178 results about "Acridine" patented technology

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention discloses an acridine-derived thermally activated delayed fluorescent material and an electroluminescent device thereof, and belongs to the technical field of organic luminescent materials. According to the fluorescent material, any electron withdrawing group is used as a receptor, an acridine derivative is used as a donor, nitrogen atoms of the acridine derivative are directly connected with the receptor, a dihedral angle between an electron donor and the electron receptor is increased, the dihedral angle is kept at an angle close to 90 degrees, meanwhile, the large-rigidity donor structure further reduces intramolecular vibration relaxation, and the fluorescence intensity is improved. In addition, HOMO delocalization can be further realized through side conjugation modification of acridine, so that large antiintersystem crossing rate and radiation decay rate are realized, the luminescence property of molecules is further improved, and the efficiency roll-off is reduced. The material provided by the invention can be used as an active material to be applied to organic electroluminescent devices.

The present invention relates to the technical field of organic light-emitting materials, and provides a tetradentate cyclometalated platinum (II) complex based on an oxygen atom linkage and containing phenyl acridine and an application thereof. The tetradentate cyclometalated platinum (II) complex has the structure as represented by general formula (I). (I) The cyclometalated platinum (II) complex in the present invention adopts a tetradentate ligand, is high in rigidity, and can improve the light stability of a light-emitting material. At the same time, the complex molecule can strongly emit light, and therefore can be used as a light-emitting material in an OLED device.

The invention relates to the technical field of solar cells, in particular to a self-assembled monomolecular hole transport material, a preparation method and application thereof, a perovskite solar cell, a preparation method thereof and a photovoltaic module. The self-assembled monomolecular hole transport material provided by the invention has a structure as shown in a formula I. In the formula I, A1, A2 and A3 are respectively and independently anchor groups or hydrogen atoms; the anchoring groups are independently selected from phosphate groups respectively; g is selected from a substituted or unsubstituted carbazolyl group, a substituted or unsubstituted acridinyl group, a substituted or unsubstituted phenothiazinyl group, and a substituted or unsubstituted phenoxazinyl group. The self-assembled monomolecular hole transport material provided by the invention has stronger anchoring binding capacity, conjugation in molecules is enhanced through the aromatic connection unit, and transport of carriers is facilitated; polyphosphonic acid anchoring in the self-assembled monomolecular hole transport material provided by the invention can enhance adsorption and uniformity of molecules, and a formed hole transport interface has better charge transport and defect passivation effects.

The invention provides a photosensitive resin composition containing an acridine methylene quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, quaternary ammonium group substituted methylene is introduced to the ninth position of a structural main body acridine ring of the photosensitizer, and acid radical or halogen is adopted as equilibrium anion. According to the photosensitizer, a quaternary ammonium salt group is introduced to the 9 site of an acridine ring, so that the problems that a traditional 9-phenylacridine photosensitizer is poor in compatibility, prone to crystallization and precipitation, insufficient in water solubility, weak in antistatic performance and the like in a formula are effectively solved. The photosensitive resin composition disclosed by the invention shows excellent dispersion stability, high sensitivity and high resolution, and can be used for remarkably reducing precipitates in a developing process and reducing poor lamination caused by static accumulation. The photosensitive dry film prepared based on the composition is suitable for fine pattern manufacturing in the fields of dry films, paints, coatings, printing ink, forming materials and the like, and has high yield and production efficiency.

The invention discloses a nopinic alkyl acridine fluorescent probe for detecting hydrazine and viscosity as well as a preparation method and application of the nopinic alkyl acridine fluorescent probe. The probe is 2-(2-(5-(4-(3, 3-dimethyl-1, 2, 3, 4-tetrahydro-2, 4-methylene acridine-9-yl) phenyl) furan-2-yl) vinyl)-1, 1, 3-trimethyl-1H-benzo [e] indoleonium iodized salt, which is called TA-PFV-BI for short. The probe can detect the viscosity of a solution, and red fluorescence emitted by the probe is gradually enhanced along with the improvement of the viscosity of the solution under the irradiation of ultraviolet light with the wavelength of 365 nm. The probe can also have a specific reaction with hydrazine, so that the fluorescence color of a probe solution is changed from colorless to bright blue, the detection range is 0-90 mu M, the response time is within 5 seconds, the detection limit is 4 * 10 <-8 > M, and the applicable pH range is 5-10. The probe TA-PFV-BI, as a bifunctional fluorescent probe capable of simultaneously detecting hydrazine and viscosity, has the advantages of good selectivity, high sensitivity, fast response, wide application range and the like, and shows a good application prospect.

This invention relates to toners. A toner comprises toner particles containing a binder resin, wherein the toner particles further comprise a compound represented by formula (1) and a pigment having a quinacridone structure; wherein, in formula (1), R represents a straight-chain or branched alkyl group having 4 to 22 carbon atoms, and n is an integer from 1 to 4.

The application belongs to the technical field of medicine, and relates to N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compounds and a preparation method and application thereof. The preparation method of the compound is as follows: taking o-aminobenzoic acid as a starting material, performing substitution reaction, condensation reaction, alkylation reaction and hydrolysis reaction to generate a key intermediate acridone acetic acid, and finally performing condensation reaction on the acridone acetic acid and substituted pyrimidine in the presence of TCFH and NMI condensing agents to obtain the target compound. The preparation method of the N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compound provided in the application is simple and feasible, and good results are shown in in-vitro anti-tumor activity tests, and the compound has excellent anti-proliferation ability on human breast cancer cells BT-549 and MDA-MB-231 in particular.

The application discloses an acridinium ester labeled complex, which comprises a body, and a labeling group labeled on the body, wherein the body is an antibody, and the labeling group is an acridinium ester group. A preparation method of the acridinium ester labeled complex comprises the following steps: sucking a labeling buffer into a centrifugal tube; sucking an antibody to be labeled into the centrifugal tube and mixing to generate a first mixed solution; adding an acridinium ester solution and mixing, and then performing reaction at 25 DEG C in the dark for 2 hours to generate a second reaction solution; adding a termination buffer and mixing, and then performing reaction at 25 DEG C in the dark for 30 minutes to generate a third reaction solution; performing desalting purification on the third reaction solution to generate a fourth mixed solution; and filtering the fourth mixed solution with a 0.22 mu m filter membrane to generate the acridinium ester labeled complex. According to the preparation method, the labeling efficiency of the acridinium ester and the antibody is higher, the reactivity is stronger, the non-specific adsorption is lower, the sensitivity is higher, the repeatability and stability are better, and the labeling method is simple, rapid and easy to repeat.

According to the purposes of the present disclosure, as embodied and broadly described herein, the present disclosure relates, in one aspect, to scaffold molecules that exhibit potent anti-malarial activity against a variety of Plasmodium strains at different stages of a parasite, such as the red and infrared stages, and pharmaceutical compositions comprising the scaffold molecules. In one aspect, these compounds are tetrahydroacridones having Structure I described herein. In another aspect, the compounds described herein may be used to treat or prevent malaria in a subject.

The application discloses an application of a light-cured material in safety indication or metal flaw detection and a safety indication and metal flaw detection method, and the light-cured material is prepared by uniformly mixing raw materials including an organic fluorescent dye and a light-cured glue; the organic fluorescent dye is a mixture of one or more of quinacridone, acridine yellow, acridine yellow G, acridine yellow hydrochloride, sulfuric acid proflavine, acridine orange, acridone, ethidium bromide and 9-aminoacridine; the light-cured glue is a mixture of one or more of UV drop glue D-606, ultraviolet curing adhesive 3491, ultraviolet curing adhesive YY1181, V3218 and ultraviolet curing adhesive 3492; or, the organic fluorescent dye is a mixture of one or more of acridine yellow, sulfuric acid proflavine, acridine orange and 9-aminoacridine, and the light-cured glue is V3018. The light-cured material can emit afterglow under white light excitation after curing, and can be applied to large-area safety indication and metal flaw detection.

Compositions are disclosed that include acridinium esters of cyclosporin A or C. Kits containing same, as well as methods of making and using same, are also disclosed.

The invention relates to the technical field of preparation of organic photoelectric materials, in particular to a boron-nitrogen compound, an organic light-emitting device comprising the same and application of the boron-nitrogen compound and the organic light-emitting device. The boron-nitrogen compound disclosed by the invention has good electron and hole receiving capability, and close packing among luminescent molecules can be effectively inhibited by introducing a large-steric-hindrance spiro structure and asymmetric substituent groups on two acridine rings. Specifically, the boron-nitrogen compound provided by the invention is used as a functional layer, especially as an organic electroluminescent device manufactured by a luminescent layer, the current efficiency is improved, the efficiency of the device is greatly improved, and the service life of the device is greatly prolonged. It shows that after most electrons and holes are compounded, energy is effectively transmitted to the boron-nitrogen compound, and therefore higher luminous efficiency is achieved.

The invention relates to a dispersing agent for water-based color paste and a preparation method of the dispersing agent. According to the dispersing agent containing the hydrophilic and hydrophobic chain segments and capable of being specifically combined with the pigment particles, a polymerization product with narrow molecular weight distribution is obtained based on RAFT polymerization, and the problem that organic pigment is prone to agglomeration in a color paste system is avoided through wrapping of the hydrophobic chain segments of polyether in the structure on the pigment particles; a polyether solvation chain segment is introduced into the structure of the dispersing agent, so that the storage stability of the dispersing agent in a water phase is ensured; the high approximation of the acridone structure and common pigment structures such as quinacridone and isoindolinone ensures the coating effect of the dispersing agent on pigment particles, the dispersing agent has good dispersibility and compatibility in different aqueous systems, a specific dispersion effect is formed, the problems of high viscosity, difficult dispersion and the like of organic pigments in the aqueous systems are effectively solved, and the dispersing agent has good application prospects. The dispersant can be used as a dispersant or an additive of systems such as water-based color paste and water-based ink. The method can be widely used in the fields of inks and paints.

The invention relates to a synthesis method of an aminoacridine compound, and belongs to the technical field of organic synthesis. The synthesis method of the amino acridine compound comprises the following steps: reacting an aryne precursor derivative, polysubstituted o-aminobenzonitrile and fluorinion in the environment of acetonitrile and inert gas to obtain an aromatic diamine derivative, mixing the aromatic diamine derivative with a solvent, and reacting to obtain the amino acridine compound. And carrying out cyclization reaction under the action of acid to obtain the aminoacridine compound. The amino acridine compound is prepared by adopting a one-pot method, the process steps are simple, the experimental process is simplified, the raw materials are cheap and easy to obtain, and the product is easy to purify.

This application discloses a chemiluminescence detection kit for acrylonitrile magnetic microparticles and its detection method. The kit includes a magnetic bead working solution and a luminescent label. The magnetic bead working solution includes acrylonitrile monoclonal antibody A and streptavidin. The luminescent label includes acrylonitrile monoclonal antibody B, modified nano-silica, anhydrous toluene, methoxy polyethylene glycol-succinimide ester, N,N-dimethylformamide, acrylonitrile succinimide ester, glutaraldehyde, and ethanolamine. This application uses modified nano-silica as a carrier and grafts a polyethylene glycol hydrophilic layer onto its surface, which amplifies the acrylonitrile ester molecule signal, reduces non-specific adsorption, and improves the sensitivity, specificity, and reliability of the detection.

The invention is applicable to the technical field of immunodetection analysis, and provides a thromboregulatory protein quantitative detection kit and a preparation method thereof.The kit comprises a magnetic bead working solution, a biotin marker working solution, an acridinium ester marker working solution, a thromboregulatory protein calibration product and a thromboregulatory protein control product; the magnetic bead working solution is composed of streptavidin magnetic beads and a magnetic bead diluent, the biotin marker working solution is composed of a biotin-labeled thromboregulatory protein antibody and a biotin diluent, and the acridinium ester marker working solution is composed of an acridinium ester-labeled thromboregulatory protein antibody and an acridinium ester diluent. The thromboregulatory protein quantitative detection kit provided by the invention integrates high sensitivity, high specificity, high precision, strong anti-interference capability, wide linear range and excellent stability, and provides an ideal solution for realizing accurate, rapid and automatic quantitative detection of thromboregulatory protein.

The application discloses a chemiluminescence kit for detecting CA72-4 based on an acridinium ester system, which comprises magnetic microspheres connected with anti-CA72-4 monoclonal antibody mAb1, an acridinium ester label of anti-CA72-4 monoclonal antibody mAb2, CA72-4 antigen calibrators, a cleaning solution, an excitation solution and the like. The kit is simple to operate, the whole detection time is 20 min, the detection efficiency is greatly improved, the test precision is relatively high, and the CV is not higher than 5%. In addition, the test results of clinical samples show that the kit has a good clinical coincidence rate, and has important significance for the auxiliary diagnosis of various tumors.

The invention discloses a magnetic particle chemiluminescence detection kit and a detection method thereof, the kit comprises a magnetic bead working solution and a luminescent marker, the magnetic bead working solution comprises a peptin monoclonal antibody A and streptavidin, the luminous marker is prepared from a peptin monoclonal antibody B, modified nano silicon dioxide, anhydrous toluene, methoxy polyethylene glycol-succinimide ester, N, N-dimethylformamide, acridine succinimide ester, glutaraldehyde and ethanolamine. The acridinium ester molecular signal can be amplified by taking the modified nano silicon dioxide as a carrier and grafting the polyethylene glycol hydrophilic layer on the surface, the non-specific adsorption can be reduced, and the effects of improving the sensitivity, specificity and reliability of detection are achieved.

The invention discloses a display shell capable of generating a yellow smoke effect, which consists of a spherical shell body filled with explosives and effect powder and a paper cup seat loaded with propellant powder, and further comprises an ignition lead and a blasting fuse. According to the display shell provided by the invention, through the three-section synergistic effect of the effect powder, the explosive and the propellant powder, stable generation and high-altitude release of yellow smoke are realized. The effect drug takes 3, 6-diamino-10-methyl acridine hydrochloride as a color development core and is supplemented by a barium nitrate / strontium carbonate composite oxidant system; the explosive triggers the effect explosive to release through a high-heat reaction of aluminum powder-barium nitrate; the propellant ensures that the display shell is accurately lifted off through high-energy output of potassium perchlorate-magnesium aluminum alloy. The three formulas form synergy in three aspects of energy transfer, oxidant complementation and combustion regulation, so that the yellow smoke has the advantages of stable color development, uniform diffusion and long duration.

The application provides a synthesis method of aromatic primary amine compounds and relates to the technical field of organic synthesis. The synthesis method provided by the application comprises the following steps: under the action of a catalyst, aromatic hydrocarbon compounds and ammonium salt are reacted under visible light in a solvent system and a non-oxidizing atmosphere to generate aromatic primary amine compounds; and the catalyst comprises an acridine salt and a cobalt oxime complex. The application realizes primary amination of aromatic hydrocarbons by constructing C(sp 2 )‑N bonds through C‑H bond functionalization, and has the advantages of mild reaction conditions, simple operation, safety and greenness, no need of oxidants, atomic economy and step economy, and conformity to the green development concept.

The patent application discloses a kind of polyquinoline acridinedione macrocyclic derivatives and its preparation method and application.The application is by methylene bridging, multiple single-molecule fragments of quinoline acridinedione is gathered into macrocycle, the difference between the electron-withdrawing and electron-donating properties of carbonyl and nitrogen atom is synthesized into a variety of quinoline acridinedione macrocyclic derivatives containing the relative distribution structure of carbonyl and nitrogen atom, the interaction of carbonyl and nitrogen atom heterocycle is conducive to realize high color purity molecular luminescence.Because the free rotation of benzene ring and intramolecular vibration caused by single fragment molecule itself is not fixed, energy is attenuated in the form of non-radiative transition, and the benzene ring after being polymerized into ring can efficiently emit light due to the limited rotation, and improve the color purity of luminescence.

The present invention relates to the technical field of biological detection, and discloses an interleukin chemiluminescence detection kit and a detection method thereof, the kit comprises: interleukin magnetic particles coated with an interleukin antibody, the use concentration of the interleukin magnetic particles being 0.1-1 mg / mL; the interleukin luminous marker is an interleukin labeled antibody labeled by acridinium ester, and the use concentration of the interleukin luminous marker is 0.01 to 5 [mu] g / mL; and the interleukin analysis buffer solution contains a composite anti-interference component and is used for inhibiting the non-specific reaction of endogenous interfering substances in the sample to be detected. According to the present invention, the composite anti-interference component is introduced into the analysis buffer solution, such that the non-specific reaction of the heterotropism antibody, the human anti-mouse antibody, the rheumatoid factor and other endogenous interfering substances in the sample can be effectively inhibited, the detection background signal and the false positive rate are significantly reduced, and the detection accuracy under the complex sample matrix is improved.

This invention discloses a nopinel-based bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, along with its preparation method and applications. The probe is 2-(2-(5-(4-(3,3-dimethyl-1,2,3,4-tetrahydro-2,4-geomylidene-acridin-9-yl)phenyl)furan-2-yl)vinyl)-6-methoxy-3-methylbenzothiazolium iodide, abbreviated as TA-PFV-TI. This probe can specifically detect the viscosity and hypochlorous acid of a solution. Under 365 nm ultraviolet light irradiation, the probe's orange fluorescence gradually intensifies with increasing solution viscosity. The linear detection range for viscosity is 1.28 cP–1411.98 cP, with a response time within 1 second and a detection limit of 1.00 cP. Upon addition of hypochlorous acid to the probe solution, its fluorescence color changes from orange to bright blue. The linear detection range for hypochlorous acid is 0–200 μM, with a response time of 5 min and a detection limit of 2 nM. The applicable pH range is 5–9. This probe, as a bifunctional fluorescent probe capable of simultaneously detecting hypochlorous acid and viscosity, exhibits numerous advantages such as good selectivity, high sensitivity, and wide applicability, demonstrating promising application prospects.

The invention discloses an impermeable material for geotechnical engineering construction and a preparation method thereof, and relates to the technical field of geotechnical engineering, the impermeable material is prepared from the following raw materials by weight: 10-16 parts of sulphoaluminate cement, 1-3 parts of ash calcium powder, 0.8-1.2 parts of incense ash, 0.3-0.5 part of single-layer graphene oxide sheet, 15-25 parts of fly ash, 3-5 parts of rosin-based hyperbranched epoxy resin, 3-5 parts of (3, 4-dichlorophenyl)-1, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 3-5 parts of (3, 4-dichlorophenyl)-1, 3, 4-trimethyl-1, 3-pentanediol monoisobutyrate The invention discloses a high-temperature-resistant coating which is prepared from the following components in parts by weight: 1-3 parts of 2, 4-diaminoacridine-9-yl) boric acid, 1-3 parts of double-end epoxy silicone oil, 2-3 parts of a dispersing agent, 1-3 parts of 2, 4-diamino-6-phenyl-1, 3, 5-triazine, 0.2-0.4 part of a fiber material, 1-2 parts of citrus pulp powder and 5-8 parts of water. The material is high in compressive strength, remarkable in anti-seepage effect, excellent in acid, alkali and salt resistance and dry-wet cycle resistance, sufficient in frost resistance and long in service life.

The invention relates to a self-cleaning coating as well as a preparation method and application thereof, and relates to the technical field of coatings, and a self-cleaning functional component of the self-cleaning coating comprises modified titanium dioxide; the modified titanium dioxide is obtained by reacting titanium dioxide with an organic phosphonic acid compound as shown in a formula I. Under an existing self-cleaning coating formula system, titanium dioxide and an acridinyl-containing organic phosphonic acid compound are reacted according to a proper proportion, so that part of titanium dioxide is converted into an organic phosphonic acid titanium compound under the actions of acid-base neutralization, coordination and the like; modified titanium dioxide is endowed with double self-cleaning action mechanisms of a photocatalyst TiO2 and an air catalyst titanium phosphate, so that the self-cleaning effect of the coating is remarkably improved; meanwhile, the modified titanium dioxide can effectively enhance the bonding strength between the coating and the base material and improve the weather resistance of the coating, so that the self-cleaning use requirements of the surfaces of various base materials such as stones, aluminum plates and glass can be met.

The invention discloses an organic light-emitting macrocyclic material based on a boron-oxygen structure, and relates to the technical field of organic photoelectric materials. Wherein n represents the number of repetitive units, the value range of n is 3 or 4, and the Donor group is selected from one of the following groups. The invention further discloses an organic light-emitting macrocyclic material based on the boron-oxygen structure, and the organic light-emitting macrocyclic material based on the boron-oxygen structure is characterized in that a boron-oxygen multiple resonance thermal activation delayed fluorescence skeleton is covalently connected with 9, 10-dihydro-9, 9-dimethyl acridine, phenothiazine and phenoxazine groups, and a ring is formed through Buchwald-Hartwisting coupling and Friedel-Crafts alkylation reaction. According to the invention, the MR-TADF skeleton and the donor unit are selected in a modular manner to regulate the luminescence performance of the material, macrocyclic homologues with different cavity sizes are constructed, the material has the advantages of high fluorescence quantum yield, aggregation quenching resistance, high color purity and the like, and the efficiency and stability of an organic electroluminescent device can be remarkably improved.

To provide an inkjet ink which suppresses the occurrence of nozzle clogging and is excellent in storage stability.SOLUTION: In the inkjet ink, the pigment is a quinacridone pigment. The specific resins are neutralization products of specific copolymers containing an α - methylstyrene-derived unit, a styrene-derived unit, a (meth) acrylic acid-derived unit, and a (di) alkylene glycol (meth) acrylate-derived unit in specific proportions, and the specific copolymers have acid values of 50mgKOH / g or more and 300mgKOH / g or less and number-average molecular weights of 3000 or more and 18000 or less. The neutralization ratio of the specific resin is from 20% to 100%. The specific crosslinking agent contains a polyfunctional epoxy compound and has a water solubility rate of 80% or more. The crosslinking rate of the crosslinked resin is 25% or more and 90% or less. The alkali metal ion concentration in the aqueous media is 500ppm or less.SELECTED DRAWING: None

The invention belongs to the technical field of preparation of luminescent substrate solutions, and particularly relates to a single-component acridinium ester luminescent substrate solution and a preparation method thereof. The single-component acridinium ester luminescent substrate liquid comprises the following raw materials: sodium hydroxide, urea peroxide, N-methyl pyrrolidone, a surfactant, sodium percarbonate, a stabilizer, triton 405 and a catalyst, does not contain dangerous components, and is safer to use. The luminous substrate solution has the advantages of high luminous intensity, low background signal, good stability and thermal stability, low cost, convenience in use and the like. The preparation method of the luminescent substrate solution is simple and can be used for all types of magnetic particle chemiluminescence acridinium ester items.