The invention discloses an application of
lauric acid modified SOD on prevention of chronic
radiation skin lesion. A preparation method of the
lauric acid modified SOD comprises the following steps that (1) activated
lauric acid modifiers are compounded, wherein lauric acid and
thionyl chloride are subjected to reaction at 50-140 DEG C, stable returning is performed after at least 80% of lauric acid is converted, and then
cut fractions at 124-127 DEG C are collected through reduced pressure
distillation, namely the activated lauric acid modifiers; (2) the lauric acid modified SOD is prepared, wherein ox blood SOD is dissolved in a
buffer solution to form an SOD solution, the activated lauric acid modifiers are added into the solution, the mixture is stirred and reacts at 30-50 DEG C and then is quenched to stop reaction, and the lauric acid modified SOD product is obtained. The prepared lauric acid modified SOD easily permeates through the
skin and
cell membranes compared with natural SOD and is long in activity preservation time and good in
heat resistance when stored at normal temperature. Compared with the prior art, toxic catalyst
pyridine is eliminated, and the lauric acid modified SOD is suitable for being applied on the aspect of prevention of chronic
radiation skin lesion and has a better technical effect.