A kind of Periplaneta americana extract for intervening AD and its extraction method and application

A technology of Periplaneta americana and extract, which is applied in the field of Periplaneta americana extract and extraction, to achieve good palatability, reduce the number of senile plaques, and improve the effect of spatial learning and memory

Active Publication Date: 2019-09-13
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Chinese patent medicine preparations of Periplaneta americana (such as Kangfuxin liquid (anti-inflammation, trauma repair), Xinmailong injection (treatment of heart failure), Ganlong capsule (treatment of hepatitis B)) or Periplaneta americana medicinal wine (treatment of nervous system) degenerative diseases) all use ethanol as the extraction solvent, but there is no bibliographical report on the Periplaneta americana preparation that uses water as the extraction solvent and has AD intervention function

Method used

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  • A kind of Periplaneta americana extract for intervening AD and its extraction method and application
  • A kind of Periplaneta americana extract for intervening AD and its extraction method and application
  • A kind of Periplaneta americana extract for intervening AD and its extraction method and application

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preparation example Construction

[0030] The present invention provides a kind of preparation method of Periplaneta americana extract, comprises the steps:

[0031] (1) pulverizing the dried Periplaneta americana body to obtain the meal of Periplaneta americana;

[0032] (2) The American cockroach coarse powder obtained in step (1) is stirred and extracted at 50-60° C. for 0.5-2 hours with water as a solvent to obtain a water extract;

[0033] (3) Degrease the water extract to obtain the Periplaneta americana extract.

[0034] The present invention has no special limitation on the source of Periplaneta americana, and commercially available Periplaneta americana medicinal materials or fresh worms of Periplaneta americana can be used. If it is a fresh worm of Periplaneta americana, the body of Periplaneta americana needs to be dried before being used for the preparation of the extract of Periplaneta americana of the present invention. During the drying process, the drying temperature should not be higher than ...

Embodiment 1

[0043] The extraction process of the active ingredient of Periplaneta americana used to intervene in AD, the specific operation steps are as follows:

[0044] A. Periplaneta americana body pulverization: dry Periplaneta americana body pulverization (drying temperature can not be higher than 65 ℃), cross 8 mesh sieves, be the meal of Periplaneta americana;

[0045] B. Water extraction: Stir and extract the Periplaneta americana coarse powder in step A in deionized water at 60°C for 2 times, each time extracting with a material-to-liquid ratio of 1:5 and an extraction time of 1.5 hours, and combining the extracts;

[0046] C. Initial concentration: Concentrate the water extract obtained in step B under reduced pressure at a vacuum of -0.05MPa and a temperature of 50°C to 1 / 6 of the crude extract to obtain a concentrate;

[0047] D. Low-temperature degreasing: place the crude extract obtained in step C at 4°C for 24 hours to naturally precipitate and degrease.

Embodiment 2

[0049] The extraction process of the active ingredient of Periplaneta americana used to intervene in AD, the specific operation steps are as follows:

[0050] A. Periplaneta americana body pulverization: dry Periplaneta americana body pulverization (drying temperature can not be higher than 65 ℃), crosses 10 mesh screens, is Periplaneta americana meal;

[0051] B. Water extraction: the coarse powder sample of Periplaneta americana in step A was stirred and extracted in deionized water at 50°C for 3 times, each time the extraction time was 1 hour according to the ratio of solid to liquid at 1:10, and the extract was combined;

[0052] C. Initial concentration: Concentrate the water extract obtained in step B under reduced pressure at a vacuum of -0.06MPa and a temperature of 65°C to 1 / 5 of the crude extract to obtain a concentrate;

[0053] D. Low-temperature degreasing: place the crude extract obtained in step C at 1° C. for 48 hours to naturally precipitate and degrease;

[...

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Abstract

The invention belongs to the technical field of biological medicine and discloses an AD interfering American cockroach extractive as well as an extracting method and application thereof. According tothe AD interfering American cockroach extractive disclosed by the invention, deionized water is utilized as an extracting solvent to be stirred under 50 to 60 DEG C to extract for 0.5 to 2 hours, active matters in dry American cockroach crude powder are extracted, and a water extracting solution is used for removing grease to obtain the American cockroach extractive. The American cockroach water extractive disclosed by the invention has an AD interfering effect and can be applied to preparing AD interfering medicine and health-care food.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an extract of Periplaneta americana and an extraction method thereof. The extract of Periplaneta americana can prevent or treat Alzheimer's disease. Background technique [0002] Alzheimer's disease refers to the long-lasting intellectual impairment of the elderly (≥60 years old), manifested as memory, language, thinking, calculation, orientation and emotion disorders and personality changes, as well as the decline of social activity and self-life ability . At present, Alzheimer's disease is divided into: Alzheimer's disease (AD), vascular dementia and mixed dementia internationally. As the condition worsens, the patient becomes sluggish, desireless, bedridden for a long time, unable to take care of himself, and often dies from secondary physical diseases such as decubitus, fracture, pneumonia, urinary system infection, malnutrition, or exhaustion. [0003] AD a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P25/28A23L33/10
Inventor 赖仞龙承波龙爱琳吕秋敏
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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