10results about How to "Good formulation stability" patented technology

The invention provides a composition for protecting micro-ecological balance of skin and a preparation method of the composition. Comprising the following components in percentage by weight: 84.12%-92.47% of a solvent, 5%-10% of a bifidus yeast fermentation product lysate, 0.1%-0.5% of tetrahydromethylpyrimidine carboxylic acid, 0.5%-1% of panthenol, 0.5%-1% of lactobacillus / soybean milk fermentation product filtrate, 0.5%-1% of arginine / lysine polypeptide, 0.5%-1% of 1, 2-hexanediol, 0.1%-0.5% of a pH regulator, 0.03%-0.08% of a chelating agent and 0.3%-0.8% of an antioxidant. According to the scheme, probiotic strains which are carefully screened are selected as powerful cell protection factors, an ideal environment for skin flora survival is kept, and the skin health level is improved.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The invention relates to a tofacitinib citrate composition. The tofacitinib citrate composition is prepared by mixing active ingredients with a thickening agent, an osmotic pressure regulator, an adhesive and a lubricant, and then tabletting and coating. The tofacitinib citrate composition provided by the invention has the advantages of good stability and suitability for large-scale production.

The present invention aims to provide a first treatment agent for regenerated cellulose fibers having improved formulation stability. The first treatment agent for regenerated cellulose fibers of the present invention contains an iodine value of 1 gI 2 The first treatment agent for regenerated cellulose fibers is characterized in that it contains a sulfate ester salt (A) and an iodine value of less than 1 g / 100 g. 2 / 100g of nonionic surfactant (B1). The sulfate ester salt (A) is a neutralized salt of a reaction product of fat (a) and sulfuric acid and at least one selected from amines, alkali metals and alkaline earth metals.

The invention relates to the technical field of biological medicines, and particularly discloses a synthesis method of cibopadol citrate, which has the advantages that no toxic solvent is used in the synthesis process, the environmental pollution is reduced, and the cost is reduced; the purification process of the intermediate in the synthesis process is simplified, so that the operation process is simplified, and the actual production is easier; a common solvent is used in the crystallization salt forming process, the operation process is simple, and industrial production is facilitated; the citrate can promote the medicine to be better released in vivo by improving the solubility of the medicine, so that the utilization degree and the effect of the medicine are improved; the citrate has better chemical stability, so that the citrate has better preparation stability; in addition, by optimizing the release characteristics of the drug (e.g., improving the sustained release mechanism), the citrate form may play a positive role in reducing the side effects of the drug.

The invention discloses an picloram triethanolamine salt water agent auxiliary agent and a preparation method thereof. The auxiliary agent is prepared from the following components in percentage by weight: 20-45% of dihydrogenated tallow dimethyl ammonium chloride, 10-20% of triethanolamine, 10-20% of sodium chloride, 5-10% of sodium chloride, 5-10% of sodium chloride and the balance of water. 15 to 30% of hydrogenated tallow amine acetate; 10 to 20% of hexadecyl dimethyl allyl ammonium chloride; 1-2% of dioctyl sodium sulfosuccinate; and the balance water. The picloram triethanolamine ammonium salt aqueous solution processed by the method is not easy to solidify at low temperature, has the characteristics of high efficiency, high environmental and biological safety, good preparation stability and the like, is particularly suitable for northern use, and has a good application prospect.

The invention provides a melogabalin besylate oral solution and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The melogabalin besylate oral solution comprises the following components: melogabalin besylate or pharmaceutically acceptable salt thereof, a solvent, a chelating agent, a preservative, a thickening agent, a sweetening agent and a flavoring agent. The melogabalin besylate oral solution disclosed by the invention is excellent in mouth feel, high in bioavailability, convenient to take and good in stability, and the compliance of a patient is greatly improved.

The invention relates to the field of pesticides, in particular to a diflufenican and pyroxasulfone pesticide suspending agent and a preparation method thereof. The diflufenican and pyroxasulfone pesticide suspending agent provided by the invention is prepared from the following raw materials in parts by mass: 7 to 10 parts of pyroxasulfone active compound, 10 to 15 parts of diflufenican active compound, 1 to 3 parts of wetting dispersant, 5 to 10 parts of dispersant, 1 to 3 parts of suspension thixotropic agent, 5 to 10 parts of antifreezing agent, 0.1 to 0.3 part of preservative, 0.1 to 0.3 part of thickening agent, 0.1 to 0.3 part of pH regulator, 0.1 to 0.3 part of defoaming agent and 60 to 80 parts of water. Through the synergistic effect of the auxiliary agents, the storage and application stability of the preparation is guaranteed, it is also guaranteed that the effective components are evenly distributed and efficiently absorbed by weeds, the green agriculture requirement is met, and the high practical and popularization price is achieved.

The present invention relates to an oil-dispersion solid cosmetic composition and a method for preparing the same, wherein the cosmetic composition can maintain a stabilized formulation while containing caffeine, and thus can be effectively used in the manufacture of a product for improving skin elasticity.

To develop an oily cosmetic which contains a warming component and is excellent in non-stickiness, easiness in film thickness adjustment, and low stringiness. An oily cosmetic which contains the following components (A) to (D): (A) petrolatum, (B) a warming component, (C) a higher alcohol which is liquid at 25°C, and (D) a dextrin fatty acid ester.