhydride (MA) and polyethylene glycol (PEG) / methoxy polyethylene glycol (MPEG) are used as the raw materials to synthesize polyethylene glycol maleate monoester (PEG-MA) / methoxy polyethylene glycol maleate monoester (MPEG-MA); and PEG-MA / MPEG-MA, AA / AANa and methoxy polyethylene glycol metacrylic acid ester (MPEG-MAA) are used as the raw materials to synthesize a maleic polycarboxylic water reducer containing carboxyl and a polyoxyethylene (PEO) side chain structure. According to the invention, the molecular structure of the polycarboxylic water reducer introduces carboxyl and PEO with a long side chain, which enables electrostatic repulsion among cement particles to be increased, dispersibility, i.e. retentivity of dispersion of cement to be improved, and steric hindrance among cement particles is realized, thereby realizing low slump loss. Simultaneously, the preparation method provided in the invention has the advantages of a simple process, mild reaction and wide sources of cheap raw materials.

The invention discloses a preparation method of an amine-ester slow-setting polycarboxylic acid type water-reducer. The preparation method comprises the following concrete steps: 1) a unsaturated acid monomer and a hydroxyl-containing unsaturated monomer are subjected to a normal temperature oxidation-reduction free radical polymerization reaction under the action of an initiator, a reducing agent and a chain transfer agent to obtain a hydroxyl-containing copolymerization product; 2) excessive diisocyanate is added into methoxypolyethylene glycol to react under the action of a catalyst so as to obtain methoxypolyethylene glycol monoisocyanate; and 3) the hydroxyl-containing copolymerization product obtained in the step 1) is added into the methoxypolyethylene glycol monoisocyanate obtained in the step 2) to react, and then pH value is adjusted by alkali neutralization so as to obtain the amine-ester slow-setting polycarboxylic acid type water-reducer. According to the method, product performance is adjusted by controlling molecular structure / molecular weight of the hydroxyl-containing copolymerization product and molecular weight of methoxy polyethylene glycol / type of diisocyanate. Reaction efficiency is greatly raised, and reaction time is shortened. In addition, no organic solvent is used; the water-reducer is nontoxic and pollution-free; and operation is simple. The product performance is stable.

The invention discloses a preparation method of a polycarboxylic copolymer with high solid content. The preparation method comprises the following specific synthetic steps: sequentially adding methoxy polyethylene glycol, a polymerization inhibitor A, unsaturated carboxylic acid B and an esterification catalyst C into a reaction kettle; esterfying the mixture under the condition that the temperature is 110-120DEG C to synthesize a methoxy polyethylene glycol (methyl) acrylic ester macromonomer; removing the generated water in the reaction process; adding the prepared esterifying liquid into the reaction kettle; controlling the temperature at 70-80DEG C; dropping a mixed solution of an unsaturated monomer D and a chain transfer agent E by stirring for 1.5 to 2 hours; meanwhile, adding an initiator F in several times; after dropping, preserving the temperature for 1-2 hours; and finally, obtaining a product with the solid content of 100 percent. The polycarboxylic copolymer has the advantages that: firstly, the product is environment-friendly, dispenses with formaldehyde and three-waste discharge and belongs to low-alkali products; and secondly, compared with domestic like products, the polycarboxylic copolymer with the high solid content, which is disclosed by the invention, has high solid content and reduced cost in the production, transportation and storage process and reduced price of products.

The invention discloses a reduction sensitive type polyethylene glycol-medicament conjugate and a preparation method thereof. Methoxy polyethylene glycol is modified by using a disulfide-bond-containing diisocyanate, then a cytotoxic anticancer medicament is bonded to the obtained isocyanate-terminated polyethylene glycol, and the reduction sensitive type polyethylene glycol-medicament conjugate is obtained through dialysis and freeze-drying. The preparation method has the advantages of being multiple in applicable medicament kinds, easily available in raw materials, low in cost and the like; and the disulfide bonds exist in connecting arms between polyethylene glycol and the medicament in the prepared conjugate. According to the polyethylene glycol-medicament conjugate, not only the medicament can be released quickly in a tumor-cell reductibility microenvironment, but also nanoparticles can be formed via self assembly in an aqueous medium; and the polyethylene glycol-medicament conjugate is hopeful to have a long circulation life and accumulate in a tumor, thereby the purpose of improvement of anticancer medicament curative effect and reduction of toxic and side effect is realized.

The invention relates to a novel micellar drug carrying system formed by an amphiphilic block copolymer and curcumin. The amphiphilic block copolymer comprises a hydrophilic chain segment and a hydrophobic chain segment, the hydrophilic chain segment is methoxypolyethylene glycols, the hydrophobic chain segment is polycaprolactone, and the hydrophobic chain segment end group is terminated with a hydrophobic group. The hydrophobic group is a group having a t-butyloxycarboryl or benzene ring structure, compatibility of drug molecules with the hydrophobic chain segment of the block copolymer is improved, the mutual force is increased, and besides, a greater space is provided for accommodating the drug molecules. Prepared micelles can more effectively limit the drug molecules in micelle cores so as to allow the drug molecules to be not easily dissolved out, and thus the drug carrying micelles having high stability are obtained.

The invention discloses a synthesis method of fluorocyclotriphosphazene. The synthesis method includes: dissolving chlorocyclotriphosphazene in an organic solvent; adding a fluorinating agent and a catalyst for reaction for 1-20 h to obtain fluorocyclotriphosphazene. The catalyst accounts for 1-20% of total mass of raw materials and is polyethylene glycol, methoxypolyethylene glycol or polyethylene glycol dimethyl ether.Polyethylene glycol, methoxypolyethylene glycol or polyethylene glycol dimethyl ether is used as the catalyst and is nontoxic, low in price and high in catalytic capability; using of polyethylene glycol, methoxypolyethylene glycol or polyethylene glycol dimethyl ether can greatly increase fluorinating reaction speed and lower cost. Polyethylene glycol, methoxypolyethylene glycol or polyethylene glycol dimethyl ether is used, yield of synthetic fluorocyclotriphosphazene is increased, and yield is higher than 92% and is up to 99% maximumly.

The invention discloses a triblock polymer with a multi-response property for temperature and carbon dioxide. The polymer is methoxy polyethylene glycol-b-polyethylmethacrylate dimethyl betaine-b-poly dimethyl aminoethyl methacrylate; bromine-terminated methoxy polyethylene glycol serves as a macro-molecule initiator, and the triblock polymer is synthesized through an atom transfer radical polymerization reaction. The method is mild in reaction conditions, simple in operation and high in product yield; compared with an ordinary free radical polymerization reaction, the molecular structures of products are more regular, the molecular weight is controllable, and the distribution is narrower. The polymer disclosed by the invention contains a non-ionic polymer block (MPEG), a cationic polymer block (PDMAEMA) and a zwitterionic polymer block (PSBMA) at the same time, has good biocompatibility and biological fouling resistance, has the multi-response property for the temperature and the carbon dioxide in solution, and can serve as a carrier to realize load, transmission and target control release for medicine.