12 results about "Aseptic inflammation" patented technology

The invention belongs to the technical field of gene engineering, and provides shRNA (short hairpin Ribonucleic Acid) for knocking down BST2 gene expression, a recombinant vector and application of the shRNA, and the shRNA comprises Bst2-shRNA-1 or Bst2-shRNA-2; the Bst2-shRNA-1 comprises a positive-sense strand of which the nucleotide sequence is as shown in SEQ ID NO. 1 and an antisense strand of which the nucleotide sequence is as shown in SEQ ID NO. 2; the Bst2-shRNA-2 comprises a positive-sense strand of which the nucleotide sequence is as shown in SEQ ID NO. 3 and an antisense strand of which the nucleotide sequence is as shown in SEQ ID NO. 4. The shRNA disclosed by the invention plays an important role in inhibiting non-infectious aseptic inflammation, can effectively delay the ALS attack time and protect motor neurons, has a very good application prospect, and also provides a direction and a technical basis for searching, researching and developing new therapeutic drugs for treating ALS.

The utility model discloses a novel dry and wet fascia release needle which comprises a plastic handle, a rubber plug hole, a rubber plug, a hollow steel needle mounting hole, a hollow steel needle, a plastic soft sleeve, a second cone, a long strip, a hollow steel needle outer sleeve hose, a plastic hard sleeve, a long-strip-shaped protrusion and a long inserting groove. Due to the adoption of the cylindrical plastic handle, the operation is smoother, the prying and loosening effects are better, and the hollow steel needle has a medicine injection function; the plastic soft sleeve is adopted, discomfort of a patient during catheter remaining can be reduced, the long strip facilitates fixing of the adhesive tape remaining catheter more firmly, the tail of the plastic soft sleeve can be connected with an injector for medicine injection and can also be connected with a rubber plug, and the infection opportunity during catheter remaining is reduced; the rubber plug is used for preventing medicine from leaking, and infection opportunities during tube reserving are reduced. The product can be used for effectively prying, stirring and releasing and injecting medicines to prevent fascia adhesion and aseptic inflammation, so that the pain symptom of a patient with the myofascia syndrome can be improved to the greatest extent.

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

This utility model relates to medicine and can be used in neurosurgery. It is used as a means of accessing the intervertebral disc between the 5th lumbar and 1st sacral vertebrae at a 90-degree angle for laser vaporization. The utility model achieves the following technical results: 1. A minimally invasive, minimally invasive approach to the intervertebral disc at the L5-S1 level. 2. Allows to improve the effectiveness of treatment and achieve maximum pain relief in polysegmental lesions of intervertebral discs 3. Prior to this utility model, attempts were made to perform laser vaporization of the disc at the L5-S1 vertebral body level from anatomically inconvenient locations, which was accompanied by a long time interval, prolonged pain for the patient, the end of the electrode was not in the center of the nucleus pulposus, sometimes even on the cortical layer of the vertebral bodies, as a result of which the maximum effect of vaporization was not obtained, or aseptic inflammation of the bone tissue of the vertebrae was obtained. This utility model eliminates the above-mentioned issues, reducing vaporization time. The essence of this utility model is that, using this trocar and drilling stylet, we provide direct access to the L5-S1 intervertebral disc. Laser vaporization of this disc has not previously been performed due to its anatomical limitations.

Compositions for identifying a pathogenic bacterial infection include a mannitol compound with one or more substituents including radioisotopes. These radiopharmaceuticals, such as a positron-emitting mannitol analogue, [18F]fluoromannitol ([18F]FMtl), are rapidly taken up by gram-positive and gram-negative bacteria such as E. coli, S. aureus, A. baumannii, S. epidermis, P. mirabilis, S. enterica, K. pneumonia, E. faecium, E. cloacae, and M. marinum, but not non-active infection sites such as sterile inflammatory sites, cancer sites, etc. Administration of these radiopharmaceuticals to and subsequent imaging of patients, e.g., via positron emission tomography (PET), enables detection of deep-seated and difficult to manage bacterial infections, such as osteomyelitis and prosthetic joint infection, or in patients with sickle cell disease. [18F]FMtl injection detects and differentiates infection rapidly. The radiolabeled mannitol compounds can be produced via nucleophilic substitution reactions that are deployable on commercially available synthesizers, facilitating straightforward and wide accessibility, and counteracting unnecessary antibiotic use.

The invention discloses a traditional Chinese medicine composition for relieving swelling and pain and a preparation method thereof, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine components: golden cypress, dandelion, gallnut, patrinia, fructus forsythiae, safflower, corydalis tuber, pseudo-ginseng, ginkgo leaf, rice vinegar, borneol and honey. Amur corktree bark and Chinese gall have a good curative effect on acute and chronic soft tissue injuries, can relieve and eliminate local aseptic inflammation, can improve local microcirculation, can promote repair of injured tissues, and can promote skin ecchymosis and hematoma fading, the traditional Chinese medicine is an externally-applied good medicine for treating acute soft tissue injuries, the medication object is not limited, and the traditional Chinese medicine can be used for children and adults and has a good application prospect. The traditional Chinese medicine composition has the advantages that the curative effect of the traditional Chinese medicine composition meets the clinical requirements, at present, various drugs for treating contusion, tenosynovitis, bone fracture and invasive inflammation clinically exist, but most drugs take effect slowly and are poor in applicability after being used, and the traditional Chinese medicine composition preparation is remarkable in effect and convenient to use in clinical use.

The invention belongs to the technical field of nano materials and nano medicine, and particularly relates to bismuth selenide nano particles and a preparation method and application thereof.The bismuth selenide nano particles are prepared from sodium selenite, bismuth nitrate (III) pentahydrate, polyvinylpyrrolidone and hydrazine hydrate, polyvinylpyrrolidone is adsorbed on the surface of bismuth selenide generated by reaction of sodium selenite and bismuth (III) nitrate pentahydrate. After photo-thermal treatment is finished, ROS can be eliminated through the bismuth selenide nano-particles so as to reduce aseptic inflammation caused by postoperative infection, side effects caused by PTT are further reduced, and the bismuth selenide nano-particles are ideal materials for treating peritumoral infection caused by tumors.

1. The name of the design product: rehabilitation therapy instrument. 2. The use of the design product: rehabilitation therapy for sports injury, postoperative rehabilitation and aseptic inflammation of human or small animals. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

The invention discloses a nano material for inhibiting aseptic inflammation as well as a preparation method and application of the nano material. The nano material is hybrid liposome nano vesicles modified by a platelet membrane, and the mass ratio of protein to lipid is 1: 2. The nano vesicles are loaded with sylvite compounds, can target in-vivo tissue injury parts, release potassium ions under the action of ultrasound, realize intracellular pH regulation and control through hydrogen-potassium exchange, and inhibit aseptic inflammation. The hybrid liposome is formed by mixing phospholipid and cholesterol, and the potassium salt compound is potassium carbonate or potassium bicarbonate. The preparation method comprises the following steps: preparing a hybrid liposome membrane and a platelet membrane, respectively adding a sylvite compound solution to carry out ultrasonic hydration and resuspension washing, preparing hybrid liposome vesicles and platelet membrane vesicles entrapped with sylvite compounds, and carrying out ultrasonic treatment, size stabilization and dialysis to obtain the platelet membrane modified hybrid liposome nano-vesicles. Inflammation can be inhibited in the early stage of injury, and side effects of traditional drugs are avoided.

The invention relates to application of albumin functionalized tantalum sulfide nanodots in preparation of drugs for treating acute kidney injury, and belongs to the technical field of new application of nano-drugs. The albumin functionalized tantalum sulfide nanodot used in the invention is formed by simply and efficiently assembling an ideal carrier albumin which is safe, non-toxic and free of immunogenicity and a layered transition metal tantalum sulfide which is high in biocompatibility; the protein can be specifically accumulated in the kidney by passing through a glomerular filtration barrier by virtue of the ultra-small particle size of the protein, is actively internalized to proximal tubule epithelial cells by virtue of the specific binding of albumin and a giant protein receptor, and is sequentially positioned to mitochondria by virtue of the high affinity of albumin to the mitochondria. The nanodot can efficiently remove active oxygen, protect mitochondria and limit cell apoptosis, immune activation and aseptic inflammation through active valence change of tantalum ions in a pathological injury microenvironment of acute kidney injury, so that near-end tubule epithelial cell injury is relieved, and kidney functions are effectively recovered.

The invention discloses a drug-loaded fibrous membrane as well as a preparation method and application thereof. The drug-loaded fibrous membrane comprises an active drug and a matrix membrane, the active medicine comprises pecedatinib or pharmaceutically acceptable salt thereof, and the matrix membrane has a fiber structure. The preparation method comprises the following steps: carrying out electrostatic spinning on a spinning solution containing an active drug, a matrix component and a solvent, thereby obtaining the product, wherein the active medicine comprises pecedatinib or a pharmaceutically acceptable salt of the pecedatinib. The drug-loaded fibrous membrane can maintain good physical and chemical properties of the fibrous membrane while loading drugs, can ensure slow release of drugs and significantly inhibit the occurrence of aseptic inflammation problems in practical application, and shows extremely high biocompatibility and safety.

The invention belongs to the technical field of medical materials, and discloses a preparation method of a stent for repairing alveolar bone defect, which comprises the following steps: S1, preparation of magnesium-doped hydroxyapatite: mixing a water-soluble calcium salt solution and a water-soluble magnesium salt solution into a water-soluble phosphate solution, stirring, and carrying out hydrothermal reaction to obtain a magnesium-doped hydroxyapatite material; the preparation method comprises the following steps: S1, carrying out fused deposition molding on a mixed material containing magnesium-doped hydroxyapatite and racemic polylactic acid to obtain a racemic polylactic acid-based degradable material; s3, based on the CBCT image of the alveolar bone defect patient, designing a personalized alveolar bone repair stent by using a reverse engineering technology, and arranging a retention form and a nail channel for accommodating an implant on the stent; and S4, manufacturing the alveolar bone repair scaffold based on a 3D printing process and the racemic polylactic acid-based degradable material. The stent can effectively solve the problem of aseptic inflammation caused by degradation of polylactic acid in vivo; good initial stability is provided for the implant in alveolar bone defects, and the implant has a wide medical application prospect.