78 results about "Aseptic inflammation" patented technology

The preparation method of chitosan-polylactic acid graft copolymer includes the following steps: utilziing melt condensation reaction to obtain polylactic acid with lower molecular weight, and utilizing esterification and oxidation reaction to convert the hydroxyl group of polylactic acid into aldehyde group, and making the hydroformylated polylactic acid react with chitosan so as to obtain the invented product with good working property, high hydrophilic property and good biological compatibility.

The invention discloses a high strength degradable intraosseous fixation composite material. A magnesium alloy pipe is filled with a high polymer material to form a high strength degradable sandwich composite material, by weight percentage, the degradable magnesium alloy pipe accounts for 5-70%, and the balance is the high polymer material, which is preferably polylactic acid. For the degradation product, because of the neutralization reaction of magnesium hydroxide and lactic acid, later-stage rapid degradation of polylactic acid is accelerated, thus solving the problem of aseptic inflammation caused by acidic accumulation in a degradation process of polylactic acid during clinical application. And magnesium alloy degradation and basically slight expansion of polylactic acid at the early stage further strengthen the support function of the composite material, therefore the high strength degradable intraosseous fixation composite material has very good clinical application prospect.

The invention relates to a manufacture method for surgical implant-level poly(L-lactic acid). The method comprises the following steps: mixing L-lactic acid and a catalyst, performing reduced-pressure distillation to obtain a crude product DL-lactide, and performing recrystallization to obtain high-purity DL-lactide; performing a reaction on the DL-lactide, a catalyst and an end-capping agent under vacuum and nitrogen introducing circulation conditions to obtain poly(L-lactic acid); and performing dissolving, performing recrystallization, and performing drying to obtain the implant-level poly(L-lactic acid) which can be supplied for surgery. According to the poly(L-lactic acid) prepared by the manufacture method, the physical and chemical properties of the poly(L-lactic acid) can fully meet a YY/T 0661-2008 (standard specification for virgin poly(L-lactic acid) resin for surgical implants), and the poly(L-lactic acid) has remarkable effects on aspects such as monomer residues, an optical rotation and microparticle control (requirements that the number of microparticles with sizes of 10 micrometers or more in 1 g is 200 at most, and the number of microparticles with sizes of 25 micrometers or more in 1 g is 100 at most are met). The high-optical-purity poly(L-lactic acid) can be better and normally metabolized by people, and biocompatibility between the poly(L-lactic acid) and people is improved; and low-insolubility microparticles are reduced, thus possibility of aseptic inflammation is reduced.

The invention relates to a three-dimensional (3D) printing head for a biological composite material. The 3D printing head for the biological composite material comprises a push rod, a coaxial heatingjacket, a wire feeding pipe, a thermoelectric couple, a mixed extrusion head, powder feeding pipes and electric heating pipes. The mixed extrusion head is connected with the coaxial heating jacket through a screw thread; the push rod is arranged in an inner hole of a feeding cavity of the coaxial heating jacket; a degradable polymer is filled in an inner hole of the feeding cavity; and the three electric heating pipes are arranged on the coaxial heating jacket. The three powder feeding pipes and the wire feeding pipe are arranged on the mixed extrusion head; and the thermoelectric couple is arranged on an outer wall of the thermoelectric couple. The printing head can be used for manufacturing a 3D printing piece made of the continuous fiber-reinforced degradable polymer-biological ceramiccomposite material, the mechanical performance and the bone binding force of the printing piece can be effectively improved, the degradation speed of the printing piece can be controlled, and the riskof aseptic inflammation can be reduced.

The invention relates to a medicament preparation for treating gynecological disease and a preparation method and application thereof, wherein the medicament preparation for treating the gynecological disease is prepared into pills, capsules and the like through processing seven traditional Chinese medicines including cassia twig, tuckahoe, tree peony bark, red paeonia, peach kernel, angelica and spatholobus stem. The medicament preparation is a pure traditional Chinese medicine preparation, has the functions of promoting blood circulation, removing blood stasis and eliminating abdominal mass, is used for treating originally suffered abdominal mass or amenorrhea due to blood stasis of women, menstrual bellyache and postpartum lochiorrhagia, has good effect on treating the symptoms of hysteromyoma (particularly small intramural hysteromyoma), chronic pelvic inflammatory enclosed mass, endometrial irregular shedding functional bleeding, ovarian cyst, dysmenorrheal, endometrial abnormal taste and the like, avoids the side effect of long-term taken antibiotics, can not cause dual infection, has good security and no remarkable toxic or side effect, can be taken for a long time and makes up the defects of chronic aseprtic inflammation, adhesive enclosed mass antibiotics inefficacy and the like.

The invention belongs to the field of the medical application of a lauromacrogol injection, and particularly relates to application of a lauromacrogol injection as a medicament for treating internal hemorrhoid. Internal hemorrhoid is one of hemorrhoids, which occurs above the pectinate line of the anal canal and is a commonly encountered disease having the highest incidence rate among the hemorrhoids; for majorities of people, internal hemorrhoid bleeding is a disease difficult to deal with; and when the internal hemorrhoid bleeds too much, secondary anemia can be caused. In the invention, the lauromacrogol injection is injected into the hemorrhoid, so that an aseptic inflammation is produced and is then gradually fiberized, thus realizing the treatment of the internal hemorrhoid. The lauromacrogol injection can wrap veins and arterioles in the hemorrhoid, so that a protective layer can be formed at the peripheries of the veins and arterioles, thereby preventing weak blood vessels from bleeding due to damage caused by defecation and other factors; fiber textures can occlude blood vessel cavities, eliminate or lessen the expansion and congestion of the veins and atrophy the hemorrhoid; because of the fiberization process, a relaxed mucous membrane can be fixed on the muscular wall thereunder again through the fiber textures, thereby eliminating the symptom.

The invention relates to the field of biological medical apparatus and instruments, and particularly relates to an absorbable intraosseous fixing device with biological activity and plasticity and a forming method. The absorbable intraosseous fixing device comprises a bone fracture plate and bone screws, wherein the bone fracture plate is provided with fixing holes and is made by a biologically absorbable high polymer material and biologically active ceramics or biologically active glass; the biologically absorbable high polymer material is 70-95% of the total weight of a composite material in parts by weight, and the biologically active ceramics or biologically active glass takes up 5-30% of the total weight of the composite material; the biologically absorbable high polymer material is selected from one or more of polylactic acid, polycaprolactone, polylactic acid-glycolic acid copolymer, polyglycolic acid, polyhydroxyalkanoate and polyhydroxybutyrate, and the molecular weight is 100,000 to 2,000,000. The absorbable intraosseous fixing device is good in biocompatibility, and can be degraded after the device is implanted in the body; meanwhile, aseptic inflammation caused in the course of material degradation can be reduced, and the pain of a patient can be alleviated; in addition, the personalized customization can be realized.

The invention provides a pharmaceutical composition, an external plaster and a preparation method thereof, which are used for treating pains in neck, shoulder, waist and leg and hyperosteogeny. The bulk drugs for preparing the pharmaceutical composition comprise the components at the following parts by weight: 6-9 parts of hemlock parsley, 2-5 parts of Chinese ephedra, 0.5-1 parts of white mustard seed, 6-9 parts of speranskia herb, 6-9 parts of radix clematidis and 2-5 parts of scorpion. The bulk drugs of the pharmaceutical composition can also comprise the following components: 1.5-3 parts of green onion, 1.5-3 parts of ginger, 1.5-3 parts of cinnamon and 1.5-3 parts of borneol. The pharmaceutical composition of the invention can be made into an external plaster with neodymium iron boron magnet inside, which leads to the combination of the efficacies of medicine, magnet and acupuncture point, and utilizes the absorption of the sweat gland, stratum corneum and pores of skin of human to realize the treatment of internal diseases by external therapies and address both the symptoms and root causes from collateral channels to main channels, and the pharmaceutical composition of the invention can effectively relieve the local aseptic inflammation caused by the pains in neck, shoulder, waist, and leg and hyperosteogeny.

The invention discloses an unguent for treating rheumatic arthritis. The unguent comprises the following raw materials in parts by weight: 20-30 parts of ephedra, 20-30 parts of gingko root, 10-20 parts of corydalis tuber, 10-20 parts of medicinal cyathula root, 10-12 parts of radix angelicae pubescentis, 10-20 parts of herba epimedii, 15-20 parts of anisetree bark, 10-15 parts of teasel root, 8-10 parts of caulis sinomenii, 10-14 parts of radix rehmanniae preparata, 6-10 parts of rhizoma curculiginis, 10-18 parts of notopterygium root, 10-13 parts of sichuan lovage rhizome, 7-10 parts of Rhizoma Atractylodis Macrocephalae, 20-30 parts of prepared nux vomica, 10-15 parts of dried body of ground beetle, 10-20 parts of Paniculate Swallowwort Root, 10-20 parts of Astragalus membranaceus, 10-20 parts of gallnut, 6-10 parts of Filliform Cassytha Herbe and 8-10 parts of loose knot. The unguent disclosed by the invention has the functions of promoting blood circulation to remove meridian obstruction, dispelling wind, eliminating dampness, eliminating cold to stop pain and the like, mainly used for treating rheumatic diseases such as rheumatic, rheumatoid and rheumatic migraine, can effectively alleviate oppression of nerve endings and eliminate aseptic inflammation, and meanwhile has good curative effect on weakness, inhibited bending and stretching and the like.

The invention relates to a mineralized collagen based skull repairing device and a manufacturing method thereof. The mineralized collagen based skull repairing device is made of a mineralized collagen/PCL (polycaprolactone) composite material; and the appearance of the repairing device comprises a spherical segment cap at the upper part and a cylindrical plug at the lower part. A separation mold and a secondary pouring technology are adopted during preparation of the mineralized collagen based skull repairing device, and the product defect caused by air residue at the blind end of the mold is overcome. The skull repairing device made of the mineralized collagen/ PCL composite material has excellent osteogenic activity, the material is gradually and passively degraded under the creeping substitution action of cells, and growth of new bones can be guided at the skull defect part. A degradation product of the composite material is neutral, acidic materials causing aseptic inflammation cannot be generated, and new bone formation isn't affected; and through composition of PCL, the skull repairing device has excellent elasticity and toughness besides enough crush resistance and bending strength, and the repairing requirement of a skull of a human body is met.

The invention provides methods for predicting the likelihood that a subject will develop a sterile inflammation or will have an increased propensity to later develop a sterile inflammation, for determining whether a subject with tissue damage should be administered an antimicrobial agent (at full or a reduced dosage) or an anti-inflammatory agent, and for treating a subject with tissue damage. In the methods, an increased ratio of the amount of mitochondrial nucleic acid or peptide to the amount of microbial nucleic acid or peptide indicates a subject that has an increased likelihood of developing a sterile inflammation or an increased propensity to later develop a sterile inflammation, or a subject that should not be administered, or that should be administered at a reduced dosage, an antimicrobial agent or one or more anti-inflammatory agents and not an antimicrobial agent. Kits for detecting mitochondrial and/or microbial nucleic acids or peptides are provided.

The invention provides calcium phosphate bioceramics compounded with collagen as well as a preparation method and a usage method thereof. The preparation method of the calcium phosphate bioceramics compounded with collagen comprises the following steps: forming cross-linked collagen coating on surfaces of calcium phosphate bioceramics by using collagen solutions of which the concentrations are from low to high, thereby obtaining cross-linked collagen coating with which the surfaces of the calcium phosphate bioceramics are wrapped; carrying out mixing with a collagen solution, and carrying outfreeze-drying so as to obtain precursors of the calcium phosphate bioceramics compounded with collagen; and then, soaking the coating with a collagen solution, and carrying out freeze-drying so as toobtain the calcium phosphate bioceramics compounded with collagen which comprise collagen wrapping layers. The calcium phosphate bioceramics compounded with collagen prepared according to the technical scheme of the invention have improved repair ability and degradation performance, so that, aseptic inflammation caused by falling off of calcium phosphate ceramic particles in clinical use can be avoided; moreover, the calcium phosphate bioceramics compounded with collagen are plastic in shape and size as well as convenient to use, so that, many problems of bioceramics in clinical application can be solved.

The invention discloses a traditional Chinese medicine ointment for treating hyperosteogeny and a preparation method of the traditional Chinese medicine ointment and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine ointment for treating hyperosteogeny is prepared from the following raw materials in parts by weight: 1-2 parts of musk, 5-10 parts of dragon blood, 5-10 parts of saffron crocus and 10-20 parts of chicken oil. The preparation method comprises the following steps of: (1) preparing materials; (2) grinding and crushing; respectively grinding and crushing the three raw materials, i.e., the musk, the dragon blood and the saffron crocus, wherein the musk, the dragon blood and the saffron crocus are weighted according to weights, and the thickness is smaller than or equal to 60 meshes; and (3) preparing: heating the chicken oil to be in a boiling state, adding the ground musk, dragon blood and saffron crocus, uniformly stirring the musk, the dragon blood and the saffron crocus to form paste, and then, holding fire and naturally cooling. According to the formula, the muskone is used as a guiding medicine and matched with the other three traditional Chinese medicines to prepare the traditional Chinese medicine ointment which is strong in permeability and capable of rapidly penetrating bone joint barriers and deep tissues, softening and eliminating spurs, eliminating aseptic inflammation, preventing hyperosteogeny from developing and worsening, maintaining bone and dredging the channel as well as solving the problem that a common medicine is slow in taking effects and cures the symptoms but not the diseases.

The invention relates to a traditional Chinese medicine acupuncture and moxibustion needle for treating diseases in a medical department, a surgical department, a dermatological department, a gynecological department and a pain department. Patients feel afraid when seeing a traditional fire needle and refuse therapy, or the rate of fainting during acupuncture treatment is increased. A positioning electric fire needle overcomes the shortcomings. The entry depth of the traditional fire needle is totally based on experiences and feeling of a doctor, and accurate positioning cannot be realized. The traditional fire needle is heated by fire, but the positioning electric fire needle is heated by electricity and is convenient and fast in heating and is safe and sanitary. The positioning electric fire needle has effects of warming yang, removing coldness, dehumidifying, warming channels, dredging collaterals, promoting blood circulation, removing blood stasis, leading hotness to be discharged outwards, dispersing swelling, removing pus, ascending up spleen-qi, removing numbness and stopping itch. Modern medicine show that a warming effect of the fire needle can improve local or total blood circulation of a human body, metabolism of the human body is promoted, sterile inflammation is eliminated, and decompression is realized. Clinical application of the traditional Chinese medicine acupuncture and moxibustion needle does not need to be discriminated, and the needle can be used for treat diseases in aspects of wind, coldness, fire and poison.

The invention provides a high-strength degradable 3D printing material and a preparation method thereof. The high-strength degradable 3D printing material comprises 100 parts of a polyhydroxyalkanoate/hydroxyapatite compound and 0.2-2 parts of white wax oil, wherein the polyhydroxyalkanoate/hydroxyapatite compound comprises polyhydroxyalkanoate and hydroxyapatite with the mass ratio to be 8 to 2. The high-strength degradable 3D printing material has the benefits that the obtained polyhydroxyalkanoate/hydroxyapatite compound is completely degradable, cannot generate acidic metabolites and effectively avoids occurrence of aseptic inflammation complications caused by internal fixation materials clinically at present. At the same time, the hydroxyapatite can effectively improve the mechanical strength of the internal fixation materials and expands the range of application of the internal fixation materials used clinically at present.

The invention discloses an anti-bone-hyperplasia traditional Chinese medicine prescription. The anti-bone-hyperplasia traditional Chinese medicine prescription is characterized by comprising the following components in percentage by weight: 10-18% of prepared rhizome of rehmannia, 10-18% of rhizoma drynariae, 10-18% of roasted nux vomica, 10-18% of suberect spatholobus stem, 10-18% of desertliving cistanche, 5-9% of Chinese panax pseudo-ginseng, 5-9% of frankincense, 5-9% of myrrh and 5-9% of szechuan lovage rhizome. A preparation method comprises the following steps: weighing the nine traditional Chinese medicinal materials, grinding into fine powder, and refining pills with honey to ensure that the weight of each pill is 6g. An action mechanism of the prescription disclosed by the invention is that soft tissue aseptic inflammation around hyperplastic bone spurs can rapidly subside, damaged articular cartilage can be repaired, and the formed bone spurs can be stopped to develop, can be diminished, and then can subside.

The invention provides a small needle knife composed of a needle knife handle, a needle knife body and a needle knife blade connected one by one. The needle knife handle is in the shape of a horse shoe. A cylindrical needle knife tail is arranged on the tail end of the needle knife handle. When the needle knife is used, the cylindrical needle knife tail arranged at the front end of the needle knife handle allows a moxa cone to be installed on the needle knife tail for heating when the needle knife is retained in vitro partially, so that through thermal conduction, the amount of bleeding is reduced after the needle knife cuts tissues, aseptic inflammation of the diseased tissues is eliminated, muscle spasms at parts attached to bones are eliminated and relieved, and thus tissue adhesion can be more effectively loosened and softened. Meanwhile, the needle knife can warm channels and relax collaterals, and improve tissue repair of wounded parts. The needle knife can reduce the pain of patients, and integrates the treatment functions of a needle knife and a silver needle, so that the medical costs of the patients can be reduced. The design of the horse-shoe-shaped needle knife handle reduces the area of the needle knife handle and the weight of the needle knife tail, so that the needle knife body is prevented from tilting due to overweight of the needle knife tail, and the needle knife is very convenient for use.

The invention discloses a plaster capable of effectively treating hyperosteogeny and a preparation method thereof. The plaster disclosed by the invention is a pure traditional Chinese medicine plaster prepared from more than 30 carefully selected rare medicinal materials as main raw materials: xiaojiujia, amber, musk, pangolin, scorpion, centipede, spina gleditsiae, venenum bufonis, dragon blood and the like. The medicinal materials are scientifically combined to generate the synergetic effects on softening hardness to dissipate stagnation, eliminating stasis to resolve swelling, relaxing tendons and activating collaterals as well as expelling cold and relieving pain, thereby achieving the effects on eliminating aseptic inflammation, relieving muscle spasm, easing pain and softening hyperplastic bones. The clinical observation shows that under normal conditions, symptoms can be obviously relieved after 2-3 patches of plaster are applied, the hyperosteogeny can be thoroughly cured if the plaster is continuously applied for 3-6 months, the recurrence rate is very low, and the treatment effect can be stabilized for more than 3-5 years.

The invention belongs to the field of medical materials, and particularly relates to a biodegradable material and a preparation method and application thereof. The biodegradable material is prepared with PLLA (poly-L-lactic acid) and RAPA (rapamycin) as raw materials; the mass ratio of PLLA to RAPA is (900-1100):(1.2-2.5); the molecular weight of PLLA is 600,000-1,000,000. By blending the elasticdegradable polymer PLLA with the rigid polymer RAPA in a certain proportion range, the fully-degradable polymer material having different flexibility degrees and strength cycles is obtained; the biodegradable material also has the effect of relieving inflammatory reaction, RAPA also serves as a prodegradant, local pH reduction caused by the acidity of terminal carboxyl groups of a degradation product in the in-vivo degradation process of a polylactic acid polymer is relieved, and the incidence rate of aseptic inflammation is reduced.

The invention relates to a traditional Chinese medicine for treating pains in necks, shoulders, waist, and legs, a preparation method and applications thereof. The traditional Chinese medicine is prepared from unprocessed radix aconiti lateralis, unprocessed radix aconiti kusnezoffii, unprocessed radix aconiti, dragon's blood, dahurian angelica root, ground beetle, unprocessed frankincense, and unprocessed myrrh. The raw materials are grinded and mixed to prepare the traditional chine medicine. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is prepared from a plurality of natural traditional Chinese herbals through a simple technology; the traditional Chinese medicine is wrapped by gauze and fixed on the affected parts, the effective components can rapidly penetrate the skin, the tissue repairing is promoted, the aseptic inflammation in part tissues is eliminated; and the traditional Chinese medicine mainly treats lumbar disc herniation, cervical spondylosis, scapulohumeral periarthritis, hyperostosis, and rheumatic pain.

The invention belongs to the technical field of drugs, and concretely relates to an application of proadifen and pharmaceutically acceptable salts thereof in the preparation of inflammation associated disease prevention and treatment drugs. Above inflammations comprise aseptic inflammations and immune inflammations. The use of proadifen in the preparation of anti-inflammation drugs is disclosed in the invention for the first time, and a result of copper sulfate induced zebra fish inflammation model experiment researches shows that proadifen can promote regression of neutral granulocytes in the inflammation positions, and has inflammation prevention and elimination effects. The proadifen has obvious an anti-inflammatory effect on inflammation associated diseases, and can be used to prepare the inflammation associated disease prevention and treatment drugs.

The invention discloses a plaster capable of effectively treating hyperosteogeny, and a preparation method thereof. According to the present invention, the plaster is the pure traditional Chinese medicine plaster prepared by finely selecting more than 30 precious herbs such as Xiaojiujia, amber, musk, pangolin, scorpion, centipede, Chinese Honeylocust Spine, Venenum Bufonis, Daemonorops draco andthe like as main raw materials, and the precious herbs are scientifically combined so as to provide the synergistic effect, such that the plaster has effects of lump softening, knot loosening, blood stasis removing, swelling eliminating, tendon relaxing and activating, cold expelling and pain stopping so as to eliminate aseptic inflammation, relieve muscle spasm, relieve pain and softening proliferated bone; and the clinical use observation results show that the symptoms of the general cases can be significantly relieved after the 2-3 plasters are used, the hyperosteogeny can be completely cured after the plaster is continuously used for 3-6 months, the recurrence rate is extremely low, and the treatment effect can be maintained for more than 3-5 years.

The invention discloses a traditional Chinese medicinal preparation with antisepsis and anti-inflammation effects. The traditional Chinese medicinal preparation comprises the following components in parts by weight: 4-14 parts of rhizome of Chinese goldthread, 6-12 parts of fructus forsythiae, 3-10 parts of rhizoma typhonii and 3-8 parts of calcined oyster shell. The traditional Chinese medicinal preparation is a pure traditional Chinese medicinal preparation which has a significant curative effect, is safe, and has no toxic or side effects. The traditional Chinese medicinal preparation has the effects of antibiosis, anti-inflammation, heat clearing, diuresis promoting, detoxifying and bleeding stopping, and can be widely used for treating non-aseptic and aseptic inflammations caused by traumatism infection.

The invention discloses herbal medicinal liquor for treating neck, shoulder, waist and leg pain. According to the principle of a traditional Chinese medicine prescription, the herbal medicinal liquor disclosed by the invention is reasonable in prescription; various components have the synergistic effect with each other; the herbal medicinal liquor has the effects of activating blood circulation to dissipate stasis, dispelling wind and eliminating dampness, clearing and activating the channels and collaterals, warming the channels and relieving pain, diminishing swelling and relieving pain, and relaxing tendons and activating collaterals, can eliminate aseptic inflammation at an affected part and edema and adhesion of surrounding tissue, and can improve microcirculation at the affected part; therefore, the neck, shoulder, waist and leg pain is treated radically; and the herbal medicinal liquor has the advantages that the treatment effect is remarkable, the cure rate is high, the recurrence rate is low, and the like. In addition, the medicine disclosed by the invention also can be used for treating carpal tunnel syndrome, tenosynovitis, urticaria and other diseases.