18 results about "Ethyl chloroacetate" patented technology

The invention discloses a preparation method of a low-chlorine composite environment-friendly coal transportation anti-freezing agent, and belongs to the technical field of anti-freezing solutions. The anti-freezing solution is used for solving the technical problems of complex components and poor anti-freezing and metal corrosion resistance of the anti-freezing solution for coal transportation in the prior art. The preparation method of the low-chlorine composite environment-friendly coal transportation anti-freezing agent comprises the following step: uniformly mixing the compound pour point depressant, the modified corrosion inhibitor, the thickening stabilizer and the industrial water to prepare the low-chlorine composite environment-friendly coal transportation anti-freezing agent. The compound pour point depressant comprises an organic pour point depressant and an inorganic pour point depressant; the organic pour point depressant is obtained by reacting unsaturated azole, sodium methallyl sulfonate and fumaric acid; the unsaturated nitrogen is obtained by reaction of an intermediate B and benzaldehyde, and the intermediate B is obtained by reaction of triazole and ethyl chloroacetate; the modified corrosion inhibitor is obtained by carrying out a reaction on potassium thiocyanate, benzoyl chloride and chitosan vanillin Schiff base. The anti-freezing solution prepared by the invention has the advantages of moderate fluidity, good metal corrosion resistance and good anti-freezing performance.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

The invention provides an efficient water separation and purification device and process for ethyl chloroacetate. An outlet of the static mixer is connected with an inlet of the filter, an outlet of the filter is connected with an inlet of the centrifugal extraction machine, an outlet of a light phase component in the centrifugal extraction machine is automatically connected with an inlet of the second-stage centrifugal extraction machine, and an outlet of a light phase component in the second-stage centrifugal extraction machine is automatically connected with an inlet of the third-stage centrifugal extraction machine; an outlet of a light-phase component in the third-stage centrifugal extractor is automatically connected with an inlet of a rectifying tower, a light-phase outlet of the rectifying tower is automatically connected with a condenser, and the condenser is connected with a return tank. Through multi-process perfect treatment, the water content and the impurity content of ethyl chloroacetate are reduced to the greatest extent, continuous operation is realized, the time of a washing procedure is greatly shortened, the efficiency is improved, the equipment investment is saved, and the production cost is reduced. The method can be used for most ester products which need to be separated from water and have no high-boiling-point impurities in the system, and the requirement for high purity of the products is met.

The application discloses a kind of photovoltaic glass self-cleaning nano coating and its processing method, for crosslinking grafting on the surface of photovoltaic glass to control water contact angle less than 0.3 °, it is related to photovoltaic maintenance technical field, the photovoltaic glass self-cleaning nano coating includes mesoporous silica, epoxy group polyether, dimethyl diallyl ammonium chloride, enamine, ethyl chloroacetate, crosslinking agent, initiator, silane coupling agent.The application has the photovoltaic glass self-cleaning nano coating of water contact angle less than 0.3 ° formed on the surface of photovoltaic glass, so that water film spread on the surface of photovoltaic glass is separated from the photovoltaic glass self-cleaning nano coating by contaminant, and then the effect of removing contaminant is carried out by using gravity and / or wind power to drive water film to move.

The invention discloses a production method of malonic acid diester, which comprises the following steps: in a reactor, reacting raw materials containing a substrate, CO, alcohols, an alkaline substance, a solvent and a stabilizer in a carbonylation reaction system containing a catalyst to obtain the malonic acid diester, the catalyst comprises an active component, the active component comprises an active element, and the active element is at least one of Pd, Co and Ni; the substrate is at least one of methyl chloroacetate, ethyl chloroacetate and dichloromethane. According to the method, in the presence of a Pd / Co / Ni-based catalyst and methyl chloroacetate or ethyl chloroacetate or dichloromethane, CO, alcohols, alkali, phosphine ligands and solvents, malonic acid diester is prepared through one-step high-activity and high-selectivity carbonylation, and the method has industrial application prospects.

This invention discloses a slow-release methylmorpholine internal salt anti-swelling agent and its preparation method, belonging to the field of oilfield fracturing and production enhancement technology. The preparation method includes the following steps: morpholine and dimethyl carbonate are mixed and heated to a first set temperature for reaction, followed by distillation to obtain intermediate I; ethyl chloroacetate is added to intermediate I, and the mixture is stirred and reacted at room temperature before washing to obtain a solid product; the solid product is added to an aqueous hydrochloric acid solution, refluxed at room temperature, and concentrated to obtain intermediate II; N,N-dimethylformamide is added to intermediate II, the pH value is adjusted to a set pH value, then polyamine is added and heated to a second set temperature for reaction, followed by purification and separation to obtain the slow-release methylmorpholine internal salt anti-swelling agent.

The utility model relates to the technical field of fractionating tower trays, in particular to an efficient fractionating tower tray for ethyl chloroacetate rectification, which comprises a fixedly arranged upper tower drum, a liquid inlet pipe is mounted on the outer side wall of the left side of the lower part of the upper tower drum, and the tail end of the liquid inlet pipe is horizontally rightward and fixedly connected onto the outer side wall of the upper tower drum in a sealing manner; the interior of the liquid inlet pipe is communicated with an upper cavity of the upper tower drum through a liquid inlet, the outer side wall of the lower portion of the upper tower drum is sealed and movably connected to the outer side wall of the upper portion of the lower tower drum in a sleeving mode, a coaxial fluted disc is integrally formed and fixed to the outer side wall of the upper portion of the lower tower drum, and a gas-liquid mixing assembly is installed in a lower cavity of the lower tower drum. Through the structural design that the upper tower drum is sleeved with the lower tower drum and the lower tower drum can rotate circumferentially, and in combination with the arrangement of the vertical scrapers, the vertical scrapers can rotate along with the lower tower drum to scrape the liquid inlet, so that the materials near the liquid inlet are prevented from being accumulated and blocked, the liquid is ensured to smoothly enter the upper tower drum, and the stability and continuity of the fractionation process are maintained.

The invention belongs to the technical field of synthesis, and particularly relates to a synthetic method of ethyl methylthioacetate, which comprises the following steps: taking ethyl chloroacetate and sodium methyl mercaptide as raw materials, taking water and ethyl acetate as solvents, and carrying out catalytic reaction, phase splitting, desolvation and rectification of a phase transfer catalyst to obtain the ethyl methylthioacetate. According to the method, the esterification decomposition influence of the raw materials in an alkaline water phase environment is solved, and meanwhile, the process cost and the process difficulty are greatly reduced.

The present invention provides a method for efficiently synthesizing triethyl phosphoacetate, which uses diethyl phosphite and ethyl chloroacetate as reaction raw materials, adds a base (including but not limited to sodium methoxide, sodium ethoxide, sodium propoxide, sodium butoxide, sodium tert-amyloxide and other strong bases), and according to the SN2 reaction characteristics, the P-H bond can be smoothly converted into P in the reaction system. ‑ , thereby further attacking the C-Cl bond of ethyl chloroacetate. The solvation effect of polar aprotic solvents can promote the SN2 reaction. Selecting beneficial solvents (including but not limited to toluene, acetonitrile, dichloromethane, tetrahydrofuran, acetone, ether, ethanol, cyclohexane, etc.) can effectively shorten the reaction time and increase the selectivity of triethyl phosphoacetate. Triethyl phosphoacetate can be obtained in a 92% yield and 99.8% purity after a 0.5-hour reaction at room temperature. This method offers the advantages of low energy consumption, high efficiency, and simple operation steps.

The present invention provides a composition for preparing a scale inhibitor, a scale inhibitor, a preparation method thereof, and an application thereof, belonging to the field of water treatment technology. The composition comprises maleic anhydride, acrylic acid, a sulfonic acid anion monomer, a first functional monomer, a second functional monomer, an initiator, and water; raw materials for preparing the first functional monomer include 5-aminoorotic acid, a first solvent, pyridine, and maleic anhydride; and raw materials for preparing the second functional monomer include 1,2-benzisothiazolin-3-one, ethyl chloroacetate, a second solvent, and hydrazine hydrate. The scale inhibitor provided by the present invention has high scale inhibition efficiency, good corrosion inhibition effect, and excellent antibacterial properties.

The invention discloses a method and a device for synthesizing ethyl azidoacetate by a microchannel reactor, and belongs to the technical field of azide compounds. According to the technical scheme, the method for synthesizing ethyl azidoacetate through the micro-channel reactor comprises the following steps: taking one of ethyl chloroacetate and ethyl bromoacetate and sodium azide as initial raw materials, taking water as a reaction solvent, carrying out reaction by adopting the micro-channel reactor under a heating condition, and carrying out post-treatment to obtain ethyl azidoacetate, the adopted device comprises a micro-channel reactor and a controller, and the micro-channel reactor is provided with a first feed port, a second feed port and a discharge port; the microchannel reactor is provided with a plurality of reaction channels, each reaction channel comprises a plurality of mixing units, and each mixing unit is internally provided with a herringbone shunting structure and a streaming area. The method has the advantages of high reaction efficiency, high product yield, reduced solvent amount, simple post-treatment, production cost saving, and realization of efficient, safe and continuous synthesis of ethyl azidoacetate.

This invention discloses a method for preparing a low-chlorine composite environmentally friendly antifreeze agent for coal transportation, belonging to the field of antifreeze technology. This invention addresses the technical problems of existing antifreeze agents for coal transportation, such as complex composition and poor antifreeze and metal corrosion resistance. The method for preparing a low-chlorine composite environmentally friendly antifreeze agent for coal transportation includes the following steps: mixing a compound pour point depressant, a modified corrosion inhibitor, a thickening stabilizer, and industrial water. The compound pour point depressant includes organic and inorganic pour point depressants; the organic pour point depressant is obtained by reacting unsaturated nitrile, sodium methyl methacrylate, and fumaric acid; the unsaturated nitrile is obtained by reacting intermediate B with benzaldehyde, and intermediate B is obtained by reacting triazole with ethyl chloroacetate; the modified corrosion inhibitor is obtained by reacting potassium thiocyanate, benzoyl chloride, and chitosan vanillin Schiff base. The antifreeze prepared by this invention has the advantages of moderate fluidity, good metal corrosion resistance, and good antifreeze performance.

The invention discloses a heat-engine plant pipeline descaling cleaning agent and a preparation method and application thereof, and belongs to the technical field of material scientificity, glutamic acid diacetic acid is dissolved in absolute ethyl alcohol, an acid binding agent and ethyl chloroacetate are added, esterification is performed, and glutamic acid diacetic acid tetra (ethoxycarbonyl methyl) ester is obtained; the preparation method comprises the following steps: dissolving 1-hydroxyethylidene-1, 1-diphosphonic acid in dichloromethane, and adding N, N '-dicyclohexylcarbodiimide to react with tert-butyl alcohol to obtain 1-hydroxyethylidene-1, 1-diphosphonic acid di (tert-butyl) ester; the preparation method comprises the following steps: dissolving 2-mercaptobenzothiazole and sodium hydroxide in an alcohol-water mixed solution, adding epoxy chloropropane to react, reacting with an alkaline polyaspartic acid solution to obtain mercaptobenzothiazole grafted modified polyaspartic acid, dissolving the mercaptobenzothiazole grafted modified polyaspartic acid with alkyl glycoside, adding the two esters, and stirring to react to obtain the heat-engine plant pipeline descaling cleaning agent. The two esters are introduced as double precursor components, so that different scales are distinguished, the indifference effect of active components on a whole pipeline system is avoided, and the corrosion risk to a metal base material is reduced.

The present invention provides a 4,4'-bipyridyl ester salt compound and its preparation method and application. The following steps are included: 4,4'-bipyridyl, compound 1 and compound 2 are respectively dissolved in a solvent; the obtained solutions are mixed and the reaction is stirred at a constant temperature; after the reaction is completed, an anti-solvent is added for crystallization, suction filtration is performed, and the precipitate is collected, washed and dried to obtain a 4,4'-bipyridyl ester salt compound. Wherein, compound 1 and compound 2 respectively include one or more of methyl 2-chloroacetate, methyl 2-bromoacetate, ethyl 2-chloroacetate and ethyl 2-bromoacetate. The 4,4'-bipyridyl ester salt compound provided by the present invention has high-efficiency herbicidal performance under neutral conditions and can be used as an active substance for controlling weeds in the soil environment; in an acidic environment, it can be rapidly degraded to avoid harm to the human body. It has significant advantages such as a simple synthesis method, low production cost, high yield, and no harmful residual substances left after use, and can be used as a safe and friendly new herbicide.

The invention discloses a method for synthesizing ethyl chloroacetate, which comprises the following steps of: adding ethanol and chloroacetic acid in a certain proportion into a rectification reaction kettle, filling a solid catalyst into a fixed bed reactor, extracting the ethanol and the chloroacetic acid from the bottom of the reaction kettle through a circulating pump, passing through the fixed bed reactor, returning to the reaction kettle, and heating to react; after the material steam passes through the rectifying tower, an azeotrope of ethanol and water is condensed to a membrane separation dehydration device through a condenser, the dehydrated ethanol returns to the reaction kettle, and the reaction is stopped until the chloroacetic acid is completely reacted; through vacuum distillation, ethanol and a small amount of water are collected to a membrane separation dehydration device and can be recycled after dehydration, ethyl chloroacetate is collected to a product collection tank, and normal-pressure synthesis of ethyl chloroacetate and vacuum distillation purification operation are realized in the same reaction kettle. According to the method, the production steps are simplified, and the condition of product deterioration caused by catalyst or metal ion residues is avoided.

The application provides a phenanthroimidazole Schiff base iron ion fluorescent probe compound and synthesis and application thereof, and belongs to the fields of chemical synthesis and cation detection. The application uses 4,4',4''-methylene triphenol, ethyl chloroacetate, hydrazine hydrate, phenanthraquinone and 4,4'-diphenyl dimethyl formaldehyde as raw materials to synthesize the target product in three steps, and the process is simple, the reaction condition is mild, the reaction time is short, and the synthesis is rapid, efficient, safe, reliable, green and environment-friendly; in the synthesis, no mercury salt and other toxic substances are used, the toxic side effects in the reaction are reduced, the synthesis process is simplified, the comprehensive cost of synthesis is effectively reduced, the yield of the final product is high, and the purity is high; the compound can recognize Fe 3+ with high sensitivity and high selectivity, and has a good industrial analysis application prospect.

The present invention discloses a pyrazole carboxylic acid compound and its preparation method and application, which belongs to the field of industrial circulating cooling water treatment technology. The compound is based on ethyl 3-hydroxypyrazole-4-carboxylate and ethyl chloroacetate as starting materials, first by heating to produce a two-molecule substitution reaction on the pyrazole ring, and the intermediate product is then prepared by hydrolysis reaction. Its chemical name is 3-carboxymethyloxy-1-carboxymethylpyrazole-4-carboxylic acid. This application introduces multiple flexible carboxyl groups on the pyrazole ring mother nucleus, so that the compound has both excellent water solubility and good corrosion inhibition, scale inhibition and bactericidal properties, and can be successfully used as a water treatment agent for industrial circulating cooling water systems. The compound is stable in nature, simple in preparation method, does not contain phosphorus, has no impact on the environment, is a novel green water treatment agent, and has good application prospects and value.

The utility model relates to the technical field of related sampling in an ethyl chloroacetate synthesis process, in particular to a sampling device based on ethyl chloroacetate and an intermediate product mixture, which comprises a plurality of sample storage units arranged at intervals, the bottom of each sample storage unit is detachably mounted in a bottom restraint unit below the sample storage unit, and the sample storage units are connected with the sample storage units. A sampling drainage unit is arranged above each sample storage unit, the inlet end of each sampling drainage unit is connected with a sampling port of an upstream chemical reaction kettle, and the inside of the chemical reaction kettle is used for storing raw materials and intermediate products for synthesizing ethyl chloroacetate. The sampling device is mainly used for sampling a mixture of an intermediate product and an internal original solution in the reaction process of ethyl chloroacetate in the synthesis process of ethyl chloroacetate, and can be directly mounted at a chemical reaction degree sampling port in a matched manner, and the mixture can be quickly sampled as required by directly utilizing a metering pump during sampling; and the sampling accuracy is ensured.