19 results about "Dinitrophenol" patented technology

Embodiments provided herein include methods and compositions comprising anti-dinitrophenol chimeric antigen receptors (CARs). Some embodiments include nucleic acids encoding such CARs, polypeptides encoded by such nucleic acids, cells comprising such nucleic acids or polypeptides, and methods utilizing such cells. Some embodiments also include the use of dinitrophenol (DNP) and derivatives thereof.

The present invention provides novel 2,4-dinitrophenol (DNP) derivatives and prodrugs thereof as modulators of mitochondrial function. The present invention also provides pharmaceutical compositions comprising the compounds of the present invention and methods for using the same to treat various diseases and conditions associated with or related to mitochondrial dysfunction (e.g., obesity, diabetes, insulin resistance, liver disease, heart or kidney failure, neurodegenerative diseases, and aging-related diseases, including but not limited to sarcopenia, osteoporosis, etc.).

The invention belongs to the technical field of nitration reaction product separation, and particularly relates to a mixed dinitrobenzene extraction separation process applied to nitration reaction. Through three-section gradient dilution and accurate concentration control, the problem of incomplete separation caused by high solubility of high-concentration sulfuric acid to nitrobenzene is effectively solved, meanwhile, the hidden danger of pipeline blockage caused by dinitro compound crystallization is eliminated, and the production safety and the product purity are remarkably improved. According to the invention, a complete material closed-loop system is established, the extractant-nitrobenzene is directly reused for nitration reaction after deep dehydration and impurity removal, and the waste sulfuric acid is completely returned to a production system for recycling after being treated, so that the utilization rate of raw materials is greatly improved, and the discharge of waste acid is reduced. According to the method, key parameters such as temperature, concentration and flow are monitored in real time, so that the nitration reaction yield is stabilized at 97.2% or above, the operation cycle of the device is effectively prolonged, and reliable technical guarantee is provided for industrial production.

The invention relates to the technical field of paint preparation, in particular to fire-resistant and wear-resistant epoxy resin paint. The coating is prepared from the following components in parts by weight: 1835 to 2400 parts of epoxy resin, 1300 to 2600 parts of silicon carbide, 1600 to 2200 parts of dinitrophenol, 2300 to 2800 parts of nano aluminum oxide, 2100 to 3250 parts of titanium dioxide, 1100 to 2000 parts of polyethylene glycol, 1350 to 2000 parts of 2-ethylhexyl acrylate, 1200 to 2100 parts of vermiculite, 1200 to 2600 parts of sodium polyacrylate dispersing agent, 1700 to 2600 parts of stearic acid and 1500 to 2000 parts of calcium naphthenate. The fireproof coating has the beneficial effects that 1, the fireproof coating has excellent fireproof performance, the integrity of the coating can be kept for a long time in a high-temperature environment, flame spreading and heat transfer are effectively prevented, and a base material is protected from high-temperature damage; 2, the coating has excellent wear resistance, can resist mechanical friction, impact and the like, and prolongs the service life of protected equipment or facilities; and 3, all the components are mutually matched and cooperated, the comprehensive performance is excellent, the fire resistance and wear resistance are outstanding, the good adhesive force, weather resistance, chemical corrosion resistance and the like are achieved, and the coating can be widely applied to protection requirements of various industrial fields.

The application discloses a 2,4-dinitrophenol / Pb (II) double-template imprinted polymer adsorbent and a preparation method thereof. The double-template imprinted monolithic adsorbent is prepared by using in-situ polymerization technology, 2,4-dinitrophenol and Pb (II) are used as imprinting templates, 4-vinylpyridine and dimethylaminopropyl acrylamide are used as functional monomers. The functional monomers and the templates are effectively combined through hydrogen bond action and coordination action, and then a porogen and a crosslinking agent are added to react to form a polymer. The double templates are eluted, and a three-dimensional cavity structure with specific recognition function is left. The specific binding sites and shapes on the cavity are used to realize selective extraction of NP S and Pb (II). Meanwhile, the prepared double-template imprinted adsorbent has the advantages of simple operation, good permeability, low cost and wide application range, and therefore the double-template imprinted polymer monolithic adsorbent prepared by the application has good practical application value.

The invention provides application of a group of plasma metabolism markers in preparation of a reagent product for pulmonary nodule diagnosis, and relates to the technical field of disease diagnosis reagents. The metabolic marker is prepared from trigonelline, 4-methylcatechol, 2, 4-dinitrophenol, 3, 4-dihydroxyphenylacetic acid, N-(2-furfuryl) glycine, mevalonic acid and formononetin, and the metabolic marker is prepared from the following raw materials: the trigonelline, the 4-methylcatechol, the 2, 4-dinitrophenol, the 3, 4-dihydroxyphenylacetic acid, the N-( According to the application, ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC / MS) is adopted to carry out metabonomics analysis on plasma samples before and after an early pulmonary nodule operation, and a group of plasma metabolites (trigonelline, 4-methylcatechol, 2, 4-dinitrophenol, 3, 4-dihydroxyphenylacetic acid, N-(2-furfuryl) glycine, mevalonic acid and formononetin) are identified; and the group of metabolites is utilized to form a diagnosis model, so that benign and malignant pulmonary nodules can be accurately diagnosed, and early-stage differential diagnosis and risk assessment are facilitated.

The method for simultaneously determining multiple nitrophenol compounds in different food matrices according to the present invention involves preparing a series of mixed solutions with different concentrations of 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, and 3,5-dinitrophenol using acetonitrile-acetic acid solution as standard samples; the food matrices to be tested are then subjected to extraction and purification treatment. The sample was obtained through a process; then, high-performance liquid chromatography-tandem mass spectrometry was used to detect the sample and standard to obtain the concentrations of 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, and 3,5-dinitrophenol in the sample. The content of each nitrophenol compound in the food matrix was then calculated based on the concentrations of 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, and 3,5-dinitrophenol in the sample.

The present invention provides novel 2, 4-dinitrophenol (DNP) derivatives and prodrugs thereof as modulators of mitochondrial function. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of their use in the treatment of various diseases and conditions associated or associated with mitochondrial dysfunction (e.g., obesity, diabetes, insulin resistance, liver disease, heart failure or renal failure, neurodegenerative disease, or aging-related disease).

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

The invention discloses a preparation method of 2, 4-dinitroanisole. According to the method, phenol is taken as a starting raw material, in the first step, phenol reacts with nitrate under photocatalysis to obtain 2, 4-dinitrophenol, and in the second step, the target product 2, 4-dinitroanisole is prepared from 2, 4-dinitrophenol and dimethyl sulfate under the action of alkali. The synthesis technical route is different from the traditional synthesis method. The method does not need to use a large amount of excessive acid and alkali, and is simple to operate, mild in condition, environment-friendly, free of the problem of corrosivity and high in yield.

The present invention provides methods and compositions comprising an anti-dinitrophenol chimeric antigen receptor (CAR). [Solution] The present invention includes nucleic acids encoding anti-dinitrophenol chimeric antigen receptors (CARs), polypeptides encoded by this nucleic acid, cells containing this nucleic acid or polypeptide, and methods utilizing these cells. Some embodiments further include the use of dinitrophenol (DNP) and its derivatives.

Compositions and methods for treating neuromuscular, neuromuscular degenerative, neurodegenerative, autoimmune, developmental, traumatic, hearing loss-related, and / or metabolic diseases including Spinal Muscular Atrophy (SMA) syndrome (SMA1, SMA2, SMA3, and SMA4, also known as Types I, II, III, and IV), Traumatic Brain Injury (TBI), concussion, keratoconjunctivitis sicca (dry eye disease), glaucoma, Sjogren's syndrome, rheumatoid arthritis, post-LASIK, antidepressant use, Wolfram syndrome, and Wolcott-Rallison syndrome. The compositions are selected from 2,3-DNP, 2,4-DNP, 2,5-DNP, 2,6-DNP, 3,4-DNP, or 3,5-DNP, bis 2,3-dinitrophenol, 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, or 3,5-dinitrophenol (2,3-DNP, 2,4-DNP, 2,5-DNP, 2,6-DNP, 3,4-DNP, or 3,5-DNP) prodrugs; bisprodrug, bioprecursor molecules, and combinations thereof.

The application discloses a mixed dinitrobenzene extraction separation tower for a nitration reaction, which comprises an extraction tower body, a heavy liquid inlet and a light liquid inlet are arranged on one side of the extraction tower body near top and bottom ends respectively, a light liquid outlet is arranged on the top of the extraction tower body, and a heavy liquid outlet is arranged on the bottom of the extraction tower body; a plurality of blocking discs are arranged in the extraction tower body at equal intervals, and the blocking discs are provided with liquid passing holes. The application realizes the periodic pulse opening and closing of a fluid channel through the plurality of blocking discs arranged in the tower at equal intervals and the stirring blocking mechanism matched with the blocking discs. After vertical bars are inserted into the liquid passing holes and are lifted, the recesses on the vertical bars form a periodically changed gap, so that instantaneous impact turbulent flow of the fluid is generated, the laminar flow boundary of two-phase fluid is effectively broken, the contact and mixing between the heavy liquid and the light liquid are greatly enhanced, the mass transfer resistance is reduced, and therefore the extraction efficiency of mixed dinitrobenzene is remarkably improved.

A treated mesh sheeting containing an insecticide such that the mesh sheeting acts as a physical and chemical barrier to impede the ingress of insects into a structure, in particular a building structure. The insecticide maybe selected from any one or more of the group comprising pyrethrum, synthetic pyrethroids, organo-chlorines, organo-sulfurs, carbamates, organo-phosphates, formamidines, neonicotinoids, nicotinoids, spinosyns, phenylpyrazoles, pyrroles, pyrazoles, dinitrophenols, pyridazinones, quinazolines, and benzoylureas. The mesh sheeting can be integrally attached to a building structure to impede the ingress of insects, particular termites.

The invention relates to the technical field of photocatalytic materials, and discloses a carbon quantum dot loaded colloidal clay composite material as well as a preparation method and application thereof. The composite material is formed by compounding magnetic bentonite, sodium alginate, carbon quantum dots and an oxalic acid modified product. The preparation method comprises the following steps: mixing magnetic bentonite prepared by a chemical coprecipitation method with sodium alginate, and soaking and modifying by using an oxalic acid solution to construct a three-dimensional network carrier with a hierarchical porous structure; and loading the carbon quantum dots synthesized by a hydrothermal method on the carrier, and reacting and drying to finally obtain the composite material. The composite material is applied to photocatalytic degradation of water organic pollutants such as 2, 4-dinitrophenol under the visible light condition. Through a three-dimensional porous structure cooperatively constructed by sodium alginate and oxalic acid, efficient and stable loading of carbon quantum dots and in-situ enrichment of pollutants are realized, the problems that active components are easy to agglomerate and the catalytic efficiency is low are solved, and the photocatalytic degradation performance is remarkably improved.

The present invention provides novel 2,4-dinitrophenol (DNP) derivatives and their prodrugs as modulators of mitochondrial function. The invention also provides pharmaceutical compositions comprising the compounds of the present invention, and methods thereof, for the treatment of various diseases and disorders related to or associated with mitochondrial dysfunction (e.g., obesity, diabetes, insulin resistance, liver disease, heart failure or renal failure, neurodegenerative diseases, or age-related diseases).

Disclosed herein are compositions, methods, devices, and systems for detection of T1D autoantibodies. Bridging complexes for use in enzyme-linked immunosorbent assays (ELISAs) are disclosed. The bridging complexes can be used to detect insulin autoantibodies (lAAs) in human and animal blood or serum. The disclosed compositions, methods, devices, and systems can form complexes between a biotin-labeled proinsulin molecule, an TAA, and a dinitrophenol (DNP)-labeled proinsulin molecule.

The application discloses a kind of medium voltage fireproof cable and preparation method thereof, it is related to cable technical field.The application is when preparing medium voltage fireproof cable, mica base fire resistance layer is coated on the surface of conductor, copper protective layer is coated on the surface of mica base fire resistance layer, protective sleeve is coated on the surface of copper protective layer;The protective sleeve is prepared by modified polyethylene, modified silicon dioxide, catalyst, plasticizer, lubricant;The modified polyethylene is obtained by grafting 3-amino-1-phenyl-2-pyrazoline-5-ketone after maleic anhydride grafting polyethylene, and diazonium salt reaction, and then reacting with allyl boronic acid;The modified silicon dioxide is obtained by reacting with 3,4-dinitrophenol after polymerization on the surface of silicon dioxide modified by p-hydroxystyrene and vinyltrimethoxysilane, and then reducing, and reacting with 2-((2-nitrobenzyl)thio)ethylamine, and then deprotecting.The medium voltage fireproof cable prepared by the application has good fire resistance and anti-aging performance.

The invention discloses a water-wiping three-primary-color painting pigment and a preparation method thereof, and belongs to the field of environment-friendly painting materials. The pigment is composed of 1.5-3% of alcohol-soluble acid-base indicator dye, 10-15% of sodium bicarbonate, 0.5-1.0% of polyethylene glycol, 0.5-1.0% of sodium dodecyl benzene sulfonate and 83-85% of anhydrous calcium carbonate, and the dye is selected from quinoline blue, 2, 4-dinitrophenol and 1-naphthol which correspond to fuchsin, yellow and cyan respectively. The pigment and sodium bicarbonate form a weak base color development system through an acid-base indicator, bright color is kept in a solid state, the pH of the system is reduced after the pigment meets water, and the dye is converted into a colorless state and dissolved, so that the removable characteristic is realized. The preparation method comprises the steps of dye dissolving, mixing, alkaline color developing agent and carrier dispersing, film forming and drying and the like, the process is simple, and raw materials are environmentally friendly. The pigment is pure in color development and clean to erase, and has application values of repeated use, teaching demonstration and environment-friendly painting.