36 results about "Dentin hypersensitivity" patented technology

The present invention pertains to the technical field of materials. Disclosed are a polymer composite hydrogel and a preparation method therefor, and a tooth desensitization material. The polymer composite hydrogel consists of a GelMA hydrogel and BP nanosheets composited inside the GelMA hydrogel, wherein the GelMA hydrogel is prepared by crosslinking gelatin methacryloyl via double bonds under the action of a photoinitiator. Under the photothermal effect, the polymer composite hydrogel of the present invention can enhance the resistance of dentin to external stimuli and promote the formation of stable and effective occlusion of dentinal tubules. Moreover, the occlusion effect on the dentinal tubules exhibits acid resistance, corrosion resistance, and stability, preventing the possibility of short-term reopening of the occluded dentinal tubules. This is of great significance for the treatment of occluded dentin hypersensitivity (DH).

The invention provides a composite Janus particle. The composite Janus particle disclosed by the invention can be used for treating the dentin hypersensitivity, not only can be accurately oriented on the surface of the dentin, but also has the effects of inducing mineralization and inhibiting bacteria on the two sides respectively, and has great application potential for treating the dentin hypersensitivity and preventing decayed teeth.

The invention discloses a surface-modified bioactive glass tooth desensitizer as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: sequentially adding prepared MBG nanoparticles and dopamine hydrochloride into a Tris-HCI buffer solution, stirring at room temperature, centrifuging, collecting a product, washing, taking precipitate, adding deionized water, carrying out ultrasonic dispersion, dissolving gelatin into the deionized water, mixing with an MBG (at) PDA solution, stirring, centrifuging, collecting a product, washing, and carrying out vacuum freeze drying to obtain MBG (at) PDA (at) Gel powder. The medicine provided by the invention is a medicine for treating dentin hypersensitivity more safely and lastingly, so that generated mineral substances are tightly combined with dentin tubule walls, and long-acting dentin desensitization is realized by resisting a complex oral environment.

The invention relates to a bioactive glass material, an oral care composition, toothpaste and a preparation method thereof. The bioactive glass material belongs to a Na2O-CaO-SiO2-P2O5 system and is prepared from the following components in percentage by weight: 40 to 60 percent of SiO2, 1 to 10 percent of P2O5, 18 to 30 percent of CaO and 10 to 30 percent of Na2O. An X-ray diffraction pattern of the bioactive glass material comprises diffraction peaks with the following 2 theta angle values: 33.6 + / -0.2 degrees and 34.2 + / -0.2 degrees. The bioactive glass material provided by the invention has a special crystal structure, elements such as calcium, phosphorus, silicon and the like can be dissolved out more quickly, a silica glass network and hydroxyapatite are generated, the bioactive glass material can react with the tooth surface more quickly, remineralization of the dentin surface is realized, and the effect of relieving or treating dentin hypersensitivity is achieved.

A complex for blocking dentinal tubules, characterized in that the complex is formed by means of polymerizing catecholamine and metal ions. The catecholamine comprises one or more of dopamine, norepinephrine, tannic acid, gallic acid, phlorotannins, phloroglucinol monomers and epigallocatechin gallate; and the metal ions comprise one or more of V 2+, Cr 2+, Cr 3+, Mn 2+, Mn 3+, Fe 2+, Fe 3+, Co 2+, Ni 2+, Cu 2+ and Sr 2+. A reagent for treating dentin allergy comprises the complex for blocking dentinal tubules, can block nearly 85% of dentinal tubules within 3 minutes, and can form a crystal structure similar to hydroxyapatite after being mineralized in vitro for 7 days. In addition, in 7-day animal experiments with SD rats, results consistent with in-vitro mineralization experiments are also observed. Moreover, the complex can not only be rapidly prepared, but also has antibacterial ability against pathogenic bacteria of dental caries, and also has good biocompatibility.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

An aqueous dentifrice formulation, comprising: a bioactive glass exhibiting at least one of: a hydrolytic resistance of glass grains (HGB) of at most 4, when measured by International Organization for Standardization section 719 (ISO 719); a weight loss of 5 wt. % or less after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; an XRD spectrum substantially free of crystalline phase after soaking 5 g of the bioactive glass in powder form in 100 mL of deionized water for 7 days at 37° C.; or any combination thereof; wherein, when the bioactive glass is contacted with artificial saliva, the bioactive glass forms a bioactive crystalline phase. A method of using the aqueous dentifrice formulation to remineralize enamel of the tooth, treat caries of the tooth, treat dentin hypersensitivity of the tooth, or any combination thereof.

The invention discloses a buccal element as well as a preparation method and application thereof, and belongs to the technical field of oral cleaning supplies. The method comprises the following steps: firstly, adding 2.8 to 3.5 parts of glacial acetic acid, 0.005 to 0.015 part of sodium benzoate, 0.005 to 0.015 part of sodium cyclamate, 0.08 to 0.12 part of lactic acid and 0.04 to 0.06 part of citric acid into 100 parts of water, and mixing to form acetic acid mother liquor; then, putting 3.7-4.6 parts of sodium bicarbonate and 0.08-0.12 part of calcium carbonate into a container, adding the acetic acid mother solution into the container, and stirring to form a mixed solution; adjusting the pH value of the mixed solution to 6.8-7.2, then sequentially adding 0.08-0.12 part by weight of lovastatin, 0.02-0.04 part by weight of peppermint water and 0.08-0.12 part by weight of a clove extracting solution, and uniformly stirring, so as to obtain the traditional Chinese medicine composition. The method disclosed by the invention is simple, and the prepared buccal essence is non-toxic and non-irritant, is high in decayed tooth inhibition rate and can quickly relieve decayed tooth pain and dentin hypersensitivity.

A composition for treating dentin hypersensitivity, comprising: a first component comprising: (i) a first rheology modifying polymer; (ii) a calcium ion source; (iii) a positively charged basic amino acid; and (iv) an acidifying agent, wherein the first component has a pH in the range of about 2.0 to about 7.0; a second component comprising: (i) a second rheology modifying polymer; (ii) a phosphate ion source; and (iii) an alkalizing agent, wherein the second component has a pH in the range of about 7.0 to about 14.0; wherein the first component and the second component are combined into a mixture such that a cationic amorphous calcium phosphate gel composition is created instantly when the pH of the mixture reaches a pH range of about 7.0 to about 9.5.

The invention relates to the field of oral care, in particular to toothpaste capable of resisting dentin hypersensitivity, a preparation method of the toothpaste and a method for resisting dentin hypersensitivity. The dentin hypersensitivity-resistant toothpaste comprises an extrusion container, a first paste body and a second paste body, the extrusion container comprises: a container body; the container body comprises at least two sub-chambers along the extension direction of the container body, and the first paste body and the second paste body are respectively accommodated in one sub-chamber; the first paste body comprises bioactive glass; and the second paste body comprises water. When in use, the first paste body and the second paste body are contacted and mixed, the bioactive glass is rapidly activated by water to release activity, and the activated bioactive glass can block exposed dentin in a targeted mineralization manner, so that the problem of dentin sensitivity is fundamentally improved.

This invention discloses a highly antibacterial oral sealant for treating dentin hypersensitivity, its preparation method, and its application. The sealant's raw materials include calcium oxalate, diammonium hydrogen phosphate, tetraethyl orthosilicate, and cerium nitrate hexahydrate. It is a bioactive material that can generate hydroxyapatite in a short time and exhibits good biocompatibility. This sealant regulates and stabilizes Ce... 3+ Ce 4+ The ratio of these components results in high antibacterial properties, making it suitable for use as an oral sealant. It primarily works by sealing the gaps between the pits and fissures of teeth to block bacterial invasion, thereby improving the acid resistance of tooth enamel and preventing cavities. At the same time, this material has good bactericidal properties, allowing for deeper bacterial removal and ensuring a clean oral environment.

The present disclosure relates to a composition for occluding dentinal tubules and an oral product including the same, and more specifically, to a composition that has excellent dentinal tubule-occluding ability and is capable of preventing or alleviating dentin hypersensitivity.

One method embodiment disclosed herein occludes exposed openings of dentin tubules. The method includes applying a debriding gel formulation to a surface of a tooth in order to coagulate and detach organic material from a surface of a dentin tubule opening, forming a debrided area. The method also includes rinsing the debriding gel formulation from the debrided area and at least partially drying the debrided area to form a dried debrided area. The method further includes applying an occluding gel formulation to the dried debrided area to form occluded tubules and rinsing the occluding gel from the occluded tubules. Both the debriding gel formulation and occluding gel include water. The water concentration in the debriding gel is about 10% to 30% of the water concentration of the occluding gel.

To provide a dentin hypersensitivity-suppressing composition enabling easy retention on a tooth surface.SOLUTION: The dentin hypersensitivity-suppressing composition comprises, based on the composition, 0.3 mass% or more and 5.0 mass% or less of aluminum lactate, 3.0 mass% or more and 6.5 mass% or less of a polymer containing a carboxyl group, and 0.05 mass% or more and 7.0 mass% or less of a chelating agent.SELECTED DRAWING: None

The invention provides a toothpaste composition with tooth strengthening and strengthening effects as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The toothpaste composition comprises active components and auxiliary materials, wherein the active components comprise halite, gypsum, fructus psoraleae, pepper, radix angelicae, mint, eclipta alba, divaricate saposhnikovia root, asarum, radix aconiti lateralis praeparata and compound probiotic freeze-dried powder; the compound probiotic freeze-dried powder consists of kluyveromyces marxianus freeze-dried powder and lactobacillus salivarius freeze-dried powder; the auxiliary material comprises a compound bacteriostatic agent; the compound bacteriostatic agent is prepared from chamomile blue and a tussilago farfara extract. The toothpaste composition prepared by respectively extracting the raw materials through a specific preparation method is not only good in stability, but also capable of remarkably improving various inflammations and bleeding of periodontal diseases, improving the tooth health problem of users with dentin sensitivity and meeting the requirements of various users.

The invention discloses an integrated measuring system for evaluating the curative effect of dentin hypersensitivity. The integrated measuring system comprises a first applying module, a second applying module and a third applying module, the application force of the tactile stimulus is incremented at a preset gradient, and recording a tactile threshold of the patient representing an uncomfortable time; the second applying module applies cold air stimulation to the teeth of the patient; the temperature and the pressure of the cold air stimulation are controlled within a preset range, and the reaction score of the patient according to the Schiff cold air sensitivity scale is recorded; the association module associates the touch threshold with the reaction score to obtain comprehensive evaluation data; the acquisition module takes an initial touch threshold value and an initial reaction score obtained by measuring teeth of a patient for the first time or before treatment as baseline data; and the evaluation module obtains an evaluation result of the curative effect of the dentin hypersensitivity according to the comprehensive evaluation data and the baseline data. By simultaneously applying tactile stimulation and cold air stimulation, the one-sidedness of single stimulation evaluation is avoided, and the accuracy of evaluation of the curative effect of dentin hypersensitivity is improved.

A gel composition comprising immediate formation of cationic amorphous calcium phosphate (ACP) for the treatment of dentin hypersensitivity, methods of using the composition, and systems for making the gel composition.

The present invention relates to an oral composition comprising a potassium ion, a phosphate ion, an organic zinc compound, and a polyphosphate. The composition according to the present invention demonstrates excellent tooth whitening, tooth enamel strengthening, and improving dentin hypersensitivity, and thus, it can be effectively used for tooth whitening, tooth enamel strengthening, or improving, preventing, or treating dentin hypersensitivity.

The invention discloses application of L-theanine and a composite material thereof in preparation of a product for preventing and treating dentin hypersensitivity, and belongs to the technical field of biological medicines. The invention discloses application of L-theanine and a composite material thereof in preparation of a product for preventing and treating dentin hypersensitivity on the first aspect. On the second aspect, the invention discloses a product for preventing and treating dentin hypersensitivity. The product comprises L-theanine or / and a composite material thereof and a pharmaceutically acceptable carrier. The invention discloses a product for preventing and treating dentin hypersensitivity on the third aspect. The product comprises a medical device with a coating on the surface, the coating comprises L-theanine or / and a composite material of the L-theanine. The L-theanine is found to have the effects of mineralizing and sealing dentinal tubules and reducing nervous excitability of dental pulp for the first time, and the L-theanine is used for preventing and treating dentin hypersensitivity and has an exact effect.

The invention discloses composite hydrogel for treating dentin hypersensitivity and a preparation method of the composite hydrogel, and belongs to the field of biomedical materials. The composite hydrogel comprises bioactive glass, gel network composition molecules and water. The composite hydrogel disclosed by the invention has good biocompatibility and can reside in an oral environment for a long time; the excellent induced mineralization characteristic of bioactive glass is reserved, and dentinal tubules can be effectively sealed within 24 hours, so that dentin hypersensitivity is remarkably relieved; the dentin hypersensitivity inhibitor has good plasticity and stability, can be customized according to specific requirements of different patients, is expected to be developed into a novel dentin hypersensitivity treatment medicine, and shows extremely high commercial application potential and value.

The present invention relates to a cationic material for tooth desensitization, a preparation method therefor, and an application thereof, for use in solving the technical problems in the prior art of long time consumption and limited treatment effect of materials for dentin hypersensitivity. The cationic material comprises a main chain skeleton polymer and a cationic group derived on the main chain skeleton polymer, and the main chain skeleton polymer is connected to the cationic group by means of a covalent bond. The present invention can be used for preparing a drug for treating the dentin hypersensitivity.

This invention belongs to the field of biomaterials technology, specifically an antibacterial magnesium and strontium-reinforced bioactive glass ceramic and its applications. Its composition, by weight percentage, is as follows: SiO2: 30-50; P2O5: 5-20; CaO: 10-35; Na2O: 10-20; SrO: 5-20; MgO: 2-10; ZnO: 5-15; B2O3: 0-10; K2O: 3-10; CuO: 0.05-5; F: 1.5-5; Ag: 0.05-0.9. It possesses good biocompatibility, is non-toxic and harmless to the human body, and effectively inhibits and kills bacteria. It can be used as a special additive in oral care products such as toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum, promoting tooth surface mineralization and reducing dentin hypersensitivity during the teeth cleaning process.

The present invention provides a composition useful for reducing dentin hypersensitivity, alleviating periodontitis, inhibiting halitosis, and promoting gingival recovery, the oral composition having an effect of inhibiting tooth sensitivity, improving periodontitis (decayed tooth), and can be effectively used in oral hygiene-related fields since it has an excellent effect of inhibiting halitosis.

The invention provides a bionic remineralized polypeptide and a preparation method and application thereof, and relates to the technical field of polypeptides, the bionic remineralized polypeptide comprises at least one of a first peptide chain, a second peptide chain and a third peptide chain; the amino acid sequence of the first peptide chain is as shown in SEQ ID NO. 1; the amino acid sequence of the second peptide chain is as shown in SEQ ID NO. 2; and the amino acid sequence of the third peptide chain is as shown in SEQ ID NO.3. The biomimetic remineralized polypeptide is adopted, the biomimetic remineralized polypeptide has the advantages of being small in molecular weight, low in cost, easy to synthesize, good in biocompatibility and the like, the modified polypeptide improves the adsorption capacity of mother peptide to type I collagen, a calcium-phosphorus solution can be stabilized, an amorphous mineralized precursor can be formed, remineralization of demineralized dentin can be promoted, and the biomimetic remineralized dentin is obtained. The oligopeptide disclosed by the invention is convenient to synthesize, relatively low in cost and good in remineralization effect, and provides an ideal new way for preventing and treating caries and dentin hypersensitivity.

The invention relates to the field of oral care products, and particularly discloses a preparation method of whitening and antiallergic toothpaste which comprises the following raw materials: deionized water, an abrasive, a traditional Chinese medicine extract, sodium phytate, a microcapsule desensitizer, torreya grandis seed oil, sorbitol, cocamidopropyl betaine, xanthan gum and sodium carboxymethyl cellulose. The preparation method comprises the following steps: mixing the xanthan gum, the sodium carboxymethyl cellulose, the sorbitol and the deionized water, stirring and dispersing, then adding the abrasive, the sodium phytate and the cocamidopropyl betaine, stirring and dispersing in vacuum, finally adding the traditional Chinese medicine extract, the microcapsule desensitizer and the torreya grandis seed oil, continuously stirring and dispersing, and vacuumizing, discharging and filling in a vacuum state. The whitening and antiallergic toothpaste is obtained. The whitening anti-allergic toothpaste prepared by the invention is proper in friction value, excellent in tooth stain and dental plaque removal effect, remarkable in tooth whitening effect, capable of solving the problem of dentin hypersensitivity in multiple aspects and remarkable in anti-allergic effect.

The present invention relates to a particle composition comprising XRD amorphous calcium magnesium phosphate particles and a method for manufacturing such a composition. The XRD amorphous calcium magnesium phosphate particles are spherical particles with a hollow core. The particle-containing paste may be used in dental products such as toothpaste to treat dentin hypersensitivity by mineralizing and occluding exposed dentin tubules.

This invention relates to a pharmaceutical composition for reducing dentin hypersensitivity and its preparation method, belonging to the field of biomedical technology. The pharmaceutical composition includes *Candida chinensis* extract, *Candida pubescens* leaf extract, eggshell membrane protein peptides, and *Bifidobacterium thermophilum* fermentation extract. The *Candida chinensis* extract is obtained by sequentially hydrolyzing *Candida chinensis* with a complex enzyme, ginger protease, and serrata peptides, followed by purification of the hydrolysate using an AB-8 macroporous resin column. The *Candida pubescens* leaf extract is obtained by ultrasonic extraction of *Candida pubescens* leaves with an ethanol-water solution, followed by purification of the extract using a composite packing adsorption column. The eggshell membrane protein peptides are obtained by co-hydrolyzing the eggshell membrane with ginger protease and fig protease, followed by purification of the hydrolysate using a G-25 dextran gel column. The *Bifidobacterium thermophilum* fermentation extract is obtained by purifying the fermentation broth of *Bifidobacterium thermophilum* using an SP agarose gel FF column. The components are combined in specific proportions for synergistic effects, achieving multi-functional and safe relief of dentin hypersensitivity.

This invention relates to the field of oral care, and particularly to an anti-dentin hypersensitivity mineralizing solution, its preparation method, and its application. The anti-dentin hypersensitivity mineralizing solution provided by this invention, on the one hand, due to the ultra-small size of the ions and ion clusters in the solution and its fluidity, ensures effective diffusion into the dentinal tubules after being coated on the dentin surface; on the other hand, when the mineralizing solution comes into contact with saliva or bodily fluids, it produces a biocompatible mineral—strontium-containing calcium phosphate stable by polyphosphate—which can block exposed dentinal tubules; moreover, the introduced strontium ions can passivate the nerve conduction of external stimuli, thereby alleviating the symptoms of tooth sensitivity; polyphosphate also provides certain antibacterial properties; strontium ions and polyphosphate can jointly regulate the mineralization properties of the mineralizing solution. Therefore, the anti-dentin hypersensitivity mineralizing solution provided by this invention can effectively prevent and treat dentin hypersensitivity and other symptoms related to tooth demineralization.

The present invention relates to a cationic material having a tooth desensitizing effect, which is formed by covalently bonding a main chain skeleton polymer and a cationic group derived therefrom, and a method for producing the same and its application, and solves the problems that the treatment of dentin hypersensitivity using materials in the prior art takes time and has limited therapeutic effect. The present invention is useful for the production of a therapeutic drug for dentin hypersensitivity.

The invention discloses an oral care composition for resisting dentin hypersensitivity and a preparation method thereof, the oral care composition comprises an anti-allergy agent, and the anti-allergy agent comprises sylvite, fluoride, a hydroxyapatite growth promoter and anti-allergy silicon dioxide. According to the oral care composition and the preparation method thereof, the multiple and efficient oral care composition capable of resisting dentin hypersensitivity and the preparation method of the oral care composition can be provided.