42 results about "Esophageal mucosa" patented technology

A tissue engineering combined human body lumen succedaneum adopts a tectorial elastic supporting pipe with connecting pieces, wherein an absorbable coating is attached on the outer wall of the supporting pipe, and planted with seed cells thereon. The connecting pieces can reduce the effect of the gullet peristalsis to the planted elastic supporting pipe, and the elastic supporting pipe has favorable flexibility and stronger supporting force, therefore, the tissue engineering combined human body lumen succedaneum provided by the invention can avoid anastomotic leakage, early trachea cannula exodus and newly-born narrow gullet; in addition, the absorbable coating attached on the outer wall of the elastic supporting pipe is planted with the seed cells, thus being capable of inducing or improving the growth and covering of the newly-born esophageal mucosa. After the newly-born esophageal mucosa is covered completely, and the scar tissues of newly-born gullet are stable, the planted succedaneum can be taken out or removed under the direct view of a digestive endoscopy.

The invention discloses a compound iodine staining diagnostic kit set for esophageal mucosa. The kit set comprises a compound iodine solution and a neutralization solution, wherein the compound iodine solution is a KI and I2 compound solution, and the mass percent concentration of I2 is 1%-2.5%; the neutralization solution is a sodium thiosulfate water solution with the mass percent concentration of 3%-3.5%. The kit set is convenient to use and has a good iodine staining effect; adverse effects of patients can be effectively removed through the neutralization solution.

The invention relates to a Chinese patent medicament for treating reflux esophagitis and a preparation method thereof, and belongs to the field of Chinese medicinal preparations. The Chinese patent medicament is prepared from the following raw materials in part by weight: 10 to 25 parts of rabdosia rubescens, 20 to 30 parts of stir-fried immature bitter orange and 6 to 15 parts of liquorice root. The Chinese patent medicament is a pure Chinese medicinal preparation and is a novel gel oral administration preparation, can be adhered to esophageal mucosa for a long time after oral administration to play a role in local treatment, can avoid the first pass effect caused by oral administration, has the advantages of high medicament carrying rate, strong wall-hanging properties, continuous and complete absorption of medicaments, lasting medicinal effect and quick response, and can be adhered to the esophageal mucosa for a long time after the oral administration to play a role in local inflammation resistance.

The invention discloses a method for isolated culture of esophagus epithelial stem cells. The method comprises the steps of taking esophagus mucosa tissue and epithelium adhering to the esophagus mucosa tissue, removing muscular tissue, taking a basal layer of epithelium mucosae tissue, shearing the basal layer of epithelium mucosae tissue into bits, conducting digestion centrifugation, and spreading obtained cells in a culture flask, culture plate or culture dish coated with a matrix; then adding a DMEM/Ham's F-12 culture solution containing HEPES, sodium bicarbonate, L-glutamic acid, FBS, EGF, insulin, hydrocortisone, vibrio cholerae toxin, transferring, BPE, quasi-vitamin A and cell signaling pathway inhibitor; finally, placing the culture flask, culture plate or culture dish containing cell suspension in a 37 DEG C incubator for culture, and obtaining the single-layer epithelial stem cells in 10-14 days. According to the method, operation is convenient, safety performance is high, the esophagus epithelial stem cells are obtained through separation, the activity of the stem cells is high, and application prospects in tissue engineering and regenerative medicine are broad.

The invention discloses a preparation method of an artificial esophagus with histological structure. The method is characterized by comprising the steps of: extracting a basilemma membrane protein solution from animal esophageal mucosa tissue; then preparing electrospinning / acellular matrix bracket; then preparing a polyurethane sheet with a double-sided microgroove; and finally coating the polyurethane sheet on the electrospinning / acellular matrix bracket and splicing into a tube shape longitudinally, so as to obtain the artificial esophagus with histological structure. The invention has the advantage that the method can prepare the artificial esophagus simulating histological structure of normal human esophageal, and utilizes the principles of tissue engineering to construct in vitro the artificial esophagus with similar microstructure and function as human esophagus; and the artificial esophagus is seamed with residual esophagus after resection of lesion esophagus layer by layer, so that the artificial esophagus gradually grows into a real esophagus and integrates with the original esophagus in the human body. Compared with the traditional alternatives, the artificial esophagus has structure and function similar to those of natural esophagus, and can alleviate the suffering of patients and prolong the patient's life.

The invention provides a medicament carrying film capable of being absorbed by an oral cavity, which is characterized in that: the medicament carrying film capable of being absorbed by the oral cavityis prepared from active components of a small dose of medicaments, a water-soluble high polymer material and a pharmaceutically acceptable pharmaceutic adjuvant, wherein the pharmaceutically acceptable pharmaceutic adjuvant may be one or more of a stabilizer, a colorant, a sweetener, a correctant, a freshener and an emulsifier. The medicament carrying film capable of being absorbed by the oral cavity can be quickly dissolved in the oral cavity; the small dose of medicaments are absorbed in a form of a nonionic medicament in the pH value environment of the oral cavity; and a considerable amount of medicaments enter general blood circulation through the oral cavity, a throat and esophageal mucosa and can quickly reach the maximum plasma concentration. The medicament carrying film capable ofbeing absorbed by the oral cavity cannot generate any irritation to oral mucosa and has the advantages of adjustable mouthfeel, fragrant smell, and cool, refreshing and sweet taste. The medicament carrying film not only can refresh breath but also can better exert general action. The medicament carrying film not only can improve the compliance of patients, but also can improve the bioavailabilityof certain medicaments.

The invention belongs to the technical field of medical image processing, and particularly relates to a deep detection network for quantifying esophageal mucosa IPCLs vascular morphological distribution. The deep detection network comprises a feature extraction network, a feature pyramid, a region candidate network, an interest region pooling and clustering distribution priori self-embedded cancerlesion classification network and a system for visualization on a narrow-band imaging endoscope image. The feature extraction network extracts a feature map of the input image; the feature pyramid fuses the features of different scales; the region candidate network proposes a possible lesion region; the region of interest is pooled, and the features are pooled to a suspicious lesion region; the cancer lesions are classified by a clustering distribution priori self-embedded cancer lesion classification network; and finally, visualizing is carried out on a narrow-band imaging endoscopic image,and frame selection marking is carried out on the cancer lesion by using different colors. The cancer focus of the early esophageal squamous cell carcinoma existing in the image is detected and diagnosed, the diagnosis efficiency can be effectively improved, and a doctor is assisted in obtaining higher diagnosis precision.

Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical composition, a cosmetic composition, an immunostimulant for preventing the infection by pathogens or viruses that invade through the respiratory or esophageal mucosa, and an intestinal immunostimulant for preventing or alleviating food poisoning, each of which contains the lactic acid bacterium or treated cells of the lactic acid bacterium.

The present invention relates to the administration of Keratinocyte Growth Factor-2 (KGF-2) to stimulate proliferation of platelets and to increase levels of fibrinogen, albumin, globulin and total serum protein. Further, the present invention relates to administering KGF-2 to protect or treat the bladder and prostate. Moreover, the present invention relates to administering KGF-2 to stimulate growth of nasal, oral, and esophageal mucosa, lacrimal glands, salivary glands and Goblet cells.

The invention discloses an esophageal-mucosa staining combination set. The esophageal-mucosa staining combination set is characterized by being prepared from a staining solution and a neutralization solution; the staining solution is a compounded solution of KI and I2, wherein the mass percent concentration of the I2 in the staining solution is 1%-2.5%; the neutralization solution is a sodium thiosulfate aqueous solution with the mass percent concentration of 1%-3.5%. The esophageal-mucosa staining combination set is a combination set kit of the compounded iodine stain and a neutralization reagent, and is stable in concentration, convenient to use, rapid in neutralization and capable of rapidly removing discomfort of a patient.

A system for inserting an element into a target tissue includes an endoscope comprising a working channel extending therethrough and an end cap comprising a cavity extending therein from an open proximal end sized to receive a distal end of the endoscope therein and a closed distal end. The cavity is open to an exterior of the end cap via a window extending laterally through a side wall thereof so that a target tissue may be received within the cavity via the window. The system also comprises a needle sized to be passed through the working channel of the endoscope so that a distal end of the needle is insertable into the cavity thereby, the needle extending longitudinally from a proximal end to a distal end and comprising a lumen for housing an element to be delivered to the target tissue.

The invention discloses a stomach tube. The problem is solved that because all nursing personnel master the pull-out or plug-in length of a current stomach tube by themselves according to personal nursing experience and lack uniform operation specifications and operation rules when pulling out and plugging in the stomach tube, the esophageal mucosa or the gastropore mucosa is easily damaged due to the too small or too large plug-in length of the stomach tube. According to the technical scheme, the stomach tube further includes a positioning sleeve, wherein a stomach tube body is sleeved with the positioning sleeve; an inlet and an outlet which coordinate with the stomach tube body to make the stomach tube body get through are formed in the front and rear side walls of the positioning sleeve respectively; a distance detector is arranged in the positioning sleeve and is connected with a drive mechanism controlled by the distance detector; the drive mechanism is connected to a distance indicating mechanism. By the adoption of the stomach tube, it is convenient for the nursing personnel to accurately master the pull-out or plug-in length of the stomach tube, and the situation is avoided that because the stomach tube is incorrectly plugged in, the esophageal mucosa or the gastropore mucosa is damaged.

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine preparation for treating esophageal cancer inflammation. Esophageal cancers are malignant tumors occurring at esophageal mucosa, most of the esophageal cancers are squamous cell carcinomas, and a few esophageal cancers are adenocarcinoma, undifferentiated carcinoma and intratumoral carcinoma. As the esophagus is blocked by the cancer, food and saliva cannot pass through the esophagus to cause vomiting, and finally a patient suffers from insufficient nutrition and dehydration. Conventional methods for treating the esophageal cancer include surgical resection, radiotherapy and chemotherapy, but the actual curative effect is not ideal; the living quality of the patient is low, the death rate is high, the pain is great and the cost is high; and in order to relieve the pain of the patient to a certain extent, the invention hopefully provides the traditional Chinese medicine preparation for treating the esophageal cancer inflammation. The traditional Chinese medicine preparation for treating the esophageal cancer inflammation comprises 5-15 g of spica prunellae, 5-15 g of radix scrophulariae, 3-10 g of cortex phellodendri, 5-15 g of flos lonicerae, 5-15 g of fructus forsythiae, 5-15 g of herba taraxaci, 0.5-1.5 g of fructus gleditsiae, 0.5-2 g of borneol, 2-10 g of herba menthae, 2-10 g of fructus arctii, 2-10 g of radix sophorae tonkinensis, 2-10 g of bombyx batryticatus and 2-10 g of radix glycyrrhizae.

The invention discloses a clinical diagnosis sampling device for the digestive system department, which comprises an inner tube, an outer tube is arranged on the outer side of the inner tube, and an air passage for air flow to pass through is arranged between the outer tube and the inner tube; the sampling mechanism is mounted on the outer side of the outer tube, the sampling mechanism is communicated with the outer tube, and the sampling mechanism is inflated to expand and then scrapes in the esophagus, so that esophageal exfoliated cells are collected; the inflating mechanism is mounted at the end parts of the inner pipe and the outer pipe, and the inflating mechanism is used for inflating gas into the sampling mechanism; sampling can be conducted at different positions of the esophagus of a patient in a staged mode through the single air bag, the specific position of a focus can be conveniently determined, on the premise that the air bag is kept inflated through the inflation mechanism, friction resistance between the air bag and the inner wall of the esophagus of the patient is reduced, and the esophagus of the patient can be more accurately positioned. The possibility of esophageal mucosa damage of a patient is reduced, and the patient can conveniently and comfortably sample.

The invention relates to a novel esophageal dilation balloon catheter. The novel esophageal dilation balloon catheter comprises an upper-end esophageal dilation balloon, a lower-end anti-reflux balloon and a central nasal feeding tube; a stenotic esophagus is dilated by the novel esophageal dilation balloon catheter through injecting water (gas) into the upper-end balloon; gastroesophageal refluxis prevented by injecting water (gas) into the lower anti-reflux balloon; and nasal feeding can be performed through the central nasal feeding tube when the balloon is expanded or not expanded. The novel esophageal dilation balloon catheter is used after esophageal anastomosis or is used for patients with esophageal stricture, and is used for performing intermittent expansion on a stenotic esophagus or esophageal anastomosis. The water (gas) in the esophageal dilatation balloon is pumped back during dilatation intervals, so that ischemic necrosis of the esophageal mucosa due too long compression is avoided. After eating, the lower-end anti-reflux balloon is expanded so as to avoid anastomotic leakage or stenosis caused by reflux of gastric contents. According to the design, frequency of gastroscopy and contrast examinations of patients is reduced by intermittent dilation of the esophageal dilation balloon.

The invention relates to a kit for staining esophageal mucosa. A staining solution used in esophageal mucosa staining by the kit is a compound iodine solution, and a neutralizing solution is a vitaminC solution. The staining solution is 20mL of the compound iodine solution and consists of iodine, potassium iodide and distilled water, wherein each milliliter of the compound iodine solution contains 0.02g iodine and 0.04g potassium iodide, the iodine content of the compound iodine solution is 2%, and the concentration of iodine is 60mg/mL. The neutralizing solution is 20mL of the vitamin C solution, wherein the vitamin C content is 2%. The invention overcomes the defect that iodine can stimulate and erode mucosa of upper digestive tracts. According to the invention, the standardization kitset comprising the compound iodine solution staining solution and vitamin C solution neutralization solution is convenient to use, can neutralize iodine staining in time, relieves discomfort symptomsof patients after iodine staining in time, and improves compliance of the patients, so that the detection rate of esophageal squamous dysplasia and canceration is greatly increased.