54results about How to "Enhanced barrier function" patented technology

The invention relates to a weight-losing enzyme and a preparation method thereof, and belongs to the technical field of biology, and the weight-losing enzyme comprises a fruit enzyme, a vegetable enzyme, a seed enzyme and a lotus leaf extract; the fruit enzyme is obtained by performing enzymolysis on mixed fruit pulp of apples, lemons, grapefruits and haws through pectinase, performing enzymolysis through pepsase and performing co-fermentation through bifidobacterium longum and lactobacillus acidophilus; the vegetable enzyme is obtained by performing enzymolysis on mixed vegetable pulp of wax gourd pulp, celery and spinach through pectinase, performing enzymolysis through pepsin and performing fermentation through lactobacillus plantarum and bifidobacterium adolescentis; the seed enzyme is obtained by carrying out trypsin enzymolysis on mixed powder of semen raphani and phaseolus calcaratus, then carrying out nattokinase enzymolysis and then fermenting with bifidobacterium breve; the lotus leaf extract is obtained by sequentially carrying out enzymolysis on lotus leaves through hemicellulase, snail protease and nattokinase. All the components are matched for use, so that the weight-losing food has the effects of promoting digestion, inhibiting fat absorption, regulating intestinal flora, promoting metabolism and the like, and has a good weight-losing effect.

The invention discloses a centella asiatica plant extraction repairing agent and application thereof in cosmetics. The centella asiatica plant extraction repairing agent comprises the following components: an olive leaf extract, a centella asiatica root extract and an oat kernel extract. According to the preparation process of the centella asiatica plant extraction repairing agent, plant water-soluble active ingredients are obtained by adopting enzymolysis and alcohol extraction modes, plant oil-soluble active ingredients are obtained by adopting critical CO2 extraction, and then a novel preparation is prepared by adopting an ultrasonic emulsification technology, so that the repairing agent can permeate into skin cuticles more easily, the effect of active matters can be brought into full play, and the repairing agent has a good application prospect. When the composition is applied to cosmetics, a good repairing effect can be realized.

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

The invention provides anti-aging collagen peptide mask liquid and a preparation method thereof. The mask liquid is prepared from the following components in percentage by mass: 1 to 2 percent of tremella polysaccharide, 3 to 4 percent of herba portulacae extract, 2 to 3 percent of radix gentianae extract, 0.3 to 0.8 percent of nicotinamide, 1.2 to 1.6 percent of alpha-arbutin, 0.2 to 0.6 percent of chrysanthellum indicum extract, 0.7 to 1.5 percent of geranium flower / leaf / stem extract, 0.4 to 0.8 percent of aloe barbadensis extract, 0.7 to 1.3 percent of radix sophorae flavescentis extract, 0.3 to 0.9 percent of herba houttuyniae extract, 1.2 to 1.7 percent of herba centellae extract and the balance of water. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: 0.2 to 0.6 percent of fructus hippophae extract, 0.02 to 0.06 percent of peony root bark extract, 0.06 to 0.09 percent of scutellaria baicalensis root extract, 0.04 to 0.08 percent of rosemary extract, 0.01 to 0.04 percent of pearl powder and the like. The mask liquid prepared by the invention has an anti-aging effect.

The invention discloses a camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition and application thereof, and relates to the technical field of cosmetics. The invention provides a camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition. The camellia nitidissima flower extract-containing anti-pollution acne-sensitive skin repairing composition is prepared from the following components in parts by weight: 1 to 5 parts of camellia nitidissima flower extract, 1 to 5 parts of seaweed oligosaccharide, 0.01 to 1 part of o-cymene-5-ol and 0.01 to 1 part of tocopherol retinoate. According to the anti-pollution acne-sensitive skin repairing composition containing the camellia nitidissima flower extract, four components including the camellia nitidissima flower extract, the seaweed oligosaccharide, the o-cymene-5-ol and the tocopherol retinoate in proper parts by weight are selected to cooperate with one another, so that the composition has better anti-pollution and antibacterial effects and has very good acne removing, repairing and soothing effects.

The invention discloses a composition for resisting porcine viral diarrhea and application of the composition. The composition for resisting porcine viral diarrhea is prepared from the following components in parts by mass: 2 parts of phloretin, 1 part of N-acetyl-D-galactosamine and 100 parts of proline. The composition can further comprise one or more auxiliary materials of absolute ethyl alcohol, propylene glycol, dimethyl sulfoxide, edible oil, water, tween-80, lactose, defatted rice bran, corncob powder, soluble starch, bran, silicon dioxide, montmorillonite, vermiculite, medical stone, zeolite powder, white carbon black and the like. The composition can significantly inhibit the proliferation of PEDV, TGEV and PoRV, and inhibit the infection of PEDV, TGEV and PoRV on cells, and further, the composition can be used for preparing drugs or feed additives for resisting porcine diarrhea diseases caused by viruses such as PEDV, TGEV and PoRV.

The invention discloses a whitening and antibacterial knitted fabric and a preparation method thereof, and belongs to the technical field of functional clothing, Zn (NO3) 2.6 H2O and 1, 4-phthalic acid (H2BDC) are fully dissolved and dispersed through N, N-dimethylformamide (DMF) and dried to prepare Zn-BDC MOF powder, then nicotinamide and chitosan with whitening, spot fading and antibacterial functions pass through N, N-dimethylformamide (DMF) through interaction of subjects and guests, and the functional clothing is obtained. And dissolving N, N-dimethylformamide, and embedding into MOF pores to obtain the whitening skin-care antibacterial functional MOF material. And finally, adding a polyvinyl alcohol solution to obtain a functional finishing agent, and finishing the finishing agent on knitted garments to obtain the knitted fabric with the whitening, skin-care and antibacterial composite functions. The obtained knitted fabric has good whitening, skin care and antibacterial effects and can be applied to sportswear worn in daily life, and knitted garments made of the knitted fabric have the whitening and skin care effects, are good in use comfort and efficiently resist bacteria.

The invention discloses a plant composition for regulating scalp micro-ecology and application thereof. The plant composition is mainly prepared from the following raw materials: Fuding white tea extract, pepper extract, viola mandshurica extract / butterfly bean flower extract and oat peptide extract in a mass ratio of (15-30): (15-30): (15-30): (10-25). When the plant composition disclosed by the invention is applied to a washing and caring product, the washing and caring product contains 4.5-15% of the plant composition disclosed by the invention, 12-24% of a surfactant, 0.5-1.5% of a hair conditioner, 0.5-1.5% of a humectant and the balance of water, wherein the total percentage is 100%. According to the invention, four plant raw materials with respective effects are scientifically compounded, so that various effective components play a synergistic effect, and the scalp micro-ecology can be regulated, scalp flora balance can be rebuilt, and a scalp barrier function can be enhanced, so that the effects of effectively inhibiting bacteria and maintaining scalp health can be achieved.

The invention discloses a preparation method of compound polysaccharide microspheres capable of releasing NO. The preparation method comprises the following steps: cross-linking swallow polysaccharide with L-ARG, and preparing L-ARG-containing swallow polysaccharide hydrogel through a Mannich reaction; then loading EGCG (epigallocatechin gallate) onto the L-ARG-containing swallow polysaccharide hydrogel through a Schiff base reaction, and obtaining the compound polysaccharide microspheres capable of releasing NO by utilizing an emulsification method. The invention also discloses an application thereof. The hydrogel microsphere capable of targeting the colon is prepared, and the hydrogel microsphere can be accurately exploded at the colon part after being swallowed. A dextran sodium sulfate (DSS)-induced IBD mouse model is established to test the drug effect, and the result shows that the compound polysaccharide microspheres have a remarkable treatment effect on DSS-induced ulcerative colitis, can obviously improve the symptoms of ulcerative colitis, and provides a theoretical basis and a clinical basis for new drugs for clinically preventing and treating ulcerative colitis.

The invention discloses a soothing and moisturizing composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a soothing and moisturizing composition. The soothing and moisturizing composition is prepared from the following components in parts by weight: 1 to 10 parts of chondrus crispus extract, 1 to 10 parts of water temple porphyra polysaccharide, 1 to 10 parts of crithmum maritimum extract, 0.05 to 2 parts of oligopeptide-1 and 0.05 to 2 parts of palmitoyl pentapeptide-4. The inventor discovers that when existing at the same time, the chondrus crispus extract, the laver polysaccharide, the crithmum maritimum extract, the oligopeptide-1 and the palmitoyl pentapeptide-4 can cooperate with one another and act together from multiple aspects, and the effects of multi-channel, deep moisturizing, soothing and skin barrier enhancing are better achieved.

The invention discloses a copper ion-luteolin nano-composite and application thereof in treatment of inflammatory bowel disease, the obtained nano-composite has very strong stability and active oxygen scavenging ability, and has excellent anti-oxidation and anti-inflammatory ability, specifically, the nano-composite is negatively charged, can effectively target intestinal inflammation lesion, and can be used for treating inflammatory bowel disease, so that the copper ion-luteolin nano-composite can be applied to treatment of inflammatory bowel disease. Mucosal barrier repair is promoted, intestinal flora is regulated, and the inflammation microenvironment is remarkably regulated; the antioxidant and anti-inflammatory capacities of cells can be enhanced by regulating and controlling an oxidative stress pathway of a nuclear factor erythroid 2 related factor 2 / heme oxygenase-1 (Nrf2 / HO-1) and a nuclear factor kappa B (NF-kappa B) signal pathway; the compound shows a good treatment effect in a typical inflammatory bowel disease mouse model, including ulcerative colitis and Crohn's disease. The invention provides a new way for constructing a multi-layer treatment platform for treating the inflammatory bowel disease by using natural products.

The invention discloses salt-corrosion-resistant epoxy resin modified concrete and a preparation method thereof.According to the epoxy resin modified concrete, the surface of an inorganic material is treated through a silane coupling agent, the interface bonding force among cement, sand, stone and an epoxy resin matrix is improved, and the adhesion and structural stability of the material are ensured; meanwhile, by introducing an epoxy resin toughening technology, the flexibility and crack resistance of a resin matrix are enhanced, so that the resin matrix can cope with temperature difference change and mechanical impact in a marine environment; besides, through the synergistic effect of graphene oxide and nano silicon dioxide, the compactness and barrier performance of the concrete are further improved, permeation paths of water and chloride ions are reduced, corrosion of steel bars and deterioration of the concrete are effectively prevented, the material is endowed with excellent corrosion resistance, the wear resistance and mechanical strength of the material are remarkably improved, and the service life of the material is prolonged. Therefore, the service life of the concrete in a severe environment is prolonged.

The invention discloses a pharmaceutical composition for redness removal and repair and a preparation method thereof, belonging to the technical field of skin disease treatment, which is an ointment prepared from raw materials according to the following weight ratio: 8-10 parts of chamomile, 6-12 parts of oriental rhizome, 5-10 parts of sophora flavescens, 6-12 parts of cnidium monnieri, 6-15 parts of kochia scoparia, 1-5 parts of small molecule sodium hyaluronate, 9-15 parts of ectoine, 3-10 parts of safflower, 6-12 parts of ophiopogon japonicus, 9-12 parts of mountain peony, 9-12 parts of white peony; the ointment is composed of an ointment matrix, a nanostructured lipid carrier of a Chinese medicine extract and glycerol, and the ointment matrix is ​​honey. The pharmaceutical composition for redness removal and repair finally prepared can increase the thickness of the stratum corneum, has a good healing effect on patients with persistent facial flushing and already formed telangiectasia, and can remove redness from the face.

The invention discloses superaustenitic stainless steel based on the synergistic effect of Mo and N and a preparation method of the superaustenitic stainless steel, and belongs to the technical field of high-performance metal materials. The stainless steel comprises the following components in percentage by mass: 26.0%-26.5% of Cr, 3.48%-4.52% of Mo, 0.29%-0.51% of N, 23.0%-25.0% of Ni, less than or equal to 0.01% of C, 0.40%-0.65% of Mn and the balance of Fe and inevitable impurities. According to the method, on the premise that the PREN value is kept basically unchanged, the point corrosion resistance of the stainless steel in a chloride ion-containing medium is remarkably improved by synergistically reducing the Mo content and increasing the N content and utilizing the interaction effect of Mo and N. The synergistic effect is embodied in inhibiting pitting initiation, slowing down pitting extension, promoting repassivation and forming a more protective passive film structure. The material is especially suitable for harsh corrosive environments such as offshore oil and gas exploitation and seawater desalination.

An absorbent article is provided comprising a chassis comprising a central longitudinal axis and an absorbent core. The base structure includes a front waist region and a landing region and an elastic waist feature both positioned in the front waist region. The resilient waist feature includes a first end edge positioned proximate the front waist edge. The elastic waist feature: overlaps a portion of the landing zone at a longitudinal distance Y; and in overlapping relationship with a portion of the absorbent core in the front waist region at a longitudinal distance X. The resilient waist feature has a longitudinal distance W between the first end edge and the second end edge. The ratio of the distance X to the distance W is at least 0.4, and the ratio of the distance Y to the distance W is at least 0.4.

The application discloses a kind of low morbidity feed for California bass antibiotic-free breeding and preparation method thereof, belong to aquatic feed field.The feed is composed of 60~80 parts of basic feed component, 10~20 parts of fermented plant protein, 2~6 parts of functional compound additives.Fermented plant protein is prepared by compound fermentation of butyric acid clostridium and bacillus subtilis from soybean meal, bran, rice bran, brown sugar and the like.Functional compound additives include pre-embedded material and microcapsule coated sodium butyrate, and the pre-embedded material is prepared by embedding treatment of astaxanthin, lutein and rosemary extract with β-cyclodextrin and gum arabic.The application significantly reduces the incidence of intestinal inflammation of California bass through the synergistic effect of fermented plant protein, pre-embedded antioxidant combination and microcapsule sodium butyrate, enhances antioxidant capacity, improves body color, improves the stability of active ingredients and feeding rate, and realizes low morbidity under antibiotic-free breeding conditions.

The invention belongs to the technical field of biomedical materials, and provides a gel composition as well as a preparation method and application thereof. The gel composition provided by the invention takes the combination of the recombinant mussel mucin, the Ectoine, the sodium hyaluronate and the carboxymethyl chitosan as main preparation raw materials, and the raw material components can play a very good synergistic effect, so that the gel composition not only has extremely good biocompatibility, safety and stability, but also can be used for preparing the gel composition. The skin damage symptom can be well relieved, skin moisturizing and wound healing after beauty treatment are promoted, damaged skin repairing is promoted, the skin barrier function can be improved, and the health condition of damaged skin can be improved.

The application provides a recombinant human K14 keratin and a preparation method and application thereof, and relates to genetic engineering technology. The recombinant human K14 keratin has cell adhesion activity and comprises at least x continuous amino acid residues in SEQ ID NO. 10; wherein, 472 > x > 36. The recombinant human K14 keratin has higher cell proliferation activity and skin repair function, has low production cost, and is suitable for large-scale production.

The invention provides an antibacterial calamine lotion and a preparation method thereof, and belongs to the technical field of biological medicine manufacturing. The antibacterial calamine lotion is prepared from calamine powder, zinc oxide, vitamin B6, borneol, starch sodium octenylsuccinate, polyvinyl alcohol PVA-2488 and a traditional Chinese medicine extract, the traditional Chinese medicine extract is obtained by performing enzymolysis on golden cypress, honeysuckle and purslane. Wherein the calamine powder and the zinc oxide have the effects of astringing and relieving itching, the vitamin B6 has the effects of enhancing the skin barrier function and relieving inflammatory response, the borneol has the effects of promoting transdermal penetration, cooling, relieving itching and resisting bacteria and diminishing inflammation, the traditional Chinese medicine extract has the effects of clearing away heat and toxic materials, eliminating dampness and resisting bacteria, diminishing inflammation and relieving itching, and the starch sodium octenylsuccinate and the polyvinyl alcohol PVA-2488 can improve the stability of the calamine lotion. All the components have a synergistic effect, antibacterial activity on various microorganisms is achieved, and the skin disease treatment effect is remarkable. Clinical experiment results show that the total effective rate of the calamine lotion for treating the bacterial dermatosis reaches up to 98%.

The invention belongs to the technical field of functional coatings, and particularly relates to a preparation method of a photo-thermal self-healing and self-repairing epoxy coating. According to the preparation method disclosed by the invention, the composite corrosion inhibitor is prepared by loading 2-mercaptobenzothiazole (MBT) and capsaicin (capsaicin) on hollow mesoporous Fe3O4 nano microspheres with photothermal conversion performance and relatively good loading performance, and the composite corrosion inhibitor is used as a coating filler, so that the prepared epoxy coating has good barrier function, photothermal self-healing performance and self-repairing function at the same time; the corrosion resistance and the service life of the Q235 carbon steel can be effectively improved.

The invention belongs to the technical field of masks, and particularly relates to a manufacturing method of a cereal mask. The invention provides a preparation method of a cereal mask. The cereal mask comprises rice starch, rice flour, a mung bean extract, a hydrolyzed rice extract and an oat extract. The rice starch is used as a substrate and mixed with water which is 1.5 times of the raw materials, and then other materials are sequentially added for stirring and mixing. According to the mask, pure cereal ingredients are adopted, rice starch is used as a substrate, and meanwhile, natural cereal ingredients such as the rice flour, the mung bean extract, the hydrolyzed rice extract and the oat extract are added, so that skin is protected, absorption and metabolism of the skin are facilitated, the prepared mask is mild in performance, good protection is provided for the skin, and the purpose of maintaining beauty and keeping young is achieved.

The application discloses a pet nutrition composition based on intestinal-brain axis regulation and application thereof, and the composition comprises 5-20% of probiotics, 10-25% of prebiotics, 2-10% of neurotransmitter precursors, 5-15% of anti-inflammatory and neurotrophic factors, 1-10% of plant extracts and the rest of carriers. The application remolds intestinal microecology by the synergy of probiotics and prebiotics, promotes the synthesis of 5-hydroxytryptamine and dopamine by neurotransmitter precursors, exerts the neuroprotective and anti-inflammatory effects by omega-3 fatty acids, vitamin B group and magnesium elements, realizes the anti-anxiety and tranquilizing effects by L-theanine, chamomile and lavender extracts, and forms a regulation link of multi-target point synergistic intervention of intestinal-brain axis. According to animal experiment verification, the application can significantly improve the anxiety behavior of pets, improve the content of fecal short-chain fatty acids, remodel the intestinal flora structure, and realize the synergistic effect of 'intestinal health-nerve regulation-behavior improvement'.

The present invention relates to the technical field of skin care products, and discloses an acne skin relieving gel containing swallow and folium artemisiae argyi components, the acne skin relieving gel comprises the following components by weight: 2-3% of an oat kernel extract; 2%-3% of a folium artemisiae argyi extract; 5%-8% of a humectant; 0.5%-0.8% of an antioxidant; 0.1% to 0.2% of matrine; 4.65% to 7.4% of a skin conditioning agent; according to the invention, the oat kernels and the folium artemisiae argyi extract are compounded, so that the anti-allergy and anti-oxidation performance is synergistically improved, and redness, stabbing pain and inflammation are effectively relieved. The composite moisturizing system is combined with natural components, so that double effects of water absorption and water locking are realized, and dryness and roughness are improved permanently. All the components are natural and mild, do not contain artificial essence, pigment or preservative, and are suitable for sensitive skin. The preparation process is simple and controllable, high in batch stability and suitable for large-scale production.

The present invention discloses a composition for improving mitochondrial activity and activating cell energy, and its preparation and medical and cosmetic applications. The composition includes: citrulline, sodium DNA, taurine, arginine / lysine polypeptide, coenzyme Q10, NAD+, creatine, adenosine, ATP, glutamine, inositol, carnosine, glutathione, etc. The present invention activates cells and replenishes energy to improve skin cell vitality from the aspects of improving skin microcirculation, activating mitochondrial function, supplementing nutrition, and maintaining cell metabolism stability through a specific combination. The composition is applied in dermatology to provide energy for important cell functions such as cell renewal and wound repair, and accelerate wound healing; it is applied in skin beauty to fill skin cells with energy, and can effectively improve the volume, depth and area of ​​crow's feet, improve skin roughness, and improve skin elasticity, firmness and glossiness.

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging repairing composition and a cosmetic. The anti-aging repairing composition comprises needle-like silica and a nucleic acid tetrahedron solution. According to the composition and the cosmetic, controlled skin injury is formed through the needle-like silica, skin pore blockage is relieved, natural stripping of aged cuticle is accelerated, microcirculation of skin cells below the cuticle is activated, the overall metabolic condition of epidermis is improved, a natural skin repairing mechanism is stimulated, and under the synergistic effect of tFNA, the skin can be effectively repaired. Synthesis of important construction substances such as collagen, elastin and hyaluronic acid is promoted, the skin barrier function is repaired, and the skin health state is improved. Therefore, various skin defects such as skin photoaging, roughness, relaxation, wrinkles, dryness, hyperpigmentation, sensitivity and angiotelectasis are remarkably improved.

The invention provides a composition with a whitening effect as well as a preparation method and application thereof. The composition comprises the following raw materials in percentage by mass: 2-10% of polyhydric alcohol; 2-15% of grease; 0.1-1% of a thickening agent; 0.1-2% of an emulsifier; 1-5% of nicotinamide; 0-3% of 3-o-ethyl ascorbic acid; 0 to 0.4 percent of phenylethyl resorcinol; 0 to 1% of alpha-arbutin; 0-0.5% of a plant whitening compound II; 10% to 0.5% of nonapeptide-10%; 0 to 0.5% of tocopheryl acetate; 0 to 0.5 percent of inositol; 0-0.5% of a purslane extract; 0 to 0.5 percent of bisabolol; and the balance water. According to the composition with the whitening effect, through synergistic interaction of multiple components, the whitening effect is good, and meanwhile, the composition has the anti-allergy and soothing effects.

The present invention belongs to the field of protein technology, and relates to an active peptide for enhancing intestinal barrier function, a preparation method and an application thereof, wherein the amino acid sequence of the peptide is LIPR. The active peptide enhances the intestinal barrier function by promoting the expression of claudin, occludin and ZO-1 protein, thereby reducing toxin invasion and maintaining intestinal health. The present invention also provides a preparation method and an application of the active peptide for enhancing intestinal barrier function.

This invention discloses the use of phytic acid in the preparation of drugs or functional foods for regulating intestinal flora imbalance caused by Streptococcus mutans, belonging to the field of biomedicine and microecological regulation technology. This invention is the first to discover that oral phytic acid can effectively inhibit the abnormal colonization of Streptococcus mutans in the intestine, restore intestinal flora diversity, increase the abundance of beneficial bacteria (such as Bifidobacterium and Lactobacillus), reduce the proportion of pro-inflammatory bacteria, and improve intestinal barrier function and inflammatory status. This invention provides a new strategy for regulating intestinal flora imbalance caused by Streptococcus mutans.

The utility model relates to sound barrier technical field, concretely is a kind of sound barrier with protective structure, comprising: metal barrier, installation hole is equipped in the installation of metal barrier, recessed and convex plate is fixedly connected in the inside of metal barrier, mounting bracket is installed at the bottom of metal barrier, and mounting rail is set up in the assembling of mounting bracket;Beneficial effect is: PC board is installed on metal barrier by sliding mode, can be covered outside metal barrier, can be rust-proof, coating aging covering outside metal barrier, it is convenient for user to manually integral sliding assembling in metal barrier inside, need not regular inspection replacement, when PC board yellowing, transmittance drop, edge cracking etc., metal barrier is still protected in railway, highway etc. Traffic both sides, carry out protective installation, double-layer PC board and metal barrier not only can improve barrier effect, but also can be replaced at any time, PC board and metal barrier replacement process, can still work.

The invention provides nicotinamide whitening, moisturizing and beautifying cream and a preparation method thereof, and belongs to the technical field of cosmetics. According to the nicotinamide whitening, moisturizing and beautifying cream, the nicotinamide derivative, the fermentation extract and other components are added, so that the prepared nicotinamide whitening, moisturizing and beautifying cream has better functions of whitening, moisturizing, diminishing inflammation, resisting bacteria and enhancing skin barrier, the absorption of active components by skin can be improved, the addition amount of the active components is reduced, the cost is reduced, the effect is improved, and the nicotinamide whitening, moisturizing and beautifying cream has a good application prospect. Wide application prospects are realized.