The invention discloses a method for establishing a
small animal dilation
line model. Comprising the following steps that an incision is formed in the
tail portion of the back
skin of a rat, a subcutaneous bag is created below the corium layer of the incision through
tweezers, a
tissue expander is placed in the incision and close to the position close to the neck and above the
vertebra, the subcutaneous bag is closed, and the incision is sewed and closed; smearing the
hydrocortisone ointment every day to uniformly cover the
skin of the modeling part, and continuously intervening for 3 days; the smearing part is away from the incision part; normal
saline is injected into the tissue
dilator every day; and taking out the
tissue expander after 21 days, standing for 7 days, observing the back condition of the rat, and when the characteristics conforming to early red lines of dilatation lines are observed, indicating that modeling succeeds. The purpose of stretching the
skin is achieved by implanting the
tissue expander in a
small animal body and increasing the size of the tissue expander along with time, and the expansion line generation condition is simulated. The method is simple, convenient to operate and high in success rate.