120 results about "Ethyl chloroacetate" patented technology

The invention provides a preparation method and applications of a lamivudine twin drug. Lamivudine, and ursolic acid or oleanolic acid are condensed into the lamivudine-ursolic acid or lamivudine-oleanolic acid twin drug at a low temperature by using ethyl chloroacetate (ethyl bromoacetate) or ethyl chloropropionate (ethyl bromopropionate) as the linking group. The twin drug possibly has a dual-action mechanism; and the twin drug has the action of antivirus, and also has the actions of resisting inflammations, protecting the liver cell membranes, improving the liver function and resisting fibrosis. Thus, the invention organically combines the antivirus therapy and the liver protection treatment and provides a new concept for the research and development of drugs for treating hepatitis.

The invention relates to the field of pharmaceutical synthesis, in particular to a preparation method of strontium ranelate, which includes the following steps: reacting 5-amino-4-cyan-3-carbethoxy methyl-thiophene-2-carboxylic acid ethyl ester with a bifunctional alkylating agent in the presence of a catalyst to generate 5-[2-(carbomethoxy)amino]-4-cyan-3-carbethoxy methyl-thiophene-2-carboxylicacid ethyl ester, and then adding strontium chloride aqueous solution after hydrolysis of III in sodium hydroxide aqueous solution for salifying, thus obtaining the strontium ranelate. The preparation method is characterized in that the catalyst is polyethylene glycol, and the bifunctional alkylating agent is methyl chloroacetate or ethyl chloroacetate. In the preparation method, the low-price and environment-friendly catalyst and bifunctional alkylating agent are adopted, so as to be beneficial to industrial production.

The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 2-(5-fluoro-2,4-dinitrophenoxy)acetate. The preparation method comprises the following steps that: step 1, 2, 4-difluoronitrobenzene is used as a raw material, and is hydrolyzed by a base to form 5-fluoro-2,4-dinitrophenol; step 2, a catalyst A and a catalyst B are added into 5-fluoro-2,4-dinitrophenol and ethyl chloroacetate under the action of additives, and a nucleophilic substitution reaction is carried out to obtain the 2-(5-fluoro-2,4-dinitrophenoxy)acetate; the preparation method has the significant advantages of high yield, simple reaction, easy operation and low production costs.

The invention discloses a method for preparing phenylacetaldehyde with a high conversion rate, which comprises the following steps: using methyl benzoate as a raw material, contacting the methyl benzoate with a catalyst, hydrogenation reaction occurs to generate benzaldehyde, and simultaneously in the reaction A diluent is added to the reaction system; benzaldehyde and ethyl chloroacetate generate an epoxy ester under the action of a base, a catalyst and an organic solvent; the epoxy ester is hydrolyzed under alkaline conditions and decarboxylated to obtain phenylacetaldehyde. The method has mild process conditions, low equipment requirements, easy separation of products and high synthesis rate.

The invention provides a method for synthesizing fluoro-ethyl acetate and fluoro-methyl acetate. The method includes: using chloro-alkyl imidazole ionic liquid and / or bromo-alkyl imidazole ionic liquid as catalysts, using ethyl chloroacetate or methyl chloroacetate and alkali metallic fluoride as raw materials, using polar non-proton solvent as reaction medium, reacting for a period of time at a set temperature, filtering, and removing inorganic salts to obtain the fluoro-ethyl acetate or fluoro-methyl acetate.

The invention relates to a synthetic method for glycine betaine hydrochloride. The synthetic method comprises the following steps: successively adding monochloro acetic acid, a catalyst and ethanol into a reaction bottle; then raising the temperature to 100-115 DEG C; dehydrating a molecular sieve in a reflux position; carrying out a reaction for 2-8 hours; washing a reaction liquid twice; distilling separated ethyl chloroacetate at a reduced pressure; adding ethyl monochloroacetate into the reaction bottle; adding a certain amount of water; introducing trimethylamine gas; keeping the temperature at 20-45 DEG C; carrying out a reaction for 2-6 hours; then adding hydrochloric acid to raise the temperature and hydrolyze to distill water and ethanol therein; and reducing the temperature by 10-15 DEG C and carrying out crystallization and centrifugalization to obtain the glycine betaine hydrochloride. By synthesizing ethyl monochloroacetate from monochloro acetic acid and ethanol, synthesizing ethyl glycine betaine hydrochloride from the obtained pure ethyl monochloroacetate and trimethylamine, raising the temperature to hydrolyze in the presence of hydrochloric acid to obtain ethanol,and cooling the concentrated liquor to separate out glycine betaine hydrochloride, the purity of the prepared glycine betaine hydrochlorid is over 99% and the yield reaches over 97%. Inorganic salt solid waste is avoided.