321 results about "Oxazines" patented technology

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I

having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

Laundry detergent compositions comprise (a) surfactant, and (b) a hueing dye selected from triarylmethane blue and violet basic dyes, methine blue and violet basic dyes, anthraquinone blue and violet basic dyes, azo dyes basic blue 16, basic blue 65, basic blue 66 basic blue 67, basic blue 71, basic blue 159, basic violet 19, basic violet 35, basic violet 38, basic violet 48, oxazine dyes, basic blue 3, basic blue 75, basic blue 95, basic blue 122, basic blue 124, basic blue 141, Nile blue A and xanthene dye basic violet 10, and mixtures thereof.

The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′-and/or 6′ halo and/or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety.

The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.

The invention provides a benzoxazine resin composition having excellent resistance to heat and moisture and providing excellent handleability when made into prepreg, and prepreg and a fiber-reinforced composite material prepared from the composition. The composition contains (A) a compound having in its molecule a benzoxazine ring represented by the formula (1), (B) an epoxy resin, (C) a curing agent, and (D) a toughness improver:

(R₁: C1 to C12 chain alkyl group, etc., and H is bonded to at least one of C of the aromatic ring at o- or p-position to the carbon atom to which the oxygen atom is bonded).

The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R¹, R², R^a, R^b, R^c, R^d, R^g, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

The invention discloses a halogen-free flame-retardant thermosetting resin composition of an integrated circuit, a prepreg and a laminate. Totaling 100 parts, the resin composition contains the following ingredients in parts by solid weight: (a) 10-50 parts of an allyl modified bismaleimide resin prepolymer, (b) 10-30 parts of an acid-anhydride compound, (c) 5-30 parts of benzoxazine resin, (d) 5-30 parts of epoxy resin and (e) 20-40 parts of phosphoric active ester. The resin composition disclosed by the invention has a high glass transition temperature, excellent moist heat resistance and a relatively low dielectric constant, can better meet the design requirements on multilayer board impedance and is beneficial to application in the field of high-performance printed circuit boards, such as high-density interconnected integrated circuit package.

The present invention provides a thermosetting resin having a benzoxazine ring structure represented by the following formula (I):

wherein X is a residue of a diol compound having a molecular weight or a number average molecular weight in terms of polystyrene measured by GPC of 5,000 or less; Y is a residue of a diamine compound; and n is an integer of 2 to 200.

A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR³; R¹ is a hydrogen atom or a halogen atom; R² is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R³ is a halogen atom. However, R¹ is a halogen atom when X is CR³). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.

Phosphorus-containing benzoxazine-based bisphenols and derivatives thereof are disclosed. The phosphorus-containing benzoxazine-based bisphenols are prepared by reacting DOPO with benzoxazine to form the phosphorus-containing benzoxazine-based bisphenols. The phosphorus-containing benzoxazine-based bisphenols can further to form advanced epoxy resins. The advanced epoxy resins can further be cured to form flame retardant epoxy thermosets.

The invention provides a novel synthetic method of a bis-benzoxazine ketone ultraviolet absorbent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: A, stirring, anhydrides, used as raw materials, of o-aminobenzoic acid and (o-, m-, p-) phthaloyl dichloride or (o-, m-, p-)phthalic acid for a certain time in a non-polar solvent; B, adding chemical dehydrating agent or physical dehydrating agent in a reaction system without separating, slowly heating and refluxing for a certain time to obtain (o-, m-, p-)substituted bis-benzoxazine ketone ultraviolet absorbent; wherein the stirring time in the step A is not less than 1 hour, the refluxing time is 5-10 hours in the step B, the chemical dehydrating agent used in the step B is various dehydrating agents reacted with the water, including but not limited to alkaline calcium oxide, soda lime, acidic concentrated sulfuric acid, concentrated phosphoric acid, polyphosphoric acid, phosphorus pentoxide, thionyl chloride, acetic anhydride and the like, neutral molecular sieve, water-absorbent, anhydrous cupric sulfate and the like; the physical dehydrating agent comprises but not limited to non-protonic solvent such as benzene, methylbenzene, xylene and the like. The method provided by the invention has the advantages of being simple in operation flow, low in cost, simple in equipment, and suitable for the scale industrial production.

The invention discloses a fluorescent dye having phenazine condensed structure, of which the structural formula is represented as one of the formulas (I) to (IV). The fluorescent dye having phenazinecondensed structure is prepared through steps of: reactions of cyclohexanedione condensation, sodium borohydride reduction, Vilsmeier formylation and the like are carried out to obtain an intermediatecompound; and then reactions with 4-subsituent amino-2-nitrosophenol, benzophenone acid, trans-4-subsituent amino-salicylaldehyde and the like compounds are carried out. Compared with classical fluorescent dyes (e.g. rhodamine, oxazine, squaric acid, anthocyanin dyes), the fluorescent dye in the invention has high photo-stability, is near-infrared in fluorescence emission wavelength of 635-829 nm, and has large Stokes shift capable of reaching 122 nm and high fluorescence quantum yield capable of reaching 0.43. The fluorescent dye can be applied to fields such as luminescent materials, bio-fluorescence probes, multicolor fluorescence imaging, etc.

The invention discloses a halogen-free resin composition, and a prepreg and laminated board prepared from the same. The halogen-free resin composition comprises the following components in parts by weight (on solid basis): 10-50 parts of benzoxazine resin, 10-60 parts of epoxy resin, 15-50 parts of phosphorus-containing active ester compound, 0-40 parts of curing agent and 0-3 parts of curing accelerator. The phosphorus-containing active ester compound is prepared by reacting organic phosphorus compound with benzoic acid compound at 90-130 DEG C. The halogen-free resin composition has the advantages of favorable heat resistance, low dielectric constant and low hydroscopicity, and solves the problems of poor dielectric properties and low hydroscopic property caused by halogen-free flame retardancy; and the laminated board prepared from the resin composition is suitable for high-performance printed wiring boards for high-density interconnection integrated circuit packaging.

The present invention relates to 1,4 Oxazines of formula I

having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

The present invention provides 1,4 Oxazines of formula I

having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.