14 results about "Aerodynamic diameter" patented technology

A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.

The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in the form of an aerosol, and wherein the aerosol is produced by nebulizing the pharmaceutical composition using a nebulizer (100), which nebulizer comprises: a) an aerosol generator (101) comprising: - a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and a vibrating membrane (110) with a plurality of apertures, which apertures are adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 4.0 gm as measured with aqueous 0,9% (w / v) sodium chloride solution; b) a chamber (105) for temporarily receiving the aerosol produced by the aerosol generator (101), wherein the chamber has an internal lumen with a volume in the range of about 50 to about 150 ml; and c) a mouthpiece (40) for delivering the aerosol provided by the nebulizer (100) to the subject, wherein the mouthpiece has an exhalation filter (30).,

A disposable, flat-fold respirator is presented that includes a mask body that includes a plurality of panels which may fold in towards each other and may unfold into an open configuration. The mask body includes a single layer of charged filter material. The plurality of panels includes an upper panel, a lower panel, and a central panel. The central panel is connected to the upper panel and lower panel. The respirator filters at least 95% of airborne particles with a mass median aerodynamic diameter of 0.3 µm. A harness is secured to the mask body.

The invention discloses an on-line automatic pollen monitoring system and method, and relates to the technical field of environment detection, and the method comprises the steps: separating charged particles according to an aerodynamic diameter through an inertial impact effect, and collecting pollen particles in a target particle size range to the surface of a carrier tape; applying an electrostatic field to the carrier band to enable the surface of the carrier band to have charges with polarity opposite to the known polarity, and purging the carrier band by utilizing directional airflow to remove impurity particles which are not adsorbed; carrying out electrostatic neutralization treatment on the purified pollen particles, blowing the neutralized pollen particles from the surface of the carrier band into a detection channel by adopting pulse gas, and collecting corresponding light resistance pulse signals and multi-wavelength light scattering signals generated when the pollen particles pass through; and processing the light resistance pulse signal, extracting a dynamic characteristic sequence of the light resistance pulse signal along with time change, and judging whether the pollen particles are effective pollen particles or not based on particle physical characteristics reflected by the dynamic characteristic sequence.

The application provides a method for tracing air pollutants by using bubbles with different sizes and densities, comprising the following steps: determining a target density value of a tracing bubble according to the density of a gaseous pollutant to be traced, or determining the target density value of the tracing bubble according to the aerodynamic diameter of a solid particle-shaped and droplet-form pollutant to be traced; preparing the tracing bubble with the target density value, and releasing the tracing bubble in air of a test area; collecting position information of the tracing bubble in the test area; and determining a motion direction, a motion trajectory and a motion speed of the tracing bubble in the test area according to the position information. The method for tracing air pollutants by using bubbles with different sizes and densities solves the problem of tracing particulate matters and gaseous pollutants carried in air.

The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, which is administered by inhalation in form of an aerosol, and wherein the aerosol is generated by a nebulizer comprising: a) an aerosol generator comprising a fluid reservoir and a vibratable membrane having a plurality of apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter of up to about 4.0 μm as measured with a 0.9% (w / v) aqueous solution of sodium chloride; b) a chamber for temporarily accommodating the aerosol having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece for delivering the aerosol supplied by the nebulizer to the subject, the mouthpiece having an exhalation filter.

To provide an aerosol system to deliver clinically and economically feasible inhaled dose with a neonatal CPAP device.SOLUTION: A method of delivering an aerosolized agent to an infant includes interfacing an aerosolization device with an airway of an infant and aerosolizing, using the aerosolization device, a volume of surfactant into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 μm at a rate of at least 0.1 ml / min. The surfactant is aerosolized within about 1 to 8 cm from a patient interface. Aerosol is generated for up to approximately 80% or each inspiration. The method also includes delivering the aerosolized surfactant to the infant's airway.SELECTED DRAWING: Figure 9

The invention belongs to the field of medicine powder preparations, and relates to itraconazole inhalation type dry powder as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing an itraconazole eutectic through a solvent evaporation method, forming an eutectic nano suspension from the itraconazole eutectic through a medium grinding method, mixing the nano suspension with an excipient, and preparing dry powder through spray drying. The particles of the dry powder composition are spherical, and the aerodynamic diameter is smaller than 4 microns. The emptying rate is greater than 90%, the fraction of fine particles is greater than 40%, and the aerosol can be quickly dispersed after in-vitro atomization and has a good in-vivo lung positioning effect.

The invention belongs to the technical field of flue gas monitoring, and discloses a system for monitoring particulate matters in flue gas discharged by a coal-fired power plant and a use method. In the system, a sampling probe is connected with a pretreatment device through a sampling pipe, and the other end of the pretreatment device is connected with a first chamber; a first layer of filter membrane is arranged between the first chamber and the second chamber; a second layer of filter membrane is arranged between the second chamber and the third chamber; the diameter of the first layer of filter membrane is smaller than the aerodynamic diameter of inhalable particles and larger than or equal to the aerodynamic diameter of fine particles; the second layer of filter membrane is smaller than the aerodynamic diameter of fine particles and larger than or equal to the aerodynamic diameter of superfine particles; one end of the filter membrane collecting and filtering device is connected with the third chamber, the other end of the filter membrane collecting and filtering device is connected with the dissolving container, and the other end of the dissolving container is connected with the ion chromatograph. According to the invention, the detection accuracy and reliability are improved; and a scientific basis can be provided for evaluating the environmental protection performance of the coal-fired power plant and formulating targeted pollution control measures.

This invention belongs to the field of pharmaceutical powder formulations, and relates to an itraconazole inhalation dry powder, its preparation method, and its application. The preparation involves preparing itraconazole cocrystals via solvent evaporation, then forming a cocrystal nano-suspension through media milling. The nano-suspension is mixed with an excipient and then spray-dried to prepare the dry powder. The dry powder composition of this invention has spherical particles with an aerodynamic diameter of less than 4 μm. It exhibits an air displacement rate greater than 90%, a fine particle fraction greater than 40%, rapid dispersion after in vitro atomization, and good localization effect in the lungs in vivo.

Disclosed herein is a method of preparing an atomized droplet. Provided herein is a device having an acoustic wave interaction surface provided with an array of cavities, the array of cavities opening toward the acoustic wave interaction surface. The acoustic wave transducer generates and propagates acoustic waves to the acoustic wave interaction surface. Atomized liquid is contained in the cavity. The acoustic wave transducer is operated at a first input power to produce atomized droplets having a first aerosol particle size distribution. The acoustic wave transducer is operated at a second input power greater than the first input power to produce atomized droplets having a second aerosol particle size distribution having a mass median aerodynamic diameter (MMAD) greater than the mass median aerodynamic diameter of the first aerosol particle size distribution.

An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and / or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 μm.

An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and / or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 μm.

A method for determining airborne concentrations of an ensemble of particulate matter below the size fraction 2.5 μm in aerodynamic diameter (PM2.5). The method is to be composed of a sharp cut PM2.5 cyclone, optical sensor capable of producing scattering coefficients dependent on particle size, temperature and humidity sensors for adapting to changes in the environment, and a processing system for applying logic-based algorithm to convert raw sensor values into PM concentrations. The optical sensor is a dual wavelength integrating nephelometer capable of yielding particle characteristic scattering coefficients at two wavelengths. The particle scattering ratios between two wavelengths are used in conjunction with temperature and humidity in the method's algorithm to reduce particle growth bias and to ultimately yield PM2.5 concentrations.