18 results about "American cockroach" patented technology

The invention discloses nitrogen-doped carbon quantum dots derived from American cockroach dregs as well as a preparation method and application of the nitrogen-doped carbon quantum dots, and belongs to the technical field of nitrogen-doped carbon quantum dots. The nitrogen-doped carbon quantum dots are prepared from the American cockroach dregs by a one-step hydrothermal method, optimal synthesis parameters are obtained through experimental optimization of synthesis conditions, and the prepared nitrogen-doped carbon quantum dots have excellent optical characteristics and stability; the invention also provides an application of the nitrogen-doped carbon quantum dot in Ag < + > detection, the nitrogen-doped carbon quantum dot has good selectivity, sensitivity and anti-interference performance on Ag < + >, a detection mechanism is an internal filtering effect and light-induced electron transfer, and the nitrogen-doped carbon quantum dot can be used as a preferred fluorescent material of an Ag < + > fluorescent sensor. The nitrogen-doped carbon quantum dots synthesized by the method not only have an Ag < + > sensing function, but also realize high-valued utilization of medicine residues, and also provide a new thought for self-doping of heteroatoms.

The invention discloses a composite solution for treating reflux esophagitis and a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations, the composite solution is formed by physically mixing drug-loaded microspheres and a gastric buoyant raft matrix solution; wherein the drug-loaded microspheres are solid particles which take thiolated pectin as a carrier, are crosslinked and cured through divalent metal ions and are coated with a periplaneta americana extract; the gastric buoyant raft matrix solution comprises a hydrophilic colloid, a component capable of generating gas when encountering acid and a stabilizer. The magnesium mercapto pectin microspheres provide excellent mucous membrane adhesion, and the acting time of the medicine on the esophageal focus is prolonged; the gastric buoyant raft substrate forms a physical barrier in a gastric acid environment to inhibit regurgitation of gastric contents. Through cooperation of the two, a dual treatment mechanism of local repair and source control is realized. The preparation can remarkably prolong the in-vivo residence time and effectively promote esophageal mucosa healing, and the curative effect is better than that of a pure periplaneta americana extract preparation.

This invention discloses a composition and its preparation method for treating human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), belonging to the field of traditional Chinese medicine technology. The formula consists of 6-15 parts of American cockroach, 5-11 parts of hawthorn, 5-11 parts of chicory, 3-9 parts of *Scutellaria baicalensis*, 8-20 parts of *Sophora flavescens*, and 6-15 parts of *Cnidium monnieri*, and also contains 0.01-1 parts by weight of toad venom. The dosage form is one or more of the following: external gel, rinse, foam, suppository, and film preparation. It has high safety and is suitable for HPV infection and CIN changes, solving the problem of poor efficacy in existing treatments.

The invention discloses a functional beverage produced by compounding insects and plants. The functional beverage is prepared from insect raw materials, plant raw materials and a solvent, the insect raw material is periplaneta americana, the plant raw material is sweet-scented osmanthus, and the solvent is distilled liquor; the material ratio of the periplaneta americana to the sweet-scented osmanthus is 1-2, and the material-liquid ratio of the total mass of the periplaneta americana and the sweet-scented osmanthus to the distilled liquor is 1: (15-30) g / mL. The functional beverage is prepared by scientific compatibility of periplaneta americana and sweet-scented osmanthus.

The present application relates to the technical field of medicine, and in particular to Periplaneta americana L. extract, a preparation thereof, a preparation method and application thereof. The method for preparing Periplaneta americana L. extract includes the steps: 1) soaking fresh Periplaneta americana L. extract with ethanol; 2) reflux extracting with ethanol, and then filtering and combining the filtrates; and 3) concentrating the filtrate into extractum. The method uses environmental protection reagents such as ethanol, increases the content of bioactive substances of Periplaneta americana L. extract, saves time, human and material resources, saves energy and reduces production cost. The Periplaneta americana L. extract obtained by the present method has better anti-inflammatory activity and higher content of amino acids.

The application provides an American cockroach glucan Pa1-B1 and a preparation method and application thereof, and belongs to the technical field of biological medicines. The American cockroach glucan Pa1-B1 is a glucan with an alpha (1→4) linked main chain, and glucose on the side chain is alpha (1→6) connected to the main chain, and the weight average molecular weight is 36000 kDa to 42000 kDa. The American cockroach glucan Pa1-B1 is obtained by crushing whole American cockroaches, defatting with 95% ethanol, extracting under alkaline conditions by enzymatic hydrolysis, and then alcohol precipitation, ion exchange column chromatography and gel column chromatography separation and purification. The American cockroach glucan Pa1-B1 is a novel polysaccharide first discovered in American cockroaches, has the activity of enhancing immune regulation, and can effectively train the body immunity, significantly inhibit malignant tumor metastasis, prolong the survival period of tumor-bearing mice, and has long-term anti-tumor effect after training immunity. Therefore, the American cockroach glucan Pa1-B1 can be used for preparing an immune function enhancing, training immunity anti-tumor or anti-tumor metastasis drug.

This invention belongs to the field of pharmaceutical technology, specifically relating to the preparation of liposomes based on American cockroach oil and their application as delivery carriers for American cockroach extracts. This invention is the first to introduce active oils from American cockroaches as a functional membrane component into a liposome construction system, successfully achieving partial substitution of traditional cholesterol and reducing the amount of cholesterol used in traditional liposomes. Simultaneously, the introduction of active oils may endow liposomes with additional biological functions, such as anti-inflammatory and repair-promoting effects, while also increasing the stability of the liposomes. This lays the foundation for the subsequent development of multifunctional carriers with synergistic therapeutic effects.

The invention relates to the technical field of periplaneta americana powder microscopic flaking, and discloses a periplaneta americana powder microscopic identification method which comprises the following steps: S1, sample degreasing: dividing a periplaneta americana adult into five parts, namely a head part, a chest back plate, wings, an abdomen part and chest feet by using tweezers, respectively grinding into powder, taking 100g of powder of each part of the periplaneta americana, and uniformly mixing the powder with the powder of each part of the periplaneta americana; respectively filling the materials into a filter paper tube, putting the filter paper tube into an extraction tube of a Soxhlet extractor, soaking the American cockroach powder with an extracting solution, and removing grease; s2, sample tabletting: taking the degreased powder, respectively adding distilled water, chloral hydrate and dilute glycerol for tabletting, and preparing a water-loaded tablet, a chloral hydrate cold-loaded tablet and a chloral hydrate permeabilized tablet; s3, microscopic observation: placing the prepared loading sheet under an optical microscope, and carrying out image acquisition and analysis on powder characteristics by using image processing software equipped for the microscope; and S4, identification standard. Compared with the prior art, the method has the advantages that grease is convenient to remove, the observation definition and accuracy are improved, a microscopic identification standard is established, and an identification system is perfected.

The invention belongs to the technical field of aquaculture, pet breeding and animal protection, and discloses an atail frog anesthesia ointment, a preparation method and application, every 100 g of the atail frog anesthesia ointment is prepared from the following components by weight: 50-80 g of vaseline, 5-10 g of beeswax, 5-10 g of a periplaneta americana extract, 1-5 ml of eugenol and sterile plaster cloth. According to the preparation method of the anesthetic ointment, the anesthetic efficiency is improved, and the anesthetic risk is reduced. And the blank of the antail frog anesthetic ointment in the market is filled. Effective animal welfare is provided for surgery, treatment, collection and protection of the frogs without tail eyes in the future.

The utility model discloses a periplaneta americana breeding device which is provided with an oxygen concentration sensor, the oxygen concentration sensor is in signal connection with a controller, an oxygen concentration signal in a box body is transmitted to the controller, and the controller controls a temperature control ventilation assembly to adjust the oxygen concentration in the box body. The temperature control ventilation assembly is provided with a fresh air valve, an air inlet fan, an air return valve and an air exhaust fan, and fresh air with high oxygen concentration enters the box body through an air inlet pipe by closing the air return valve and opening the fresh air valve and the air inlet fan; and the exhaust fan is started, so that the air with lower oxygen concentration in the box body is discharged out of the box body through the exhaust pipe, and external circulation of the air is realized. When the oxygen concentration sensor detects that the oxygen concentration in the box body meets the requirement, the fresh air valve and the air exhaust fan are closed, the air return valve is opened, the air exhaust pipe is communicated with the air inlet fan, air is fed into the box body again through the air inlet pipe from the air exhaust pipe, air internal circulation is formed, and heat loss in the box body is reduced.

This invention discloses the application of methyl N-hydroxybenzoxime acid in the preparation of cockroach attractants, and also provides a composition for attracting American cockroaches, comprising an effective amount of methyl N-hydroxybenzoxime acid as an attractant, wherein the mass percentage of methyl N-hydroxybenzoxime acid is 0.01% to 10%. The composition may further include auxiliary attractants selected from 3-hydroxy-2-butanone, butyric acid, isovaleric acid, oleic acid, linoleic acid, nonanal, decanal, hexadecanoic acid, and stearic acid, or mixtures thereof. The composition also contains an attractant-acceptable carrier, such as at least one of food substrates, solvents, and solid inert materials, and can be formulated into liquid, gel, granule, or aerosol formulations for monitoring American cockroach population dynamics and / or trapping American cockroaches. This attractant component is derived from the insect itself, exhibiting good biocompatibility and environmental friendliness, providing a new technical means for the green control of American cockroaches.

This invention discloses a modified American cockroach polypeptide derivative, its preparation method, polypeptide composition, and applications. The amino acid sequence of the polypeptide derivative is shown in SEQ ID NO: 1 (PA1702); it is modified by replacing the asparagine at position 13 of the natural polypeptide PA1701 with glutamine, and can be prepared by Fmoc solid-phase polypeptide synthesis. Network pharmacology predicts that it acts on 59 core anti-inflammatory targets, enriched in pathways such as PI3K-Akt and MAPK. Molecular docking shows that PA1702 has a strong binding affinity for TNF-α and AKT1. In vitro experiments confirm that PA1702 is non-cytotoxic, can inhibit LPS-induced release of NO, TNF-α, IL-6, and IL-1β, and promote cell migration. The above-mentioned polypeptide derivative can be used as an active ingredient in cosmetics or pharmaceutical compositions; it has anti-inflammatory, skin barrier repair, and wound healing promotion effects, and can be used to prepare anti-inflammatory, skin barrier repair, and wound healing-promoting cosmetics or drugs.

The invention provides a powerful hemostatic adhesive prepared by taking American cockroach dregs as a main raw material. The preparation method comprises the following steps: firstly, extracting and preparing chitin whiskers from waste American cockroach dregs, taking the chitin whiskers as a polymer matrix of the adhesive, taking an aqueous solution of a deep eutectic solvent as a system medium, taking thrombin as a hemostatic functional substance, and improving the overall mechanical properties by gelatin, thereby finally obtaining the biological adhesive with good adhesion and hemostatic performance. According to the product, under the condition that a cross-linking agent does not need to be used, through heating-cooling operation, a polymer skeleton network is constructed through interaction between chitin whiskers and gelatin, a channel is provided for transmitting moisture and nutrient substances to damaged tissues, and the product has degradability while achieving an ideal adhesion effect; the whole system effectively fuses the components, is friendly and easy to prepare, and integrates respective advantages. In addition, the activity and the stability of the thrombin in the eutectic solvent are both in ideal states, so that the adhesive can play a powerful hemostatic role.

The invention discloses the technical field of biology, and particularly relates to a CYP9E22 gene and application of the CYP9E22 gene in regulation and control of resistance of periplaneta americana to cyhalothrin, and the nucleotide sequence of the CYP9E22 gene is shown as SEQ ID NO.1.

The application discloses an American cockroach glucan PaN, a pharmaceutical composition of the American cockroach glucan PaN, a preparation method of the American cockroach glucan PaN and application of the American cockroach glucan PaN in enhancing immune function of a body, and belongs to the technical field of biological medicines.The American cockroach glucan PaN is an alpha (1→6) linked glucan, and the weight average molecular weight is 3000 Da to 4000 Da.The preparation method comprises the following steps: crushing American cockroach whole worm, degreasing by using ethanol, extracting by using an enzymolysis method, and separating and purifying by using a fractional alcohol precipitation, an ion exchange column chromatography method and / or a gel column chromatography method.The American cockroach glucan PaN can enhance the phagocytosis of macrophage RAW264.7, and dose-dependently promotes the macrophage to release NO and to secrete cytokines (IL-6, TNF-alpha).Therefore, the American cockroach glucan PaN and the composition thereof can be used in preparation of an immune-regulating medicine or food.

This invention provides a method for preparing and applying an aqueous extract of American cockroaches, belonging to the technical field of preparation and application of aqueous extracts of natural insects. The main method involves freeze-drying and pulverizing American cockroaches under two months old, followed by water extraction, enzymatic hydrolysis with trypsin, and defatting to prepare the extract. The American cockroach extract prepared by this invention has moisturizing, anti-inflammatory, antioxidant, and anti-allergic effects, and is odorless and has a fine texture, making it suitable for use in the cosmetics field.

The invention relates to the technical field of medicines, in particular to skin antibacterial cream and a preparation method thereof. In order to solve the technical problem, the technical scheme provided by the invention is as follows: the skin antibacterial cream is prepared by mixing the following raw materials in parts by weight: 0.06 to 1.1 parts of American cockroach extract, 0.06 to 1.1 parts of lithospermum extract, 8 to 35 parts of zinc oxide, 0.05 to 2.2 parts of borneol, 0.001 to 0.12 part of dichlorophenoxychlorophenol and 0.07 to 0.15 part of chlorhexidine acetate. Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.1 to 0.7 part of American cockroach extract, 0.1 to 0.7 part of radix arnebiae seu lithospermi extract, 12 to 32 parts of zinc oxide, 0.1 to 1.6 parts of borneol, 0.002 to 0.1 part of dichlorphenoxychlorophenol and 0.1 to 0.8 part of chlorhexidine acetate. The periplaneta americana ointment has the beneficial effects that the healing speed is high, the periplaneta americana extract can accelerate cell proliferation and migration, the wound healing time is shortened, and the wound healing time is averagely shortened by 30% or above. All the raw materials have a synergistic effect, so that pathogenic microorganisms can be effectively inhibited, the infection risk is reduced, granulation tissue formation and epithelization are promoted, and the healing quality is improved.

The invention provides application of polypeptide PA1 in preparation of products for preventing alopecia, protecting hair or promoting hair growth. The product for promoting hair growth contains a periplaneta americana polypeptide tissue repair factor PA1 or a pharmaceutically acceptable salt thereof or a stereoisomer thereof or a prodrug molecule thereof or a metabolite thereof, and can promote proliferation and migration of human dermal papilla cells (hDPCs) and promote hair growth of mice. The tissue repair factor PA1 or pharmaceutically acceptable salts thereof or stereoisomers thereof or prodrug molecules thereof or metabolites thereof can be used for preparing medicines for preventing and treating alopecia or daily chemical products for preventing alopecia, growing hair and protecting hair, and has a good application prospect.