Block polymer with multi-response property for temperature and carbon dioxide and preparation method thereof

A carbon dioxide, responsive technology, applied in the field of functional polymer materials, to achieve the effects of good biocompatibility and resistance to biological damage, good resistance to biofouling, and mild reaction conditions

Inactive Publication Date: 2015-01-07
SHANDONG JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After retrieval, a triblock copolymer with multiple responses to temperature and carbon dioxide - methoxypolyethylene glycol-b-polyethylmethacrylate dimethyl betaine-b-polymethacrylate dimethyl Aminoethyl esters, which have not been reported so far

Method used

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  • Block polymer with multi-response property for temperature and carbon dioxide and preparation method thereof
  • Block polymer with multi-response property for temperature and carbon dioxide and preparation method thereof
  • Block polymer with multi-response property for temperature and carbon dioxide and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1) Under the protection of nitrogen atmosphere (the reaction system must be strictly deoxygenated), 1 part of active bromine-terminated methoxypolyethylene glycol (MPEG-Br, number average molecular weight is 2130g / mol) As the initiator, 1 part of cuprous bromide as the catalyst, 1 part of 1,2-bipyridine as the catalyst ligand and 30 parts of ethyl methacrylate dimethyl betaine as the monomer, with deionized water and methanol The mixture was the solvent (volume ratio of deionized water to methanol 3:2). After 3 cycles of freezing-vacuumizing-thawing, the reaction mixture was reacted at room temperature for 5 h, then the product was dissolved in pure water, placed in a dialysis bag, and dialyzed in water for 48 hours (changing the water every 12 hours), to Remove residual monomers and other small molecules. The liquid in the dialysis bag was distilled under reduced pressure and dried in vacuum for 24 hours to obtain bromine-terminated methoxypolyethylene glycol-b-polyet...

Embodiment 2

[0024] 1) Except for 1 part of methoxypolyethylene glycol (MPEG-Br, the number average molecular weight is 5130g / mol), the others are the same as step 1 in Example 1);

[0025] 2) except that dimethylaminoethyl methacrylate monomer is 100 parts, other are the same as step 2 in embodiment 1);

[0026] A methoxy polyethylene glycol-b-polyethyl methacrylate dimethyl betaine-b-polydimethylaminoethyl methacrylate triblock copolymer is obtained.

Embodiment 3

[0028] 1) Except for 1 part of methoxypolyethylene glycol (MPEG-Br, the number average molecular weight is 5130g / mol), the others are the same as step 1 in Example 1);

[0029] 2) except that dimethylaminoethyl methacrylate is 200 parts, other are with step 2 in embodiment 1);

[0030] A methoxy polyethylene glycol-b-polyethyl methacrylate dimethyl betaine-b-polydimethylaminoethyl methacrylate triblock copolymer is obtained.

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Abstract

The invention discloses a triblock polymer with a multi-response property for temperature and carbon dioxide. The polymer is methoxy polyethylene glycol-b-polyethylmethacrylate dimethyl betaine-b-poly dimethyl aminoethyl methacrylate; bromine-terminated methoxy polyethylene glycol serves as a macro-molecule initiator, and the triblock polymer is synthesized through an atom transfer radical polymerization reaction. The method is mild in reaction conditions, simple in operation and high in product yield; compared with an ordinary free radical polymerization reaction, the molecular structures of products are more regular, the molecular weight is controllable, and the distribution is narrower. The polymer disclosed by the invention contains a non-ionic polymer block (MPEG), a cationic polymer block (PDMAEMA) and a zwitterionic polymer block (PSBMA) at the same time, has good biocompatibility and biological fouling resistance, has the multi-response property for the temperature and the carbon dioxide in solution, and can serve as a carrier to realize load, transmission and target control release for medicine.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and relates to a block polymer with multiple responses to temperature and carbon dioxide and its preparation, in particular to a methoxy polyethylene glycol-b-polyethyl methacrylate Dimethylbetaine-b-polydimethylaminoethyl methacrylate and its preparation method. Background technique [0002] Environmentally responsive polymers are a class of polymer materials with special functions, also known as "smart materials", which have a wide range of applications in the fields of material separation, drug carriers, optoelectronic devices, and sensors. Under certain conditions, environmentally responsive polymers can change their physical and chemical properties by producing stimuli responsiveness to changes in external environmental factors (such as temperature, light, ionic strength, pH value, electromagnetic field or special gases, etc.). The study of temperature-responsive polyme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F220/38C08F220/34A61K47/32
Inventor 唐新德张群庞来学裴梅山韩念风周德杰
Owner SHANDONG JIAOTONG UNIV
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