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404 results about "Bioluminescence" patented technology
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Bioluminescence is the production and emission of light by a living organism. It is a form of chemiluminescence. Bioluminescence occurs widely in marine vertebrates and invertebrates, as well as in some fungi, microorganisms including some bioluminescent bacteria and terrestrial invertebrates such as fireflies. In some animals, the light is bacteriogenic, produced by symbiotic organisms such as Vibrio bacteria; in others, it is autogenic, produced by the animals themselves.
In vivo biosensor apparatus and method of use
InactiveUS6673596B1Less can be administeredCost-effective administration of drugBioreactor/fermenter combinationsBiological substance pretreatmentsIn vivoGenetically engineered
Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in reponse to the amount of target analyte present in the body fluids.
Owner:UNIV OF TENNESSEE RES FOUND +1
System and method for conditioning animal tissue using laser light
InactiveUS20100049180A1Promote wound repairEnhances surgical wound healingSurgical instrument detailsLight therapyLaser lightHsp70 expression
Systems and methods for prophylactic measures aimed at improving wound repair. In some embodiments, laser-mediated preconditioning would enhance surgical wound healing that was correlated with hsp70 expression. Using a pulsed laser (λ=1850 nm, Tp=2 ms, 50 Hz, H=7.64 mJ / cm2) the skin of transgenic mice that contain an hsp70 promoter-driven luciferase were preconditioned 12 hours before surgical incisions were made. Laser protocols were optimized using temperature, blood flow, and hsp70-mediated bioluminescence measurements as benchmarks. Bioluminescent imaging studies in vivo indicated that an optimized laser protocol increased hsp70 expression by 15-fold. Under these conditions, healed areas from incisions that were laser-preconditioned were two times stronger than those from control wounds. Our data suggest that these methods can provide effective and improved tissue-preconditioning protocols and that mild laser-induced heat shock that correlated with an expression of Hsp70 may be a useful therapeutic intervention prior to or after surgery.
Owner:LOCKHEED MARTIN CORP +2
Apparatus and method for detecting and identifying infectious agents
Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.
Owner:PROLUME
Nanoparticular targeting and therapy
The present invention provides biocompatible, low molecular weight nanoparticulate formulations that are designed to retain and deliver therapeutics over an extended time course. The therapeutic may be conjugated or adsorbed to the periphery of the corona or conjugated to a core polymer. The nanoparticles comprise targeting ligands also conjugated or adsorbed to the periphery of the corona and / or a contrast agent in the core of the nanoparticle. As such, methods of selective targeting and / or methods of noninvasive imaging using bioluminescence and / or magnetic resonance imaging. Also provided are methods of delivering to and, optionally, imaging of a cell or tissue. Further provided are methods of producing the nanoparticles in batch or continuous mode via simple mixing or laminar flow.
Owner:VANDERBILT UNIV
Sample collection and bioluminescent analysis system
ActiveUS20140004548A1Promote useReduce power consumptionBioreactor/fermenter combinationsBiological substance pretreatmentsPhoton detectionPhoton counter
Methods and apparatus for evaluating the quality of an environment or process by measuring light emitted from a bioluminescent sample containing ATP, ADP, or alkaline phosphatase. The apparatus comprises a sample collection and analysis system used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The system includes an instrument having a photon detection assembly for use with the sample testing device and one or more probe assemblies that optically cooperate with the instrument. The instrument includes a dark chamber with a reflective interior surface which may be concave or preferably spherical, and a photon detection sensor such as a multi-pixel photon counter sensor. A substantially transparent portion of the probe assembly, and liquid contained therein, focus bioluminescence toward the photon detection sensor.
Owner:BIOCONTROL SYST
Nitrogen, phosphorus and sulphur doping or co-doping carbon dot and batch controllable preparing method and application thereof
InactiveCN104987863ASimple processShort synthesis timeNanoopticsFluorescence/phosphorescenceAir atmosphereSilica gel
The invention provides a nitrogen, phosphorus and sulphur doping or co-doping carbon dot and a batch controllable preparing method and application thereof. The method comprises the steps that a carbon source, a nitrogen source, a phosphorus source and a sulphur source are evenly mixed, and a mixture is obtained, wherein the molar ratio of C to N to P to S in the mixture is 1 to 0-0.8 to 0-0.4 to 0-0.4, and the contents of N, P and S are prevented from being zero at the same time; in the air, the mixture is heated to be fused, the reaction is carried out for 3 min to 60 min, natural cooling is carried out till the indoor temperature is reached, a reaction product is separated by a silicagel column, raw materials which do not react are removed, and the nitrogen, phosphorus and sulphur doping or co-doping carbon dot is obtained. According to the method, the technology is simple, the compound time is short, batch producing can be achieved, the doping amount can be adjusted and controlled accurately, the fluorescence color of the prepared carbon dot ranges from blue to green, the application can be achieved on bioluminescence marking and cell imaging aspects, and the good economic benefit and the application prospect are achieved.
Owner:XI AN JIAOTONG UNIV
System and Method for Normalized Flourescence or Bioluminescence Imaging
A system and method provide normalized fluorescence epi-illumination images and normalized fluorescence transillumination images. The normalization can be used to improve two-dimensional (planar) fluorescence epi-illumination images and two-dimensional (planar) fluorescence transillumination images. The system and method can also provide normalized bioluminescence epi-illumination images and normalized bioluminescence transillumination images. In some arrangements, the system and method can provide imagine of small animals, into-operative imaging, endoscopic imaging, and / or imaging of hollow organs.
Owner:THE GENERAL HOSPITAL CORP
Bioluminescent biosensor device
InactiveUS6544729B2Less stressRapid and sensitive detectionAnalysis using chemical indicatorsSugar derivativesBacteroidesBacterial strain
Disclosed are methods and devices for detection of bacteria based on recognition and infection of one or more selected strains of bacteria with bacteriophage genetically modified to cause production of an inducer molecule in the bacterium following phage infection. The inducer molecule is released from the infected bacterium and is detected by genetically modified bacterial bioreporter cells designed to emit bioluminescence upon stimulation by the inducer. Autoamplification of the bioluminescent signal permits detection of low levels of bacteria without sample enrichment. Also disclosed are methods of detection for select bacteria, and kits for detection of select bacteria based on the described technology.
Owner:UNIVERSITY OF TENNESSEE +1
Nanoparticular tumor targeting and therapy
InactiveUS20050008572A1Ultrasonic/sonic/infrasonic diagnosticsPowder deliveryNoninvasive imagingTumor targeting
The present invention provides a series of biocompatible, nanoparticulate formulations that are designed to retain and deliver peptides such as anti-angiogenic factors over an extended time course. The nanoparticles can be targeted to a cell or tissue by targeting ligands crosslinked or conjugated to the corona of the nanoparticles. In addition to selective targeting, the nanoparticles also may perform noninvasive imaging using bioluminescence and / or magnetic resonance imaging via a contrast agent in the core of the nanoparticle. Also provided are methods of delivering to and, optionally, imaging of a cell or tissue. Furthermore, methods of producing the nanoparticles in batch or continous mode via simple mixing or micromixing.
Owner:VANDERBILT UNIV
Aerated solids particle laser analyzer
ActiveCN101398367ADistinctive featuresThe test result is accurateBiological testingFluorescence/phosphorescenceFluorescenceUltraviolet
The invention provides an aerosol particle laser analyzer which online and continuously detects the aerodynamic diameter and particle quantity of the aerosol particles in the air one by one in real-time and identifies whether the particles are biological particles; the aerosol particle laser analyzer comprises a particle beam queuing acceleration sampling system wrapped by shell flows, a dual-peak laser aerodynamic diameter measurement system, a biological particle fluorescent detection system induced by ultraviolet laser, an ineffective and superposed particle identification circuit, data processing, displaying and memorizing software, and a communication module. The aerosol particle laser analyzer can not only detect the physical parameters such as aerodynamic diameter, particle quantity and the like of the aerosol particles, but also can judge whether the particles are active biological particles or not according to the natural characteristic that the active biological particle emits bioluminescence when being induced and can measure the parameters of the active biological particles such as the quantity, the concentration and the like; the aerosol particle laser analyzer has exact detection results and can be used conveniently and fast for detection; and the parts have long service life and the volume of the aerosol particle laser analyzer is small, thus being convenient for movable usage.
Owner:MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI +1
Methods for cellular or microorganism capture and quantification using bioluminescence regenerative cycle (BRC) assays
InactiveUS20050112601A1High detection sensitivityLong integration timeBioreactor/fermenter combinationsBiological substance pretreatmentsMicroorganismAssay
The methods, apparatus and compositions disclosed herein concern the detection, identification and / or quantification of target cells and / or microorganisms in samples. The assays are based on light emission detected from a bioluminescence regenerative cycle (BRC). Light emission may be related to cell and / or microorganism number through the number of ATP and PPi molecules per cell or microorganism. In certain embodiments of the invention, specific target cells and / or microorganisms may be separated from samples using one or more capture molecules, such as antibodies. The cells and / or microorganisms may be lysed, the contents purified in whole or in part and the ATP and PPi contents determined by BRC. Other embodiments of the invention concern apparatus comprising a series of chambers connected by a monodirectional flow channel, each chamber comprising an affinity matrix with one or more binding moieties attached. In certain embodiments, a multiplex assay may be performed using both antibodies and oligonucleotide probes specific for a pathogen of interest.
Owner:XAGROS TECH
Bioreporter for detection of microbes
InactiveUS20070072174A1Large amplificationGood signal amplificationMicrobiological testing/measurementDNA preparationSignalling moleculesOrganism
A recombinant phage system has been developed for the rapid detection of bacteria, particularly fecal coliform indicator bacteria. The systems of the invention link phage infection events to quorum sensing signal molecule biosynthesis and bioluminescent bioreporter induction, facilitating the detection of pathogens that may be present in low numbers. The phage-based systems of the invention maintain specificity for the pathogen while still producing significant signal amplification for sensitive and quantitative detection. The systems require only the combination of sample with phage and bioreporter organisms; no extraneous addition of any substrates or user intervention of any kind is necessary, making this approach significantly less technical than standard molecular or immunological methods.
Owner:UNIV OF TENNESSEE RES FOUND
Luciferase expression cassettes and methods of use
InactiveUS6737245B1Improve translationBroadening the range of wavelength of light emittedFungiSugar derivativesLuciferase GeneBacterial luciferase
The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and methods of making and using such cassettes.
Owner:XENOGEN CORP
Multi-mode molecular tomography system
InactiveCN101984928ADoes not involve spatial registration issuesConsistent geometric coordinatesSurgeryComputerised tomographsSoft x rayOptical tomography
The invention relates to a multi-mode molecular tomography system which is characterized by comprising one or more light sources of an X-ray source, a near infrared laser light source and a finite spectral width light source for projecting scanning light to an object to be scanned, an electric loading device, an imaging device and a control and processing device, wherein the imaging device is used for obtaining intensity distribution data of x-rays, visible light or near infrared light emerging from the surface of the object to be scanned after scanning, and inputting the intensity distribution data into the control and processing device; the control and processing device is used for controlling the actions of the object to be scanned through the electric loading device; and the control and processing device comprises a tomography module, the tomography module is used for receiving the data of the imaging device, utilizing XCT (X-ray computed tomography) and DOT (diffuse optical tomography) modes to reconstruct an outer boundary and similar information of all internal organizations during marginalization, fusing and reconstructing XCT, DOT, FMT (fluorescence molecular tomography) and BLT (bioluminescence tomography) single-mode or multi-mode tomography image after fusion and outputting. The multi-mode molecular tomography system is applicable to the field of x-ray and optical biomedical imaging.
Owner:PEKING UNIV
Luminescence-based methods and probes for measuring cytochrome P450 activity
ActiveUS7692022B2Improve stabilityExtended service lifeCompounds screening/testingCompound screeningMetabolitePresent method
Owner:PROMEGA CORP
Metal-enhanced bioluminescence: an approach for monitoring biological bioluminescent processes
ActiveUS20120028270A1Perfect detection systemIncrease speedBioreactor/fermenter combinationsBiological substance pretreatmentsPlasmonic couplingChemical reaction
The present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metallized particles thereby enhancing the signal. Importantly, these plasmonic emissions emitted from metallic particles generated without an external excitation source but instead from induced electronically excited states caused by the bioluminescent chemical reaction.
Owner:UNIV OF MARYLAND BALTIMORE COUNTY
Multicolor luminous carbon nanodot as well as preparation method and application thereof
InactiveCN103396793ALow costEasy to prepareNanoopticsNano-carbonFreeze-dryingBiocompatibility Testing
The invention discloses a multicolor luminous carbon nanodot as well as a preparation method and an application thereof, belonging to the field of nanomaterial science and solving the technical problems that the emitted light peak position of a carbon nanodot generates red shift and the strength is weakened with increase of wavelength of excited light and a preparation method of the carbon nanodot is high in cost, complex to operate, time-consuming and labor-consuming in the prior art. According to the preparation method, with a polycarboxylic or polyhydric organic compound or an amino acid as a carbon source and long-chained organic diamine as a surface passivation modifier, the multicolor luminous carbon nanodot is prepared by the steps of low-temperature pyrolysis, precipitation washing, dialysis separation and freeze drying. The preparation method of the multicolor luminous carbon nanodot is simple, low in cost and can be conveniently put into large-scale production; the prepared carbon nanodot is at a solid state, is convenient to store, has high fluorescence quantum efficiency and good biocompatibility, can respectively emit strong green light, orange light and red light under the excitation of blue light, green light and yellow light, and can be used as a bioluminescence probe and an optical imaging marker.
Owner:CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
Phage-Mediated Bioluminescent Detection of Yersinia Pestis
InactiveUS20110076672A1Eliminate needMicrobiological testing/measurementBiological material analysisMicroorganismBiotechnology
The present disclosure relates to compositions, methods, systems and kits for the detection of microorganisms of the Yersinia species including Yersinia pestis. The disclosure relates to recombinant phage operable to infect a Yersinia microorganism, the phage comprising a detectable reporter. Detection systems of the disclosure may comprise a phage operable to infect a Yersinia microorganism, and may comprise a reporter nucleic acid expressible upon infection of a Yersinia microorganism by the phage. The system may be operable to detect the expression of the reporter. A detectable reporter may comprise any gene having bioluminescent, colorimetric and / or visual detectability. For example, a detectable reporter may comprise one or more luxAB genes detectable by emission, enhancement and / or change in spectrum of bioluminescent light. Live and infectious Yersinia microbes may be detected by the compositions, methods, systems and kits described herein.
Owner:GUILD ASSOCS
Optical imaging contrast agents and uses thereof
The invention relates to microbubble contrast agent compositions comprising a gas core encapsulated by a monolayer shell, said shell comprising a first surfactant, a second surfactant having a higher water solubility than said first surfactant, an anchor molecule attached to said shell at the gas-shell interface and an optically-active probe, said probe being detectable by fluorescence, near-infrared, bioluminescence, or other optical imaging methods. Uses of the described compositions for imaging and therapeutic applications are contemplated.
Owner:TARON
Periodic lighting device
InactiveUS20110109236A1Prevent penetrationSimplify disassemblyAnimal huntingBaitBiological bodyRadiation pulse
There is presented a detailed electronic method for simulation of a firefly, other insects, or organisms producing bioluminescence and with light radiation functions similar to a real firefly, other insects, or organisms producing bioluminescence. An illuminated artificial firefly, other insects, or organisms producing bioluminescence can be placed on trees and shrubs in landscape, or at home to produce radiation, at night time, and blinking a gradually decaying light. More particularly it relates to a decorative type of device in the form of a firefly, other insects, or organisms producing bioluminescence and with light radiation functions similar to a real firefly, other insects, or organisms producing bioluminescence. The light is simulated by an electronics program that is a part of compact device with the form of a real firefly, other insects, or organisms producing bioluminescence. Short radiation pulses of microsecond-millisecond duration time in violet and ultraviolet range of radiation wavelengths can be utilized for scaring birds or other animals from undesirable or dangerous places of human activity, such as airports, contaminated ponds, wind turbines, electorized fences and antennas.
Owner:SCHAAL HERBERT RUDOLF +1
Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor
InactiveUS7176345B2Modify activityUltrasonic/sonic/infrasonic diagnosticsCompound screeningBinding siteUbiquitin ligase
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.
Owner:DANA FARBER CANCER INST INC
Fluorescence nanometer probe and preparation method thereof
The invention relates to a fluorescence nanometer probe, comprising an inner core formed by polyglycolide lactide, a middle layer formed by phospholipid surrounding on the surface of the inner core and a shell formed by distearoyl phosphatidyl ethanolamine-polyethylene glycol which contains amino or carboxyl and partially penetrates through the middle layer, wherein indocyanine green is dispersed in the inner core. According to the invention, a core-shell structure is formed to ensure that the indocyanine green is wrapped in the polyglycolide lactide, therefore, the indocyanine green is effectively avoided from being aggregated and decomposed and the stability is increased; and the wrapped indocyanine green has a near-infrared fluorescence characteristic to ensure that the background fluorescence penetrating tissues is small and then can be relatively accurately applied to bioluminescence labeling.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses
InactiveUS6689391B2Quick estimateEnzymologyMammal material medical ingredientsEchinodermFluorescence
Owner:COUNCIL OF SCI & IND RES
Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses
InactiveUS20030021851A1Cutting costsRapid bioassayCosmetic preparationsToilet preparationsEchinodermFluorescence
The present invention discloses a process of extraction, purification and characterization of a non-polar fluorescent dye from a marine echinoderm Holothuria scabra, compositions containing the dye and various applications of the dye, said dye is a natural, cell permeant, nontoxic and environmentally friendly non-polar fluorescent dye.
Owner:COUNCIL OF SCI & IND RES
Detection of transmembrane potentials by optical methods
InactiveUS7173130B2Improve spatial resolutionCompound screeningMethine/polymethine dyesSubcellular organelleMembrane potential
Owner:RGT UNIV OF CALIFORNIA
Lysosome-targeted fluorescent dye capable of realizing red emission and near-infrared emission, and preparation method and application thereof
InactiveCN107098923AImprove targetingStable structureAzo dyesGroup 3/13 element organic compoundsLysosomal targetingReaction temperature
The invention discloses a lysosome-targeted fluorescent dye capable of realizing red emission and near-infrared emission, and a preparation method and application thereof, belonging to the field of bioluminescence analysis. The preparation method comprises the following steps: dissolving a compound with the substituent R in an anhydrous organic solvent and adding morpholinoindolal and a catalyst under the condition of introduction of nitrogen, wherein a mol ratio of morpholinoindolal to the compound with the substituent R is 1-10: 1; and carrying out a reaction at a reaction temperature of 25 to 200 DEG C for 1 to 24 h, concentrating an obtained solution and carrying out silica-gel column chromatography so as to obtain the target fluorescent dye. The fluorescent dye prepared in the invention is applicable to targeted imaging of lysosomes in cells, fluorescent probes or laser dyes. The fluorescent dye has the advantages that the emission wavelength of the fluorescent dye is in a range from red zone to near-infrared zone; the fluorescent dye can prevent interference of biological background fluorescence and has high fluorescence quantum efficiency and good light stability; and the fluorescent dye can be specifically localized in lysosomes, so the fluorescent dye has high application value.
Owner:TIANJIN UNIVERSITY OF TECHNOLOGY
System and Method for Normalized Diffuse Emission Epi-illumination Imaging and Normalized Diffuse Emission Transillumination Imaging
Owner:THE GENERAL HOSPITAL CORP
V-shaped conjugated light-absorbing organic salt compound and its use
InactiveCN1887883AHigh reaction efficiencyNot easily affectedOrganic chemistryNon-linear opticsFluorescenceOrganic compound
The present invention belongs to the field of organic polymer chemistry and material chemistry, and is especially V-shaped conjugated light-absorbing organic salt compound and its use. The V-shaped conjugated light-absorbing organic salt compound is prepared with corresponding organic salt and heterocyclic dialdehyde, and through condensation or reaction with halogenated compound in V-shaped conjugation system. It has the structure as shown. The V-shaped conjugated light-absorbing organic salt compound may be as photsensitizer and / or initiator for single or double photon polymerization, as single or double photon bioluminescence probe with microM level use concentration, and as second order non-linear optical material; and its crystal may be used as electro-optical material and tera Hz beat frequency generator.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Method for Detecting Transferase Enzymatic Activity
InactiveUS20100021949A1Easy to measureEliminate needMicrobiological testing/measurementBiological testingQuenchingTransferase
Methods and kits for detecting transferase activity in a sample by measuring ATP using a composition comprising an ATP-dependent bioluminescence-generating enzyme, a luminogenic molecule and one or more transferase quenching agents.
Owner:PROMEGA
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