17 results about "Acridone" patented technology

The application belongs to the technical field of medicine, and relates to N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compounds and a preparation method and application thereof. The preparation method of the compound is as follows: taking o-aminobenzoic acid as a starting material, performing substitution reaction, condensation reaction, alkylation reaction and hydrolysis reaction to generate a key intermediate acridone acetic acid, and finally performing condensation reaction on the acridone acetic acid and substituted pyrimidine in the presence of TCFH and NMI condensing agents to obtain the target compound. The preparation method of the N-methyl-2-(9-oxoacridin-10(9H)-yl)acetamide compound provided in the application is simple and feasible, and good results are shown in in-vitro anti-tumor activity tests, and the compound has excellent anti-proliferation ability on human breast cancer cells BT-549 and MDA-MB-231 in particular.

Provided herein are methods, systems, and kits for determining the concentration or level of an analyte of interest using a competitive and sandwich immunoassay. Also provided herein are acridinium-containing and acridone-containing compounds for use in assays to detect the presence of or determine the concentration or level an analyte of interest in a sample, e.g., a biological sample.

The invention relates to a dispersing agent for water-based color paste and a preparation method of the dispersing agent. According to the dispersing agent containing the hydrophilic and hydrophobic chain segments and capable of being specifically combined with the pigment particles, a polymerization product with narrow molecular weight distribution is obtained based on RAFT polymerization, and the problem that organic pigment is prone to agglomeration in a color paste system is avoided through wrapping of the hydrophobic chain segments of polyether in the structure on the pigment particles; a polyether solvation chain segment is introduced into the structure of the dispersing agent, so that the storage stability of the dispersing agent in a water phase is ensured; the high approximation of the acridone structure and common pigment structures such as quinacridone and isoindolinone ensures the coating effect of the dispersing agent on pigment particles, the dispersing agent has good dispersibility and compatibility in different aqueous systems, a specific dispersion effect is formed, the problems of high viscosity, difficult dispersion and the like of organic pigments in the aqueous systems are effectively solved, and the dispersing agent has good application prospects. The dispersant can be used as a dispersant or an additive of systems such as water-based color paste and water-based ink. The method can be widely used in the fields of inks and paints.

The invention belongs to the field of pharmaceutical chemicals, and relates to an acridone compound as shown in a formula I, a racemate or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof or a hydrate thereof, and an application of the acridone compound as a novel STING synergistic agonist in preparation of STING-related antiviral or malignant tumor drugs. # imgabs0 #

The invention discloses a preparation method of a colorful and white-light long-afterglow luminescent material and full-color display application thereof.The preparation method of the long-afterglow luminescent material comprises the steps that a luminous body solution is dropwise added to a polymer matrix, hot pressing is conducted at the temperature of 190-210 DEG C for at least 5 minutes, cooling is conducted to the room temperature, and the long-afterglow luminescent material is obtained, the luminous body solution comprises luminous small molecules and a solvent, the luminous small molecules are one or a mixture of more of sarranine, coumarin and acridone, the polymer matrix comprises a polymer, and the polymer is a styrene-acrylonitrile copolymer. The white light afterglow luminescent material with chromaticity coordinates closer to standard white light can be obtained only by taking sarranine, coumarin and acridone as luminescent micromolecules without complicated energy transfer while colorful afterglow luminescence is induced.

The invention discloses a polymer containing an acridone derivative unit, a preparation method of the polymer and application of the polymer in a zinc ion battery, and aims to solve the problem that the redox potential of an existing n-type organic material needs to be improved. The preparation method comprises the following steps: adding 10-methyl-2, 7-bis (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaboro-2-yl) acridine-9 (10H)-ketone and 4, 7-dibromo-5, 6-dinitrobenzo [c] [1, 2, 5] thiadiazole into an organic solvent, heating, stirring and dissolving, adding a catalyst, carrying out a heating reflux reaction, and purifying to obtain a polymer product. The main chain of the polymer containing the acridone derivative unit and the benzothiadiazole derivative unit is a conjugated system, an electron-deficient unit of the benzothiadiazole derivative is introduced into the acridone derivative, and the defect of low redox potential of acridone is overcome. The rigid conjugated skeleton of the polymer enhances the structural stability, widens the ion transmission channel, and improves the rate capability of the battery.

A fluoropolymer composition comprising a fluoropolymer and one or more heat resistant additives selected from the group consisting of acridones, anthranones, diaminoanthraquinones, acridines, substituted acridones, substituted anthranones, substituted diaminoanthraquinones, and substituted acridines, and a cured fluoropolymer composition formed by curing the fluoropolymer composition.

The present application provides a molecular probe targeting stimulator of interferon genes (STING). The probe has a structure of an interferon gene targeting group - acridone derivative, and different lengths of alkyl side chains are connected to the N atom site in the structure, or a short polyethylene glycol chain with 1, 2, 3 - triazole, or a side chain containing a chelating group with different numbers of alkyl groups. The small molecule targeting STING of the present application, as a STING agonist, can be used for STING - related immunotherapy. The fluorescence performance of the small molecule itself can be used for STING - targeted fluorescence imaging. After being labeled with radionuclides, the small molecule can be used as a radioactive tracer for in - vivo PET / SPECT imaging and treatment of STING - related diseases such as tumors and inflammation.

The application discloses a light-emitting compound or a derivative thereof, which is based on an acridone as a main structure, a conjugate plane formed by the acridone and an intermediate benzene ring as a light-emitting center plane, and a hydrogen atom at at least one position of the intermediate benzene ring is replaced by a substituent group, a plane where the substituent group is located and the light-emitting center plane form an included angle alpha, and the alpha satisfies the following relationship: 0° < alpha < 180° or 180° < alpha < 360°. The application further provides an organic light-emitting material with narrow spectral band emission and a preparation method and application thereof. The light-emitting compound or the derivative thereof has the conjugate plane formed by the acridone and the intermediate benzene ring as the light-emitting center, and after a group changing the planarity is introduced, the problems of low color purity of an OLED device based on the acridone derivative and obvious spectral broadening under a high doping concentration are solved.

The present invention relates to a method for the rapid synthesis of 2-hydroxyacridone by an ultrasonic-assisted one-pot method. 2-Bromobenzoic acid is dissolved in DMF to form solution A, and p-methoxyaniline is dissolved in DMF to form solution B. Copper powder is added as a catalyst in a reaction vessel, and then solution A and solution B are added thereto. The resulting reaction mixture is placed in an ultrasonic reactor, and the reaction is assisted by ultrasound for 45-60 min. After cooling, distillation is carried out under reduced pressure, and then hot water is added to extract the product. The crude 2-hydroxyacridone obtained is purified by recrystallization with ethanol to obtain high-purity 2-hydroxyacridone. The present invention rapidly, efficiently and with high yield prepares the target product 2-hydroxyacridone by an ultrasonic-assisted one-pot method at a reaction temperature of about 50 °C. The process steps are simple, the operation is convenient, the reaction time is short, the reaction conditions are mild, the raw materials are easily available, the yield is high, the loss of raw materials is greatly reduced, the reaction time is shortened, and the reaction energy consumption is reduced.

The present invention relates to the field of pigments, particularly quinacridone pigments and quinacridone solid solution pigments and their preparation methods, specifically an improved method for manufacturing quinacridone solid solution pigments. A quinacridone solid solution pigment, by mass percentage, comprises 10% - 90% of a disubstituted quinacridone having the formula (1), and 10% - 90% of 1,3,6,9,11,14 - hexahydroimidazo[4'5':5,6]quinolino[3,2 - i]imidazo[4,5 - α]acridine - 2,8,10,16 - tetrone having the formula (2). The present invention provides a manufacturing technique for quinacridone solid solution pigments, and the colored matter obtained by this technique has more excellent heat resistance than classical quinacridone pigments.

Provided herein are methods, systems, and kits for determining the concentration or level of an analyte of interest using a competitive and sandwich immunoassay. Also provided herein are acridinium-containing and acridone-containing compounds for use in assays to detect the presence of or determine the concentration or level an analyte of interest in a sample, e.g., a biological sample.

The invention discloses preparation and transparent display application of a temperature response type blue light long-afterglow luminescent material.The preparation method of the temperature response type blue light long-afterglow luminescent material.The preparation method of the temperature response type blue light long-afterglow luminescent material comprises the steps that a luminous body solution is dropwise added to a polymer matrix, hot pressing is conducted at the temperature of 170-220 DEG C, cooling is conducted to the room temperature, and the temperature response type blue light long-afterglow luminescent material is obtained; the luminous body solution comprises luminous micromolecules and a solvent, the luminous micromolecules are acridone, the polymer matrix comprises a polymer, and the polymer comprises at least one of polycarbonate and polystyrene. The proportion of the peak area of a TADF peak to the peak area of an RTP peak can be regulated and controlled at room temperature by selecting a proper polymer, dual-mode afterglow luminescence is realized, and the long-afterglow luminescent material with blue afterglow luminescence can be obtained at room temperature.

The invention belongs to the technical field of solar cells, and particularly relates to an acridone derivative, a hole transport layer and a perovskite solar cell. The structural general formula of the acridone derivative is as shown in formula 1. On the basis of an acridone parent nucleus, the organic micromolecule hole transport material which is low in cost, simple in structure, easy to synthesize and easy to chemically modify is designed, so that the photoelectric conversion efficiency of PSCs is improved, the material can achieve high hole mobility, meanwhile, the material has excellent heat and humidity stability and interface compatibility, and the material has good application prospects. And the efficiency and the stability of the perovskite solar cell device are synergistically improved.

The invention provides a modified oxime ester type photoinitiator and a preparation method thereof, and the modified oxime ester type photoinitiator is obtained by taking an acridone compound as an initial raw material, performing Friedel-Crafts acylation and nitrosation, and esterifying with aromatic acyl halide. Aryl in the acridone compound is substituted with strong electron donating groups such as alkyl and / or alkoxy, the strong electron donating groups, carbon-oxygen double bonds substituted on aromatic acyl halide, the alkyl and / or alkoxy form D-pi-A-pi-D structures on the two sides of an oxime ester group, and a large conjugated system and a strong intramolecular electron transfer characteristic exist. The maximum absorption wavelength of the modified oxime ester type photoinitiator has remarkable red shift, the modified oxime ester type photoinitiator has high sensitivity to the emission wavelength of a commercial LED light source, and the stability and the photosensitive activity of the modified oxime ester type photoinitiator are greatly improved; in addition, secondary amino contained in the acridone compound is used as a hydrogen donor, so that the photopolymerization initiation rate and the monomer conversion rate of the modified oxime ester photoinitiator in a system are relatively high.

The present invention discloses an acridone-based organic storage material, a preparation method, and its application, belonging to the technical field of organic storage materials. The acridone-based organic storage material has the general structural formula: #imgabs0#, wherein n is 1-22, and Ar is any one of the following structural formulas: #imgabs1#. The present invention utilizes a simple, low-cost process to prepare the organic storage material, which can serve as a charge-trapping layer for memory devices. It can be applied to OFET memories and exhibits excellent storage capacity and response speed.

The invention provides an aza fused ring derivative containing acridone and an electroluminescent device of the aza fused ring derivative. Relates to the technical field of organic photoelectric materials and semiconductor devices. According to the derivative, acridone is used as a mother nucleus, a multiple resonance framework is constructed through an aza fused ring, rigidity is enhanced through a spirofluorene structure, HOMO / LUMO spatial separation and delta EST minimization are achieved through a large-steric-hindrance phenyl, naphthyl, aryl or heteroaryl substituent, and therefore narrow-spectrum TADF emission is obtained. When the material is applied to an OLED light-emitting layer, under the same device structure, compared with a contrast material, the half-peak width is reduced, the external quantum efficiency is improved, the service life of the device is prolonged, and the advantages of high color purity, high efficiency and long service life are achieved.