The invention discloses a preparation method of a composite filling
microsphere with a multilayer core-shell structure and a product and application of the composite filling
microsphere with the multilayer core-shell structure, collagen is wrapped in an inner core of a poly-L-
lactic acid microsphere through an emulsification technology, a stable
sodium hyaluronate layer is attached to the surface of the poly-L-
lactic acid microsphere, and a collagen-poly-L-
lactic acid-
sodium hyaluronate composite microsphere with the multilayer structure is formed.
Sodium hyaluronate on the
surface layer of the composite filling microsphere with the multi-layer core-shell structure rapidly absorbs water and swells, and after injection, recesses are immediately smoothed, the outline is supported, and meanwhile, a moisturizing film is formed, so that the filling part is natural in touch and is not rigid. The inner core poly-L-lactic acid microspheres are slowly degraded, continuously release biological signals, accurately stimulate
fibroblast proliferation and push self collagen regeneration, the homology of the wrapped collagen and the self collagen of the
human body is high, instant filling can be assisted, a template can be provided for new collagen, the regenerated collagen structure is more regular, and the
skin elasticity is more lasting.