4results about How to "Formula stable" patented technology

The application discloses a transdermal patch containing phosphodiesterase 7 inhibitors and application thereof, and relates to the technical field of external drug preparations. The transdermal patch comprises a backing layer, a drug-containing functional layer and an anti-adhesion protective layer. The drug-containing functional layer contains phosphodiesterase 7 inhibitors and pharmaceutically acceptable adjuvants. The phosphodiesterase 7 inhibitors are selected from OMS527 or 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one. The transdermal patch can be used alone or in combination with nicotine. In vitro transdermal experiments show that the cumulative release rate reaches 70% to 96% in 24 hours. Skin irritation tests show that the Draize score is less than or equal to 0.4, belonging to extremely slight irritation. Animal efficacy experiments show that the patch can significantly inhibit nicotine self-administration behavior, prevent relapse and relieve withdrawal symptoms. The transdermal patch has novel action mechanism, no addiction, long-lasting drug efficacy, safe and convenient use, and can be used for smoking cessation or relieving nicotine withdrawal symptoms.

This utility model provides a high-efficiency emulsification and mixing device for low-fat hot pot base, relating to the field of food processing equipment technology. It includes a base, a pre-emulsification tank on top of the base, a tank cover on top of the pre-emulsification tank, a solid feed inlet and a liquid feed inlet on top of the tank cover, a conveying pipe on one side of the pre-emulsification tank, a metering system at the other end of the conveying pipe, a motor on one side of the metering system, a high-efficiency emulsification tank at the bottom of the motor, a mixing buffer tank at the bottom of the high-efficiency emulsification tank, and a support leg and a discharge pipe at the bottom of the mixing buffer tank. By using a pre-emulsification tank, a spiral guide plate and stirring device designed using fluid dynamics are used to create a strong vortex during the initial material fall and pumping. This not only initially disperses solid materials but also allows water, oil, and powder to be initially and evenly wetted, avoiding subsequent "clumping" and laying the foundation for high-efficiency emulsification. This is faster than traditional mixing tanks and is a continuous process.

Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an organic acid excipient, and a basic drug are described, along with related methods.

This invention relates to flavor compositions comprising γ-nonanolactone, γ-undecanolactone, γ-caprolactone, and γ-decanolactone, wherein, based on 100 parts by weight of γ-nonanolactone, the amount of γ-undecanolactone is about 50 to about 1200 parts by weight, the amount of γ-caprolactone is about 100 to about 700 parts by weight, and the amount of γ-decanolactone is about 100 to about 3000 parts by weight. The invention also relates to aqueous food compositions comprising the flavor compositions, methods for preparing the aqueous food compositions, uses of the flavor compositions or aqueous food compositions, and beverages, gel-type snack foods, nutritional formula foods, nutritional supplements, pharmaceuticals, or medical products comprising the flavor compositions or aqueous food compositions.