Multi-optical spectrum autofluorescence dislocation imaging reconstruction method based on single view

Abstract

The invention relates to a multi-spectrum auto fluorescence fault imaging reconstruction method based on single view, which belongs to the optical molecular imaging field. The method is based on the diffusivity equation model, considers the uneven characteristics of small animal body, and simultaneously also considers the spectrum and the practical application characteristics of the auto fluorescence light source. In order to achieve the purpose, the multi-spectrum auto fluorescence fault imaging reconstruction method based on single view comprises the flowing steps: firstly, data acquisition; secondly, the dispersing processing of finite element; thirdly, the optimization of the selection of the feasible light source zone; fourthly, the reconstruction of the light source. The method overcomes the defects that the reconstruction light source of the auto fluorescence fault imaging reconstruction method is inaccurate, the reconstruction speed is low, the real-time processing is not convenient, and error can exist during the multi-spectrum data acquisition.

Description

technical field [0001] The invention relates to an optical molecular imaging modality-autofluorescence tomography (BLT) technology, in particular to a single-view-based multispectral autofluorescence tomography reconstruction method. Background technique [0002] In the past few years, molecular imaging has received increasing attention due to its ability to reveal molecular and cellular information in vivo. Therefore, it has become an important tool for disease diagnosis and drug efficacy evaluation. As a small animal molecular imaging modality, optical imaging technology, especially autofluorescence tomography, has been rapidly developed and widely used because of its high performance, low price and non-invasive characteristics. Autofluorescence tomography is a recently developed optical imaging technique used to reconstruct the distribution of autofluorescent light sources in small living animals. Fluorescence occurs when luciferin and luciferase are exposed to oxygen a...

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of inaccurate reconstruction of light sources in autofluorescence tomography reconstruction methods, slow reconstruction speed, unfavorable real-time processing and possible errors in multispectral data acquisition, and proposes a multispectral based on single view Autofluorescence tomography reconstruction method, which is based on the diffusion equation model, and considers the non-uniform characteristics of small animals, and also considers the spectrum of the autofluorescence light source and the characteristics of practical applications

Images