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Application of lauric acid modified SOD on prevention of chronic radiation skin lesion

A technology of radioactive skin and lauric acid, which is applied in the application field of lauric acid modified SOD in the prevention and treatment of chronic radioactive skin damage, to achieve the effects of good heat resistance, long storage activity time, and long-term storage and maintenance of activity time

Active Publication Date: 2015-09-16
CHINA PETROLEUM & CHEM CORP QINGDAO RES INST OF SAFETY ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no reports on the application of modified SOD to personnel with chronic radiation skin injury, practitioners exposed to radiation, radiation protection for radiation therapy patients, and prevention and treatment of occupational skin diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Synthesis of activated lauric acid modifier

[0027] Take lauric acid, dissolve it in a water bath at 50°C, add thionyl chloride, the weight ratio of lauric acid to thionyl chloride is 5:1, the reaction pressure is normal pressure, and the rate of adding thionyl chloride is controlled at 2.5 hours. Add 25% of the total amount, and the reaction temperature is 65°C. After 90% of the lauric acid has been converted, it is stably refluxed for 1 hour. Then distilled under reduced pressure to evaporate excess unreacted substances. Then continue to distill, collect 110~134 ℃ distillate, distillate speed 0.7~0.8 drop / second. It takes 40 minutes in total, and the fraction above 140°C is left and discarded. Re-distill the fraction at 110-134°C twice, collect the fraction at 124-127°C to obtain a high-purity activated lauric acid modifier, and store it in the refrigerator for later use.

[0028] (2) Preparation of lauric acid modified SOD

[0029] Dissolve bovine blood SOD ...

Embodiment 2

[0032] (1) Synthesis of activated lauric acid modifier

[0033] Take lauric acid, dissolve it in a water bath at 60°C, add thionyl chloride, the weight ratio of lauric acid to thionyl chloride is 7:1, the reaction pressure is normal pressure, and the rate of dropping thionyl chloride is controlled at 2.5 hours. Add 25% of the total amount, and the reaction temperature is 135°C. After 80% of the lauric acid has been converted, the reflux is stabilized for another 2.5 hours. Then distilled under reduced pressure to evaporate excess unreacted substances. Then continue to distill, collect 110~134 ℃ distillate, distillate speed 0.7~0.8 drop / second. It takes 35 minutes in total, and the fraction above 140°C is left and discarded. Re-distill the fraction at 110-134°C twice, collect the fraction at 124-127°C to obtain a high-purity activated lauric acid modifier, and store it in the refrigerator for later use.

[0034] (2) Preparation of lauric acid modified SOD

[0035] Dissolve ...

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Abstract

The invention discloses an application of lauric acid modified SOD on prevention of chronic radiation skin lesion. A preparation method of the lauric acid modified SOD comprises the following steps that (1) activated lauric acid modifiers are compounded, wherein lauric acid and thionyl chloride are subjected to reaction at 50-140 DEG C, stable returning is performed after at least 80% of lauric acid is converted, and then cut fractions at 124-127 DEG C are collected through reduced pressure distillation, namely the activated lauric acid modifiers; (2) the lauric acid modified SOD is prepared, wherein ox blood SOD is dissolved in a buffer solution to form an SOD solution, the activated lauric acid modifiers are added into the solution, the mixture is stirred and reacts at 30-50 DEG C and then is quenched to stop reaction, and the lauric acid modified SOD product is obtained. The prepared lauric acid modified SOD easily permeates through the skin and cell membranes compared with natural SOD and is long in activity preservation time and good in heat resistance when stored at normal temperature. Compared with the prior art, toxic catalyst pyridine is eliminated, and the lauric acid modified SOD is suitable for being applied on the aspect of prevention of chronic radiation skin lesion and has a better technical effect.

Description

technical field [0001] The invention relates to an application method of lauric acid modified SOD, in particular to the application of lauric acid modified SOD in the prevention and treatment of chronic radiation skin damage. Background technique [0002] 1. Background technology of natural SOD and modified SOD [0003] Superoxide dismutase (SOD) is a metalloenzyme widely present in organisms, which catalyzes superoxide anion free radicals (O · 2 - ) disproportionation reaction enzymes are superoxide anion free radicals (O · 2 - ) scavenger, is also a medicinal enzyme with important clinical application value, it can treat superoxide anion free radicals (O · 2 - ) related diseases of injury. It is clinically used to treat tumors induced by oxygen free radicals, inflammation, ischemia-reperfusion injury, oxygen poisoning, Parkin's syndrome, Alzheimer's disease, rheumatoid arthritis, aging, various skin diseases, etc. [0004] Natural SOD has problems such as short h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44C12N9/96C12N9/02A61P17/16
CPCA61K38/446C12N9/0089C12N9/96C12Y115/01001A61K38/00
Inventor 巫志鹏王建伟王林
Owner CHINA PETROLEUM & CHEM CORP QINGDAO RES INST OF SAFETY ENG
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