362 results about "Epigallocatechin gallate" patented technology

An oral composition for at least one or treating and inhibiting an oral inflammatory condition comprising:

• • a Camellia extract including at least about 30% epigallocatechin gallate, at least about 50% total catechins, and at least about 60% total polyphenols; and a substantially water insoluble non-cationic anti-bacterial agent.

A satiety promoting beverage and a weight control regimen using it are described comprising: fiber, protein, sweetener and preferably calcium and a catechin, such as purified epigallocatechin gallate derived from green tea. The ingredients are employed in amounts sufficient that a single serving provides a feeling of satiety, both initially and after a period of at least one hour. In a preferred form, a serving of the beverage will comprise fiber in an amount sufficient to supply from 10 to 30% of the DV for fiber; milk protein in an amount sufficient to supply from 4 to 10 grams protein; calcium in an amount sufficient to supply from 10 to 40% of the DV for calcium; a low calorie sweetener and, preferably, the catechin in an amount sufficient to supply from 2 to 4 cup equivalents. The ingredients are homogenized and packaged to provide a smooth textured beverage with a creamy mouthfeel and from about 50 to about 150 calories per serving of from about 4 to 12 ounces. A Fullness Index of greater than 4, and preferably 5 is evidence of both very high volume to calorie and (fiber plus protein) to calorie ratios.

A composition is provided to treat and/or prevent for treating skin conditions including fine lines and wrinkles, acne rosacea, surface irregularities of the skin and hyper-pigmentation melasma of the skin, which includes use of a topically applied composition such as an ointment, lotion, cream, serum, gel or pad applied formulation, containing an effective amount of polyphenols, such as green tea based polyphenols, including but not limited to catechins, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicathechin 3-gallate (ECG) and epicatechin (EC). The formulation is preferably composed of 90 percent polyphenol isolates, derived from green tea with potent antioxidant properties, to assist in minimizing free-radical induced skin damage.

The present invention proposes formative agent of protein complex, in which a polyphenol is useful component, and the agent is useful as gene complex, cell adhesion inhibitor or immune tolerogen. The polyphenol of forming the agent is selected from catechin group consisting of epigallocatechin-gallate, tannic acids, or proanto-dianisidine, a protein of the protein complex is selected from proteins consisting of animal proteins composed of polypeptide chain of peptide-combined amino acids, vegetative proteins, nucleus proteins, glycogen proteins, lipo-proteins and metal proteins, the gene complex comprises by compositing genes by polyphenol catechins in order to introduce genes to cells of animals or human bodies, a cell composed of the cell adhesion inhibitor is selected from cells consisting of an animal cell including a stem cell, skin cell, mucosa cell, hepatocyte, islet cell, neural cell, cartilage cell, endothelial cell, epidermal cell, osteocyte or muscle cell isolated from human or animal organism, or sperm, ovum or fertilized egg of domestic animals or fishes and a tissue or an organ for transplantation of the immune tolerogen is selected from the tissue or the organ consisting of skin, blood vessel, cornea, kidney, heart, liver, umbilical cord, bowels, nerve, lung, placenta or pancreas.

The invention provides an epigallo-catechin gallate (EGCG) with high purity and a preparation method thereof. The EGCG content is 98.0 percent to 99.9 percent. The preparation method mainly comprisesthe working procedures of extracting, separating by a chromatography and crystallizing. The invention has favorable reproducibility of preparation process, high acquired EGCG content, low cost and stable and controllable quality and is suitable for industrialized production.

The invention is a product that produces a feeling of satiety, suppresses appetite and promotes a higher metabolic rate, while providing nutrients for a balanced meal in a fruit flavored meal substitute. The product for weight management comprises fruit juice and protein, and further comprises green tea extract comprising epigallocatechin gallate. The product can be made to further comprise caffeine at a level over and above that provided by the green tea extract, and added calcium. Other aspects of the invention include methods to provide a human with a product that aids in the feeling of satiety and contributes to weight management, comprising administering to a human in need thereof the food product described.

The invention relates to a gel preparation for maintaining the activity of cryopreserved cells and a stem cell gel preparation containing stem cells. The gel preparation comprises the following components by the mass percentage: 1-3% of sodium alginate, 1-5% of dimethyl sulfoxide, 1-5% of propylene glycol, 1-5% of epigallocatechin gallate, 2-10% of dextran, 1-5% of human blood albumin, and water or a phosphate solution added to make the total amount be 100%. The gel preparation has the advantages of good biocompatibility and simple operation, can maintain high activity of cells, can be directly used for low temperature preservation, and has no need of traditional liquid nitrogen cryopreservation; the cell gel preparation after resuscitation can still maintain high activity of the cells and dryness of the cells, and can be applied for treatment of skin injury or mucosal injury.

The invention belongs to the field of medicine and gene engineering, and provides a composition for inhibiting the proliferation of tumor cells. The composition contains epigallocatechin gallate (EGCG) and daunorubicin (DNR), and the mass ratio of the epigallocatechin gallate to the daunorubicin is 600: 1-1: 2. The combination of the EGCG and the DNR, on one hand, ensures that the effect of inhibiting the proliferation of the tumor cells is more obvious than the superposition of single use effects, on the other hand, the combination of the EGCG and the DNR obviously reduces the using amount of the DNR, greatly reduces the cardiac toxicity of the DNR, and strengthens the anti-tumor effect of the DNR at the same time. The EGCG is a natural tea extract, has rich resource and low price, and almost has no toxic side effect after more than one thousand years of drinking, so the combination of the EGCG and the DNR relatively reduces the using amount of the DNR and drug cost. The invention provides a high-efficiency cheap anti-tumor pharmaceutical composition, which improves the inhibition rate of tumor and reduces the treatment cost of tumor patients at the same time.

The invention discloses a glycosylated casein-based tea polyphenol (epigallocatechin gallate, EGCG) nano capsule capable of inhibiting casein aggregation and precipitation caused by high concentrations of polyphenols. The preparation method of the nano capsule capable comprises the following steps: glycosylated casein is obtained by dry heat treatment of casein and dextran and then ultrafiltration for removal of free reactants, the glycosylated casein is physically mixed with EGCG to obtain the EGCG-combined nano capsule. The EGCG encapsulation efficiency of the prepared nano capsule can reach up to 90%, the average nano capsule particle size is 70-140nn, the EGCG retention rate is 60%-70% after 10 days of storage, particle size change during storage is smaller, in the case of high EGCG loading capacity, uniform dispersion state of the system can be maintained, and no flocculent precipitate is generated. The nano capsule capable remarkably improves the binding rate of the casein and the EGCG, can be used as a nano carrier of EGCG and other polyphenols, and is widely used in food, health care products and other industries.

A method for stabilizing an extra cellular matrix layer in the vascular system of the body is disclosed herein. The method can comprise placing a vascular catheter adjacent to the extra cellular matrix layer, delivering a solution containing a bioflavonoid to the extra cellular matrix layer with the vascular catheter, and cross-linking protein in the extra cellular matrix layer. The bioflavonoid can be a catechin, particularly epigallocatechin gallate (EGCG).

The invention provides a low-fat low-osmosis low-residue type enteral nutritional powder for patients with inflammatory bowel diseases. The powder is prepared from protein, fat, carbohydrate, vitamin complex, minerals and epigallocatechin gallate, and does not contain gluten, wherein the protein is supplied by whey protein powder and L-glutamine; the fat is supplied in a mode of long-chain fatty acid and medium-chain fatty acid, and a ratio of (omega-6) to medium-chain fatty acid to (omega-3) to (omega-9) is 40% to 40% to 10% to 10%; and the carbohydrate is maltodextrin. The enteral nutritional powder is suitable for people who are relatively poor in gastroenteric function and easily have diarrhea or people requiring low-fat low-residue diet, such as patients with inflammatory bowel diseases, pancreatitis patients who are in transition of initial oral diet, heart failure patients, patients who initially use enteral nutrition after fasting, patients with cholecystitis or gall-stone, patients subjected to cholecystectomy, obesity people, patients in preparation of bowel surgery, patients after gastrointestinal surgery and the like. The enteral nutritional powder can be used for supplying balanced nutrition support, is easy to brew and store, is convenient to control dosage and osmotic pressure, and can be used for improving the living quality of patients.

Providing a compound capable of continuously taking and having a vascular endothelial function improving effect by enhancing NO function from the vascular endothelial cells.

A compound represented by Formula (I) wherein R₁, R₂, R₃ and R₄ are each independently H or a gallate group, a vascular endothelial function improving agent, food and drink or pharmaceutical composition containing the compound.

The invention relates to a beverage, in particular to a fish collagen composite fruit flavored beverage. The fish collagen composite fruit flavored beverage comprises, in parts by mass, 100 parts of purified water, 4 to 30 parts of fish collagen powder, 3 to 24 parts of berry powder, 2 to 10 parts of pomegranate fruit powder, 1 to 8 parts of pear cactus powder, 0.1 to 1 part of oligochitosan, 0.01 to 0.32 part of epigallocatechin gallate, 0.1 to 30 parts of functional sweeteners, and 0.1 to 1 part of an acidity agent. The fish collagen composite fruit flavored beverage disclosed by the invention is taken as a health drink which combines a variety of natural substances, and is scientific in formula, balanced in nutrition, fresh in fruity taste, and beneficial to firming and moisturizing skin, enhancing elasticity and keeping female reproductive health. The invention further provides a preparation method of the fish collagen composite fruit flavored beverage.

The disclosure provides compositions treating traumatic brain injuries such as concussions. In one embodiment, the composition comprises phosphatidylserine, phosphatidylcholine, quercetin, astaxanthin, R-alpha lipoic acid, N-acetyl cysteine, taurine, L-glutamine, carnitine, D-ribose, creatine, epigallocatechin gallate, melatonin, ginkgo leaf extract, curcumin and L-glycine. The disclosure also provides methods for treating traumatic brain injuries such as concussions by administering an effective amount of the compositions described within.

The invention relates to a method for preparing high-purity monomer epigallocatechin gallate from processed leftovers of tea leaves. The method comprises the following steps of: extracting tea polyphenol, namely performing enzymolysis of the processed leftovers, which serve as raw materials, of fresh tea leaves, pruned tea leaves and non-fermented tea leaves by adding complex enzyme which consists of cellulose, protease and pectinase to extract the tea polyphenol; and separating a catechin out for purifying, namely precipitating the tea polyphenol by using a mixed precipitant which consists of CaCl2 and ZnCl2, performing primary separation by a macroporous resin chromatographic column, and performing secondary purification by the macroporous resin chromatographic column to obtain the high-purity monomer epigallocatechin gallate (EGCG). According to the method, chloroform is not used, the join from the extraction process to the refining and purification processes is compact, and the quality and yield of the product are high.

The invention belongs to the fields of nano material preparation technique and biological material, in particular to a method for preparing an antibacterial EGCG (Epigallocatechin Gallate)_Cu(II)/PVA (Polyvinyl Alcohol) nanofibre composite membrane by utilizing electrostatic spinning and an application thereof. The method of the invention comprises the following steps of weighing copper sulfate and EGCG according to a ratio; dissolving in distilled water; regulating the pH value to prepare an EGCG_Cu (II) complex; mixing the EGCG_Cu (II) complex and PVA according to a ratio; and generating the EGCG_Cu (II) /PVA nanofibre composite membrane by utilizing an electrostatic spinning technique. The invention has the advantage that the sterilizing rate on escherichia coli can reach 99%. The nanofibre composite membrane has the advantages of good toughness and biocompatibility, and wide application prospects in the field of the biological materials.

A combination cancer therapy based upon catechins, the major biologically active polyphenol in plant products, including green tea extract, and one or more chemotherapeutic agents. A common complication of cancer chemotherapy is neutropenia, and in spite of advances in its prophylactic management is a major cause of risk for the development of serious microbial infections leading to increased morbidity and mortality in both humans and animals. The use of cathechins such as those found in green tea (Camellia sinensis), including but not limited to epigallocatechin gallate (EGCG) as nontoxic adjuvant to aid in the prevention of opportunistic microbial infections in patients undergoing immunosuppressive chemotherapy is a novel application. Also contemplated are methods using catechins to ameliorate the immunosuppressive effects of cancer chemotherapy by administering the compound to a patient in need thereof.

The invention discloses a near-infrared light response nanoparticle which comprises a nano-carrier, a nano-carrier entrapped substance, a photosensitizer and a near-infrared light response phase change material for packaging, wherein the nano-carrier entrapped substance comprises an H2S donor and an anticancer drug. Hydrophobic DATS, hydrophilic indocyanine green and epigallocatechin gallate are encapsulated into mesoporous polydopamine nanoparticles by utilizing the amphiphilic property of myristyl alcohol, and finally, the MPDA-ICG/DATS/EGCG@TD nanoparticles are obtained. After the nano system is irradiated by near-infrared laser, ICG in the nano system can effectively convert NIR into heat; and the phase change material TD responds to temperature rise and is changed into liquid from solid, so that rapid release of DATS and EGCG is promoted.

The invention relates to a skin-whitening and freckle-removing formula and a preparation method for gel with the formula, and belongs to the field of pharmaceutical chemicals. The formula comprises high-purity EGCG (epigallocatechin gallate) and dipotassium glycyrrhizinate. The formula is characterized in that the mass ratio of EGCG to dipotassium glycyrrhizinate is (2 to 1) to (1 to 3), preferably (1 to 1) to (1 to 2), and the gel prepared by a dipotassium glycyrrhizinate hydrate, namely a gel matrix can be used for whitening skin and removing freckles. The preparation method has the advantages of high pharmaceutical activity, remarkable freckle-removing and inflammation-diminishing effects, simple process, stable state and the like, and is suitable for industrial production.

The invention discloses a preparation for inhibiting coronavirus infections. The preparation provided by the invention is applied to (1) or (2) as follows: (1) preparing of products for inhibiting the coronavirus infections; (2) inhibiting of coronavirus infections. The preparation is prepared mainly through mixing epigallocatechin gallate, tannin and astragalus polysaccharides, wherein the mass proportioning ratio of the epigallocatechin gallate to the tannin to the astragalus polysaccharides is (0.5 to 1.0): (0.5 to 1.0): (0.5 to 1.5). The cytotoxicity of the compounded preparation provided by the invention is not higher than that of a control sample, i.e., ribavirin which has already obtained security permission, so that the preparation is safer. The coronavirus infections can be effectively inhibited through using the preparation provided by the invention in a preventive manner in case of safe working concentration, so that the preparation has a commercial value in being further researched and developed into a coronavirus infection inhibitor.

The invention provides a yoghourt, a method for preparing the yoghourt and a bottled yoghourt. By weight, 1,000 parts of yoghourt are prepared from 860 parts to 940 parts of raw milk, 12 parts to 20 parts of stabilizers, 3 parts to 8 parts of single cream, 65 parts to 90 parts of white granulated sugar, 1 part to 5 parts of whey protein powder and the balance antioxidants. The antioxidants are prepared from at least two kinds of sodium ascorbate, epigallocatechin gallate, tea polyphenol, liquorice antioxidants, vitamins A, ascorbic acid, ascorbyl palmitate, EDTA, tocopherol, gallate, BHA, BHT, D-sodium isoascorbiate, phospholipid, phosphate and rosemary extract. The yoghourt has the at least one advantage of being high in stability, quite good in relish and taste, high in nutritive value and long in shelf life.

According to the formula (I), a epigallocatechin gallate glycoside derivative and a pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing thesame as an active ingredient, and an anti-cancer composition in combination with an anti-cancer drug are provided. Compared with the anti-cancer drug alone, the combination of the EGCG derivative andthe anti-cancer drug has better tumor inhibiting effect. The invention further discloses the application of the compounds in preparing the anti-tumor pharmaceutical composition and the preparation.

The present invention discloses a nutritional composition for improving oral health. The nutritional composition comprises the following raw materials in parts by weight: 5-30 parts of probiotics, 20-80 parts of prebiotics and 0.1-2 parts of epigallocatechin gallate; the probiotics are selected from at least one of lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus helveticus, and lactobacillus salivarius; and the prebiotics are selected from at least one of inulin, oligofructose, galactooligosaccharide, xylooligosaccharide, stachyose, oligoisomaltose, raffinose, trehalose, and lactitol. At the same time, the present invention also provides a use of the nutritional composition in preparations of oral health-care products. The provided nutritional composition can inhibit colonization of caries inducing streptococcus mutans, reduces adhesion of subgingival gingiva pathogenic bacteria, inhibits bad breath, promotes the proliferation of the oral probiotics, prevents the occurrence and development of dental erosion and oral cancers, and can effectively solve the oral problems caused by alcoholism, smoking, staying up late, irregular diet, long-term consumption of acidic substances, etc.

The invention discloses a composite capable of preventing bacteria, viruses, oxidation and pigment deposition, which is characterized by being prepared from the following raw materials in proportion by weight: 0.1-10 of epigallocatechin gallate (EGCG), 0-10 of chlorogenic acid, 0-10 of asiaticoside and 0-10 of ginkgolide. The invention also discloses application of the composite in preparing drugs, health-care food and cosmetics, which are capable of preventing bacteria, viruses, oxidation and pigment deposition. The composite of the invention has favorable safety, is suitable for curing respiratory tract infection, condyloma acuminatum, herpes progenitalis, chromatosis and other diseases, simultaneously has anti-oxidation and skin whitening functions, protects cells and DNA from being damaged, can prevent and cure dementia and chloasma, and also can be used for cancer adjuvant therapy.

The present invention provides a composition containing tangeretin as an active ingredient for external application to the skin. The present invention also provides a composition containing tangeretin and EGCG for external application to the skin. The present invention also provides a composition for external application to the skin, comprising, as an active ingredient, mandarin peel extracts containing tangeretin. The present invention also provides a composition for external application to the skin comprising mandarin peel extracts containing tangeretin and further comprising green tea extracts containing Epigallocatechin gallate (EGCG). The composition has excellent antioxidative effects, and therefore can be applied as a cosmetic composition, a pharmaceutical composition or a health food composition. Furthermore, the composition may have superior effects of preventing skin erythema, improving skin tone and preventing skin aging.