Esophageal local drug delivery device for acute radiation esophagitis

Abstract

The invention discloses an esophageal local drug delivery device for acute radiation esophagitis, and aims to solve the problems that liquid medicine is difficult to stay on the surface of esophageal mucosa or stays for a short time, and the liquid medicine is difficult to take and eat by swallowing. The drug delivery device comprises a capsule, a hose and a fixator, wherein the fixator comprises an ear hook, one end of the hose is connected with the capsule, an adaptive connecting piece is connected between the other end of the hose and the ear hook, the capsule comprises a capsule shell and a micro-transmission mechanism fixed in the capsule shell, the capsule shell comprises an elastic head membrane and a capsule body, A micro-motor in the micro-transmission mechanism is electrically connected with a power supply and a microcontroller, the micro-transmission mechanism comprises a spiral mechanism and a stretching mechanism, and the spiral mechanism drives the stretching mechanism to stretch the elastic head membrane, so that a gap between the periphery of the elastic head membrane and an esophageal wall is reduced, a liquid medicine column is formed, and the retention time of medicine acting on the surface of the esophageal mucosa is prolonged.

Description

Technical field: [0001] The invention belongs to the technical field of medical devices, and relates to a local esophageal drug delivery device, in particular for local drug delivery to the esophagus when clinical symptoms of acute radiation esophagitis occur during radiotherapy. Background technique: [0002] Radiation therapy is one of the main means of tumor treatment. It can effectively kill tumor cells, but at the same time it will inevitably cause radiation damage to normal tissues and organs around the tumor, resulting in various complications and sequelae. Acute radiation esophagitis is a complication of local radiotherapy, which often occurs during radiotherapy for lung cancer, esophageal cancer and other chest tumors. The time of occurrence is mostly when the cumulative radiation dose to the esophagus reaches DT20Gy-40Gy. Acute radiation esophagitis is an aseptic inflammation caused by radiation damage to the esophageal mucosa. Ulceration, erosive and exudative ch...

AI Technical Summary

Problems solved by technology

[0005] The invention provides a local esophageal drug delivery device for acute radiation esophagitis, aiming to solve the problem of difficulty in staying on the surface of the esophageal mucosa or the short stay time of the medicine when taking a liquid preparation slowly to treat acute radiation esophagitis, and the problem of swallowing and taking medicine. Difficulty eating

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