33 results about "Oxazines" patented technology

The invention discloses a high-temperature-resistant resin glue solution for a copper-clad plate and a preparation method of the high-temperature-resistant resin glue solution, and relates to the technical field of copper-clad plates. The high-temperature-resistant resin glue solution is prepared from the following raw materials in parts by mass: 60 to 80 parts of dicyclopentadiene phenol type epoxy resin, 20 to 40 parts of fluorinated benzoxazine, 10 to 30 parts of dicyclopentadiene phenol type phenolic resin, 5 to 10 parts of hyperbranched polysiloxane, 90 to 100 parts of solvent, 5 to 8 parts of additive and 10 to 20 parts of inorganic filler. Wherein trifluoromethyl and naphthalene rings are introduced into the fluorinated benzoxazine, so that the heat-resistant stability and the dielectric property of the resin glue solution are effectively improved; a copper-clad plate sample prepared from the resin glue solution has a good application effect.

The application provides an oxazinane compound, a preparation method, a pharmaceutical composition and application, and a general formula of the oxazinane compound or a pharmaceutically acceptable salt thereof is shown as formula (I). The oxazinane compound has obvious proliferation inhibition effect on cancer cells, especially human head and neck squamous cell carcinoma cell strains HSC4, HSC3, HSC2, CAL33, SCC4 and human glioma cell strain U251, can block the cell cycle, effectively inhibit the phosphorylation level of key proteins in the PI3K / AKT / mTOR pathway at the molecular level, has the potential to be prepared into a new antitumor drug, and has a good market prospect.

The present invention relates to the field of the synthesis of polymers. Disclosed are a polypropyleneimine derivative, and a preparation method therefor and a use thereof. The method comprises: firstly, initiating polymerization of an oxazine derivative monomer by means of an initiator, then removing a side chain from a polymer to obtain polypropyleneimine, selecting the polypropyleneimine for a further reaction to obtain a zwitterionic precursor polymer, and finally, hydrolyzing the precursor polymer to obtain a polypropyleneimine zwitterionic derivative. The polypropyleneimine zwitterionic derivative prepared in the present application contains a zwitterionic group in each or some of repeating units. The zwitterionic group endows the polymer with good hydrophilicity and anti-protein non-specific adsorption properties. The polymer has no immunogenicity, will not be recognized by the immune system and captured by immune cells, can be used as a drug carrier and a gene vehicle, and has good blood circulation stability. Alternatively, the polymer is used as a biological material, a medical device, an implantable material, or a cell delivery material and has good anticoagulation, anti-rejection, and biofilm properties.

A crosslinkable thermoplastic resin composition may include a polymer formed from the reaction between a bis-benzoxazine monomer and a bifunctional comonomer having phenol, amine, and / or thiol functional groups, wherein the polymer contains at least one crosslinkable group. A method of forming a crosslinkable thermoplastic resin composition may include reacting a bis-benzoxazine monomer and a bifunctional comonomer to form a polymer containing at least one crosslinkable group. A method of forming a cured thermoplastic resin may include curing the crosslinkable thermoplastic resin composition by applying an external stimulus.

The invention relates to the technical field of thin film materials, and discloses a lanthanum gallium silicon thin film material substrate and a preparation method thereof.The preparation method comprises the steps that styrene modified benzoxazine, styrene, a gallium silicon liquid gold compound and lanthanum are added into a double-screw extruder, melt extrusion is conducted, the mixture is added into a model machine, cooling is conducted, and the lanthanum gallium silicon thin film material substrate is obtained; according to the present invention, the rigid benzoxazine structure is introduced into the polyethylene to increase the rigidity of the polyethylene, and is subjected to blending modification with the gallium-silicon liquid gold compound and the lanthanum to improve the mechanical property of the polyethylene, and the benzoxazine can form the heat-resistant phenolic resin structure at the high temperature so as to provide the high thermal decomposition temperature and the high temperature resistance of the lanthanum gallium-silicon film material substrate;

The invention relates to the technical field of thermosetting materials, and discloses a preparation method of benzoxazine and bismaleimide transparent resin alloy, which comprises the following steps: preparing required materials: mixing bismaleimide and benzoxazine according to a certain proportion, adding a proper amount of solvent, and stirring for a period of time to form a uniform mixture; adding a proper amount of cross-linking agent into the mixture, fully stirring, casting a blend solution on a glass plate pretreated with dimethyldichlorosilane, drying at 50 DEG C for 4-6 hours, and then respectively carrying out heat treatment at different temperatures for 1-3 hours to obtain an alloy membrane; and testing the performance of the alloy film. According to the process, bismaleimide and benzoxazine are used as main raw materials, and the transparent bismaleimide resin alloy material with excellent performance is prepared through a specific formula and process steps. The alloy material not only has high transparency and excellent heat resistance, but also has relatively high mechanical strength and chemical stability.

The present invention relates to the use of 3,4-dihydro-2H-benzo-[1,4]oxazine drugs or salts thereof in the preparation of drugs for inhibiting ferroptosis, in particular to the use of 3,4-dihydro-2H-benzo-[1,4]oxazine compounds or salts thereof in the preparation of drugs for treating ferroptosis-related diseases, wherein the ferroptosis-related diseases include brain trauma, stroke, cardiovascular disease, liver and kidney failure, inflammation and neurodegenerative diseases, such as Parkinson's disease and schizophrenia.

The invention belongs to the technical field of polymer composite materials, and provides a PEEK / CF wear-resistant composite material and a preparation method thereof. The wear-resistant composite material is prepared from the following raw materials: PEEK powder, modified CF, B-a type benzoxazine, a compound lubricant, an antioxidant and a dispersing agent, the preparation of the modified CF comprises the following steps: carrying out plasma activation, bifunctional grafting and nanoparticle anchoring on chopped CF to obtain the modified CF; the compound lubricant comprises hydroxylated boron nitride and polyimide micro powder with the particle size of 1-5 microns according to the mass ratio of 2: 1. The preparation method comprises the following steps: (1) mixing PEEK powder subjected to vacuum drying, B-a type benzoxazine, a compound lubricant, an antioxidant and a dispersing agent to obtain a premix; (2) adding the premix and the modified CF into a double-screw extruder, and carrying out melt blending; and (3) after injection molding, cooling and demolding the mold, and drying at constant temperature to obtain the product. According to the preparation method, the wear resistance, the mechanical property, the high-temperature property and the processability of the composite material can be synchronously improved.

This invention provides a method for preparing 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one, relating to the field of compounds. The preparation method of this invention includes the following steps: (1) reacting anthranilic acid with terephthaloyl chloride in an organic solvent to generate intermediate A; (2) centrifuging the reaction product of step (1) to separate the wet crystalline intermediate A and the centrifugal mother liquor; (3) performing a cyclization reaction between the wet crystalline intermediate A from step (2) and acetic anhydride; (4) centrifuging, washing, and drying the reaction product of step (3) to obtain the target 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one product. This invention prepares 2,2'-(1,4-phenylene)bis-4H-3,1-benzoxazin-4-one with not only low yellowness values ​​and high purity, but also high yield. The preparation method of the present invention has significant industrial value, and is particularly applicable to the field of polymer material additives where strict requirements are placed on product purity and yellowness.

Lipid-polymer conjugates and associated lipid nanoparticles are described herein. Such conjugates can comprise polyoxazolines and / or poly oxazines, thereby obviating the use of PEG-based treatments.

The invention belongs to the technical field of electronic elements, and discloses an electrophoretic paste and a preparation method and application thereof. The electrophoretic slurry is prepared from the following components in parts by weight: 22 to 32 parts of modified epoxy resin, 3 to 7 parts of cationic emulsifier, 0.1 to 0.3 part of silane coupling agent, 10 to 16 parts of benzoxazine crosslinking agent, 50 to 65 parts of solvent, 10 to 20 parts of pigment and 3 to 5 parts of inorganic filler, the modified epoxy resin is a copolyester compound with an epoxy resin group at a terminal group. The electrophoresis slurry obtained by compounding the modified epoxy resin, the cationic emulsifier, the silane coupling agent, the benzoxazine cross-linking agent, the solvent, the pigment and the inorganic filler can be used in an electrophoresis protection layer of the chip resistor, so that the prepared chip resistor still has excellent stability under extreme conditions; the influence of extreme environments (temperature, humidity, overload current and the like) on the performance of the resistor is remarkably reduced, and the stable operation of the resistor in a complex environment can be ensured.

The application discloses a preparation method of 2-oxo-4-phenyl oxazine sulfonyl fluoride, and belongs to the field of organic chemical synthesis. The method is that a cinnamyl (fluorosulfonyl) carbamate compound is used as a substrate, and reacts under the action of a catalyst and a base in specific tetrahydrofuran solvent, and a 2-oxo-4-phenyl oxazine sulfonyl fluoride compound is obtained. The application uses cheap and easily obtained iodobenzene diacetic acid and potassium tert-butoxide as the catalyst and the base respectively, the substrate has wide applicability, the raw material is simple and easy to obtain, the economic cost is low, and the target product can be obtained in a good yield.

The invention discloses a preparation method and application of a trans-dimming film material, and relates to the technical field of dimming films.The preparation method comprises the steps that 1, a photosensitive benzoxazine orientation agent is prepared; 2) a coating process; 3) exposure patterning treatment; 4) performing low-temperature thermocuring; 5) assembling and packaging; through the synergistic effect of a benzoxazine phenol-rich aromatic structure and hexafluoropropyl, the flame retardant has excellent oxidation resistance, yellowing and aging are effectively resisted, and the service life is prolonged; a highly aromatized skeleton and catalytic cross-linking design endows the material with a high carbon formation rate, and the thermal stability and flame-retardant safety are enhanced; a dual covalent bond locking mechanism formed by photo-dimerization and thermal polymerization ensures the extreme stability of an oriented pattern, so that the dimming performance is durable and reliable; the obtained dimming film material is suitable for the field of dimming films of intelligent windows and privacy partitions.

The invention discloses a low-dielectric-loss hydrocarbon resin glue solution for a copper-clad plate and a preparation method of the low-dielectric-loss hydrocarbon resin glue solution, and relates to the technical field of copper-clad plates. 1, 2-polybutadiene and a hydrogenated styrene-butadiene block copolymer are compounded to guarantee low dielectric loss; hydrocarbon resin is introduced into a cyanate ester-bismaleimide-benzoxazine resin system to prepare a composite resin system, bisphenol A cyanate ester is pre-polymerized under catalysis of zinc acetylacetonate, a triazine ring structure is formed through trimerization, the glass transition temperature is increased, the dielectric constant is reduced, phenolphthalein polyarylether sulfone improves toughness and impact strength, and the dielectric constant is reduced. Bismaleimide is added to improve the adhesive force and thermal stability, and benzoxazine is subjected to ring-opening polymerization to provide phenolic hydroxyl groups and secondary amine which participate in crosslinking to form a low-dielectric thermosetting network. The modified ammonium polyphosphate and the silica powder form a heat insulation layer, phosphorus-silicon synergistic flame retardance is formed, and UL-94V-0-level flame retardance is achieved. The copper-clad plate provided by the invention is especially suitable for the high-end fields of 5G high-frequency copper-clad plates, aerospace thermal protection coatings and the like.

This invention discloses a highly efficient selective UV-absorbing film based on polyvinyl acetal and its preparation method, belonging to the technical field of polymer functional membrane materials. The UV-absorbing film comprises the following components in parts by weight: 55-95 parts of matrix resin, 5-45 parts of plasticizer, 0.005-1.2 parts of core UV absorber, 0.01-0.3 parts of auxiliary UV absorber, 0.01-0.8 parts of composite antioxidant, 0.01-0.8 parts of light stabilizer, and 0.0025-0.0065 parts of metal ion additive. The core UV absorber is an alkyl-modified benzoxazinone compound, and the composite antioxidant is a combination of a hindered phenolic resin as the main antioxidant and a thiophosphate ester as the auxiliary antioxidant. This invention achieves highly efficient blocking of UV-B radiation and high transmittance of UV-A radiation. Simultaneously, the film material has advantages such as low initial yellowing, excellent long-term anti-yellowing performance, good thermal stability, good compatibility with the matrix, and no exudation. The present invention also provides a method for preparing the core UV absorber and a method for preparing the membrane, which are simple processes and suitable for industrial production.

The invention discloses a preparation method of a poly (benzoxazine-siloxane) copolymer emulsion, and relates to the technical field of experimental design, and the preparation method comprises the following steps: 1, mixing bisphenol A, amino silicon oil and paraformaldehyde according to a ratio, and carrying out a polymerization reaction to obtain a benzoxazine monomer; according to the preparation method, bisphenol A, amino silicon oil and paraformaldehyde are subjected to a copolymerization reaction to obtain a poly (benzoxazine-siloxane) copolymer, an emulsifier and the poly (benzoxazine-siloxane) copolymer are stirred and mixed, the emulsifier with a specific HLB value is combined to prepare a stable emulsion,-NH2 of the amino silicon oil is used as an amine source of a benzoxazine monomer, and the stable emulsion is prepared. By controlling the ammonia value of the amino silicon oil, the proportion of the benzoxazine monomer is smaller than or equal to 5%, flexibility and surface energy can be balanced, the curing temperature of the emulsion is reduced to 120 DEG C from 200 DEG C, the surface energy is smaller than or equal to 15 mN / m, the wear resistance is larger than or equal to 500 times of demolding circulation, and the preparation method is more suitable for industrial production.

The invention discloses a high-temperature-resistant hot melt adhesive and a preparation method thereof, and relates to the technical field of hot melt adhesives. The high-temperature-resistant hot melt adhesive is prepared from the following raw materials in parts by weight: 25 to 35 parts of modified polyimide resin, 20 to 30 parts of modified benzoxazine resin, 8 to 12 parts of carboxyl-terminated nitrile rubber, 5 to 8 parts of C5 / C9 copolymerized petroleum resin, 3 to 5 parts of hydrophobic modified nano silicon dioxide, 1 to 2 parts of silicone powder, 0.5 to 1.0 part of antioxidant 1010, 0.3 to 0.8 part of zinc stearate and 0.05 to 0.1 part of tetrabutylammonium bromide. The high-temperature-resistant hot melt adhesive is scientific in raw material ratio, core resin is modified to improve heat resistance and compatibility, filler such as hydrophobic nano silicon dioxide is added to enhance performance, the preparation process is controllable, nitrogen protection is achieved in the whole process, moisture absorption is prevented through granulation and drying treatment, and a finished product is excellent in high-temperature resistance, good in comprehensive performance and good in storage stability.

The invention discloses high-wear-resistance self-repairing leather and a production process thereof. The high-wear-resistance self-repairing leather comprises the following raw materials: a non-woven fabric, a soaking material and a coating, the production process comprises the following steps: 1) pretreating the base material; (2) precise gravure transfer coating; (3) stepped drying and curing; 4) an embossing process; and (5) rolling. The preparation method comprises the following steps: firstly, adding 2-mercaptoethanol on cardanol for subsequent polyurethane synthesis, then generating cardanol benzoxazine with a furan side group through a Mannich reaction, constructing a DA bond through a DA reaction to obtain self-repairing polyurethane resin, and using the self-repairing polyurethane resin as a main material of a soaking material and a coating of a leather surface layer for actual production, so that the self-repairing polyurethane resin has a good application prospect. Finally, the self-repairing leather material with high strength, wear resistance and high flame retardance is obtained.

The invention discloses a silicone tube with an internal braided structure and a preparation method thereof. The preparation method comprises the following steps: 1) preparing modified silicone rubber; 2) mixing the fluorosilicone rubber composite material; 3) extrusion molding and weaving reinforcement; and 4) vulcanization molding. The preparation method comprises the following steps: synthesizing high vinyl MVQ, grafting side chain amino, generating a benzoxazine group, and obtaining the modified silicone rubber with the benzoxazine group; a rigid phenolic network is obtained creatively through high-temperature self-ring-opening cross-linking of benzoxazine, and interpenetrates with a fluorine-silicon covalent bonding cross-linked network to form an interpenetrating polymer network structure; then aramid fiber weaving, filler anchoring and other means are used, so that the silicone tube with the inner weaving structure can normally work at the extreme temperature of-60-200 DEG C, the small size change rate is kept, the excellent mechanical property and chemical medium resistance are achieved, and the problems of high-temperature deformation and low-temperature embrittlement of the silicone tube in the prior art are solved.

The application provides a benzoxazine spiro compound and a preparation method and application thereof, and belongs to the technical field of chemical synthesis. 1 H or CH3; R2 is H or t-Bu.The 2-isocyano phenoxy diene, 1-isocyano-4-methyl-2-(prop-1,2-dien-1-yloxy) benzene and 4-(tert-butyl)-2-isocyano-1-(prop-1,2-dien-1-yloxy) benzene provided by the application are subjected to three-component tandem cyclization reaction with o-phenylphenol and acetone respectively, the reaction sites of isonitrile and phenol and acetone are combined, and the spiro derivative can be efficiently synthesized, thereby providing a new idea for new drug research and development and natural product research.

The invention relates to the technical field of thermosetting materials, and discloses a bisphenol A type benzoxazine and bismaleimide transparent resin alloy preparation method which comprises the following steps: preparing required materials; and casting the blend solution on a glass plate pretreated with dimethyldichlorosilane, and drying at 50 DEG C for 4-6 hours. Then respectively carrying out heat treatment for 1-3 hours at different temperatures to obtain an alloy film; and the prepared alloy films with different mixing ratios and different heat treatment temperatures are subjected to performance testing. According to the process, bismaleimide and bisphenol A type benzoxazine B-a are used as main raw materials, and the transparent bismaleimide resin alloy material with excellent performance is prepared through a specific formula and process steps. The alloy material not only has high transparency and excellent heat resistance, but also has relatively high mechanical strength and chemical stability.

The present application relates to the field of hydrogel preparation, and discloses an anti-fouling zwitterionic hydrogel and a preparation method and application thereof. First, a double-hydroxyl polyoxazine is generated by initiating polymerization of an oxazine derivative monomer through a double-end initiator. Then, the side chain of the polymer is removed to obtain a double-hydroxyl polypropylene imine. After that, the double-hydroxyl polypropylene imine is selected for further reaction to generate a zwitterionic precursor polymer, and the zwitterionic precursor polymer is hydrolyzed to obtain a polypropylene imine zwitterionic derivative. Finally, the two end hydroxyl groups are converted to synthesize a zwitterionic macromolecular crosslinking agent, and the zwitterionic macromolecular crosslinking agent is polymerized and crosslinked in an aqueous solution to prepare the anti-fouling zwitterionic hydrogel. The hydrogel formula of the present application is simple, and the hydrogel is composed of a zwitterionic crosslinking agent only, has excellent anti-fouling properties such as anti-protein adsorption, anti-bacterial adsorption and anti-cell adsorption, and is suitable for biological materials, medical devices, implant materials and cell delivery materials.

The application discloses a low-forming-temperature thermosetting composite material for aviation and a preparation method thereof, and belongs to the technical field of thermosetting materials for aviation. The thermosetting composite material comprises 10-20 parts of an amine curing agent, 5-15 parts of a cyanate ester monomer, 0.3-2.0 parts of a divalent metal salt, 80-100 parts of a thermosetting resin and 10-20 parts of a toughening agent. The application innovatively prepares a ternary composite curing agent system capable of significantly improving a curing forming rate by using the amine curing agent, the cyanate ester monomer and the divalent metal salt. The amino group and the phenolic hydroxyl group in the benzoxazine resin can accelerate the curing rate of the epoxy resin and the bismaleimide resin, so that the toughening agent has the effects of improving toughness and self-catalysis. The reinforced thermosetting composite material prepared by the application has low forming temperature and excellent use performance, and can be used for manufacturing high-temperature-resistant aviation resin matrix composite material parts.

The application discloses a benzopyrazoloxazine derivative or a pharmaceutically acceptable salt thereof, which is shown as formula I, R is selected from hydrogen, halogen, alkyl and alkoxy; m is an integer from 1 to 3; X is selected from oxygen or sulfur; R1 is selected from hydrogen, alkyl and acyl. The application also discloses application of the benzopyrazoloxazine derivative in preparation of a medicine for preventing and treating diseases caused by absence of PP2A activity or reduction of PP2A function. The application discloses application of the benzopyrazoloxazine derivative in preparation of a protein phosphatase agonist.

A resin composition and a metal foil layer substrate are disclosed. The resin composition includes 20 to 40 parts by weight of an epoxy resin, 40 to 60 parts by weight of a modified benzoxazine resin, 2 to 10 parts by weight of a maleimide resin, and 25 to 50 parts by weight of a filler. The modified benzoxazine resin has a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide group. The 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide group accounts for 10 to 20 percent by weight based on a total weight of the modified benzoxazine resin, which is 100 percent by weight.

The present invention relates to compounds of the formula (I) that are potent degraders or inhibitors of hematopoietic progenitor kinase 1 (HPK1). The compounds are useful to treat or prevent cancer and / or inflammatory and / or autoimmune diseases or symptoms thereof.

The present application provides a kind of metal foil laminate, printed circuit board and its manufacturing method.The metal foil laminate includes: a substrate, which is covered with a toughened resin composition outside;And a metal foil;Wherein, the resin composition includes a toughened modified compound, which includes a polybenzoxazine compound, an anhydride grafted olefin polymer and a diisocyanate compound;Wherein, the diisocyanate in the toughened modified compound is bonded to the polybenzoxazine compound and the anhydride grafted olefin polymer respectively.The present application has high toughness and excellent mechanical properties, so it can be widely used in the field of electronics, aerospace, etc.

The application discloses a high-strength antistatic nylon 6 composite material and a preparation method thereof, and belongs to the field of composite material processing. The high-strength antistatic nylon 6 composite material is made of the following raw materials in parts by weight: modified antistatic filler (BZ-ACB@Ag) 3-8 parts, and nylon 6 particles 92-97 parts. Carbon black (CB) is gradually modified by 4-aminobenzoyl, silver nanoparticles and benzoxazine groups. After the acylation reaction, active sites are formed on the surface of the carbon black particles, then silver is loaded on the surface through a reaction, and finally the interaction between the carbon black and the polymer is adjusted through benzoxazine modification to improve the dispersibility of the carbon black in the matrix. BZ-ACB@Ag obtains a more extensive and complete conductive network in the nylon 6 matrix. A high-strength antistatic nylon 6 composite material is prepared by adopting the methods of melt blending, extrusion granulation and injection molding, and the high-strength antistatic nylon 6 composite material has good mechanical properties and thermal stability while maintaining excellent antistatic properties, and has a wide application prospect.

The invention (I) relates to the chemistry of heterocyclic organic compounds and to pharmaceutical compositions containing same. These compounds and their corresponding pharmaceutical compositions inhibit the activity of ataxia teleangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) serine / threonine protein kinases. The invention further relates to a method for using said compounds and compositions in the treatment and / or prophylaxis of oncological diseases as a monotherapy and / or in combination with radiotherapy, chemotherapy and / or immunotherapy. The technical result lies in the activity of the chemical compounds toward ATM and DNA-PK kinases and an increase in selectivity toward related kinases.