282 results about "Acridine" patented technology

The invention discloses a chemiluminescence heparin binding protein kit and a determination method thereof. The kit comprises reagent components of a reagent R1, a reagent R2 and a reagent R3, as well as a matched calibrator, a matched quality control product, a matched pre-excitation liquid, a matched excitation liquid and a matched cleaning liquid, wherein the reagent R1 contains magnetic particles coated with streptavidin, and the reagent R2 and the reagent R3 are respectively monoclonal antibodies which are labeled by acridinium ester and biotin and are used for recognizing different epitopes of human HBP. The kit shows better sensitivity, wider detection range and high specificity, and can effectively reduce potential endogenous and exogenous interference in clinical samples of potential interference people.

The invention is suitable for the technical field of solar cells, and provides a perovskite solar cell module and a preparation method thereof. The perovskite solar cell module comprises an anode, a hole transport layer, a perovskite layer, an electron transport layer and a cathode which are sequentially laminated. An optical active material used for preparing the perovskite layer is metal halide perovskite, and the specific chemical formula is Cs0. 15FA0. 85PbI3; and a cathode interface material used for preparing the cathode interface layer is quinacridone derivative (DCNQA-PyBr). According to the invention, DCNQA-PyBr is used as the cathode interface material to be applied to the perovskite (such as a Cs0. 15FA0. 85PbI3 system) solar cell module, the thick film processing of the cathode interface material can be realized, the energy conversion efficiency of the perovskite solar cell module is improved, and the cathode interface material is suitable for large-scale production and can meet the requirement of large-area industrial production.

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention relates to an acridine sulfonamide carboxylic acid derivative as well as a preparation method and application thereof, and the preparation method comprises the following steps: in an alkaline environment, acridine sulfonamide and amino acid or an amino acid derivative are subjected to amidation reaction in an organic solvent, and the acridine sulfonamide carboxylic acid derivative is obtained after purification; wherein the acridine sulfonamide carboxylic acid derivative has two acridine sulfonamide-like groups, and the two acridine sulfonamide-like groups are connected through the amino acid or the amino acid derivative. The yield of the preparation method exceeds 70%, and the luminous efficiency of the prepared acridine sulfonamide carboxylic acid derivative is higher and is about two times that of acridine sulfonamide NSP-SA-NHS.

The invention belongs to the photovoltaic field, and particularly relates to a hole transport layer compound, a hole transport layer, a photovoltaic device and a preparation method. The hole transport layer compound disclosed by the invention has a structure as shown in a formula I, wherein the definitions of X1, X2, A and L are described in the specification. The hole transport layer compound provided by the invention is an acridine derivative, has better film forming uniformity as a hole transport material, can improve the performance of a large-size perovskite photovoltaic device, and has very high commercial application prospects. # imgabs0 #

The invention discloses a method for preparing a biological hydrocarbon compound by organic photocatalysis higher fatty acid decarboxylation, which comprises the following steps: adding higher fatty acid, a hydrogen atom transfer catalyst and an acridine photocatalyst / solid-phase acridine photocatalyst into a reaction solvent, stirring and reacting for 12-24 hours under the conditions of blue light irradiation and room temperature to obtain a reaction solution, filtering, washing and drying to obtain the biological hydrocarbon compound. And removing the reaction solvent of the obtained reaction solution under reduced pressure, and purifying by thin layer chromatography / column chromatography to obtain the long-chain alkane compound after decarboxylation of the higher fatty acid. The method is simple in step, mild in reaction condition and high in product yield, does not use any metal compound, and has the characteristics of high atom economy and environmental protection. And for unsaturated carboxylic acid, olefin configuration before and after decarboxylation is not influenced. When solid-phase acridine is used as a photocatalyst for reaction, the catalyst can be recycled through simple washing, filtering and recycling, excellent catalytic activity can still be kept after the catalyst is recycled for more than 10 times, and the reaction cost is further reduced.

The invention discloses an acridine-derived thermally activated delayed fluorescent material and an electroluminescent device thereof, and belongs to the technical field of organic luminescent materials. According to the fluorescent material, any electron withdrawing group is used as a receptor, an acridine derivative is used as a donor, nitrogen atoms of the acridine derivative are directly connected with the receptor, a dihedral angle between an electron donor and the electron receptor is increased, the dihedral angle is kept at an angle close to 90 degrees, meanwhile, the large-rigidity donor structure further reduces intramolecular vibration relaxation, and the fluorescence intensity is improved. In addition, HOMO delocalization can be further realized through side conjugation modification of acridine, so that large antiintersystem crossing rate and radiation decay rate are realized, the luminescence property of molecules is further improved, and the efficiency roll-off is reduced. The material provided by the invention can be used as an active material to be applied to organic electroluminescent devices.

The invention belongs to the technical field of photocuring, and particularly relates to an acridine-anthracene compound and a photosensitizer or photoinitiator containing the acridine-anthracene compound. Specifically, the structure of the compound disclosed by the invention is shown as a formula (I), and compared with the existing commercial sensitizer, the compound disclosed by the invention has the advantages of higher curing hardness, no frosting phenomenon and excellent solubility and photosensitive activity, and can be applied to the field of photocuring as a sensitizer or a photoinitiator.

The invention relates to a kit for jointly detecting markers A beta 1-40 and A beta 1-42 as well as a preparation method and application of the kit, and relates to the technical field of immunodetection. The kit comprises a first reagent and a second reagent, the first reagent comprises a magnetic bead working solution and a magnetic microsphere coated with an A beta polyclonal antibody; and the second reagent comprises a labeled antibody diluent and an acridinium ester labeled anti-A beta antibody. According to the method, an anti-A beta 1-40 antibody and an anti-A beta 1-42 antibody with high specificity are adopted, and the ratio of A beta 1-40 to A beta 1-42 is calculated; a magnetic bead working solution and a labeled antibody diluent are adopted, so that the sensitivity and the stabilizer of the kit are further improved; the detection time is 8 minutes, the result can be obtained, the repeatability is within 4%, the lowest detection limit of A beta 1-40 is 1.08 pg / ml, and the lowest detection limit of A beta 1-42 is 1.08 pg / ml.

The present invention relates to the technical field of organic light-emitting materials, and provides a tetradentate cyclometalated platinum (II) complex based on an oxygen atom linkage and containing phenyl acridine and an application thereof. The tetradentate cyclometalated platinum (II) complex has the structure as represented by general formula (I). (I) The cyclometalated platinum (II) complex in the present invention adopts a tetradentate ligand, is high in rigidity, and can improve the light stability of a light-emitting material. At the same time, the complex molecule can strongly emit light, and therefore can be used as a light-emitting material in an OLED device.

The invention relates to the technical field of solar cells, in particular to a self-assembled monomolecular hole transport material, a preparation method and application thereof, a perovskite solar cell, a preparation method thereof and a photovoltaic module. The self-assembled monomolecular hole transport material provided by the invention has a structure as shown in a formula I. In the formula I, A1, A2 and A3 are respectively and independently anchor groups or hydrogen atoms; the anchoring groups are independently selected from phosphate groups respectively; g is selected from a substituted or unsubstituted carbazolyl group, a substituted or unsubstituted acridinyl group, a substituted or unsubstituted phenothiazinyl group, and a substituted or unsubstituted phenoxazinyl group. The self-assembled monomolecular hole transport material provided by the invention has stronger anchoring binding capacity, conjugation in molecules is enhanced through the aromatic connection unit, and transport of carriers is facilitated; polyphosphonic acid anchoring in the self-assembled monomolecular hole transport material provided by the invention can enhance adsorption and uniformity of molecules, and a formed hole transport interface has better charge transport and defect passivation effects.

The invention provides a photosensitive resin composition containing an acridine methylene quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, quaternary ammonium group substituted methylene is introduced to the ninth position of a structural main body acridine ring of the photosensitizer, and acid radical or halogen is adopted as equilibrium anion. According to the photosensitizer, a quaternary ammonium salt group is introduced to the 9 site of an acridine ring, so that the problems that a traditional 9-phenylacridine photosensitizer is poor in compatibility, prone to crystallization and precipitation, insufficient in water solubility, weak in antistatic performance and the like in a formula are effectively solved. The photosensitive resin composition disclosed by the invention shows excellent dispersion stability, high sensitivity and high resolution, and can be used for remarkably reducing precipitates in a developing process and reducing poor lamination caused by static accumulation. The photosensitive dry film prepared based on the composition is suitable for fine pattern manufacturing in the fields of dry films, paints, coatings, printing ink, forming materials and the like, and has high yield and production efficiency.

The invention discloses a nopinic alkyl acridine fluorescent probe for detecting hydrazine and viscosity as well as a preparation method and application of the nopinic alkyl acridine fluorescent probe. The probe is 2-(2-(5-(4-(3, 3-dimethyl-1, 2, 3, 4-tetrahydro-2, 4-methylene acridine-9-yl) phenyl) furan-2-yl) vinyl)-1, 1, 3-trimethyl-1H-benzo [e] indoleonium iodized salt, which is called TA-PFV-BI for short. The probe can detect the viscosity of a solution, and red fluorescence emitted by the probe is gradually enhanced along with the improvement of the viscosity of the solution under the irradiation of ultraviolet light with the wavelength of 365 nm. The probe can also have a specific reaction with hydrazine, so that the fluorescence color of a probe solution is changed from colorless to bright blue, the detection range is 0-90 mu M, the response time is within 5 seconds, the detection limit is 4 * 10 <-8 > M, and the applicable pH range is 5-10. The probe TA-PFV-BI, as a bifunctional fluorescent probe capable of simultaneously detecting hydrazine and viscosity, has the advantages of good selectivity, high sensitivity, fast response, wide application range and the like, and shows a good application prospect.

The invention discloses an MALDI-MSI method for visually analyzing distribution of active ingredients of rhizoma smilacis glabrae in tissues in a rat body. The space metabolism distribution characteristics of the rhizoma smilacis glabrae bioactive components in a rat body are analyzed by utilizing an MALDI-MSI mass spectrum imaging technology, 9-aminoacridine is creatively used as a matrix based on the characteristics of the rhizoma smilacis glabrae active components, and the concentration of the 9-aminoacridine matrix and MALDI mass spectrum parameters are optimized, so that the sensitivity of the rhizoma smilacis glabrae bioactive components is improved. The ion inhibition effect of the matrix on the glabrous greenbrier rhizome active component is eliminated, the signal response of the glabrous greenbrier rhizome active component is obviously enhanced, the mass spectrum imaging quality level is improved, and the in-situ visual detection of the glabrous greenbrier rhizome active component in different tissues and organs of rats is successfully realized.

This invention relates to toners. A toner comprises toner particles containing a binder resin, wherein the toner particles further comprise a compound represented by formula (1) and a pigment having a quinacridone structure; wherein, in formula (1), R represents a straight-chain or branched alkyl group having 4 to 22 carbon atoms, and n is an integer from 1 to 4.

The application belongs to the technical field of medicine, and relates to N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compounds and a preparation method and application thereof. The preparation method of the compound is as follows: taking o-aminobenzoic acid as a starting material, performing substitution reaction, condensation reaction, alkylation reaction and hydrolysis reaction to generate a key intermediate acridone acetic acid, and finally performing condensation reaction on the acridone acetic acid and substituted pyrimidine in the presence of TCFH and NMI condensing agents to obtain the target compound. The preparation method of the N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compound provided in the application is simple and feasible, and good results are shown in in-vitro anti-tumor activity tests, and the compound has excellent anti-proliferation ability on human breast cancer cells BT-549 and MDA-MB-231 in particular.

Provided herein are methods, systems, and kits for determining the concentration or level of an analyte of interest using a competitive and sandwich immunoassay. Also provided herein are acridinium-containing and acridone-containing compounds for use in assays to detect the presence of or determine the concentration or level an analyte of interest in a sample, e.g., a biological sample.

The application discloses an acridinium ester labeled complex, which comprises a body, and a labeling group labeled on the body, wherein the body is an antibody, and the labeling group is an acridinium ester group. A preparation method of the acridinium ester labeled complex comprises the following steps: sucking a labeling buffer into a centrifugal tube; sucking an antibody to be labeled into the centrifugal tube and mixing to generate a first mixed solution; adding an acridinium ester solution and mixing, and then performing reaction at 25 DEG C in the dark for 2 hours to generate a second reaction solution; adding a termination buffer and mixing, and then performing reaction at 25 DEG C in the dark for 30 minutes to generate a third reaction solution; performing desalting purification on the third reaction solution to generate a fourth mixed solution; and filtering the fourth mixed solution with a 0.22 mu m filter membrane to generate the acridinium ester labeled complex. According to the preparation method, the labeling efficiency of the acridinium ester and the antibody is higher, the reactivity is stronger, the non-specific adsorption is lower, the sensitivity is higher, the repeatability and stability are better, and the labeling method is simple, rapid and easy to repeat.

The present invention relates to a method for evaluating the binding affinity of a bioactive substance to cardiolipin based on the use of an acridinium salt as a fluorescent probe.

The invention discloses an isolongifolanone-based fluorescent probe for detecting hydrazine as well as a preparation method and application of the isolongifolanone-based fluorescent probe. Isolongifolanone is used as a raw material and is subjected to condensation with 2-amino-4 '-bromobenzophenone, the condensation product and 4-hydroxyphenylboronic acid are subjected to Suzuki coupling, the coupling product and urotropine are subjected to formylation, the formylation product and 1-bromobutane are etherified, and the isolongifolanone derivative is obtained. The preparation method comprises the following steps: reacting 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-[1, 1'-biphenyl]-3-yl) vinyl)-3-ethyl-benzothiazole-3-onium (abbreviated as ABP-BBT) by using 2-(2-(4-butoxy-4 '-(1, 1, 5, 5-tetramethyl-1, 3, 4, 5, 6, 12b-hexahydro-2H-2, 4a-arbor methyl benzacridine-7-yl)-1, 1'-biphenyl)-1, 2, 4, 5-tetramethyl-1, 3, 4, 5 The compound ABP-BBT can specifically recognize hydrazine, the detection limit of hydrazine reaches 7.5 nM, and the compound ABP-BBT has a good application prospect.

According to the purposes of the present disclosure, as embodied and broadly described herein, the present disclosure relates, in one aspect, to scaffold molecules that exhibit potent anti-malarial activity against a variety of Plasmodium strains at different stages of a parasite, such as the red and infrared stages, and pharmaceutical compositions comprising the scaffold molecules. In one aspect, these compounds are tetrahydroacridones having Structure I described herein. In another aspect, the compounds described herein may be used to treat or prevent malaria in a subject.

The application discloses an application of a light-cured material in safety indication or metal flaw detection and a safety indication and metal flaw detection method, and the light-cured material is prepared by uniformly mixing raw materials including an organic fluorescent dye and a light-cured glue; the organic fluorescent dye is a mixture of one or more of quinacridone, acridine yellow, acridine yellow G, acridine yellow hydrochloride, sulfuric acid proflavine, acridine orange, acridone, ethidium bromide and 9-aminoacridine; the light-cured glue is a mixture of one or more of UV drop glue D-606, ultraviolet curing adhesive 3491, ultraviolet curing adhesive YY1181, V3218 and ultraviolet curing adhesive 3492; or, the organic fluorescent dye is a mixture of one or more of acridine yellow, sulfuric acid proflavine, acridine orange and 9-aminoacridine, and the light-cured glue is V3018. The light-cured material can emit afterglow under white light excitation after curing, and can be applied to large-area safety indication and metal flaw detection.

The invention belongs to the field of photoelectricity, and discloses an acridine unit-containing polymer as well as preparation and application thereof. The acridine unit has strong hole transport performance, and sp3 hybridized carbon atoms enable the acridine unit to have certain planarity, so that the hole transport performance is further enhanced. The acridine unit also has the advantages of wide band gap and high chemical stability, and the prepared polymer material has high singlet energy level. In addition, due to better planarity of the acridine unit, the energy disorder degree of the polymer can be reduced, the tail state distribution of an energy level band is reduced, and the electron blocking capability is improved. The acridine unit-containing polymer has high potential as a hole transport layer of photoelectric devices such as a quantum dot light-emitting diode, an organic light-emitting diode, a perovskite light-emitting diode, a perovskite photovoltaic device and the like, and different energy levels and mobility can be realized by adjusting the content of a polymerization unit. And the film has good solubility, and can be used for preparing a large-area film through solution processing methods such as spin-coating, ink-jet printing, printing and the like.

Compositions are disclosed that include acridinium esters of cyclosporin A or C. Kits containing same, as well as methods of making and using same, are also disclosed.

The present application relates to the field of chemiluminescent immunoassay, and specifically to water-soluble acridine sulfonamide derivatives, preparation methods, applications thereof, and kits. In some embodiments, the water-soluble acridine sulfonamide derivatives can label sulfhydryl groups under weakly alkaline or acidic conditions and are water-soluble, thereby being applicable to carbohydrate antigen detection.

The invention belongs to the technical field of organic electroluminescent materials, and particularly discloses a blue luminescent material based on benzotri (triazole). The novel blue light-emitting material is synthesized by taking benzotri (triazole) as a molecular structure center and then respectively taking bis (3, 5-di-tert-butylphenyl) amine, bis (3, 5-diphenyl) amine, bis (3, 5-dimethoxyphenyl) amine, 9, 9-dimethyl acridine, 3, 6-di-tert-butylcarbazole or 4, 4-difluorodiphenylamine as electron-donating groups. Due to a relatively large torsion angle between a donor and an acceptor, the overall planarity of molecules is reduced, so that the molecular accumulation is favorably inhibited, and the quenching of excitons is further reduced; a central core of triazole has a relatively rigid structure, so that relatively high fluorescence quantum yield (PLQY) can be provided, and blue light emission with short wavelength of 434-486nm is realized; and the method has important significance for constructing a novel blue light-emitting material.

The present invention discloses a class of quinoacridine-5,9-diketone MR-TADF red light emitting materials and their preparation methods and applications, belonging to the technical field of organic photoelectric materials. The molecules of this type of material promote the minimization of bonding / antibonding of frontier molecular orbitals through the resonance effect generated by electron-deficient nitrogen / carbonyl and electron-rich oxygen / nitrogen. In addition, the rigid conjugated skeleton suppresses the structural relaxation of the molecular excited state and the vibration coupling between the excited state and the ground state, thereby obtaining a red light emitting material with a narrow half-width (<70nm) and high luminous efficiency; the introduction of a tert-butyl group on the periphery of the molecule can reduce the reorganization energy of the molecule; grafting different substituent units can regulate the stacking and film-forming properties of the molecule. The maximum emission peak of the obtained doped red light electroluminescent device is located at 601 nm, the half-width is 68 nm, and the corresponding maximum external quantum efficiency is 9.38%, which has a wide range of applications in the fields of organic electroluminescent displays and biological imaging.

The invention relates to the technical field of preparation of organic photoelectric materials, in particular to a boron-nitrogen compound, an organic light-emitting device comprising the same and application of the boron-nitrogen compound and the organic light-emitting device. The boron-nitrogen compound disclosed by the invention has good electron and hole receiving capability, and close packing among luminescent molecules can be effectively inhibited by introducing a large-steric-hindrance spiro structure and asymmetric substituent groups on two acridine rings. Specifically, the boron-nitrogen compound provided by the invention is used as a functional layer, especially as an organic electroluminescent device manufactured by a luminescent layer, the current efficiency is improved, the efficiency of the device is greatly improved, and the service life of the device is greatly prolonged. It shows that after most electrons and holes are compounded, energy is effectively transmitted to the boron-nitrogen compound, and therefore higher luminous efficiency is achieved.

The invention relates to a dispersing agent for water-based color paste and a preparation method of the dispersing agent. According to the dispersing agent containing the hydrophilic and hydrophobic chain segments and capable of being specifically combined with the pigment particles, a polymerization product with narrow molecular weight distribution is obtained based on RAFT polymerization, and the problem that organic pigment is prone to agglomeration in a color paste system is avoided through wrapping of the hydrophobic chain segments of polyether in the structure on the pigment particles; a polyether solvation chain segment is introduced into the structure of the dispersing agent, so that the storage stability of the dispersing agent in a water phase is ensured; the high approximation of the acridone structure and common pigment structures such as quinacridone and isoindolinone ensures the coating effect of the dispersing agent on pigment particles, the dispersing agent has good dispersibility and compatibility in different aqueous systems, a specific dispersion effect is formed, the problems of high viscosity, difficult dispersion and the like of organic pigments in the aqueous systems are effectively solved, and the dispersing agent has good application prospects. The dispersant can be used as a dispersant or an additive of systems such as water-based color paste and water-based ink. The method can be widely used in the fields of inks and paints.

The invention relates to a synthesis method of an aminoacridine compound, and belongs to the technical field of organic synthesis. The synthesis method of the amino acridine compound comprises the following steps: reacting an aryne precursor derivative, polysubstituted o-aminobenzonitrile and fluorinion in the environment of acetonitrile and inert gas to obtain an aromatic diamine derivative, mixing the aromatic diamine derivative with a solvent, and reacting to obtain the amino acridine compound. And carrying out cyclization reaction under the action of acid to obtain the aminoacridine compound. The amino acridine compound is prepared by adopting a one-pot method, the process steps are simple, the experimental process is simplified, the raw materials are cheap and easy to obtain, and the product is easy to purify.