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147results about How to "Formula stable" patented technology

Microsphere type embolic agent and preparation technology thereof

The invention provides a microsphere embolic agent, which is an elastic microsphere formed by the crosslink polymer of the functionalized macromolecules with the biocompatibility, and the particle size of the microsphere ranges from 1 Mum to 1500 Mum. The preparing technology includes the steps as follows: in a covalent link, linking a crosslinkable micromolecules with an acrylic acid structure on the polyvinyl alcohol, polyethylene glycol or polysaccharide macromolecules, forming the functionalized macromolecules; after that, the functionalized macromolecules and the monomer of the 2- acrylamide-2-methyl propanesulfonic acid undertakes opposite suspension polymerization, obtaining the crosslink polymeric microsphere embolic agent. The embolic agent has comparatively large retractility and elasticity, whose particle size is controllable and has perfect dispersiveness; moreover, the raw material is non-toxic and at the same time has good biocompatibility and stability. The preparing technology is a real chemosynthesis technology, whose material and preparing process does not produce any virus pollution, according with various requirements of the international embolic agent, which can replace various import and domestic expensive embolic agent products and is extensively applicable to various surgeries in the interventional radiology field.
Owner:SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD

Preparation technology for microspheric embolization agent

The invention relates to a preparation technology for a microspheric embolization agent. The preparation technology is used for preparing elastic microspheres cross-linked and polymerized by functionalized macromolecules with biocompatibility, wherein the grain range of the microspheres is 1-1500mu m. The preparation technology comprises the following steps that: a cross-linkable micromolecule with a crylic acid structure is connected on a polyvinyl alcohol, polyethylene glycol or polyose macromolecule in form of a covalent bond to form a functionalized macromolecule; and reversed phase suspension polymerization is conducted to the functionalized macromolecule and a 2-acrylamide-2-methylpropanesulfonic acid monomer to prepare cross-linked and polymerized microspheric embolization agent. The embolization agent has the advantages that the flexibility and the elasticity are high, the grain is even and is controllable, the dispersity is good, the raw materials are nontoxic and the biocompatibility and the stability are good. The preparation technology is a pure chemical synthesis technology, no virus pollution is caused to the raw materials and the preparation process, the requirements on international embolization agents are satisfied, and the embolization agent can substitute for all kinds of imported or domestic expensive embolization agent products and can be widely used in surgeries in the field of interventional therapy.
Owner:SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD

Quick disintegrating tablet in buccal cavity and production process thereof

The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
Owner:ASTELLAS PHARMA INC

Treatment process for expanded tobacco stems

ActiveCN104207322ASave warehouse spaceReduce mistTobacco treatmentAfter treatmentMicrowave
The invention relates to a treatment process for expanded tobacco stems, and belongs to the technical field of main material and auxiliary material processing in the tobacco industry. The microwave expanded tobacco stems are classified according to the thickness and/or the length, the expanded tobacco stems are placed into a pressure vessel, nitrogen with the purity being larger than 78% is connected into the pressure vessel, the tobacco stems and the nitrogen are evenly mixed, the pressure in the vessel is normal pressure to 8 MPa, the pressure is kept for 10 seconds to 40 minutes, the nitrogen in the pressure vessel is exhausted, the nitrogen can be recycled after purification and compressing treatment, the expanded tobacco stems after treatment are taken out, and the expanded tobacco stems are boxed or bagged in a classified mode for standby application; or moisture regain is conducted directly, so that products such as stem shreds, stem strip shreds and stem particles are manufactured. The microwave expanded tobacco stems treated through the process do not need to be stored any more, wooden odors and offensive odors in the tobacco stems are reduced, the tobacco stems cannot retract after moisture regain, and good elasticity and processing resistance are achieved. By means of the treatment process for the expanded tobacco stems, the requirement for the conditions such as warehouse space, manpower and logistics in the storage link is met, and therefore enterprise cost is greatly lowered.
Owner:姚波

Slow-release preservative for fruits and vegetables and preparation method thereof

The invention relates to a slow-release preservative for fruits and vegetables. Adsorbing carrier adsorbing ethanol solution is loaded into a slow-release bag made of a polyethylene slow-release film, and the slow-release bag is then packaged by an air-permeable paper bag; the adsorbing carrier is powder or a shaped block, and the components of the adsorbing carrier include silica gel, diatomite and polydivinylbenzene porous adsorbent. The invention adopts the method of slowly releasing ethanol to inhibit the yellowing and rotting of fruits and vegetables, and the slow-release preservative has a remarkable effect in reducing the loss of the moisture of fruits and vegetables and inhibiting the growth of pathogenic bacteria and the aging of fruits and vegetables, and is a pollution-free, non-toxic and recyclable preservative product for fruits and vegetables. Compared with conventional products, the slow-release preservative can decrease the weight loss rate of different fruits and vegetables in the storage period by 10 to 30 percent and the rotting rate by 15 to 40 percent and prolong the shelf life by 30 to 50 percent, thus having a good preservation effect, and is applicable to the preservation of various fruits and vegetables. The formulation of a preparation method is simple, material resources are rich, the slow-release preservative is easy to prepare, the cost is low, and moreover, the slow-release preservative is convenient to use.
Owner:MICROBIOLOGY INST OF SHAANXI

Polylactic acid film blowing processing aid and preparation method and application thereof

InactiveCN103602048AImprove blown film processabilitySimple production processSilicon dioxideSurface modification
The invention discloses a preparation method of a polylactic acid film blowing processing aid, which comprises the following steps of (1) performing surface modification on nano silicon dioxide by use of a silane coupling agent, adding 0.01-6 weight parts of isocyanate substrate, and reacting at over 25 DEG C for more than 4 hours for secondary modification on the silicon dioxide; (2) taking the silicon dioxide after the secondary modification and a polylactic acid prepolymer as raw materials, preferably adding 50-200 parts of polylactic acid prepolymer into each part of silicon dioxide, introducing nitrogen into the reaction kettle, adding a metal lithium or tin catalyst, magnetically stirring at 25-140 DEG C, and heating and reacting for 1-24 hours to finally obtain solid powder; drying in a vacuum oven for 24 hours to obtain the polylactic acid film blowing processing aid. The invention also discloses an application of the polylactic acid film blowing processing aid. In the method disclosed by the invention, polylactic acid is directly grafted to the surface of the silicon dioxide to obtain polylactic acid-grafted silicon dioxide modified particles which are used as a polylactic acid processing aid, and the film blowing processability of polylactic acid is effectively improved.
Owner:SICHUAN UNIV
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