22 results about "Dentin hypersensitivity" patented technology

The present invention pertains to the technical field of materials. Disclosed are a polymer composite hydrogel and a preparation method therefor, and a tooth desensitization material. The polymer composite hydrogel consists of a GelMA hydrogel and BP nanosheets composited inside the GelMA hydrogel, wherein the GelMA hydrogel is prepared by crosslinking gelatin methacryloyl via double bonds under the action of a photoinitiator. Under the photothermal effect, the polymer composite hydrogel of the present invention can enhance the resistance of dentin to external stimuli and promote the formation of stable and effective occlusion of dentinal tubules. Moreover, the occlusion effect on the dentinal tubules exhibits acid resistance, corrosion resistance, and stability, preventing the possibility of short-term reopening of the occluded dentinal tubules. This is of great significance for the treatment of occluded dentin hypersensitivity (DH).

The invention provides a composite Janus particle. The composite Janus particle disclosed by the invention can be used for treating the dentin hypersensitivity, not only can be accurately oriented on the surface of the dentin, but also has the effects of inducing mineralization and inhibiting bacteria on the two sides respectively, and has great application potential for treating the dentin hypersensitivity and preventing decayed teeth.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

The invention discloses a buccal element as well as a preparation method and application thereof, and belongs to the technical field of oral cleaning supplies. The method comprises the following steps: firstly, adding 2.8 to 3.5 parts of glacial acetic acid, 0.005 to 0.015 part of sodium benzoate, 0.005 to 0.015 part of sodium cyclamate, 0.08 to 0.12 part of lactic acid and 0.04 to 0.06 part of citric acid into 100 parts of water, and mixing to form acetic acid mother liquor; then, putting 3.7-4.6 parts of sodium bicarbonate and 0.08-0.12 part of calcium carbonate into a container, adding the acetic acid mother solution into the container, and stirring to form a mixed solution; adjusting the pH value of the mixed solution to 6.8-7.2, then sequentially adding 0.08-0.12 part by weight of lovastatin, 0.02-0.04 part by weight of peppermint water and 0.08-0.12 part by weight of a clove extracting solution, and uniformly stirring, so as to obtain the traditional Chinese medicine composition. The method disclosed by the invention is simple, and the prepared buccal essence is non-toxic and non-irritant, is high in decayed tooth inhibition rate and can quickly relieve decayed tooth pain and dentin hypersensitivity.

A composition for treating dentin hypersensitivity, comprising: a first component comprising: (i) a first rheology modifying polymer; (ii) a calcium ion source; (iii) a positively charged basic amino acid; and (iv) an acidifying agent, wherein the first component has a pH in the range of about 2.0 to about 7.0; a second component comprising: (i) a second rheology modifying polymer; (ii) a phosphate ion source; and (iii) an alkalizing agent, wherein the second component has a pH in the range of about 7.0 to about 14.0; wherein the first component and the second component are combined into a mixture such that a cationic amorphous calcium phosphate gel composition is created instantly when the pH of the mixture reaches a pH range of about 7.0 to about 9.5.

This invention discloses a highly antibacterial oral sealant for treating dentin hypersensitivity, its preparation method, and its application. The sealant's raw materials include calcium oxalate, diammonium hydrogen phosphate, tetraethyl orthosilicate, and cerium nitrate hexahydrate. It is a bioactive material that can generate hydroxyapatite in a short time and exhibits good biocompatibility. This sealant regulates and stabilizes Ce... 3+ Ce 4+ The ratio of these components results in high antibacterial properties, making it suitable for use as an oral sealant. It primarily works by sealing the gaps between the pits and fissures of teeth to block bacterial invasion, thereby improving the acid resistance of tooth enamel and preventing cavities. At the same time, this material has good bactericidal properties, allowing for deeper bacterial removal and ensuring a clean oral environment.

One method embodiment disclosed herein occludes exposed openings of dentin tubules. The method includes applying a debriding gel formulation to a surface of a tooth in order to coagulate and detach organic material from a surface of a dentin tubule opening, forming a debrided area. The method also includes rinsing the debriding gel formulation from the debrided area and at least partially drying the debrided area to form a dried debrided area. The method further includes applying an occluding gel formulation to the dried debrided area to form occluded tubules and rinsing the occluding gel from the occluded tubules. Both the debriding gel formulation and occluding gel include water. The water concentration in the debriding gel is about 10% to 30% of the water concentration of the occluding gel.

To provide a dentin hypersensitivity-suppressing composition enabling easy retention on a tooth surface.SOLUTION: The dentin hypersensitivity-suppressing composition comprises, based on the composition, 0.3 mass% or more and 5.0 mass% or less of aluminum lactate, 3.0 mass% or more and 6.5 mass% or less of a polymer containing a carboxyl group, and 0.05 mass% or more and 7.0 mass% or less of a chelating agent.SELECTED DRAWING: None

The invention provides a toothpaste composition with tooth strengthening and strengthening effects as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The toothpaste composition comprises active components and auxiliary materials, wherein the active components comprise halite, gypsum, fructus psoraleae, pepper, radix angelicae, mint, eclipta alba, divaricate saposhnikovia root, asarum, radix aconiti lateralis praeparata and compound probiotic freeze-dried powder; the compound probiotic freeze-dried powder consists of kluyveromyces marxianus freeze-dried powder and lactobacillus salivarius freeze-dried powder; the auxiliary material comprises a compound bacteriostatic agent; the compound bacteriostatic agent is prepared from chamomile blue and a tussilago farfara extract. The toothpaste composition prepared by respectively extracting the raw materials through a specific preparation method is not only good in stability, but also capable of remarkably improving various inflammations and bleeding of periodontal diseases, improving the tooth health problem of users with dentin sensitivity and meeting the requirements of various users.

The invention discloses an integrated measuring system for evaluating the curative effect of dentin hypersensitivity. The integrated measuring system comprises a first applying module, a second applying module and a third applying module, the application force of the tactile stimulus is incremented at a preset gradient, and recording a tactile threshold of the patient representing an uncomfortable time; the second applying module applies cold air stimulation to the teeth of the patient; the temperature and the pressure of the cold air stimulation are controlled within a preset range, and the reaction score of the patient according to the Schiff cold air sensitivity scale is recorded; the association module associates the touch threshold with the reaction score to obtain comprehensive evaluation data; the acquisition module takes an initial touch threshold value and an initial reaction score obtained by measuring teeth of a patient for the first time or before treatment as baseline data; and the evaluation module obtains an evaluation result of the curative effect of the dentin hypersensitivity according to the comprehensive evaluation data and the baseline data. By simultaneously applying tactile stimulation and cold air stimulation, the one-sidedness of single stimulation evaluation is avoided, and the accuracy of evaluation of the curative effect of dentin hypersensitivity is improved.

The invention discloses application of L-theanine and a composite material thereof in preparation of a product for preventing and treating dentin hypersensitivity, and belongs to the technical field of biological medicines. The invention discloses application of L-theanine and a composite material thereof in preparation of a product for preventing and treating dentin hypersensitivity on the first aspect. On the second aspect, the invention discloses a product for preventing and treating dentin hypersensitivity. The product comprises L-theanine or / and a composite material thereof and a pharmaceutically acceptable carrier. The invention discloses a product for preventing and treating dentin hypersensitivity on the third aspect. The product comprises a medical device with a coating on the surface, the coating comprises L-theanine or / and a composite material of the L-theanine. The L-theanine is found to have the effects of mineralizing and sealing dentinal tubules and reducing nervous excitability of dental pulp for the first time, and the L-theanine is used for preventing and treating dentin hypersensitivity and has an exact effect.

The invention discloses composite hydrogel for treating dentin hypersensitivity and a preparation method of the composite hydrogel, and belongs to the field of biomedical materials. The composite hydrogel comprises bioactive glass, gel network composition molecules and water. The composite hydrogel disclosed by the invention has good biocompatibility and can reside in an oral environment for a long time; the excellent induced mineralization characteristic of bioactive glass is reserved, and dentinal tubules can be effectively sealed within 24 hours, so that dentin hypersensitivity is remarkably relieved; the dentin hypersensitivity inhibitor has good plasticity and stability, can be customized according to specific requirements of different patients, is expected to be developed into a novel dentin hypersensitivity treatment medicine, and shows extremely high commercial application potential and value.

This invention belongs to the field of biomaterials technology, specifically an antibacterial magnesium and strontium-reinforced bioactive glass ceramic and its applications. Its composition, by weight percentage, is as follows: SiO2: 30-50; P2O5: 5-20; CaO: 10-35; Na2O: 10-20; SrO: 5-20; MgO: 2-10; ZnO: 5-15; B2O3: 0-10; K2O: 3-10; CuO: 0.05-5; F: 1.5-5; Ag: 0.05-0.9. It possesses good biocompatibility, is non-toxic and harmless to the human body, and effectively inhibits and kills bacteria. It can be used as a special additive in oral care products such as toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum, promoting tooth surface mineralization and reducing dentin hypersensitivity during the teeth cleaning process.

The present invention provides a composition useful for reducing dentin hypersensitivity, alleviating periodontitis, inhibiting halitosis, and promoting gingival recovery, the oral composition having an effect of inhibiting tooth sensitivity, improving periodontitis (decayed tooth), and can be effectively used in oral hygiene-related fields since it has an excellent effect of inhibiting halitosis.

The present invention relates to a particle composition comprising XRD amorphous calcium magnesium phosphate particles and a method for manufacturing such a composition. The XRD amorphous calcium magnesium phosphate particles are spherical particles with a hollow core. The particle-containing paste may be used in dental products such as toothpaste to treat dentin hypersensitivity by mineralizing and occluding exposed dentin tubules.

This invention relates to a pharmaceutical composition for reducing dentin hypersensitivity and its preparation method, belonging to the field of biomedical technology. The pharmaceutical composition includes *Candida chinensis* extract, *Candida pubescens* leaf extract, eggshell membrane protein peptides, and *Bifidobacterium thermophilum* fermentation extract. The *Candida chinensis* extract is obtained by sequentially hydrolyzing *Candida chinensis* with a complex enzyme, ginger protease, and serrata peptides, followed by purification of the hydrolysate using an AB-8 macroporous resin column. The *Candida pubescens* leaf extract is obtained by ultrasonic extraction of *Candida pubescens* leaves with an ethanol-water solution, followed by purification of the extract using a composite packing adsorption column. The eggshell membrane protein peptides are obtained by co-hydrolyzing the eggshell membrane with ginger protease and fig protease, followed by purification of the hydrolysate using a G-25 dextran gel column. The *Bifidobacterium thermophilum* fermentation extract is obtained by purifying the fermentation broth of *Bifidobacterium thermophilum* using an SP agarose gel FF column. The components are combined in specific proportions for synergistic effects, achieving multi-functional and safe relief of dentin hypersensitivity.

This invention relates to the field of oral care, and particularly to an anti-dentin hypersensitivity mineralizing solution, its preparation method, and its application. The anti-dentin hypersensitivity mineralizing solution provided by this invention, on the one hand, due to the ultra-small size of the ions and ion clusters in the solution and its fluidity, ensures effective diffusion into the dentinal tubules after being coated on the dentin surface; on the other hand, when the mineralizing solution comes into contact with saliva or bodily fluids, it produces a biocompatible mineral—strontium-containing calcium phosphate stable by polyphosphate—which can block exposed dentinal tubules; moreover, the introduced strontium ions can passivate the nerve conduction of external stimuli, thereby alleviating the symptoms of tooth sensitivity; polyphosphate also provides certain antibacterial properties; strontium ions and polyphosphate can jointly regulate the mineralization properties of the mineralizing solution. Therefore, the anti-dentin hypersensitivity mineralizing solution provided by this invention can effectively prevent and treat dentin hypersensitivity and other symptoms related to tooth demineralization.

The invention relates to a composition comprising galangin, oleic acid and adenosine. Said composition can be used as an oral care composition or as a medicament for use in the prevention from or treatment of a disease or symptoms of a disease in a subject, e.g. dentin hypersensitivity, periodontitis and / or gingivitis.

The present specification discloses a stabilized liquid composition of a peptide comprising an amino acid sequence represented by SEQ ID NO: 1. In particular, the present invention provides a composition that exhibits improved storage stability and handleability through adjustment of a pH range so that purity and the content of related substances meet the standards even under refrigerated and room-temperature conditions in a liquid state. Such a liquid composition is applied as a cosmetic, a quasi-drug, or a pharmaceutical product, and thus can provide a long-term shelf life while maintaining the original functionality of peptides for treating dentin hypersensitivity.

The present invention relates to compositions for use in oral care and various methods of their use. In particular, it relates to compositions comprising phosphoproteins and their use in the treatment and prevention of dentine hypersensitivity and the treatment and prevention of xerostomia. Preferred compositions comprise osteopontin and derivatives thereof.

The invention discloses composite hydrogel, a preparation method thereof and a tooth desensitization material, and belongs to the technical field of hydrogel materials. The composite hydrogel is prepared from a black phosphorus (BP) nanosheet and a polyethylene glycol-block-poly (L-methionine)-block-poly (L-lysine) hydrogel, wherein the surface of the black phosphorus nanosheet is coated with the polyethylene glycol-block-poly (L-methionine)-block-poly (L-lysine) hydrogel. As a tooth desensitization material, the composite hydrogel can efficiently and stably close exposed dentinal tubules accompanied by dentin hypersensitivity (DH) and promote the biomineralization function of teeth, so that the problems that the DH open dentinal tubules are low in closing rate and insufficient in immediate effectiveness and long-term stability are solved.

The invention discloses composite hydrogel for treating dentin hypersensitivity and a preparation method of the composite hydrogel, and belongs to the field of biomedical materials. The composite hydrogel comprises bioactive glass, gel network composition molecules and water. The composite hydrogel disclosed by the invention has good biocompatibility and can reside in an oral environment for a long time; the excellent induced mineralization characteristic of bioactive glass is reserved, and dentinal tubules can be effectively sealed within 24 hours, so that dentin hypersensitivity is remarkably relieved; the dentin hypersensitivity inhibitor has good plasticity and stability, can be customized according to specific requirements of different patients, is expected to be developed into a novel dentin hypersensitivity treatment medicine, and shows extremely high commercial application potential and value.