3 results about "Keratoconjunctivitis" patented technology

The present application provides compositions and methods for reducing tear evaporation and for treatment of dry eye diseases. In one example, a composition is provided comprising a semi-fluorinated alkane compound such as, e.g., perfluorohexyloctane; and an additive selected from paraffin, medium chain triglycerides, propylene glycol diacetate, and combinations thereof, wherein the topical ophthalmological composition is free from any other active pharmaceutical compound useful for the treatment of dry eye disease, dry eye syndrome, meibomian gland disfunction, or keratoconjunctivitis sicca. Eye drops comprising the compositions are also provided. Methods of using the compositions are also provided and include methods for reducing one or more symptoms of dry eye disease, dry eye syndrome, meibomian gland disfunction, keratoconjunctivitis sicca, and methods for reducing or modifying tear evaporation rate, increasing tear retention time, protecting tear film, preventing tear evaporation, producing a soothing effect, or improving tear quality in an eye of a subject.

The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and / or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and / or conjunctiva, and / or to the Meibomian gland.