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The application discloses a transdermal patch containing phosphodiesterase 7 inhibitors and application thereof, and relates to the technical field of external drug preparations. The transdermal patch comprises a backing layer, a drug-containing functional layer and an anti-adhesion protective layer. The drug-containing functional layer contains phosphodiesterase 7 inhibitors and pharmaceutically acceptable adjuvants. The phosphodiesterase 7 inhibitors are selected from OMS527 or 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one. The transdermal patch can be used alone or in combination with nicotine. In vitro transdermal experiments show that the cumulative release rate reaches 70% to 96% in 24 hours. Skin irritation tests show that the Draize score is less than or equal to 0.4, belonging to extremely slight irritation. Animal efficacy experiments show that the patch can significantly inhibit nicotine self-administration behavior, prevent relapse and relieve withdrawal symptoms. The transdermal patch has novel action mechanism, no addiction, long-lasting drug efficacy, safe and convenient use, and can be used for smoking cessation or relieving nicotine withdrawal symptoms.

Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an organic acid excipient, and a basic drug are described, along with related methods.

This invention relates to flavor compositions comprising γ-nonanolactone, γ-undecanolactone, γ-caprolactone, and γ-decanolactone, wherein, based on 100 parts by weight of γ-nonanolactone, the amount of γ-undecanolactone is about 50 to about 1200 parts by weight, the amount of γ-caprolactone is about 100 to about 700 parts by weight, and the amount of γ-decanolactone is about 100 to about 3000 parts by weight. The invention also relates to aqueous food compositions comprising the flavor compositions, methods for preparing the aqueous food compositions, uses of the flavor compositions or aqueous food compositions, and beverages, gel-type snack foods, nutritional formula foods, nutritional supplements, pharmaceuticals, or medical products comprising the flavor compositions or aqueous food compositions.