491 results about "Acridine" patented technology

Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.

The invention discloses a waterproof anticorrosive coating and a preparation method and application thereof, and relates to the technical field of coatings, and the waterproof anticorrosive coating is prepared from the following raw materials in parts by weight: 30-40 parts of carboxyl-terminated hyperbranched polyester resin, 20-30 parts of carboxyl-terminated functional polyamide, 10-15 parts of hyperbranched polyurethane containing epoxy groups, 15-20 parts of filler, 1-3 parts of (3, 6-diamino acridine-9-yl) boric acid, 1-3 parts of 1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5- the component A is prepared from the following components in parts by weight: 3-5 parts of 2, 3, 5-triglycidyl-S-triazinetrione, 1-2 parts of a coupling agent, 0.8-1.2 parts of a flatting agent and 0.6-1.3 parts of a defoaming agent; the carboxyl-terminated functional polyamide comprises a structural unit introduced by the following monomers: N-(4H-1, 2, 4-triazole-4-yl) diphenylamine-4, 4 '-dicarboxylic acid, and 3, 3'-diamino-4, 4 '-difluorodiphenyl sulfone. The coating is good in waterproof and anti-corrosion performance, high in adhesive force with a base material, sufficient in solvent resistance and aging resistance and long in service life.

The invention provides a hole transport material, a preparation method thereof and a perovskite solar cell. The chemical structural formula of the hole transport material is # imgabs0 #, wherein each A is independently a heteroatom. A thiophene-methoxy triphenylamine group and a thiophene-methylthio triphenylamine group are introduced into an acridine phosphate side chain, and a series of novel hole transport materials are provided. The hole transport material has higher decomposition temperature, better thermal stability and higher hole mobility, thereby being beneficial to hole extraction and transport. The hole transport material has a deep HOMO energy level matched with perovskite, and can be used in a perovskite solar cell without doping any additive, so that the perovskite solar cell has higher photoelectric conversion efficiency, photovoltaic performance and stability, and the material has repeatability.

The invention relates to the technical field of immunodetection and immunodiagnosis, in particular to a chemiluminescence substrate solution, a chemiluminescence detection kit and a detection method. The chemiluminescent substrate solution comprises a substrate solution 1, or comprises the substrate solution 1 and a substrate solution 2, the substrate solution 1 comprises sodium hydroxide, a surfactant and a blue light absorbent for absorbing blue light with the wavelength of 400-500 nm; the substrate solution 2 comprises inorganic acid and hydrogen peroxide. According to the application, the blue light absorbent is added into the chemiluminescent substrate liquid, so that blue light emitted by acridinium ester can be absorbed, a luminescent signal is reduced, and particularly, the luminescent value of a background caused by non-specific adsorption is reduced, so that the signal-to-noise ratio is increased.

The invention discloses a magnetic particle chemiluminiscence detection kit for human non-phosphorylated Tau217 protein and a preparation method of the magnetic particle chemiluminiscence detection kit. The kit comprises a micro magnetic particle coupled with a human non-phosphorylated Tau217 protein capture antibody, an acridinium ester labeled human non-phosphorylated Tau217 protein detection antibody, a human non-phosphorylated Tau217 protein calibration product and a quality control product. The direct chemiluminescence method established by the invention has the advantages of high sensitivity, strong specificity, accuracy, rapidness and short detection time, the detection result has higher accuracy and repeatability, and the kit can be used for various luminescence detection instruments.

The invention discloses a halogen-free low-splashing environment-friendly solder wire and a preparation method thereof, and relates to the technical field of electronic welding materials, and the halogen-free low-splashing environment-friendly solder wire is prepared from the following raw materials in percentage by mass: 1-4wt% of halogen-free scaling powder and the balance of lead-free solder; the lead-free solder is composed of the following components of Cu, Bi, Al, Ga, Ir, Ca, In and Sn. The halogen-free scaling powder comprises the following components: (3, 6-diamino acridine-9-yl) boric acid, glycerol triabietate, 3-(N-morpholinyl)-2-hydroxy propanesulfonic acid sodium salt, 3-trihydroxymethyl methylamino-2-hydroxy propanesulfonic acid, hexahydro-1, 3-ethoxy-s-triazine, a functional copolymer, a surface active agent, a corrosion inhibitor, a halogen-free activity reinforcing agent, an antioxidant, a solvent and rosin resin. The solder wire is low in splashing rate, high in surface resistivity and welding spot reliability, free of obvious corrosivity and good in weldability.

The invention provides a myosin binding protein C detection kit which comprises 1) a magnetic bead coupled with a first antibody and 2) a second antibody coupled with acridinium ester, and the first antibody and the second antibody are human myosin binding protein C antibodies but are combined with different epitopes. The myosin binding protein C detection kit can detect the content of myosin binding protein C in serum with high sensitivity through a double-antibody sandwich method and the chemiluminescence characteristic of acridinium ester.

The invention relates to the technical field of A beta 1-42 detection, and discloses a novel magnetic particle chemiluminescence detection kit for A beta 1-42 and a preparation method of the novel magnetic particle chemiluminescence detection kit for A beta 1-42. A double-antibody sandwich method is adopted, A beta 1-42 and reagents form a sandwich structure compound when a sample is incubated with a reagent R1 and a reagent R2, and the sandwich structure compound is used for detecting A beta 1-42. The acridinium ester in the reagent can emit light with specific wavelength under the action of excitation liquid, a full-automatic chemiluminescence immunoassay analyzer is used for detecting a luminescence value, and the content of Abeta1-42 is measured according to a standard curve of concentration-luminescence value of Abeta1-42. According to the present invention, the damage of the antibody and biotin coupling process and the labeled antibody and marker coupling process to the immunocompetence of the Abeta1-42 mouse anti-human IgG antibody is avoided, the reactivity and the sensitivity of the detection are significantly improved, the reaction time is shortened, particularly, the sensitivity is significantly higher than that of other methodologies, and the detection rate of the Abeta1-42 in the human serum is improved.

The invention belongs to the technical field of chemiluminescence immunoassay, and particularly relates to an acridinium ester luminescent substrate and application thereof.The acridinium ester luminescent substrate comprises a pre-excitation solution and an excitation solution, the pre-excitation solution is a hydrogen peroxide acid solution containing 0.05-0.2% of polyvinylpyrrolidone and / or 0.1-0.3% of polyethylene glycol, and the excitation solution is an acridinium ester luminescent substrate. The excitation liquid is an alkali solution containing 0.5 to 2 percent of triton. The polyvinylpyrrolidone and / or polyethylene glycol in the pre-excitation liquid and triton in the excitation liquid are matched, so that the reaction intensity of a substrate and acridinium ester molecules can be enhanced, the light production efficiency of acridinium ester in unit time is improved, and the method has good effects on background or background control, signal-to-noise ratio improvement and the like.

The inorganic quick-setting filling material comprises a material A and a material B. The material A is prepared from the following components in parts by weight: 25-35 parts of sulphoaluminate cement, 30-40 parts of blast furnace slag, 10-20 parts of waste gypsum, 1-3 parts of recycled alumina fiber, 5-10 parts of volcanic ash and 0.8-1.2 parts of (3, 6-diamino acridine-9-yl) boric acid. The material B is prepared from the following raw materials in parts by weight: 4 to 6 parts of functional water-soluble resin, 1 to 2 parts of sodium 3-(N-morpholinyl)-2-hydroxypropanesulfonate, 0.5 to 0.8 part of sucralose, 0.1 to 1 part of sodium lignin sulfonate, 0.8 to 1.2 parts of 1, 3, 5-triglycidyl-S-triazinetrione and 0.1 to 0.5 part of sodium N-(trimethoxysilylpropyl) ethylenediamine triacetate. The material is good in rapid hardening effect, high in compressive strength, good in flame-retardant and antistatic performance and long in service life.

The invention discloses a chemiluminescence heparin binding protein kit and a determination method thereof. The kit comprises reagent components of a reagent R1, a reagent R2 and a reagent R3, as well as a matched calibrator, a matched quality control product, a matched pre-excitation liquid, a matched excitation liquid and a matched cleaning liquid, wherein the reagent R1 contains magnetic particles coated with streptavidin, and the reagent R2 and the reagent R3 are respectively monoclonal antibodies which are labeled by acridinium ester and biotin and are used for recognizing different epitopes of human HBP. The kit shows better sensitivity, wider detection range and high specificity, and can effectively reduce potential endogenous and exogenous interference in clinical samples of potential interference people.

The invention is suitable for the technical field of solar cells, and provides a perovskite solar cell module and a preparation method thereof. The perovskite solar cell module comprises an anode, a hole transport layer, a perovskite layer, an electron transport layer and a cathode which are sequentially laminated. An optical active material used for preparing the perovskite layer is metal halide perovskite, and the specific chemical formula is Cs0. 15FA0. 85PbI3; and a cathode interface material used for preparing the cathode interface layer is quinacridone derivative (DCNQA-PyBr). According to the invention, DCNQA-PyBr is used as the cathode interface material to be applied to the perovskite (such as a Cs0. 15FA0. 85PbI3 system) solar cell module, the thick film processing of the cathode interface material can be realized, the energy conversion efficiency of the perovskite solar cell module is improved, and the cathode interface material is suitable for large-scale production and can meet the requirement of large-area industrial production.

The invention provides a naphthalimide compound as well as a preparation method and application thereof, and belongs to the technical field of organic compounds. N-(4-tert-butylphenyl) naphthalimide is used as an acceptor unit (a group A), 9, 9-dimethyl acridine, 9, 9-diphenyl acridine, phenoxazine, phenothiazine, 7H-benzo [c] carbazole or 9H-dibenzo [a, c] carbazole is used as an electron donor unit (a group D), and the donor unit and the acceptor unit are connected through ortho-positions or meta-positions of benzene bridges or derivatives thereof; the formation of the 3CT state depends on the CT effect between the D group and the A group, the specific D group and the benzene bridge unit are selected to control the distance and the dihedral angle between the D unit and the A unit so as to realize the regulation and control of the service life of the 3CT state, and meanwhile, the fine adjustment of the energy of the 3CT state is realized by virtue of the substituent group on the benzene bridge unit, so that the service life of the 3CT state is prolonged. Therefore, the naphthalimide compound has a long charge transfer triplet state lifetime in a single molecule state.

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention discloses a functional polyester yarn and a preparation method thereof. The functional polyester yarn is formed by blending functional synthetic fibers and bamboo fibers according to the mass ratio of (3-5): 0.5. The functional synthetic fiber is prepared from the following raw materials: polyester chips, a functional copolymer, a compatilizer, an antioxidant, a lubricant, 1, 4-diamino-2, 3-dicyanoanthraquinone and (3, 6-diamino-9-acridinyl) boric acid. The functional copolymer comprises structural units introduced by the following monomers: diphenyl (4-vinyl phenyl) phosphine oxide, 4-methyl-5-vinyl thiazole, 1-allyl-3-methyl imidazole chloride, 3-(1, 1-difluoro-2-propylene-1-yl)-2 (1H)-quinoxalinone, and 1, 3-bis (oxiranyl methyl)-5-(2-allyl)-1, 3, 5-triazine-2, 4, 6 (1H, 3H, 5H)-triketone. The yarn is good in anti-ultraviolet performance, flame retardant performance and antibacterial performance.

The invention provides a terephthalic acid hydrogenation catalyst and a preparation method and application thereof, and belongs to the technical field of catalysts.The preparation method includes the steps that S1, after nanometer ytterbium oxide, potassium hydrogen oxalate, acridone acetic acid and polyarylene ether nitrile are mixed, heat treatment, cooling, ultrasonic treatment, washing and drying are conducted, and a catalyst carrier of a porous structure is obtained; s2, adding 4-(tert-butyldimethylsiloxy) phenylboronic acid into ethanol, stirring, adding the pretreated nickel-copper-iron-magnesium powder, homogenizing, heating, stirring, cooling, centrifuging, washing and drying to obtain catalyst powder; s3, adding the suspension of the catalyst powder into the suspension of the catalyst carrier, heating, stirring, cooling, centrifuging, washing and carrying out heat treatment to obtain the terephthalic acid hydrogenation catalyst. The catalyst provided by the invention not only can realize an excellent hydrogenation catalysis effect, but also has certain cost benefits.

The invention provides a chemiluminiscence detection kit for A beta 1-40 and application of the chemiluminiscence detection kit. The invention provides a preparation method of an acridinium ester labeled A beta 1-40 antibody compound solution for chemiluminescence detection of A beta 1-40, according to the method, an antibody preservation solution is replaced, factors such as glycerol or some preservatives, antibody fragments, residues and the like which are not beneficial to labeling in the original preservation solution can be removed, and the stability of an antibody to be labeled is improved; the invention provides a labeling buffer solution formula for improving the labeling efficiency of an acridinium ester antibody complex. The invention provides a formula of a blocking buffer solution for improving the stability of an acridinium ester antibody complex. The invention provides a separation buffer solution formula for column separation of an acridinium ester antibody compound and free acridinium ester. The labeling efficiency of the acridinium ester antibody compound can be improved by eluting a chromatographic column with the separation buffer solution according to the formula. The kit has the advantages of simple operation process, high sensitivity, high accuracy, strong stability, short detection time, reliable result, low cost and the like.

The invention discloses antistatic medical gauze and a preparation method thereof. The antistatic medical gauze is formed by blending carbon nanotube graphene conductive fibers, medical chitosan fibers and functional synthetic fibers, the functional synthetic fiber is prepared from the following raw materials in parts by weight: 100 parts of a functional synthetic copolymer and 3-5 parts of (3, 6-diamino-9-acridinyl) boric acid, the functional synthetic copolymer comprises structural units introduced by the following monomers: 1-allyl-3-methylimidazole chloride, N-vinyl oxazolidinone, 3-[N, N-dimethyl-[2-(2-methylpropyl-2-enoyloxy) ethyl] ammonium] propane-1-sulfonic acid inner salt, N-(4-cyano-3-trifluoromethylphenyl) methacrylamide, 1, 2, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, the catalyst is 1, 3-bis (oxiranyl methyl)-5-(2-propenyl)-1, 3, 5-triazine-2, 4, 6 (1H, 3H, 5H)-triketone. The gauze is good in antibacterial property, excellent in air permeability and antistatic property and long in service life.

The invention belongs to the technical field of in-vitro diagnosis, and discloses a chemiluminescence-based FGF21 detection kit and a preparation method thereof, and the kit comprises magnetic microspheres of which the surfaces are coupled with FGF21 specific antibodies, the FGF21 specific antibodies containing acridinium ester labels, a sample diluent, a luminescence pre-excitation liquid, an excitation liquid and FGF21 calibrators with different concentrations. According to the FGF21 detection kit disclosed by the invention, a method for preparing magnetic bead microspheres, carrying out surface modification and carrying out surface coupling on an FGF21 specific antibody is deeply explored, and the FGF21 specific antibody containing an acridinium ester label and a luminescence excitation system are matched, so that the prepared FGF21 detection kit can be used for accurately detecting FGF21 protein; and the detection kit has the advantages of high sensitivity, good accuracy, good repeatability and high automation degree of test operation, can treat a large batch of samples, further provides effective detection products and methods for clinical detection, and has strong practicability.

The invention relates to an acridine sulfonamide carboxylic acid derivative as well as a preparation method and application thereof, and the preparation method comprises the following steps: in an alkaline environment, acridine sulfonamide and amino acid or an amino acid derivative are subjected to amidation reaction in an organic solvent, and the acridine sulfonamide carboxylic acid derivative is obtained after purification; wherein the acridine sulfonamide carboxylic acid derivative has two acridine sulfonamide-like groups, and the two acridine sulfonamide-like groups are connected through the amino acid or the amino acid derivative. The yield of the preparation method exceeds 70%, and the luminous efficiency of the prepared acridine sulfonamide carboxylic acid derivative is higher and is about two times that of acridine sulfonamide NSP-SA-NHS.

The invention belongs to the photovoltaic field, and particularly relates to a hole transport layer compound, a hole transport layer, a photovoltaic device and a preparation method. The hole transport layer compound disclosed by the invention has a structure as shown in a formula I, wherein the definitions of X1, X2, A and L are described in the specification. The hole transport layer compound provided by the invention is an acridine derivative, has better film forming uniformity as a hole transport material, can improve the performance of a large-size perovskite photovoltaic device, and has very high commercial application prospects. # imgabs0 #

The invention discloses a method for preparing a biological hydrocarbon compound by organic photocatalysis higher fatty acid decarboxylation, which comprises the following steps: adding higher fatty acid, a hydrogen atom transfer catalyst and an acridine photocatalyst / solid-phase acridine photocatalyst into a reaction solvent, stirring and reacting for 12-24 hours under the conditions of blue light irradiation and room temperature to obtain a reaction solution, filtering, washing and drying to obtain the biological hydrocarbon compound. And removing the reaction solvent of the obtained reaction solution under reduced pressure, and purifying by thin layer chromatography / column chromatography to obtain the long-chain alkane compound after decarboxylation of the higher fatty acid. The method is simple in step, mild in reaction condition and high in product yield, does not use any metal compound, and has the characteristics of high atom economy and environmental protection. And for unsaturated carboxylic acid, olefin configuration before and after decarboxylation is not influenced. When solid-phase acridine is used as a photocatalyst for reaction, the catalyst can be recycled through simple washing, filtering and recycling, excellent catalytic activity can still be kept after the catalyst is recycled for more than 10 times, and the reaction cost is further reduced.

The invention discloses a method for detecting beta-amyloid protein in urine by magnetic particle chemiluminescence based on acridinium ester. The method comprises the following steps: (1) coupling carboxyl magnetic beads with an A beta 42 N-terminal antibody; (2) labeling acridinium ester and a Lec antibody; and (3) respectively diluting the A beta calibrator, the urine sample to be detected, the magnetic bead compound and the acridinium ester-Lec antibody compound, and carrying out luminescence detection on a luminescence instrument.

The invention discloses an acridine-derived thermally activated delayed fluorescent material and an electroluminescent device thereof, and belongs to the technical field of organic luminescent materials. According to the fluorescent material, any electron withdrawing group is used as a receptor, an acridine derivative is used as a donor, nitrogen atoms of the acridine derivative are directly connected with the receptor, a dihedral angle between an electron donor and the electron receptor is increased, the dihedral angle is kept at an angle close to 90 degrees, meanwhile, the large-rigidity donor structure further reduces intramolecular vibration relaxation, and the fluorescence intensity is improved. In addition, HOMO delocalization can be further realized through side conjugation modification of acridine, so that large antiintersystem crossing rate and radiation decay rate are realized, the luminescence property of molecules is further improved, and the efficiency roll-off is reduced. The material provided by the invention can be used as an active material to be applied to organic electroluminescent devices.

The invention discloses an electrolytic adhesive tape, which relates to the technical field of adhesives and sequentially comprises a first release film layer, a first electrolytic adhesive layer, an aluminum foil base material layer, a second electrolytic adhesive layer and a second release film layer from top to bottom, the first electrolytic adhesive layer and the second electrolytic adhesive layer are mutually independently prepared from the following raw materials in parts by weight: 100 parts of functional copolymer, 6-15 parts of metal lithium salt, 1-2 parts of surfactant, 4-6 parts of amphoteric organic ion salt, 3-5 parts of (3, 6-diamino acridine-9-yl) boric acid, 0.3-1 part of flatting agent and 30-50 parts of solvent. The electrolytic adhesive tape is small in ion exudation amount, good in bonding strength before energization, low in bonding strength after energization and free of adhesive residues during stripping.

The invention belongs to the technical field of photocuring, and particularly relates to an acridine-anthracene compound and a photosensitizer or photoinitiator containing the acridine-anthracene compound. Specifically, the structure of the compound disclosed by the invention is shown as a formula (I), and compared with the existing commercial sensitizer, the compound disclosed by the invention has the advantages of higher curing hardness, no frosting phenomenon and excellent solubility and photosensitive activity, and can be applied to the field of photocuring as a sensitizer or a photoinitiator.

Sulfonated 2(7)-aminoacridone and 1-aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis The invention relates to fluorescent dyes with multiple negatively charged groups in their ionized form which are aminoacridone sulfonamides or 1-aminopyrenes having of one of the following general formulae A-D: Formula (A), Formula (B), Formula (C), Formula (D), wherein the ionizable groups X are typically selected from the following: SH, COOH, SO3H, OSO3H, OP(O)(OH)2, OP(O)(OH)Ra, P(O)(OH)2, P(O)(OH)Ra, where Ra═C1-C4alkyl or substituted C1-C4alkyl. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans.

The invention relates to a kit for jointly detecting markers A beta 1-40 and A beta 1-42 as well as a preparation method and application of the kit, and relates to the technical field of immunodetection. The kit comprises a first reagent and a second reagent, the first reagent comprises a magnetic bead working solution and a magnetic microsphere coated with an A beta polyclonal antibody; and the second reagent comprises a labeled antibody diluent and an acridinium ester labeled anti-A beta antibody. According to the method, an anti-A beta 1-40 antibody and an anti-A beta 1-42 antibody with high specificity are adopted, and the ratio of A beta 1-40 to A beta 1-42 is calculated; a magnetic bead working solution and a labeled antibody diluent are adopted, so that the sensitivity and the stabilizer of the kit are further improved; the detection time is 8 minutes, the result can be obtained, the repeatability is within 4%, the lowest detection limit of A beta 1-40 is 1.08 pg / ml, and the lowest detection limit of A beta 1-42 is 1.08 pg / ml.

The invention belongs to the technical field of acridine derivatives, and provides a tri-substituted acridine derivative as well as a preparation method and application thereof. The structural formula of the tri-substituted acridine derivative disclosed by the invention is # imgabs0 #. The tri-substituted acridine derivative has excellent selectivity and stability on a four-helix structure (G4-DNA), has broad-spectrum anti-tumor activity including but not limited to ovarian cancer, prostatic cancer, colorectal cancer, lung cancer, liver cancer, gastric cancer and the like, and has low toxic and side effects on normal cells and tissues.

The embodiment of the invention provides a cycloolefin copolymer, a preparation method thereof, an optical product and electronic equipment. Wherein the chemical formula of the cycloolefin copolymer is # imgabs0 #, x is the monomer number of a nitrogen-containing heterocyclic ring polymeric monomer, y is the monomer number of norbornene, n is 3 or 4, and R is a nitrogen-containing heterocyclic ring group and comprises at least one of pyridyl, quinolyl and acridinyl. According to the preparation method of the cycloolefin copolymer in the embodiment of the invention, the cycloolefin copolymer with high refractive index can be provided.