47 results about "Dentin hypersensitivity" patented technology

New oral rinse solutions and mouthwashes are provided. The oral rinse solutions comprise essential oil and alcohol, supplemented with hydrogen peroxide, and natural extracts. The essential oil and / or alcohol can be provided as part of a base composition. The most preferred base compositions are antiseptic mouthwashes containing the essential oil and / or alcohol. Alternatively, the ingredients can be individually added to the inventive composition. The oral rinse solutions provide antimicrobial activity while soothing oral inflammations and irritations, thus being useful for treating, alleviating, and promoting healing of a wide variety of oral ailments such as periodontal disease (gingivitis and periodontitis), plaque, oral inflammation, toothaches, oral ulcerations, dry socket, dentin hypersensitivity, and halitosis, as well as address aesthetic issues such as bad breath and tooth discoloration.

The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.

The purpose of the present invention is to provide a sole component that can exhibit a function as an oral composition, such as the prevention of dentinal caries, the prevention or amelioration of dentin hypersensitivity, the inhibition of the formation of stains, the removal of stains or the like, or a combination of two or more of such components. The present invention provides an oral composition containing a component (A) which is a compound having at least one lactam skeleton selected from the group consisting of a gamma-lactam skeleton, a delta-lactam skeleton and an epsilon-lactam skeleton and also having an acidic group and / or a salt of the compound.

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

The invention discloses a desensitizer for treating dentin hypersensitivity and a preparation method thereof. The desensitizer is prepared from two parts: solid powder and dispersion liquid. Before use, the solid powder and the dispersion liquid are separately packaged, when in use, the solid powder and the dispersion liquid are mixed, and after the solid powder and the dispersion liquid are mixed uniformly, paste is formed and coated on an exposed dentin surface; the solid powder is made of micro-nano bioactive glass beads of a Si-Ca-P ternary system; the dispersion is sodium alginate-phosphate buffer solution. The preparation process of the desensitizer comprises preparation of the micro-nano bioactive glass beads of the Si-Ca-P ternary system and preparation of the sodium alginate-phosphate buffer solution. The desensitizer disclosed by the invention can effectively block and seal up a dentin tubule, induces to form a reparative dentin layer, is high in response speed, does not influence tooth attraction, and can be used as a desensitization material for dentin hypersensitivity; meanwhile, the preparation method disclosed by the invention is simple in process, does not require complex equipment, and is mild in preparation condition and easy to popularize.

The invention discloses an oral desensitization paste and a preparation method thereof. The oral desensitization paste comprises, by weight, 50-60 parts of calcium powder, 0.8-1.5 parts of silica, 0.8-1.5 parts of carboxymethyl cellulose, 4-5.5 parts of strontium chloride, 10-15 parts of potassium nitrate, 10-15 parts of fluoride, 0.5-1 part of gel, 2-6.5 parts of sodium dodecyl sulfate and 0.8-1.5 parts of an essence. The preparation method comprises the following steps: respectively preparing an oil phase and a water phase, adding the oil phase to the water phase, mixing and stirring the oil phase and the water phase, adding the essence, and uniformly stirring above substances to prepare the oral desensitization paste. The oral desensitization paste has the advantages of good desensitization effect, high treatment effectiveness, long effective time duration, good bacterium inhibiting and killing effects, and prevention of dentin hypersensitivity.

A dental composition for the treatment of dentinal hypersensitivity and in particular for the desensitization of exposed dentin, the desensitizing treatment of deep cavities, the desensitizing treatment when replacing dental layers, the stumps desensitizing treatment before placing dental prosthesis. The composition can be used as a solution or as a gel. In the first case two distinct liquid solutions for use successively on the exposed dentin are provided for. In the second case two distinct gel compounds spread successively on the exposed dentin are provided for. The first solution or the first gel compound comprises preferably three soluble potassium salts, whereas the second solution or the second gel compound comprises a calcium salt and a soluble strontium salt. In a preferred composition two solutions are provided for of which the first has solutes comprising potassium phosphate, potassium carbonate and potassium fluoride, and the second solution has solutes comprising calcium chloride and strontium chloride. For the gel composition, which may be used as toothpaste, two distinct gel compounds are provided, the first having solutes comprising potassium phosphate, potassium carbonate and potassium fluoride and the second gel compound having solutes comprising calcium chloride and strontium chloride.

The present invention discloses a desensitizing toothpaste. Based on the total weight of the desensitizing toothpaste, the desensitizing toothpaste includes: from 5% to 40% by weight of DP-bioglass; from 1% to 5% by weight of thickening agents; from 25% to 35% by weight of humectant; and from 1% to 5% by weight of surfactant, wherein the DP-bioglass includes: 8.4% of Na2O, 40.6% of CaO, 39% of SiO2, and 12% of P2O5 based on the total weight of the DP-bioglass. With the implementation of the present invention, the indication of dentin hypersensitivity can be greatly relieved.

The invention relates to sushuang (a brand) bioactivity mineral powder as well as a preparation method and application of the sushuang bioactivity mineral powder, and aims at solving the problems of unsatisfactory effect, tooth injury, high price and inconvenience for use in the conventional method for preventing decayed teeth and treating dentin hypersensitivity. The mineral powder is prepared by part or all of the following components: 35-55 parts of SiO2, 10-30 parts of CaO, 0.1-35 parts of K2O, 3-8 parts of P2O5, 0-20 parts of CaF2 and 0-30 parts of Na2O. The preparation method comprises the following steps of: melting the components at the temperature of 1350 DEG C, cooling, dewatering, and grinding. The mineral powder serves as an active constituent to be used for treating tooth and periodontal diseases to promote bone growth, and is convenient to use, good in treatment effect and moderate in price.

The invention relates to a tooth desensitizer as well as a preparation method and application thereof. The tooth desensitizer provided by the invention is a powdery composite material, and comprises silicon dioxide nano-particles and bioactive glass layers coated on the surfaces of the mesoporous silicon dioxide nano-particles through fusion. The preparation method for the tooth desensitizer comprises the following steps: (1), providing the silicon dioxide nano-particles; (2), providing bioactive glass, heating the bioactive glass till the bioactive glass is fused; (3), immersing the silicon dioxide nano-particles into the fused bioactive glass to enable the surfaces of the silicon dioxide nano-particles to be coated with the bioactive glass; (4), cooling the silicon dioxide nano-particles coated with the bioactive glass on the surfaces, so as to form the powdery tooth desensitizer. The powdery tooth desensitizer provided by the invention can be mixed with water into a plaster, and can be coated on surfaces of teeth having a dentin hypersensitivity symptom to seal dentinal tubules relatively deep, so that external stimulation in the oral cavity can be isolated, and the effect of curing the dentin hypersensitivity can be achieved.

The invention provides a dental self-acid etching adhesive with a remineralization effect, and a preparation method thereof. The dental self-acid etching adhesive comprises 8.0-10.5% of a resin matrix, 5-7% of an acid releasing agent, 0.7-1.2% of a photoinitiator, 2.8-4.1% of a remineralization component and the balance of auxiliary materials. According to the self-acid-etching adhesive, the remineralization component is added into the self-acid-etching adhesive and has a synergistic effect with the acid releasing agent, so that remineralization of dentin is realized on the basis of reducing dentin sensitivity, and tooth allergy caused by dentin exposure due to excessive acid etching or mechanical damage in the use process of the self-acid-etching adhesive can be avoided; meanwhile, dentin remineralization can be continuously guided for a long time, and dentin hypersensitivity can be prevented for a long time. On the one hand, the self-acid-etching adhesive does not contain fluoride, the product is safer, on the other hand, the self-acid-etching adhesive is a single-bottle self-acid-etching adhesive, the chemical stability is good, the bonding strength is high, and the ideal effect can be achieved when the self-acid-etching adhesive is used in cooperation with dental materials such as pit and fissure sealing agents.

The invention provides a bionic mineralized repairing desensitizer and a using method thereof. The bionic mineralized repairing desensitizer is characterized by comprising 1-100000 ppm dendritic macromolecule, 1%-50% of bioactive glass, 0.1%-20% of tripotassium phosphate, 1%-5% of glycerinum, 30%-70% of polyethylene glycol, 0.5%-8% of xanthan gum, 1%-10% of titanium dioxide, 0.1%-1% of essence, 0.1%-2% of sodium saccharin, 0.1%-1% of ethylparaben, and 1%-8% of lauryl sulfate. The dendritic macromolecule comprises hydroxyl-terminated, carboxyl-terminated, phosphate radical-terminated or amino-terminated 0-5-generation polyamide-amine dendritic macromolecules; and the bioactive glass comprises (CaO)x(NaO2)y(SiO2)z(P2O5)1-x-y-z, wherein x is equal to 0.25-0.45, y is equal to 0-1, and z is equal to 0.34-0.64. The invention further provides a using method of the bionic mineralized repairing desensitizer. The bionic mineralized repairing desensitizer is scraped into a medical device capableof being matched with teeth to be uniformly distributed, and is bitten in a mouth for 1 min and longer, and the medical device comprises a foam denture, a thermoplastic denture and a teeth whitening strip and the like which are seen in the market; and the fact shows that the bionic mineralized repairing desensitizer can close exposed dentin deeply for a long time, so that long-acting desensitization is realized, and the dentin hypersensitivity is relieved.

The invention discloses traditional Chinese medicinal desensitization bamboo salt chewing gum, which is prepared by the following methods: drying sea salt for later use, mixing calcined oyster, Drynaria fortunei, rehmannia glutinosa and indigo naturalis with the sea salt, adding fresh Dendrocalamus segments, and sealing with yellow mud; and calcining in a high temperature refractory kiln; and cooling to obtain traditional Chinese medicinal desensitization bamboo salt, dissolving the traditional Chinese medicinal desensitization bamboo salt in a Rhizoma coptidis extractive solution, centrifuging, collecting supernatant, adding a sweetener Neotame to remove bitter taste of Rhizoma coptidis liquid, and preparing the traditional Chinese medicinal desensitization bamboo salt chewing gum according to traditional chewing gum preparation process. The traditional Chinese medicinal desensitization bamboo salt chewing gum disclosed by the invention can not only clean oral cavity and keep mouth fresh, but also can effectively block off dentinal tubules, and treat dentin hypersensitivity; further, the traditional Chinese medicinal desensitization bamboo salt chewing gum has a distinct inhibitory effect on several common oral pathogens, and can prevent and treat dental caries and periodontitis to a certain extent.

An oral composition for reducing dentinal hypersensitivity according to the present invention comprises a phosphorylcholine-containing polymer as an active ingredient. A general consumer can use the oral composition routinely in various forms. The oral composition is brought into contact with an oral cavity of a user to reduce the dentinal hypersensitivity.

Provided is a toothpaste composition for dentin hypersensitivity that effectively prevents pain attributed to dentin hypersensitivity, instantaneously and sufficiently seals the openings of dentinal tubules in an exposed dentinal surface, and has excellent sustainability of the effect of suppressing the pain attributed to dentin hypersensitivity. The toothpaste composition for dentin hypersensitivity comprises the following components (A), (B), and (C): (A) a powder having a sparingly water-soluble property selected from a fatty acid divalent metal salt (A-1) derived from a saturated fatty acid having from 12 to 18 carbon atoms, a fatty acid acyllysine (A-2) having an acyl group derived from a saturated fatty acid having from 12 to 18 carbon atoms, and a fatty acid acyltaurine divalent metal salt (A-3) having an acyl group derived from a saturated fatty acid having from 12 to 18 carbon atoms; (B) a desensitizing agent selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate; and (C) water; in which a mass ratio ((A) / (B)) of the component (A) to the component (B) is from 0.02 to 0.5.

The invention belongs to the field of daily-use chemicals and specifically relates to an herbal multiple-effect mouthwash and its preparation method. The herbal multiple-effect mouthwash comprises the following raw materials, by weight, 10-17 parts of Chinese gall, 3-9 parts of red sage root, 10-18 parts of licorice, 5-8 parts of dahurian angelica root, 4-9 parts of radix bupleuri, 10-18 parts of sodium citrate, 12-22 parts of calcium hydrogen phosphate, 5-10 parts of sandalwood oil, 20-30 parts of ethanol and 40-60 parts of deionized water. The mouthwash provided by the invention can effectively remove residues in the oral cavity, has an excellent curative effect on dentin hypersensitivity, and can be used for diminishing inflammation, stopping bleeding and removing halitosis. The mouthwash also has excellent effects of clearing heat and relieving exterior syndrome. The mouthwash has stable performance. The preparation method of the mouthwash is simple and easy to operate, has mild conditions and is suitable for large-scale popularization and application.

The present invention relates to a composition for oral application and a method for preparing the same, more particularly, to a composition for oral application comprising a complex of specific Lewis base and specific Lewis acid, and a method for preparing the same. The composition for oral application of the present invention has excellent durability, body stability and coatibility, and thus, can effectively treat dentin hypersensitivity, and when applied before dentin hypersensitivity occurs, can prevent dentin hypersensitivity.

The invention provides tooth desensitization paste components and a preparation method, and relates to paste for treating delay sensitivity symptoms and a preparation method of the paste. The paste comprises compound galanga extractum, carboxymethyl cellulose sodium, polyoxyethylene sorbitan monoleate, glycerine, monosodium phosphate, calcium carbonate, a chlorophyll 3% aqueous solution, ethylparaben, D-sodium isoascorbiate, saccharin sodium and purified water. The tooth desensitization paste components adopt traditional Chinese medicine compatibility, have the effects of removing dirt with spices, clearing heat, removing toxicity, relieving a pain and reducing the swelling, are mild in medicinal temperament, and small in side effects, and can solve the tooth allergy fundamentally. In addition, one reason for the tooth allergy lies in that foods etch dental enamels to enable a protecting cover of a tooth to be damaged. The tooth desensitization paste components comprise calcium hydrogen phosphate and calcium carbonate, so that on one hand, the tooth desensitization paste components can be used as a pH buffering agent to neutralize acidity of the oral cavity and reduce damage to theprotecting cover, and on the other hand, natural components forming dental enamels, such as Ca and P can be released, so as to repair the protecting cover and protect the tooth at the same time.

The invention discloses an acid-resistant, wear-resistant and anticarious dentin desensitizing material and a preparation method thereof. An EGCG (epigallocatechin gallate)-loaded nano hydroxyapatite / mesoporous silicon composite material is prepared by utilizing characteristics of high biological activity and inhibition of formation of a cariogenic bacterium biofilm of EGCG, characteristics of strong adsorption, acid resistance and wear resistance of mesoporous silicon nano-particles, and characteristic of mineralization promotion of nano hydroxyapatite. The prepared composite material has the advantages of simple and convenient process, easy parameter control, stable material structure, good dispersity, uniform particle size, and high loading rate and high release rate of EGCG. The EGCG-loaded nano hydroxyapatite / mesoporous silicon composite material prepared with the preparation method provided by the invention can be used as an acid-resistant, wear-resistant and anticarious dentin desensitizing material, to effectively close dentinal tubules in treatment of dentin hypersensitivity on the one hand, and effectively inhibit the formation of the cariogenic bacterium biofilm and prevent caries diseases on the other hand.

Disclosed are compositions and methods for reducing dentin hypersensitivity. Also disclosed are compositions containing calcium fluoride nanoparticles.

The invention discloses a pharmaceutical composition for treating dentin allergy and a preparation method and application thereof. The invention belongs to the technical field of dental sclerotin regeneration. The pharmaceutical composition comprises a pharmacodynamically effective amount of amphiphilic oligopeptide, and the amphiphilic oligopeptide comprises a hydrophilic peptide and a hydrophobic tail with an amino acid sequence represented by SEQ ID No.1, and pharmaceutically acceptable pharmaceutical excipients, the oligopeptide simulating CEMP1 is used for regenerating enamel-like tissueson the surface of dentin and sealing dentinal tubules, so that the treatment of dentin allergy is improved, the self-assembled oligopeptide has very strong binding capacity to acid etching dentin, and deposition and directional growth of apatite microcrystals are promoted, so that an enamel-like structure is constructed on the surface of the dentin, then, the regenerated microcrystals are deeplydeposited in the dentin tubules, and effective blockage of the dentin tubules is ensured, therefore, the CEMP1-simulating amphiphilic oligopeptide has great application potential in the treatment on dentin hypersensitivity in the future.

The invention relates to a medical instrument for fixing dentin hypersensitivity reagents and particularly relates to a desensitization reagent fixing device for treating dentin hypersensitivity as well as a preparation method and a forming method of the fixing device. The fixing device is formed into a tooth socket shape and mainly comprises a tooth support part and a sensitive treatment region,wherein the tooth support part is formed into a stereoscopic film cavity structure matched with a whole dental arch, and an inverse concave structure is arranged at an opening of the tooth support part; and an accommodating cavity structure is preset in depth or width surface of the tooth support part in a thickness range of 0.12mm-0.28mm far away from a tooth body so as to form the sensitive treatment region. The invention aims at providing the desensitization reagent fixing device for the mass patients with dentin hypersensitivity after the radiotherapy of head and neck tumors, the patient can put desensitization reagents into a tooth body sensitive part in the device and wear the fixing device in an oral cavity, so that the convenience, accuracy, timeliness and repeatability of the patient in the use process of the desensitization reagents are improved, the problems of inconvenience, boundedness and the like of the patient in the operation process are solved, and the treatment effect of the dentin hypersensitivity is improved.

The invention belongs to the technical field of daily chemicals, and particularly relates to toothpaste with phosphosilicate glass. The toothpaste comprises the phosphosilicate glass, humectants, friction agents, binders, surfactants, sweeteners and essence. The toothpaste with the phosphosilicate glass has the advantages that the phosphosilicate glass is high in dissolution and has a stable pH (potential of hydrogen) value; the phosphosilicate glass has the quick mineralization ability in saliva in oral cavities, expression of diversified genes and formation of growth factors can be promotedby the phosphosilicate glass, accordingly, tooth wound can be repaired, dentin hypersensitivity can be relieved, and dental caries can be prevented; gingival bleeding can be inhibited, and periodontitis and the like can be relieved; oral ulcer can be prevented or treated; cementum absorption can be repaired, and effects of relieving tooth loosening and the like can be realized; tooth hypersensitivity can be prevented or treated.

The present invention relates to: composition for differentiating non-dental mesenchymal stem cells into odontoblasts comprising CPNE7 protein or gene; method for differentiating in vitro non-dental mesenchymal stem cells using the same; and also use thereof.

The invention relates to the field of oral care products, and discloses a suspension type mouthwash, which comprises the following raw materials in parts by mass: 8-20 parts of basic additives, 0.01-0.05 part of gellan gum, 0.1-1 part of potassium salt and 0.05-0.5 part of probiotics. The preparation method of the suspension type mouthwash comprises the following steps: I, adding the gellan gum, a humectant, a pH value regulator and a proper amount of water, performing uniform stirring, performing heating to completely dissolve the gellan gum, and performing cooling for later use to obtain a system I; II, uniformly stirring potassium nitrate, the probiotics, a flavoring agent, a solubilizer, a gelling agent, a preservative and a proper amount of water to form a suspension, so as to obtain a system II; and III, mixing the system I and the system II, adding essence, and performing uniform stirring to obtain the mouthwash. According to the formula of the mouthwash, potassium ions and the gellan gum have a synergistic effect; therefore, on one hand, the suspension property of the system can be improved, and uniform dispersion of the probiotics is ensured; and on the other hand, a good taste can be ensured while the dentin hypersensitivity can be relieved through synergistic interaction.

Film forming compositions and methods for occluding dentin tubules of teeth to treat dentinal hypersensitivity of the teeth are provided. The film forming compositions may include a hydrophobic copolymer, a rosin, and an orally acceptable solvent. The hydrophobic copolymer may include an acrylate / octylacrylamide copolymer, such as 2-propenoic acid, 2-methyl-, 2-methylpropyl ester, polymer with 2-propenoic acid and N-(1,1,3,3-tetramethylbutyl)-2-propenamide. Methods for treating dentinal hypersensitivity may include contacting the film forming composition with surfaces of the teeth.

The invention discloses an acid-resistant, wear-resistant and anticarious dentin desensitizing material and a preparation method thereof. An EGCG (epigallocatechin gallate)-loaded nano hydroxyapatite / mesoporous silicon composite material is prepared by utilizing characteristics of high biological activity and inhibition of formation of a cariogenic bacterium biofilm of EGCG, characteristics of strong adsorption, acid resistance and wear resistance of mesoporous silicon nano-particles, and characteristic of mineralization promotion of nano hydroxyapatite. The prepared composite material has the advantages of simple and convenient process, easy parameter control, stable material structure, good dispersity, uniform particle size, and high loading rate and high release rate of EGCG. The EGCG-loaded nano hydroxyapatite / mesoporous silicon composite material prepared with the preparation method provided by the invention can be used as an acid-resistant, wear-resistant and anticarious dentin desensitizing material, to effectively close dentinal tubules in treatment of dentin hypersensitivity on the one hand, and effectively inhibit the formation of the cariogenic bacterium biofilm and prevent caries diseases on the other hand.

The invention provides a fluorine / potassium-containing phenolic resin desensitizer which is the reaction product of the following substances: solution I: 40 wt% formalin; and solution II: 5.2g of resorcinol, 1.8g of potassium hydroxide and 5.2ml of water. The volume ratio of the solution I to the solution II is 2:1. The fluorine / potassium-containing phenolic resin desensitizer provided by the invention has excellent short-term and long-term effects for treating dentin hypersensitivity, and can be recommended for clinical application.

The invention discloses buccal tablets capable of resisting dentin hypersensitivity and a preparation method of the buccal tablets. The buccal tablets are prepared from components as follows: 8-16 mgof potassium chloride, 5-30 mg of vitamin C, 340-550 mg of sugar alcohol, 50-95 mg of lactose and 3-8 mg of stearate. The multiple components of the buccal tablets have a synergistic effect of resisting dentin hypersensitivity, so that the buccal tablets can fully play the efficacy of resisting the dentin hypersensitivity, take effect more quickly and taste good.

The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.