41 results about "Acridine" patented technology

The present invention relates to the technical field of organic light-emitting materials, and provides a tetradentate cyclometalated platinum (II) complex based on an oxygen atom linkage and containing phenyl acridine and an application thereof. The tetradentate cyclometalated platinum (II) complex has the structure as represented by general formula (I). (I) The cyclometalated platinum (II) complex in the present invention adopts a tetradentate ligand, is high in rigidity, and can improve the light stability of a light-emitting material. At the same time, the complex molecule can strongly emit light, and therefore can be used as a light-emitting material in an OLED device.

This invention relates to toners. A toner comprises toner particles containing a binder resin, wherein the toner particles further comprise a compound represented by formula (1) and a pigment having a quinacridone structure; wherein, in formula (1), R represents a straight-chain or branched alkyl group having 4 to 22 carbon atoms, and n is an integer from 1 to 4.

The application belongs to the technical field of medicine, and relates to N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compounds and a preparation method and application thereof. The preparation method of the compound is as follows: taking o-aminobenzoic acid as a starting material, performing substitution reaction, condensation reaction, alkylation reaction and hydrolysis reaction to generate a key intermediate acridone acetic acid, and finally performing condensation reaction on the acridone acetic acid and substituted pyrimidine in the presence of TCFH and NMI condensing agents to obtain the target compound. The preparation method of the N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compound provided in the application is simple and feasible, and good results are shown in in-vitro anti-tumor activity tests, and the compound has excellent anti-proliferation ability on human breast cancer cells BT-549 and MDA-MB-231 in particular.

The application discloses an acridinium ester labeled complex, which comprises a body, and a labeling group labeled on the body, wherein the body is an antibody, and the labeling group is an acridinium ester group. A preparation method of the acridinium ester labeled complex comprises the following steps: sucking a labeling buffer into a centrifugal tube; sucking an antibody to be labeled into the centrifugal tube and mixing to generate a first mixed solution; adding an acridinium ester solution and mixing, and then performing reaction at 25 DEG C in the dark for 2 hours to generate a second reaction solution; adding a termination buffer and mixing, and then performing reaction at 25 DEG C in the dark for 30 minutes to generate a third reaction solution; performing desalting purification on the third reaction solution to generate a fourth mixed solution; and filtering the fourth mixed solution with a 0.22 mu m filter membrane to generate the acridinium ester labeled complex. According to the preparation method, the labeling efficiency of the acridinium ester and the antibody is higher, the reactivity is stronger, the non-specific adsorption is lower, the sensitivity is higher, the repeatability and stability are better, and the labeling method is simple, rapid and easy to repeat.

This application discloses a chemiluminescence detection kit for acrylonitrile magnetic microparticles and its detection method. The kit includes a magnetic bead working solution and a luminescent label. The magnetic bead working solution includes acrylonitrile monoclonal antibody A and streptavidin. The luminescent label includes acrylonitrile monoclonal antibody B, modified nano-silica, anhydrous toluene, methoxy polyethylene glycol-succinimide ester, N,N-dimethylformamide, acrylonitrile succinimide ester, glutaraldehyde, and ethanolamine. This application uses modified nano-silica as a carrier and grafts a polyethylene glycol hydrophilic layer onto its surface, which amplifies the acrylonitrile ester molecule signal, reduces non-specific adsorption, and improves the sensitivity, specificity, and reliability of the detection.

The application discloses a chemiluminescence kit for detecting CA72-4 based on an acridinium ester system, which comprises magnetic microspheres connected with anti-CA72-4 monoclonal antibody mAb1, an acridinium ester label of anti-CA72-4 monoclonal antibody mAb2, CA72-4 antigen calibrators, a cleaning solution, an excitation solution and the like. The kit is simple to operate, the whole detection time is 20 min, the detection efficiency is greatly improved, the test precision is relatively high, and the CV is not higher than 5%. In addition, the test results of clinical samples show that the kit has a good clinical coincidence rate, and has important significance for the auxiliary diagnosis of various tumors.

This invention discloses a nopinel-based bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, along with its preparation method and applications. The probe is 2-(2-(5-(4-(3,3-dimethyl-1,2,3,4-tetrahydro-2,4-geomylidene-acridin-9-yl)phenyl)furan-2-yl)vinyl)-6-methoxy-3-methylbenzothiazolium iodide, abbreviated as TA-PFV-TI. This probe can specifically detect the viscosity and hypochlorous acid of a solution. Under 365 nm ultraviolet light irradiation, the probe's orange fluorescence gradually intensifies with increasing solution viscosity. The linear detection range for viscosity is 1.28 cP–1411.98 cP, with a response time within 1 second and a detection limit of 1.00 cP. Upon addition of hypochlorous acid to the probe solution, its fluorescence color changes from orange to bright blue. The linear detection range for hypochlorous acid is 0–200 μM, with a response time of 5 min and a detection limit of 2 nM. The applicable pH range is 5–9. This probe, as a bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, exhibits numerous advantages such as good selectivity, high sensitivity, and wide applicability, demonstrating promising application prospects.

This invention discloses a photosensitizer with twisted π-conjugated charge transfer properties, its preparation method, and its applications. The preparation method of the photosensitizer includes the following steps: dissolving a quinolino[3,2,1-de]acridin-5,9-dione derivative, a perylene diimide with brominated position, and a basic substance in a first solvent to obtain a mixture; reacting a palladium catalyst with the mixture under a protective atmosphere; and after the reaction, extracting and purifying to obtain the photosensitizer with twisted π-conjugated charge transfer properties. The photosensitizer prepared by this invention uses a perylene diimide photoabsorbent group as an electron acceptor, which is then coupled with an electron donor group through a ring-closure reaction to prepare a photosensitizer with a twisted π-conjugated structure. The compound prepared by this invention has a long excited-state lifetime, high intersystem crossing efficiency, and suitable energy level structure, making it an ideal candidate material for photosensitizers and suitable for upconversion luminescence systems and visible light photocatalytic oxidation reactions.

A photosensitive resin composition comprising (A) an alkali-soluble polymer, (B) a compound having an ethylenically unsaturated bond, (C) a photoinitiator, (D) a sensitizer, and (E) polymerization inhibitors, wherein (C) the photoinitiator includes one or more selected from a 2,4,5-triallyl imidazole dimer and an acridine compound, the contained amount of (C) the photoinitiator is 5.0 mass% or more with respect to the total mass of solid content of the photosensitive resin composition, (D) the sensitizer contains a specific compound represented by the compound described by formula (D1-1), and (E) the polymerization inhibitors include (E1) a first polymerization inhibitor selected from nitroso compounds and nitroxyl radicals and (E2) a second polymerization inhibitor other than the first polymerization inhibitor.

This invention discloses a method for preparing cyclohexanol by photocatalytic hydration of cyclohexene: under inert gas protection, cyclohexene (Formula II) and water undergo a hydration reaction in an organic solvent, catalyzed by a photocatalyst and a co-catalyst, and irradiated by a light source, to obtain cyclohexanol (Formula I); the photocatalyst is an acridine salt compound (Formula III). This method is highly atom-economical, produces no byproducts, is environmentally friendly, and has broad industrial application prospects. The single-pass yield of cyclohexanol prepared by the photocatalytic hydration reaction of this invention can reach over 30%, which is significantly higher than the yield of existing technologies.

This invention discloses a blue thermally activated delayed fluorescence (TADF) material, its preparation method, and its applications, belonging to the field of luminescent materials technology. Using a triazine unit as an electron acceptor and an organophosphorus-modified diphenyl acridine as an electron donor, a blue TADF luminescent material, TRz-POAc, was synthesized. Organophosphorus modification can effectively regulate the molecular twist angle, intermolecular interactions, and photophysical properties. The prepared TRz-POAc exhibits a molecular twist angle of 83.7°, with no significant π-π stacking between molecules, and a singlet-triplet bandgap (ΔEST) as low as 0.02 eV, enabling efficient reverse system crossing (RISC) processes. In doped devices, the maximum EQE reaches 22.26% with 20 wt% doping; in undoped devices, the maximum EQE is still as high as 21.00%, demonstrating excellent deep blue light emission performance and its application potential in undoped devices.

The application relates to the technical field of organic photoelectricity, and particularly discloses a bipolar photoelectric material and application thereof, the bipolar photoelectric material has the following general formula: in the general formula, R1 is hydrogen, an aromatic hydrocarbon and derivatives thereof, an electron-donor carbazole and derivatives thereof, a phenoxazine and derivatives thereof, or an acridine and derivatives thereof; R2 is an aromatic hydrocarbon and derivatives thereof, an electron-donor carbazole and derivatives thereof, a phenoxazine and derivatives thereof, or an acridine and derivatives thereof; and R3 is an aromatic hydrocarbon and derivatives thereof, an electron-donor carbazole and derivatives thereof, a phenoxazine and derivatives thereof, or an acridine and derivatives thereof; the hydrogen in R1 can be partially replaced by deuterium or fully replaced by deuterium or not replaced by deuterium; the bipolar photoelectric material is introduced with a diphenyl sulfone thiophene sulfoxide electron-deficient group as a light-emitting unit and an electron-withdrawing unit in a molecular structure, the introduction of the group can improve the carrier mobility of the material, is beneficial to charge balance, and is further beneficial to obtaining high light-emitting efficiency.

This invention belongs to the field of biotechnology detection, and particularly relates to an immunochromatographic test strip for monitoring the purification efficiency of acridine ester-labeled antibodies, comprising test strip A and test strip B; test strip A has a first detection line T1A and a second detection line T2A on its nitrocellulose membrane, as well as a control line CA; the first detection line T1A is coated with an anti-acrididine ester antibody, and the second detection line T2A is coated with an antigen that specifically binds to the antibody to be tested; test strip B has a first detection line T1B and a second detection line T2B on its nitrocellulose membrane, as well as a control line CB; the first detection line T1B is coated with an antigen that specifically binds to the antibody to be tested, and the second detection line T2B is coated with an anti-acrididine ester antibody. The immunochromatographic test strip provided by this invention for monitoring the purification efficiency of acridine ester-labeled antibodies is a simple, intuitive, rapid, and low-cost tool for monitoring purification efficiency.

The application discloses a kind of continuous flow photocatalytic decarboxylation preparation biological hydrocarbon method, belong to the technical field of biofuel preparation.The method includes the following steps: high fatty acid compound, hydrogen atom transfer catalyst and acridine photocatalyst are dissolved in organic solvent, and mixed solution is obtained;The mixed solution is passed into circulating continuous flow light reactor, and photocatalytic decarboxylation reaction is carried out at room temperature for 12-24 hours, and reaction liquid is obtained;Reaction liquid is separated by reduced pressure distillation, and the biological hydrocarbon compound after decarboxylation is obtained.The application uses continuous flow light reactor to strengthen mass transfer and heat transfer efficiency, solves the problem that light penetration depth is limited in traditional batch photoreactor, and reaction is not uniform;Metal-free catalytic system is used, and the use of noble metal and potential residual risk is avoided.The method has mild reaction condition, higher product yield, good atom economy, and for unsaturated high fatty acid, olefin configuration can be maintained before and after decarboxylation, and has good industrial application prospect.

The invention discloses a method for synthesizing a gem-difluoroolefin compound through conversion of alkane under catalysis of acridine. The gem-difluoroolefin is a multifunctional fluorine-containing synthon and is a core unit structure for improving performance in the fields of medicines, pesticides and materials. According to the method, an alpha-trifluoroolefin compound and various alkanes are taken as raw materials, and gem-difluoroallylation is directly realized under the conditions of acridine, alkali and illumination. The method has the advantages of simple preparation operation and wide substrate applicability, and contains various electron-withdrawing or electron-donating groups and various cyclic heterocyclic or non-heterocyclic alkanes. The method is mild in reaction condition, relatively high in yield and simple in subsequent treatment, and is a green chemical synthesis method with a relatively good application prospect.

The present invention provides a pigment composition which can keep black coloration even at a low concentration itself and has excellent infrared transparency. A pigment composition of the present invention includes at least a thioquinacridone-based pigment compound (A) and a pigment compound (B). The thioquinacridone-based pigment compound (A) is one or two or more thioquinacridones which may have a substituent. The substituent is one or two or more selected from the group consisting of an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, and a halogen atom. The pigment compound (B) has 0 < a*< 80 and -80 < b*< 0 in the L*a*b*color space of a pigment (BP) thereof.

This invention belongs to the field of chemiluminescence immunoassay technology and discloses an acridinium ester two-liquid substrate system for chemiluminescence immunoassay and its preparation method. The acridinium ester two-liquid substrate system includes independent substrate solution A and substrate solution B: Substrate solution A contains 0.1~0.5 w / v hydrogen peroxide, 0.01~0.05M hydrochloric acid, 20~30 v / v acetonitrile, 1~3 v / v 1,2-propanediol, with a pH of 1~2; Substrate solution B contains 0.01~0.1M sodium hydroxide, 0.5~1 v / v polyethylene glycol trimethyl nonyl ether, 0.2~0.3 w / v poloxamer 188, with a pH of 12~13. The luminescence intensity of the substrate solution of this invention is increased by approximately 50%, the background CV value is less than 10%, the sample loading repeatability CV value is less than 10%, and the real-time stability monitoring shows a retention rate of over 90% after 6 months, significantly improving the sensitivity and stability of the detection.

The application belongs to the field of biological medicine, and particularly relates to a homogeneous chemiluminescence kit for detecting platelet-monocyte aggregates and a detection method thereof. The kit comprises: R1 reagent: CD41 antibody-DNA1 conjugate; R2 reagent: CD14 antibody-DNA2 conjugate; R3 reagent: DNA3 labeled with acridinium ester; and R4 reagent: antioxidant combined with graphene oxide. The application realizes direct whole blood detection of platelet-monocyte aggregates in 5-10 minutes through homogeneous chemiluminescence+orthogonal DNA hybridization+special sample stabilizer, greatly simplifies the process, reduces the cost, and enables the sample to be stable at room temperature for 6 hours. The detection result is highly correlated with flow cytometry, and has good diagnostic efficiency for sepsis.

The application belongs to the field of biological medicine, and particularly relates to a homogeneous chemiluminescence kit for detecting platelet-monocyte aggregates and a detection method thereof. The kit comprises: R1 reagent: CD41 antibody-DNA1 conjugate; R2 reagent: CD14 antibody-DNA2 conjugate; R3 reagent: DNA3 labeled with acridinium ester; and R4 reagent: antioxidant combined with graphene oxide. The application realizes direct whole blood detection of platelet-monocyte aggregates in 5-10 minutes through homogeneous chemiluminescence+orthogonal DNA hybridization+special sample stabilizer, greatly simplifies the process, reduces the cost, and enables the sample to be stable at room temperature for 6 hours. The detection result is highly correlated with flow cytometry, and has good diagnostic efficiency for sepsis.

The application discloses a kind of thermally activated delayed fluorescence materials and preparation method, belong to the technical field of organic luminescent material.The application selects triazine as acceptor and carries out proper modification, selects acridine as donor, constructs a series of donor-acceptor type thermally activated delayed fluorescence materials, with delayed fluorescence molecular properties.The material has good luminescent performance and thermal stability in thin film state, with good device performance, and low device efficiency roll-off.The preparation process is simple and highly reproducible, and there is a possibility of large-scale industrial production.

Provided are a quinacridone compound derived from biomass, which is obtainable safely and through a clean, green, and carbon neutral approach. and a composition containing the compound. A quinacridone compound including a radioactive carbon atom 14C and having the structure represented by the following formula (B).(In the formula (B), X each independently represents —Cl, —F, —Br, —I, —OH, —NO2, a C1 to C12 alkyl group, a C1 to C12 alkoxy group, a phenyl group, —COOH, —COO—C1 to C12 alkyl, or —CO—NR, R each independently represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl group, and n each independently represents 1 or 2.)

This invention discloses an acridine-based fluorescent nanofilm, its preparation method, and its application in the fluorescence sensing detection of ethylenediamine, belonging to the field of gas phase sensing materials. The fluorescent nanofilm is prepared by the self-assembly reaction of an aldehyde-modified acridine derivative and calix[4]pyrroletetrahydrazine at the gas-liquid interface via acylhydrazone bonds. By controlling the precursor concentration and reaction time, this invention can achieve precise control of the nanofilm thickness. The prepared nanofilm has excellent self-supporting properties and a uniform porous network structure, effectively suppressing the aggregation-induced quenching effect. When this nanofilm is used as a fluorescent sensing material for the detection of ethylenediamine, it exhibits a ratiometric fluorescence response, with advantages such as fast response speed, rapid recovery, low detection limit, high selectivity, and good stability, which can meet the needs of rapid on-site visualization detection. The preparation method of this invention is simple, the reaction conditions are mild, and no template is required, which has important application prospects in the field of on-site visualization detection of ethylenediamine.

Described herein are methods for detecting one or more analytes in a sample using different chemiluminescent labels that have distinct chemiluminescence in the wavelength and kinetic domains. Also described are solid supports, reagents, and compounds for use in these methods. Generally, the methods involve detection via nearly simultaneous detection of multiple analytes in a sample conjugated to different azinium labels.

The present invention relates to relates to compounds of formula (I) wherein Ar1 comprises a substituted or unsubstituted acridine group, an organic semiconductor layer comprising at least one compound with a substituted or unsubstituted acridine group and an organic electronic device comprising the same. The invention further relates to a display device comprising the organic electronic device.

This invention relates to a detection kit for aflatoxin B1, its preparation method, and its application, belonging to the field of hazardous substance detection technology. The aflatoxin B1 detection kit provided by this invention includes a biotin-labeled aflatoxin B1 hydroxylated hapten, an acrid ester-labeled aflatoxin B1 monoclonal antibody, streptavidin magnetic beads, calibrators, a luminescent exciter, a washing solution, and a phosphate buffer mixture. This invention achieves ultrasensitive and rapid detection of aflatoxin B1 by constructing a biotin-streptavidin signal amplification system combined with the highly efficient separation characteristics of magnetic particles.

The application provides an immunochemical luminescence kit for detecting a cancer marker HPV18 E7 protein, the kit comprising biotin-labeled antibody 1 and acridinium ester-labeled antibody 2; the antibody 1 is a rabbit-derived monoclonal antibody, comprising a heavy chain and a light chain; the antibody 1 heavy chain variable region comprises VHCDR1, VHCDR2 and VHCDR3 with the amino acid sequences shown in SEQ ID NO. 1-3; the antibody 1 light chain variable region comprises VLCDR1, VLCDR2 and VLCDR3 with the amino acid sequences shown in SEQ ID NO. 9-11; the antibody 2 is a rabbit-derived monoclonal antibody, comprising a heavy chain and a light chain; the antibody 2 heavy chain variable region comprises VHCDR1, VHCDR2 and VHCDR3 with the amino acid sequences shown in SEQ ID NO. 17-19; and the antibody 2 light chain variable region comprises VLCDR1, VLCDR2 and VLCDR3 with the amino acid sequences shown in SEQ ID NO. 25-27. The application can improve the test sensitivity, improve the detection rate of weak positive samples, realize accurate quantification of HPV18 E7 protein in cervical exfoliated cells, and the detection method of the application is simple in operation, fully automatic in the detection process, and can greatly improve the detection efficiency.